Epithelium-derived kallistatin promotes CD4+ T cell chemotaxis to Th2-type inflammation in chronic rhinosinusitis

Capsule summary: Kallistatin has been demonstrated to play a role in the pathogenesis of chronic rhinosinusitis with nasal polyps ( CRSwNP ) by promoting Th2 inflammation. High expression of kallistatin has been associated with the prognosis of CRSwNP and the expression of Th2-type inflammatory cytokines. Interestingly, we discovered that kallistatin deficiency alleviates type 2 inflammation in the sinonasal mucosa, especially blunt the activation of IL-4. Further investigation revealed that kallistatin may be associated with increased IL-4 expression, possibly through the Jagged2-Notch1 signaling pathway in CD4+ T cells.

Source: Journal of Allergy and Clinical Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Lijie Jiang, Haocheng Tang, Tengjiao Lin, Yifeng Jiang, Yanmei Li, Wenxiang Gao, Jie Deng, Zhaoqi Huang, Chuxin Chen, Jianbo Shi, Ti Zhou, Yinyan Lai Source Type: research