Addressing health disparities and transitions of care in eosinophilic gastrointestinal diseases
Eosinophilic gastrointestinal diseases (EGIDs) are a group of diseases characterized by gastrointestinal symptoms and pathologic tissue eosinophilia. They include eosinophilic esophagitis (EoE), eosinophilic gastritis, eosinophilic enteritis, and eosinophilic colitis. EoE is the most common EGID, and its consensus diagnostic criteria were established in 2007. Since then, the EoE diagnostic criteria have been updated, EGID nomenclature has been defined, and guidelines for the diagnosis of pediatric non-EoE EGIDs have been published. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 7, 2024 Category: Allergy & Immunology Authors: Mirna Chehade, Elizabeth T. Jensen, Benjamin L. Wright Tags: Paradigms and perspectives Source Type: research

Addressing Health Disparities and Transitions of Care in EGIDs
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 7, 2024 Category: Allergy & Immunology Authors: Mirna Chehade, Elizabeth T. Jensen, Benjamin L. Wright Source Type: research

Targeting Inhibitory Siglec-3 to Suppress IgE-Mediated Human Basophil Degranulation
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Suzanne M. Barshow, Maidul Islam, Scott Commins, Matthew S. Macauley, James C. Paulson, Michael D. Kulis Source Type: research

IgG4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant
Studies of the pathogenesis of several inborn errors of immunity (IEI) have revealed that different variants of the same gene can cause different clinical conditions, thereby paving the way for the implementation of pathway-specific treatments.1,2 (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Blanca Garc ía-Solís, María Tapia-Torres, Ana García-Soidán, Elisa Hernández-Brito, María Teresa Martínez-Saavedra, José M. Lorenzo-Salazar, Sonia García-Hernández, Ana Van Den Rym, Karan Mayani, José Vicente Govantes-Rodríguez, Adrian Gervai Tags: Brief report Source Type: research

On mentoring and being mentored —a lifetime journey and legacy
When Zuhair Ballas and the Journal of Allergy and Clinical Immunology editors asked me to write an editorial on mentoring, I was honored to be included in a series of individuals whom I view as “giants” and role models in the field—Drs Frank Austen,1 Bill Busse,2 Dean Metcalfe,3 and Kate Sullivan4—and the equally important view from the fellow/trainee perspective by Drs Ayobami Akenroye and Corinne Keet.5 My perspective on mentoring and being mentored has literally been lifelong. I was born the daughter of an allergist, my late mother, Dr Chintana Phipatanakul, who became an allergist back in 1972, when I was 3 yea...
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Wanda Phipatanakul Tags: Editorial Source Type: research

Immunoglobulin G4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Blanca Garc ía-Solís, María Tapia-Torres, Ana García-Soidán, Elisa Hernández-Brito, María Teresa Martínez-Saavedra, José M. Lorenzo Salazar, Sonia García-Hernández, Ana Van Den Rym, Karan Mayani Mayani, José Vicente Govantes-Rodríguez, Adrian Source Type: research

On Mentoring and Being Mentored- a Lifetime Journey and Legacy
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Wanda Phipatanakul Source Type: research

Monitoring and modulating the trajectory of eosinophilic esophagitis
Current treatments of eosinophilic esophagitis (EoE) aim to eliminate esophageal mucosal inflammation and attenuate, stabilize, or reverse stricture formation. However, our ability to study the long-term course of esophageal strictures in patients with EoE is hampered by the short-term existence of this disease. It is unclear to what degree of control of inflammation is needed to prevent stricture formation. Additionally, identified phenotypes of EoE may ultimately dictate different levels of concern and time intervals for developing fibrosis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Sydney F. Pomenti, Dominique D. Bailey, David A. Katzka Tags: Review article Source Type: research

Corrigendum
With regard to the article in the April 2022 issue entitled “Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome” (J Allergy Clin Immunol 2022;151:1081-95), author Eleonora Gambineri would like to update her affiliations to read: Department of NEUROFARBA, Section of Children's Health, University of Florence, Florence, Italy; and Centre of Excellence, Division of Pediatric Oncology/Hematology, Meyer Children’s Hospital IRCCS, Florence, Italy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

News beyond our pages
Janus kinase 1 (JAK1) is critical for type 2 cytokine signaling, and gain-of-function JAK1 mutations are associated with multiple chronic allergic disorders. Tamari et al (Cell 2024;187:44-61.e17; https://doi.org/10.1016/j.cell.2023.11.027) examined the tissue-specific immunoregulatory roles of JAK1 signaling. Spontaneous allergic inflammation was observed in the skin, but not the lungs, of mice containing a pathogenic human JAK1 gain-of-function variant. Moreover, the JAK1 gain-of-function variant protected against allergen-induced airway inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Tags: News beyond our pages Source Type: research

The Editors ’ Choice
This study by Ruffner et  al (p 1063) examined esophageal biopsy tissue of pediatric (n = 51) and adult (n = 52) subjects with EoE in remission and control subjects (n = 48 pediatric, n = 167 adult) in association with the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). The authors used a traditio nal clinical cutoff ( (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Tags: The editors ’ choice Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research

Brief Overview of This Month's JACI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research