News beyond our pages
Deng et al (Cell 2023;186:5375-93.e25; https://doi.org/10.1016/j.cell.2023.10.019) identified an important role for direct activation of neurons by skin microbes in itch generation. More specifically, epicutaneous exposure to Staphylococcus aureus induced itch- and scratch-induced skin damage in mice. Mechanistically, S aureus secreted a serine protease, V8, which induced direct cleavage of proteinase-activated receptor 1 (PAR1) present on the surface of sensory neurons that mediate itch. Finally, PAR1 genetic deficiency or pharmacologic inhibition led to decreased S aureus-induced itch. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Tags: News beyond our pages Source Type: research

Erratum
With regard to the article in the May 2022 issue entitled “Thunderstorm asthma in seasonal allergic rhinitis: The TAISAR study” (J Allergy Clin Immunol 2022;149:1607-16), an editing error omitted the word “not” from the following sentence (see italicized text): “A total of 228 individuals were enrolled, of whom 35% (the I-SAR group [n = 80]) re ported isolated SAR, 37% (the O-TA group [n = 84]) had experienced TA symptoms but had not presented to the hospital, and 28% (the H-TA group [n = 64]) had presented to the hospital with TA.” The publisher apologizes for the error. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Tags: Erratum Source Type: research

The Editors ’ Choice
Treatment options for itch are limited. Antihistamines represent the most widely available class of antipruritic drugs, with over $2 billion in sales per year for itch alone. However, antihistamines exhibit poor efficacy in most chronic itch conditions, even those associated with the histaminergic itch pathway like urticaria. Thus, itch is often classified dichotomously as either histaminergic or nonhistaminergic in nature. In this issue, Trier et  al (p 852) provide evidence that suggests that this canonical distinction is likely overly simplistic. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Tags: The editors ’ choice Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

Brief Overview of This Month's JACI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

Information for Readers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

News & Notes
Help us program our next session lineup by completing a proposal for the 2025 AAAAI Annual Meeting. The submission site is open at annualmeeting.aaaai.org. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

CME Calendar-AAAAI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

A Special Thank-You to Our Reviewers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): two randomized, double-blind, placebo-controlled, phase 3 trials
Capsule Summary: Dupilumab significantly reduced urticaria activity in patients with CSU who were symptomatic despite H1-AH; with a trend towards improvement in patients with prior anti-IgE treatment. Safety was consistent with the known dupilumab safety profile. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Marcus Maurer, Thomas B. Casale, Sarbjit S. Saini, Moshe Ben-Shoshan, Ana M. Gim énez-Arnau, Jonathan A. Bernstein, Akiko Yagami, Aleksandra Stjepanovic, Allen Radin, Heribert W. Staudinger, Naimish Patel, Nikhil Amin, Bolanle Akinlade, Chunpeng Fan, Deb Source Type: research

Early-life Nasal Microbiota Dynamics Relate to Longitudinal Respiratory Phenotypes in Urban Children
Capsule SummaryWe investigated the risk factors associated with asthma in high-risk children and found evidence that early life respiratory microbiota development is influenced by exposures to environmental microbes and the genetic predisposition of the individual. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 27, 2024 Category: Allergy & Immunology Authors: Kathryn E. McCauley, Juliana Durack, Kole V. Lynch, Douglas W. Fadrosh, Kei E. Fujimura, Faith Vundla, Mustafa Özçam, Petra LeBeau, Agustin Caltroni, Preston Burns, Hoang T. Tran, Leonard B. Bacharier, Meyer Kattan, George T. O’Connor, Robert A. Wood, Source Type: research

Epithelium-derived kallistatin promotes CD4+ T-cell chemotaxis to TH2-type inflammation in chronic rhinosinusitis
The function of kallistatin in airway inflammation, particularly chronic rhinosinusitis with nasal polyps (CRSwNP), has not been elucidated. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Lijie Jiang, Haocheng Tang, Tengjiao Lin, Yifeng Jiang, Yanmei Li, Wenxiang Gao, Jie Deng, Zhaoqi Huang, Chuxin Chen, Jianbo Shi, Ti Zhou, Yinyan Lai Source Type: research

Epithelium-derived kallistatin promotes CD4+ T cell chemotaxis to Th2-type inflammation in chronic rhinosinusitis
Capsule summary: Kallistatin has been demonstrated to play a role in the pathogenesis of chronic rhinosinusitis with nasal polyps ( CRSwNP ) by promoting Th2 inflammation. High expression of kallistatin has been associated with the prognosis of CRSwNP and the expression of Th2-type inflammatory cytokines. Interestingly, we discovered that kallistatin deficiency alleviates type 2 inflammation in the sinonasal mucosa, especially blunt the activation of IL-4. Further investigation revealed that kallistatin may be associated with increased IL-4 expression, possibly through the Jagged2-Notch1 signaling pathway in CD4+ T cells. ...
Source: Journal of Allergy and Clinical Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Lijie Jiang, Haocheng Tang, Tengjiao Lin, Yifeng Jiang, Yanmei Li, Wenxiang Gao, Jie Deng, Zhaoqi Huang, Chuxin Chen, Jianbo Shi, Ti Zhou, Yinyan Lai Source Type: research