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Analysis of the features of severe asthma patients with aspirin intolerance.
NSAID-exacerbated respiratory disease(NERD) is a T2-phenotype of severe-asthma(SA), usually associated with chronic rhinosinusitis(CRS) with/without polyps and no allergy. The mean age of patients in studies is>60 years and young adults are poorly known. Moreover, most publications don ´t confirm CRS and NERD. We analyze the features of SA in younger(18-40 years) and aspirin intolerant individuals recruited from eight SA units of BIOBADALER-consortium. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Julia Rodriguez de Guzman Cejudo, Almudena Testera Montes, Laura Zubiaga Fernandez, Joan Bartra, Ibon Eguiluz Gracia, Maria Jose Torres Jaen, Carmen Rondon Segovia, Natalia P érez Sánchez, Rocio Saenz de Santamaría, Marta Ferrer Source Type: research

Using 15-Oxo-ETE for Risk Stratifying Aspirin Hypersensitivity in Asthma Patients
15-oxo-eicosatetraenoic acid (15-oxo-ETE), a downstream product on arachidonic acid (AA) via 15-lipoxygenase-1 (15- LOX-1) pathway was markedly higher in nasal polyp tissue of patients with aspirin-exacerbated respiratory disease (AERD) compared to control groups. We suggested a possible role of 15-oxo-ETE as an in vitro diagnostic biomarker for AERD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Lucyna Mastalerz, Gabriela Tr ąd, Piotr Szatkowski, Radosław Kacorzyk, Alicja Maciejska, Anna Gielicz, Hanna Plutecka, Bogdan Jakieła, Adam Ćmiel, Marek Sanak Source Type: research

Twelve-Month Health Care Utilization in Individuals Starting on Biologics for Chronic Immune-Mediated Diseases
Individuals with suboptimally controlled chronic immune-mediated diseases (IMDs) have high rates of healthcare utilization. We hypothesized that higher disease activity scores would correlate with a higher rate of non-scheduled healthcare visits among a single center cohort of patients with chronic IMDs mostly starting new biologics (Biologics and Clinical Immunology Cohort at Sinai (BACICS) ). We also sought to determine the proportion of visits related to the primary IMD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Shira Yellin, Jamie Fried, Sarah Alvi, Rashida Blackwood, Rachel Miller Source Type: research

Caregiver Willingness to use Biologics in Children
Atopic dermatitis (AD) affects around 10% of children globally, with 20% facing treatment-resistant forms. Studies favor biologics over conventional therapies. Our hypothesis is that disease severity and caregiver background and education influence biologic willingness. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Shannon Su, Idil Ezhuthachan, Gerald Lee, Melinda Rathkopf, Brian Vickery, Tricia Lee Source Type: research

MMR and Varicella Immunization Rate During Dupilumab Therapy
Current FDA guidance is to pause administration of live vaccinations during dupilumab therapy. It is currently unknown whether this recommendation results in delayed vaccination. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Hannah Seay, Marissa Perman, Jennifer Heimall, Jonathan Spergel, James Treat, Terri Brown-Whitehorn, Fahad Ahmed Source Type: research

Hypogammaglobulinemia Following Use of An Anti-neonatal Fc Receptor (FcRn) Monoclonal Antibody, Efgartigimod.
Efgartigimod, an anti-neonatal Fc receptor (FcRn) monoclonal antibody recently approved for IgG-mediated autoimmune diseases, such as myasthenia gravis, accelerates IgG destruction via FcRn inhibition. Due to recent FDA approval of efgartigimod, data regarding the risk of hypogammaglobulinemia and infections in patients receiving efgartigimod is limited. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Nancy Yang, Baijun Zhou, Joseph Hong, Sara Barmettler Source Type: research

Humoral And Cellular Immune Response To Covid-19 Vaccines After Primary Vaccination With A 3-dose Scheme And Boosters Vaccines (4th And 5th Doses) In 55 Brazilian Patients With Inborn Errors Of Immunity Compared To Healthy Controls
We investigated immune response to Covid-19 vaccines after three, four and five doses doses in 55 Brazilian patients with Inborn Errors of Immunity (IEI; 13-61y) compared to 60 healthy controls (HC; 13-71y). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Vitor Gabriel Lopes Da Silva, Carolina Aranda, Kathleen Sullivan, J úlia Barbate Pintão, Maria Izabel Haro Azinar, Maria Isabel de Moraes-Pinto Source Type: research

Inhibition Of IL-13 Cytokine-Induced Responses Do Not Affect COVID Incidence
The IL-13 inflammatory pathway is known to potentiate atopic disease entities including asthma and atopic dermatitis (AD). More recently, IL-13 signaling has been associated with COVID-19 viral propagation. Dupilumab is commonly used to treat AD through inhibition of IL-13, but the immunosuppressive effect of biologics is still being explored with respect to COVID-19 incidence and severity. We hypothesized that IL-13 inhibition in dupilumab AD patients may decrease incidence of COVID-19 infection compared to non-dupilumab AD patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Alyssa Osheim, Eric Schultz, Sofia Tovar, Sophia Schultz Source Type: research

Vaccination against yellow fever in fractionated doses without a previous skin test and egg anaphylaxis
Yellow fever is a public health problem with a high morbimortality. The vaccine against yellow fever (YFV) is effective but represents a risk for patients with egg allergy because of its ovalbumin content. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Raquel Pitchon, Adriana Pitchon Source Type: research

Dupilumab, Immune Surveillance And Malignancy: What Does The Literature Reveal?
Dupilumab is an IgG4-monoclonal antibody binding IL-4 receptor alpha, which inhibits downstream IL-4 and IL-13 signaling via JAK-STAT. Modulation of this pathway has been linked to the progression of solid and hematological malignancy. Widely used in sinusitis, asthma and eczema, the influence of dupilumab on oncogenic potential is unclear. The reports of various malignancies developing after dupilumab use are concerning and warrant investigation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Chase Rupprecht, Daaniya Rana, Sritarini Relangi, Guha Krishnaswamy Source Type: research

Analytical Validation and Stability Studies for Basophil Activation Test to Meet IVDR Certification.
Basophil Activation Tests (BAT) have gained increasing importance in the field of allergy. We hypothesize a thorough assay validation study meeting CLIA requirements is possible and performed analytical and stability studies with Flow CAST BAT assay, to achieve the new EU-IVDR compliance. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Collin Shaw, Dominik Vogt, Anna Melone, Martina Berchtold, Christina Bauer, Michele Romano, Michael Schneider, Christian-Benedikt Gerhold, Michael Gerspach, Thomas Schuster Source Type: research

Comprehensive murine model of IgE mediated multiple food-group cross-reactive anaphylaxis
Approximately 32 million people in the US suffer from food allergies. Clinically, peanut/tree nuts, fish and shellfish food groups have substantial risk of cross reactivity. A murine model of multiple food group-cross reactivity is needed for developing novel therapies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Fariba Ardalani, Ibrahim Musa, Nan Yang, Xiu-Min Li Source Type: research

Interplay of Walnut and Peanut Allergies in Pediatric Anaphylaxis: Prevalence, Cross-Reactivity, and Therapeutic Implications
This study examines its risk in a large food anaphylactic pediatric cohort enrolled in the Tolerance Induction Program (TIPTM). The evolutionary conservation between peanut and walnut proteins and the clinical observations indicating those with peanut allergy are at increased risk for walnut allergy underscores the potential utility of walnuts in advancing biosimilar protein immunotherapy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Diana Fregoso, Inderpal Randhawa, Nathan Marsteller Source Type: research

The Potential Role of Oro-Mucosal Fruit Challenges: A Less-invasive and Efficient Approach to Investigate IgE-mediated Banana Allergies
This study aimed to assess OMC's diagnostic accuracy in banana-allergic patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Irin Vichara-Anont, Torpong Thongngarm, Chamard Wongsa, Thanachit Krikeerati, Piyaporn Chokevittaya, Mongkhon Sompornrattanaphan Source Type: research

Identification of IgE cross-reactive allergens causing food allergies including pollen-food allergy syndrome (PFAS)
IgE cross-reactive allergens are often responsible for food allergies including pollen-food allergy syndrome (PFAS). However, their repertories are not fully characterized. Our goal is to identify IgE cross-reactive allergens, that potentially cause food allergies, using murine models. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Risa Yamamoto, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Nobuhiro Nakako, Jiro Kitaura Source Type: research