Pharmacokinetics, Dialysability, and Safety of Gadopiclenol, a New Gadolinium-Based Contrast Agent, in Patients With Impaired Renal Function
Conclusions
Gadopiclenol elimination half-life was prolonged in subjects with mild to severe renal impairment, yet its renal clearance remains complete or nearly complete. In ESRD subjects, gadopiclenol was effectively removed from the plasma after 1 hemodialysis session, and up to 3 hemodialysis sessions were sufficient to completely clear it. No safety concern was raised. Therefore, no dose adjustment seems necessary in this patient population. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research
Finding the Optimal Alternative for Immediate Hypersensitivity to Low-Osmolar Iodinated Contrast
Conclusions
In patients who experienced a severe index HSR to LOCM, skin test negative LOCM without a common side chain could be suggested as an option for safe reexposure. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research
Automated Detection and Quantification of COVID-19 Airspace Disease on Chest Radiographs: A Novel Approach Achieving Expert Radiologist-Level Performance Using a Deep Convolutional Neural Network Trained on Digital Reconstructed Radiographs From Computed Tomography-Derived Ground Truth
Conclusions
Our CNN trained with DRR using CT-derived airspace quantification achieved expert radiologist level of accuracy in the quantification of AD on CXR in patients with positive reverse transcriptase-polymerase chain reaction test results for COVID-19. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research
Image Quality Improvement of Dynamic Contrast-Enhanced Gradient Echo Magnetic Resonance Imaging by Iterative Denoising and Edge Enhancement
Objectives
The aim of this study was to investigate the impact of a novel edge enhancement and iterative denoising algorithm in 1.5-T T1-weighted dynamic contrast-enhanced (DCE) gradient echo (GRE) magnetic resonance imaging of the abdomen on image quality, noise levels, diagnostic confidence, and lesion detectability.
Materials and Methods
Fifty patients who underwent a clinically indicated magnetic resonance imaging with DCE imaging of the abdomen between June and August 2020 were included in this retrospective, monocentric, institutional review board–approved study. For DCE imaging, a series of 3 volume int...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Gadolinium Concentrations in Biological Matrices From Patients Exposed to Gadolinium-Based Contrast Agents
Objectives
There is increasing evidence that Gd may be retained within the skin, bones, and solid organs in patients with normal renal function after exposure to Gd-based contrast agents (GBCAs). Here we present clinical data from 19 patients who requested referral to our clinical toxicology service for assessment of potential “Gd toxicity.”
Materials and Methods
Patients had undergone a median of 2 (interquartile range [IQR], 1–5) exposures to GBCAs and were reviewed at a median of 5 months (IQR, 2–8 months) after the last GBCA exposure. Patients had a clinical assessment by a clinical toxicologist, and...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Magnetic Resonance Imaging Detection of Glucose-Stimulated Zinc Secretion in the Enlarged Dog Prostate as a Potential Method for Differentiating Prostate Cancer From Benign Prostatic Hyperplasia
In this study, we examined whether this technology can be applied in a large animal model by imaging older dogs with clinically diagnosed BPH.
Materials and Methods
Four intact male dogs 6 years or older with enlarged prostates were imaged (T1-weighted turbo spin-echo, TE/TR, 12/400 milliseconds and T2-weighted, TE/TR, 112/5000 milliseconds) using a 3 T scanner before and at multiple time points after intravenous injection of 0.05 mmol/kg GdL1 plus either (a) 2 mL/kg of 50% dextrose in 1 session or (b) 2 mL/kg normal saline in another session. The two sessions were one week apart, and their order was randomly determ...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Toward Computer-Assisted Triaging of Magnetic Resonance Imaging‐Guided Biopsy in Preoperative Breast Cancer Patients
Conclusions
The multiparametric CAD model showed potential to identify malignant disease extension with near-perfect specificity in approximately half the population of preoperative patients originally indicated for a breast biopsy. In the other half, patients would still proceed to MRI-guided biopsy to confirm absence of malignant disease. These findings demonstrate the potential to triage MRI-guided breast biopsy. (Source: Investigative Radiology)
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Intraindividual Comparison of Compressed Sensing‐Accelerated Cartesian and Radial Arterial Phase Imaging of the Liver in an Experimental Tumor Model
Conclusions
Both CS-VIBE and GRASP provide excellent results in dynamic liver MRI using extracellular and hepatocyte-specific contrast agents, in terms of IQ, peak signal intensity, and presence of artifacts. (Source: Investigative Radiology)
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Delayed Gadolinium Leakage in Ocular Structures: A Potential Marker for Age- and Vascular Risk Factor‐Related Small Vessel Disease?
Background
Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear.
Objective
We investigated the factors associated with GLOS in a cohort of patients presenting with acute neurological deficits.
Materials and Methods
This retrospective study included consecutive patients admitted to our stroke unit for acute neurological deficit between July 2017 and August 2018 who underwent baseline brain magneti...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Dual-Energy Computed Tomography for Detection and Characterization of Monosodium Urate, Calcium Pyrophosphate, and Hydroxyapatite: A Phantom Study on Diagnostic Performance
Objectives
The aim of this study was to determine the diagnostic performance of dual-energy computed tomography (DECT) to detect and distinguish crystal deposits in a phantom. The primary objective was to determine the cutoff DECT ratio and the cross-sectional area (CSA) of a crystal deposit necessary to differentiate monosodium urate (MSU), calcium pyrophosphate (CPP), and calcium hydroxyapatite (HA) using DECT. Our secondary objective was to determine the concentration for limit of detection for MSU, CPP, and HA crystal deposits. Exploratory objectives included the comparison between 2 generations of DECT scanners fr...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Navigator-Guided Motion and B0 Correction of T2*-Weighted Magnetic Resonance Imaging Improves Multiple Sclerosis Cortical Lesion Detection
Background
Cortical lesions are common in multiple sclerosis (MS). T2*-weighted (T2*w) imaging at 7 T is relatively sensitive for cortical lesions, but quality is often compromised by motion and main magnetic field (B0) fluctuations.
Purpose
The aim of this study was to determine whether motion and B0 correction with a navigator-guided gradient-recalled echo sequence can improve cortical lesion detection in T2*w magnetic resonance imaging.
Materials and Methods
In this prospective study, a gradient-recalled echo sequence incorporating a navigator allowing for motion and B0 field correction was applied to ...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research
Deep Learning‐Based Automated Abdominal Organ Segmentation in the UK Biobank and German National Cohort Magnetic Resonance Imaging Studies
Conclusion
Automated segmentation of abdominal organs is possible with high qualitative and quantitative accuracy on whole-body MR imaging data acquired as part of UKBB and GNC. The results obtained and deep learning models trained in this study can be used as a foundation for automated analysis of thousands of MR data sets of UKBB and GNC and thus contribute to tackling topical and original scientific questions. (Source: Investigative Radiology)
Source: Investigative Radiology - May 11, 2021 Category: Radiology Tags: Original Articles Source Type: research
Extravasation Volume at Computed Tomography Angiography Correlates With Bleeding Rate and Prognosis in Patients With Overt Gastrointestinal Bleeding
The objective of our proof-of-concept study was to improve triage of patients with GIB by correlating extravasation volume of first-pass CTA with bleeding rate and clinical outcomes.
Materials and Methods
All patients who presented with overt GIB and active extravasation on CTA from January 2014 to July 2019 were reviewed in this retrospective, institutional review board–approved and Health Insurance Portability and Accountability Act–compliant study. Extravasation volume was assessed using 3-dimensional software and correlated with hemostatic therapy (primary endpoint) and with intraprocedural bleeding, blood t...
Source: Investigative Radiology - May 11, 2021 Category: Radiology Tags: Original Articles Source Type: research
The Calcium Versus Hemorrhage Trial: Developing Diagnostic Criteria for Chronic Intracranial Susceptibility Lesions Using Single-Energy Computed Tomography, Dual-Energy Computed Tomography, and Quantitative Susceptibility Mapping
Conclusions
We provide the updated criteria for the classification of chronic positive susceptibility brain lesions as hemorrhagic versus calcific for each major clinically available imaging modality. These proposed criteria have greater internal consistency than the current criteria and should likely replace it as gold standard. (Source: Investigative Radiology)
Source: Investigative Radiology - May 11, 2021 Category: Radiology Tags: Original Articles Source Type: research
Acute Chelation Therapy‐Associated Changes in Urine Gadolinium, Self-reported Flare Severity, and Serum Cytokines in Gadolinium Deposition Disease
Conclusions
In this preliminary study, 24-hour urine Gd content increased markedly and similarly in GDD and GSC patients after Ca-diethylenetriaminepentaacetic acid CT. Post-CT Flare reaction developed only in GDD patients. The current study is the second finding significantly different serum cytokine levels in GDD patients compared with healthy normal controls. These differences and the difference between GDD and GSC patients' Flare and cytokine responses to CT suggest some inflammatory, immunologic, or other physiological differences in patients with GDD. Further research into the treatment and physiological underpin...
Source: Investigative Radiology - May 11, 2021 Category: Radiology Tags: Original Articles Source Type: research
