Qualitative and Quantitative Analysis of a Spiral Gradient Echo Sequence for Contrast-Enhanced Fat-Suppressed T1-Weighted Spine Magnetic Resonance Imaging
Objectives Pulse sequences with non-Cartesian k-space sampling enable improved imaging in anatomical areas with high degrees of motion artifacts. We analyzed a novel spiral 3-dimensional (3D) gradient echo (GRE) magnetic resonance imaging (MRI) sequence (“spiral,” 114.7 ± 11 seconds) and compared it with a radial 3D GRE (“vane,” 216.7 ± 2 seconds) and a conventional Cartesian 2D turbo spin echo (TSE) sequence (“TSE,” 266.7 ± 82 seconds) for contrast-enhanced fat-suppressed T1-weighted spine imaging. Materials and Methods Forty consecutive patients referred for contrast-enhanced MRI were prospectiv...
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

Deep Learning-Based Superresolution Reconstruction for Upper Abdominal Magnetic Resonance Imaging: An Analysis of Image Quality, Diagnostic Confidence, and Lesion Conspicuity
Objectives The aim of this study was to investigate the impact of a deep learning-based superresolution reconstruction technique for T1-weighted volume-interpolated breath-hold examination (VIBESR) on image quality in comparison with standard VIBE images (VIBESD). Methods Between May and August 2020, a total of 46 patients with various abdominal pathologies underwent contrast-enhanced upper abdominal VIBE magnetic resonance imaging (MRI) at 1.5 T. After data acquisition, the precontrast and postcontrast T1-weighted VIBE raw data were processed by a deep learning-based prototype algorithm for deblurring and denoi...
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

The Rate of Apparent Diffusion Coefficient Change With Diffusion Time on Breast Diffusion-Weighted Imaging Depends on Breast Tumor Types and Molecular Prognostic Biomarker Expression
Conclusions The ADC values vary with different diffusion time and vary in correlation with molecular biomarkers, especially Ki-67. Those results suggest that the diffusion time, which should be reported, might be a useful parameter to consider for breast cancer management. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

Characterization of Ascending Aortic Flow in Patients With Degenerative Aneurysms: A 4D Flow Magnetic Resonance Study
Conclusions Degenerative TAA patients show a decrease in flow vorticity and helicity, which is likely to cause perturbations in physiological flow patterns. The subsequent differing distribution of WSS might be a contributor to vessel wall remodeling and aneurysm formation. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

Pharmacokinetics, Dialysability, and Safety of Gadopiclenol, a New Gadolinium-Based Contrast Agent, in Patients With Impaired Renal Function
Conclusions Gadopiclenol elimination half-life was prolonged in subjects with mild to severe renal impairment, yet its renal clearance remains complete or nearly complete. In ESRD subjects, gadopiclenol was effectively removed from the plasma after 1 hemodialysis session, and up to 3 hemodialysis sessions were sufficient to completely clear it. No safety concern was raised. Therefore, no dose adjustment seems necessary in this patient population. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

Finding the Optimal Alternative for Immediate Hypersensitivity to Low-Osmolar Iodinated Contrast
Conclusions In patients who experienced a severe index HSR to LOCM, skin test negative LOCM without a common side chain could be suggested as an option for safe reexposure. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

Automated Detection and Quantification of COVID-19 Airspace Disease on Chest Radiographs: A Novel Approach Achieving Expert Radiologist-Level Performance Using a Deep Convolutional Neural Network Trained on Digital Reconstructed Radiographs From Computed Tomography-Derived Ground Truth
Conclusions Our CNN trained with DRR using CT-derived airspace quantification achieved expert radiologist level of accuracy in the quantification of AD on CXR in patients with positive reverse transcriptase-polymerase chain reaction test results for COVID-19. (Source: Investigative Radiology)
Source: Investigative Radiology - July 15, 2021 Category: Radiology Tags: Original Articles Source Type: research

Image Quality Improvement of Dynamic Contrast-Enhanced Gradient Echo Magnetic Resonance Imaging by Iterative Denoising and Edge Enhancement
Objectives The aim of this study was to investigate the impact of a novel edge enhancement and iterative denoising algorithm in 1.5-T T1-weighted dynamic contrast-enhanced (DCE) gradient echo (GRE) magnetic resonance imaging of the abdomen on image quality, noise levels, diagnostic confidence, and lesion detectability. Materials and Methods Fifty patients who underwent a clinically indicated magnetic resonance imaging with DCE imaging of the abdomen between June and August 2020 were included in this retrospective, monocentric, institutional review board–approved study. For DCE imaging, a series of 3 volume int...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Gadolinium Concentrations in Biological Matrices From Patients Exposed to Gadolinium-Based Contrast Agents
Objectives There is increasing evidence that Gd may be retained within the skin, bones, and solid organs in patients with normal renal function after exposure to Gd-based contrast agents (GBCAs). Here we present clinical data from 19 patients who requested referral to our clinical toxicology service for assessment of potential “Gd toxicity.” Materials and Methods Patients had undergone a median of 2 (interquartile range [IQR], 1–5) exposures to GBCAs and were reviewed at a median of 5 months (IQR, 2–8 months) after the last GBCA exposure. Patients had a clinical assessment by a clinical toxicologist, and...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Magnetic Resonance Imaging Detection of Glucose-Stimulated Zinc Secretion in the Enlarged Dog Prostate as a Potential Method for Differentiating Prostate Cancer From Benign Prostatic Hyperplasia
In this study, we examined whether this technology can be applied in a large animal model by imaging older dogs with clinically diagnosed BPH. Materials and Methods Four intact male dogs 6 years or older with enlarged prostates were imaged (T1-weighted turbo spin-echo, TE/TR, 12/400 milliseconds and T2-weighted, TE/TR, 112/5000 milliseconds) using a 3 T scanner before and at multiple time points after intravenous injection of 0.05 mmol/kg GdL1 plus either (a) 2 mL/kg of 50% dextrose in 1 session or (b) 2 mL/kg normal saline in another session. The two sessions were one week apart, and their order was randomly determ...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Toward Computer-Assisted Triaging of Magnetic Resonance Imaging‐Guided Biopsy in Preoperative Breast Cancer Patients
Conclusions The multiparametric CAD model showed potential to identify malignant disease extension with near-perfect specificity in approximately half the population of preoperative patients originally indicated for a breast biopsy. In the other half, patients would still proceed to MRI-guided biopsy to confirm absence of malignant disease. These findings demonstrate the potential to triage MRI-guided breast biopsy. (Source: Investigative Radiology)
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Intraindividual Comparison of Compressed Sensing‐Accelerated Cartesian and Radial Arterial Phase Imaging of the Liver in an Experimental Tumor Model
Conclusions Both CS-VIBE and GRASP provide excellent results in dynamic liver MRI using extracellular and hepatocyte-specific contrast agents, in terms of IQ, peak signal intensity, and presence of artifacts. (Source: Investigative Radiology)
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Delayed Gadolinium Leakage in Ocular Structures: A Potential Marker for Age- and Vascular Risk Factor‐Related Small Vessel Disease?
Background Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear. Objective We investigated the factors associated with GLOS in a cohort of patients presenting with acute neurological deficits. Materials and Methods This retrospective study included consecutive patients admitted to our stroke unit for acute neurological deficit between July 2017 and August 2018 who underwent baseline brain magneti...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Dual-Energy Computed Tomography for Detection and Characterization of Monosodium Urate, Calcium Pyrophosphate, and Hydroxyapatite: A Phantom Study on Diagnostic Performance
Objectives The aim of this study was to determine the diagnostic performance of dual-energy computed tomography (DECT) to detect and distinguish crystal deposits in a phantom. The primary objective was to determine the cutoff DECT ratio and the cross-sectional area (CSA) of a crystal deposit necessary to differentiate monosodium urate (MSU), calcium pyrophosphate (CPP), and calcium hydroxyapatite (HA) using DECT. Our secondary objective was to determine the concentration for limit of detection for MSU, CPP, and HA crystal deposits. Exploratory objectives included the comparison between 2 generations of DECT scanners fr...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research

Navigator-Guided Motion and B0 Correction of T2*-Weighted Magnetic Resonance Imaging Improves Multiple Sclerosis Cortical Lesion Detection
Background Cortical lesions are common in multiple sclerosis (MS). T2*-weighted (T2*w) imaging at 7 T is relatively sensitive for cortical lesions, but quality is often compromised by motion and main magnetic field (B0) fluctuations. Purpose The aim of this study was to determine whether motion and B0 correction with a navigator-guided gradient-recalled echo sequence can improve cortical lesion detection in T2*w magnetic resonance imaging. Materials and Methods In this prospective study, a gradient-recalled echo sequence incorporating a navigator allowing for motion and B0 field correction was applied to ...
Source: Investigative Radiology - June 16, 2021 Category: Radiology Tags: Original Articles Source Type: research