Contrast Saline Mixture DualFlow Injection Protocols for Low-Kilovolt Computed Tomography Angiography: A Systematic Phantom and Animal Study
Conclusion
DualFlow injection protocols can be tailored for low-kV CTA by reducing the IDR while overall flow rate remains unchanged. Although no differences in attenuation were found, DF injections offer a shorter time to peak closer to the reference 120 kV protocol.
This allows the use of DF injection protocols to calibrate bolus density in low-kV CTA and yields the potential for a more individualized CM administration. (Source: Investigative Radiology)
Source: Investigative Radiology - November 7, 2020 Category: Radiology Tags: Original Articles Source Type: research
Spiral 3-Dimensional T1-Weighted Turbo Field Echo: Increased Speed for Magnetization-Prepared Gradient Echo Brain Magnetic Resonance Imaging
Objectives
Spiral magnetic resonance imaging acquisition may enable improved image quality and higher scan speeds than Cartesian trajectories. We tested the performance of four 3D T1-weighted (T1w) TFE sequences (magnetization-prepared gradient echo magnetic resonance sequence) with isotropic spatial resolution for brain imaging at 1.5 T in a clinical patient cohort based on qualitative and quantitative image quality metrics. Two prototypical spiral TFE sequences (spiral 1.0 and spiral 0.85) and a Cartesian compressed sensing technology accelerated TFE sequence (CS 2.5; acceleration factor of 2.5) were compared with a ...
Source: Investigative Radiology - November 7, 2020 Category: Radiology Tags: Original Articles Source Type: research
Tomoelastography for Measurement of Tumor Volume Related to Tissue Stiffness in Pancreatic Ductal Adenocarcinomas
Objectives
Estimations of tumor volume and boundary in pancreatic ductal adenocarcinoma (PDAC) are crucial for surgery planning. The aim of the study is to evaluate tomoelastography for detection of PDAC and quantification of PDAC volume based on tissue stiffness.
Materials and Methods
From March 2018 to December 2019, a total of 102 participants (30 healthy participants and 72 patients with histologically proven PDAC) were prospectively enrolled in a multicenter study. Multifrequency magnetic resonance elastography was combined with tomoelastography postprocessing to generate maps of shear wave speed (SWS) depi...
Source: Investigative Radiology - November 7, 2020 Category: Radiology Tags: Original Articles Source Type: research
Radiation Dose to the Fetus From Computed Tomography of Pregnant Patients—Development and Validation of a Web-Based Tool
Conclusions
A tool for fetal dose assessments from CT of pregnant patients was developed and validated being freely available on a user-friendly web interface. (Source: Investigative Radiology)
Source: Investigative Radiology - November 7, 2020 Category: Radiology Tags: Original Articles Source Type: research
The Limited Sensitivity of Chest Computed Tomography Relative to Reverse Transcription Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Systematic Review on COVID-19 Diagnostics
Conclusions
The difference between the sensitivities of CT and RT-PCR for severe acute respiratory syndrome coronavirus-2 infection is lower than previously thought, as after stratifying the studies, the true sensitivity for CT based on the unbiased studies is limited. (Source: Investigative Radiology)
Source: Investigative Radiology - November 7, 2020 Category: Radiology Tags: Review Articles Source Type: research
Advocating the Development of Next-Generation, Advanced-Design Low-Field Magnetic Resonance Systems
New next-generation low-field magnetic resonance imaging systems (operating in the range of 0.5 T) hold great potential for increasing access to clinical diagnosis and needed health care both in developed countries and worldwide. The relevant history concerning the choice of field strength, which resulted in 1.5 T still dominating today the number of installed systems, is considered, together with design advances possible because of interval developments, since low field was considered for clinical use in the 1980s, and current research. The potential impact of low-cost, advanced-generation low-field magnetic resonance ima...
Source: Investigative Radiology - November 7, 2020 Category: Radiology Tags: Review Articles Source Type: research
Magnetic Resonance Imaging of Venous Stents at 1.5 T: Susceptibility Artifacts and Radiofrequency Shielding
Conclusion
Magnetic resonance imaging in the vicinity of commercially available venous stents is feasible at 1.5 T with no substantial susceptibility-induced artifacts but reduced transmit and receive B1 field strengths inside the stents. The strength and homogeneity of the intraluminal B1 depend on the stents’ fabrication (woven or laser-cut) and cell geometry. (Source: Investigative Radiology)
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Technical Note Source Type: research
Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles
We report the use of electrostatic interaction to achieve adherence of microbubbles to tumor vasculature and resulting tumor delineation by ultrasound imaging.
Methods and Materials
Microbubbles were prepared from decafluorobutane gas by amalgamation of aqueous micellar medium. Distearoyl phosphatidylcholine (DSPC) and polyethylene glycol (PEG)-stearate were used as microbubble shell-forming lipids; cationic lipid distearoyl trimethylammoniumpropane (DSTAP) was included to introduce positive electrostatic charge. Microbubbles were subjected to flotation in normal gravity, to remove larger particles. Murine colon adenoca...
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Original Articles Source Type: research
Inversion Recovery Susceptibility Weighted Imaging With Enhanced T2 Weighting at 3 T Improves Visualization of Subpial Cortical Multiple Sclerosis Lesions
Objectives
Cortical demyelination is common in multiple sclerosis (MS) and can be extensive. Cortical lesions contribute to disability independently from white matter lesions and may form via a distinct mechanism. However, current magnetic resonance imaging methods at 3 T are insensitive to cortical, and especially subpial cortical, lesions. Subpial lesions are well seen on T2*-weighted imaging at 7 T, but T2*-weighted methods on 3 T scanners are limited by poor lesion-to-cortex and cerebrospinal fluid-to-lesion contrast. We aimed to develop and evaluate a cerebrospinal fluid–suppressed, T2*-weighted sequence optimized...
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Original Articles Source Type: research
Quiet FLAIR at 7T MRI
Conclusions
Reducing sound pressure by 80% in FLAIR imaging at 7T ultra-high-field MRI is feasible while maintaining high diagnostic image quality. (Source: Investigative Radiology)
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Original Articles Source Type: research
Toward the Clinical Development and Validation of a Thy1-Targeted Ultrasound Contrast Agent for the Early Detection of Pancreatic Ductal Adenocarcinoma
Objectives
Materials and Methods
We recombinantly expressed the Thy1-scFv with a carboxy-terminus cysteine residue to facilitate its thioether conjugation to the PEGylated MBs presenting with maleimide functional groups. After the scFv-MB conjugations, we tested binding activity of the MBThy1-scFv to MS1 cells overexpressing human Thy1 (MS1Thy1) under liquid shear stress conditions in vitro using a flow chamber setup at 0.6 mL/min flow rate, corresponding to a wall shear stress rate of 100 seconds−1, similar to that in tumor capillaries. For in vivo Thy1 US molecular imaging, MBThy1-scFv was tested in the transgenic ...
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Original Articles Source Type: research
Susceptibility-Based Characterization of Cerebral Arteriovenous Malformations
Conclusions
Susceptibility changes indicating blood deoxygenation across cerebral AVMs were shown for the first time in this study and were associated with the presence of perinidal blood products. Deoxygenation measures may serve as functional characterization of AVM vasculature and may offer the potential for individual treatment assessment and possible risk stratification. (Source: Investigative Radiology)
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Original Articles Source Type: research
Accelerated T2 Mapping of the Lumbar Intervertebral Disc: Highly Undersampled K-Space Data for Robust T: 2: Relaxation Time Measurement in Clinically Feasible Acquisition Times
Objectives
Materials and Methods
Fifty-eight individuals (26 female; mean age, 23.3 ± 8.1 years) were prospectively studied at 3 T. GRAPPATINI was conducted with the same parameters as the 2D-MESE while shortening the acquisition time from 13:18 to 2:27 minutes. The setup was also validated in a phantom experiment using a 6.48-hour-long single echo-spin echo sequence as reference. The IVDs were manually segmented on 4 central slices.
Results
The median nucleus pulposus showed a strong Pearson correlation coefficient between T2GRAPPATINI and T2MESE (rp = 0.919; P (Source: Investigative Radiology)
Source: Investigative Radiology - October 8, 2020 Category: Radiology Tags: Original Articles Source Type: research
Simultaneous Dual-Contrast Imaging of Small Bowel With Iodine and Bismuth Using Photon-Counting-Detector Computed Tomography: A Feasibility Animal Study
Conclusions
Our study demonstrated the feasibility of simultaneous imaging of iodine and bismuth in small bowel of swine using PCD-CT. (Source: Investigative Radiology)
Source: Investigative Radiology - September 9, 2020 Category: Radiology Tags: Technical Note Source Type: research
Acute Kidney Injury After Radiocontrast-Enhanced Computerized Tomography in Hospitalized Patients With Advanced Renal Failure: A Propensity-Score-Matching Analysis
Conclusion
Although radiocontrast-enhanced CT is considered safe in most hospitalized patients and in ambulatory settings, the risk of PC-AKI remains significant among inpatients with substantial preimaging renal functional impairment. Caution is warranted using iodine-based enhanced CT in hospitalized patients with an eGFR of 30 mL/min/1.73 m2 or lower. (Source: Investigative Radiology)
Source: Investigative Radiology - September 9, 2020 Category: Radiology Tags: Original Article Source Type: research
