Contrast Media–Enhanced Breast Computed Tomography With a Photon-Counting Detector: Initial Experiences on In Vivo Image Quality and Correlation to Histology
Objectives
The aim of this study was to investigate the feasibility, the image quality, and the correlation with histology of dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector in patients with suspicious breast lesions after application of iodinated contrast media.
Materials and Methods
The local ethics committee approved this prospective study. Twelve women with suspicious breast lesions found in mammography or B-CT underwent contrast-enhanced spiral B-CT and supplementary ultrasound. For all lesions, biopsy-proven diagnosis and histological workup after surgical resect...
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Contrast Media Reduction in Computed Tomography With Deep Learning Using a Generative Adversarial Network in an Experimental Animal Study
Objective
This feasibility study aimed to use optimized virtual contrast enhancement through generative adversarial networks (GAN) to reduce the dose of iodine-based contrast medium (CM) during abdominal computed tomography (CT) in a large animal model.
Methods
Multiphasic abdominal low-kilovolt CTs (90 kV) with low (low CM, 105 mgl/kg) and normal contrast media doses (normal CM, 350 mgl/kg) were performed with 20 healthy Göttingen minipigs on 3 separate occasions for a total of 120 examinations. These included an early arterial, late arterial, portal venous, and venous contrast phase. One animal had to be excl...
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Effect of Contrast Agent Dose Reduction on Vascular Enhancement and Image Quality in Thoracoabdominal Dynamic 3-Dimensional Magnetic Resonance Angiography: A Systematic Intraindividual Analysis in Pigs
Objective
High spatial and temporal resolution contrast-enhanced magnetic resonance angiography (MRA) with gadolinium-based contrast agents (GBCAs) at standard dose offers both detailed anatomic information on both arterial and venous vessels and hemodynamic characteristics. Several preclinical and clinical dynamic 3-dimensional (3D) MRA studies that focused on arterial vessels only proposed that high image quality may also be achieved with significantly reduced GBCA doses, calling into question the need to use standard doses. A systematic analysis of GBCA doses and resulting image quality for both arteries and veins h...
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Different Impact of Gadopentetate and Gadobutrol on Inflammation-Promoted Retention and Toxicity of Gadolinium Within the Mouse Brain
Conclusions
In the EAE model, neuroinflammation promoted increased Gd retention in the brain for both GBCAs. Whereas in the inflamed brains, efficient clearance of macrocyclic gadobutrol during the investigated time period was observed, the Gd retention after application of linear gadopentetate persisted over the entire observational period. Gadopentetate but not gadubutrol appeared to be neurotoxic in an ex vivo paradigm of neuronal inflammation. (Source: Investigative Radiology)
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Commentary on the Association of Symptoms Associated With Gadolinium Exposure/Gadolinium Deposition Disease and Gadolinium-Based Contrast Agents
No abstract available (Source: Investigative Radiology)
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Guest Editorial Source Type: research
Use of Real-Life Safety Data From International Pharmacovigilance Databases to Assess the Importance of Symptoms Associated With Gadolinium Exposure
Conclusion
This study showed that SAGE represent a significant percentage of the bulk of AEs reported to the health authorities for each GBCA. It provided real-life arguments suggesting that SAGE may be more prevalent with linear than macrocyclic GBCAs and that gadoteridol may present a higher SAGE risk than the other macrocyclic contrast agents. (Source: Investigative Radiology)
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Next-Generation Cancer Magnetic Resonance Imaging With Tumor-Targeted Alkylphosphocholine Metal Analogs
Conclusions
We have introduced a new macrocyclic cancer-targeted Gd chelate that achieves broad-spectrum tumor uptake and prolonged retention. Furthermore, we have demonstrated in vivo stability of Gd-NM600 by ultrahigh resolution MS tissue imaging. A tumor-targeted contrast agent coupled with the enhanced imaging resolution of MRI relative to positron emission tomography may transform oncologic imaging. (Source: Investigative Radiology)
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Evaluation of Physicochemical Properties, Pharmacokinetics, Biodistribution, Toxicity, and Contrast-Enhanced Cancer MRI of a Cancer-Targeting Contrast Agent, MT218
Conclusion
The preclinical assessments showed that the targeted contrast agent MT218 has high r1 and r2 relaxivities, satisfactory physicochemical properties, pharmacokinetic, and safety profiles and produces effective tumor enhancement in multiple cancer types in rats and mice at reduced doses. (Source: Investigative Radiology)
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
Preclinical Profile of Gadoquatrane: A Novel Tetrameric, Macrocyclic High Relaxivity Gadolinium-Based Contrast Agent
Conclusions
The tetrameric gadoquatrane is a novel, highly effective mGBCA for use in MRI. Gadoquatrane provides favorable physicochemical properties (high relaxivity and stability, negligible protein binding) while showing essentially the same PK profile (fast extracellular distribution, fast elimination via the kidneys in an unchanged form) to established mGBCAs on the market. Overall, gadoquatrane is an excellent candidate for further clinical development. (Source: Investigative Radiology)
Source: Investigative Radiology - September 10, 2022 Category: Radiology Tags: Special Issue 2022-Contrast Media Source Type: research
The Fifth Edition of The Physics of Clinical MR Taught Through Images
No abstract available (Source: Investigative Radiology)
Source: Investigative Radiology - August 10, 2022 Category: Radiology Tags: Book Review Source Type: research
Effective Spatial Resolution of Photon Counting CT for Imaging of Trabecular Structures is Superior to Conventional Clinical CT and Similar to High Resolution Peripheral CT
Conclusions
The effective spatial resolution of PCCT in trabecular bone imaging was comparable with that of HR-pQCT and more than 5 times higher compared with conventional CT. For ex vivo samples and when patient radiation dose can be neglected, PCCT allows imaging bone microstructure at a preclinical level of detail. (Source: Investigative Radiology)
Source: Investigative Radiology - August 10, 2022 Category: Radiology Tags: Original Articles Source Type: research
Assessing the Sensitivity of Dual-Energy Computed Tomography 3-Material Decomposition for the Detection of Gout
Objectives
The aim of this study was to assess the accuracy and precision of a novel application of 3-material decomposition (3MD) with virtual monochromatic images (VMIs) in the dual-energy computed tomography (DECT) assessment of monosodium urate (MSU) and hydroxyapatite (HA) phantoms compared with a commercial 2-material decomposition (2MD) and dual-thresholding (DT) material decomposition methods.
Materials and Methods
Monosodium urate (0.0, 3.4, 13.3, 28.3, and 65.2 mg/dL tubes) and HA (100, 400, and 800 mg/cm3 tubes) phantoms were DECT scanned individually and together in the presence of the foot and ankle...
Source: Investigative Radiology - August 10, 2022 Category: Radiology Tags: Original Articles Source Type: research
Pseudoprospective Paraclinical Interaction of Radiology Residents With a Deep Learning System for Prostate Cancer Detection: Experience, Performance, and Identification of the Need for Intermittent Recalibration
Conclusions
Pseudoprospective paraclinical integration of fully automated CNN-based detection of suspicious lesions on prostate multiparametric MRI was demonstrated and showed good acceptance among residents, whereas no significant improvement in resident performance was found. General CNN performance was preserved despite an observed shift in CNN calibration, identifying the requirement for continuous quality control and recalibration. (Source: Investigative Radiology)
Source: Investigative Radiology - August 10, 2022 Category: Radiology Tags: Original Articles Source Type: research
Fluid and White Matter Suppression: New Sensitive 3 T Magnetic Resonance Imaging Contrasts for Cortical Lesion Detection in Multiple Sclerosis
In this study, we compared the manual detection rate of cortical lesions on MP2RAGEuni, FLAWSmin, and FLAWShco in MS patients. Furthermore, we assessed whether the combined detection rate on FLAWSmin and FLAWShco was superior to MP2RAGEuni for cortical lesions identification. Last, we compared quantitative T1 maps (qT1) provided by both MP2RAGE and FLAWS in MS lesions.
Materials and Methods
We included 30 relapsing-remitting MS patients who underwent MP2RAGE and FLAWS magnetic resonance imaging with isotropic spatial resolution of 1 mm at 3 T. Cortical lesions were manually segmented by consensus of 3 trained raters...
Source: Investigative Radiology - August 10, 2022 Category: Radiology Tags: Original Articles Source Type: research
Evaluation of Virtual Grid Processed Clinical Chest Radiographs
Objectives
We evaluated the different Virtual Grid software ratios (Fujifilm, Tokyo, Japan) on gridless clinical chest radiographs with visual grading analysis (VGA). In addition, we investigated the 2 image quality assessment algorithms (IQAAs).
Materials and Methods
Gridless chest radiographs of 50 different intensive care unit patients were collected and afterward processed with Virtual Grid software. Different software (SW) grid ratios—6:1, 10:1, 13:1, 17:1, and 20:1—were applied to investigate the image quality (IQ) improvement. Image quality improvement was assessed by 4 radiologists in a relative VGA ...
Source: Investigative Radiology - August 10, 2022 Category: Radiology Tags: Original Articles Source Type: research
