Would I do it again? Reflections on a career in academia and electrophysiology
For a young person contemplating the electrophysiology scene in 1960 ’s New York, the vistas were unlimited. The City was home to three giants: Brian Hoffman at Columbia, Tony Damato at the Public Health Service Hospital, and Paul Cranefield at the Rockefeller; and the Downstate Medical Center, whose Department of Physiology had spawned the careers of Hoffman, Cran efield, Vassalle and many others, remained a force. Also evident was the influence of David Scherf, who – having emigrated from Vienna to New York - was a regular attendee at local electrophysiology meetings, reverentially deferred to by all. (Source: Heart Rhythm)
Source: Heart Rhythm - April 6, 2018 Category: Cardiology Authors: Michael R. Rosen Source Type: research

Biatrial tachycardia utilizing Bachmann bundle
A 69-year-old woman with a history of pulmonary vein isolation for paroxysmal atrial fibrillation (AF) was admitted for recurrence of AF. After reisolation of the left superior pulmonary vein and posterior wall isolation, low-voltage electrograms on the anterior wall were ablated during AF. During the radiofrequency application, AF was organized into biatrial tachycardia (BiAT) (Supplemental Video). The activation map of BiAT showed a counterclockwise circuit using most of the mitral annulus in the left atrium (LA) (including the coronary sinus but not the LA septum) and right atrial (RA) septum with 2 interatrial connecti...
Source: Heart Rhythm - April 5, 2018 Category: Cardiology Authors: Iwanari Kawamura, Seiji Fukamizu, Satoshi Miyazawa, Rintaro Hojo Tags: Image Source Type: research

Ventricular arrhythmias and sudden cardiac arrest in Takotsubo cardiomyopathy: Incidence, predictive factors and clinical implications
Takotsubo cardiomyopathy (TTC) is a stress-related transient cardiomyopathy. Life threatening arrhythmias (LTA) can occur and worsen prognosis. (Source: Heart Rhythm)
Source: Heart Rhythm - April 5, 2018 Category: Cardiology Authors: Laurence Jesel, Charlotte Berthon, Nathan Messas, Han S. Lim, M élanie Girardey, Halim Marzak, Benjamin Marchandot, Annie Trinh, Patrick Ohlmann, Olivier Morel Source Type: research

Biatrial tachycardia utilizing Bachmann bundle
A 69-year-old woman with a history of pulmonary vein isolation for paroxysmal atrial fibrillation (AF) was admitted for recurrence of AF. After reisolation of the left superior pulmonary vein and posterior wall isolation, low-voltage electrograms on the anterior wall were ablated during AF. During the radiofrequency application, AF was organized into biatrial tachycardia (BiAT) (Supplemental Video). The activation map of BiAT showed a counterclockwise circuit using most of the mitral annulus in the left atrium (LA) (including the coronary sinus but not the LA septum) and right atrial (RA) septum with 2 interatrial connecti...
Source: Heart Rhythm - April 5, 2018 Category: Cardiology Authors: Iwanari Kawamura, Seiji Fukamizu, Satoshi Miyazawa, Rintaro Hojo Tags: Image Source Type: research

Biatrial Tachycardia Utilizing Bachmann ’s Bundle
A 69-year-old-woman with a history of pulmonary vein (PV) isolation for paroxysmal atrial fibrillation (AF) was admitted for recurrence of AF. After reisolation of the left superior PV and posterior wall isolation, low-voltage electrograms on the anterior wall were ablated during AF. During the radiofrequency application, AF was organized into a biatrial tachycardia (BiAT) (Supplemental video). The activation map of BiAT showed a counter-clockwise circuit using most of the mitral annulus in the left atrium (LA) (including the coronary sinus but not the LA septum) and right atrial (RA) septum with two interatrial connection...
Source: Heart Rhythm - April 5, 2018 Category: Cardiology Authors: Iwanari Kawamura, Seiji Fukamizu, Satoshi Miyazawa, Rintaro Hojo Source Type: research

Ventricular arrhythmias and sudden cardiac arrest in Takotsubo cardiomyopathy: Incidence, predictive factors and clinical implications
Takotsubo cardiomyopathy (TTC) is a stress-related transient cardiomyopathy. Life threatening arrhythmias (LTA) can occur and worsen prognosis. (Source: Heart Rhythm)
Source: Heart Rhythm - April 5, 2018 Category: Cardiology Authors: Laurence Jesel, Charlotte Berthon, Nathan Messas, Han S. Lim, M élanie Girardey, Halim Marzak, Benjamin Marchandot, Annie Trinh, Patrick Ohlmann, Olivier Morel Source Type: research

Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity
Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of excitation. Angiotensin II (AngII) has been implicated in the initiation and maintenance of AF through changes in Ca2+ handling and production of reactive oxygen species (ROS). (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jaime DeSantiago, Dan J. Bare, Disha Varma, R. John Solaro, Rishi Arora, Kathrin Banach Source Type: research

Loss of p21-activated kinase (Pak1) promotes atrial arrhythmic activity
Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of excitation. Angiotensin II (AngII) has been implicated in the initiation and maintenance of AF through changes in Ca2+ handling and production of reactive oxygen species (ROS). (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jaime DeSantiago, Dan J. Bare, Disha Varma, R. John Solaro, Rishi Arora, Kathrin Banach Source Type: research

Rhythm management in myotonic dystrophy: Progress has been made, but unsettled issues remain
The myotonic dystrophies (types 1 and 2) are autosomal dominant, multisystem diseases with relevancy to cardiac electrophysiologists because of the risk for arrhythmias. The more common and severe myotonic dystrophy is type 1, which is the focus of this editorial. The link between arrhythmias and myotonic dystrophy has been known almost from the first description of the disorder by Steinert in 1909. Early studies described conduction abnormalities and arrhythmias in single patients and in small series. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: William J. Groh Tags: Editorial Commentary Source Type: research

Long QT syndrome type 5-Lite: Defining the clinical phenotype associated with the potentially proarrhythmic p.Asp85Asn-KCNE1 common genetic variant
Long QT syndrome (LQTS) genetic test reports commonly exclude potentially proarrhythmic common variants such as p.Asp85Asn-KCNE1. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Conor Lane, John R. Giudicessi, Dan Ye, David J. Tester, Ram K. Rohatgi, J. Martijn Bos, Michael J. Ackerman Source Type: research

Biomarkers to noninvasively determine the atrial fibrillation progression phenotype: A bridge to individualized ablative therapy?
Finding the adequate therapy for patients with atrial fibrillation (AF) can often feel like a never-ending challenge. Although AF represents the most common age-related, progressive cardiac arrhythmia worldwide, there still is no curative therapy. Ablative therapy seemed promising, but many patients have recurrences or require multiple ablation procedures. Pulmonary vein isolation (PVI) is like flipping a coin; single-procedure freedom from atrial arrhythmia at long-term follow-up is only ∼50% in the overall population. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Roeliene Starreveld, Natasja M.S. de Groot Tags: Editorial Commentary Source Type: research

Right atrial dual-loop reentrant tachycardia after cardiac surgery: Prevalence, electrophysiological characteristics, and ablation outcomes
Right atrial (RA) dual-loop reentrant tachycardia has been described in patients who have undergone open heart surgery. However, the prevalence, electrophysiological (EP) substrate, and ablation outcomes have been poorly characterized. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jian-Du Yang, Qi Sun, Xiao-Gang Guo, Gong-Bu Zhou, Xu Liu, Bin Luo, Hui-Qiang Wei, Pasquale Santangeli, Jackson J. Liang, Jian Ma Source Type: research

Rhythm management in myotonic dystrophy: Progress, but unsettled issues remain
The myotonic dystrophies (types 1 and 2) are autosomal dominant, multisystem diseases with relevancy to cardiac electrophysiologists because of the risk for arrhythmias. The more common and severe myotonic dystrophy is type 1, which is the focus of this editorial. The link between arrhythmias and myotonic dystrophy has been known almost from the first description of the disorder by Steinert in 1909. Early studies described conduction abnormalities and arrhythmias in single patients and in small series. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: William J. Groh Tags: Editorial Commentary Source Type: research

Long QT Syndrome Type 5-Lite: Defining the Clinical Phenotype Associated with the Potentially Pro-Arrhythmic p.Asp85Asn-KCNE1 Common Genetic Variant
Long QT syndrome (LQTS) genetic test reports commonly exclude potentially pro-arrhythmic common variants such as p.Asp85Asn-KCNE1. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Conor Lane, John R. Giudicessi, Dan Ye, David J. Tester, Ram K. Rohatgi, J. Martijn Bos, Michael J. Ackerman Source Type: research

Right Atrial Dual-loop Reentry Tachycardia after Cardiac Surgery: Prevalence, Electrophysiologic Characteristics and Ablation Outcomes
Right atrial dual-loop reentry tachycardia has been described in patients with open-heart surgery. However, the prevalence, electrophysiologic substrate and ablation outcomes have been poorly characterized. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jian-du Yang, Qi Sun, Xiao-gang Guo, Gong-bu Zhou, Xu Liu, Bin Luo, Hui-qiang Wei, Pasquale Santangeli, Jackson J. Liang, Jian Ma Source Type: research

Biomarkers to Non-Invasively Determine the Atrial Fibrillation Progression Phenotype: A Bridge to Individualized Ablative Therapy?
Finding the adequate therapy for patients with atrial fibrillation (AF) can often feel like a never-ending challenge. Although AF represents the most common age-related, progressive cardiac arrhythmia worldwide, there still is no curative therapy. Ablative therapy seemed promising, but many patients have recurrences or require multiple ablation procedures. Pulmonary vein isolation (PVI) is like flipping a coin, as single-procedure freedom from atrial arrhythmia at long-term follow-up is only ∼50% in the overall population. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Roeliene Starreveld, Natasja M.S. de Groot Source Type: research

The Loss of p21-Activated Kinase (Pak1) Promotes Atrial Arrhythmic Activity The Role of Pak1 in Atrial Arrhythmia
Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of excitation. Angiotensin II (AngII) has been implicated in initiation and maintenance of AF through changes in Ca2+ handling and production of reactive oxygen species (ROS). (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jaime DeSantiago, Dan J. Bare, Disha Varma, R.John Solaro, Rishi Arora, Kathrin Banach Source Type: research

Rhythm Management in Myotonic Dystrophy: Progress but Unsettled Issues Remain
The myotonic dystrophies (types 1 and 2) are autosomal dominant, multisystem diseases with relevancy to cardiac electrophysiologists because of the risk for arrhythmias. The more common and severe myotonic dystrophy is type 1 which is the focus of this editorial. The link between arrhythmias and myotonic dystrophy has been known almost from the first description of the disorder by Steinert in 1909. Early studies described conduction abnormalities and arrhythmias in single patients or in small series. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: William J. Groh Source Type: research

Long QT Syndrome Type 5-Lite: Defining the Clinical Phenotype Associated with the Potentially Pro-Arrhythmic p.Asp85Asn-KCNE1 Common Genetic Variant
Long QT syndrome (LQTS) genetic test reports commonly exclude potentially pro-arrhythmic common variants such as p.Asp85Asn-KCNE1. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Conor Lane, John R. Giudicessi, Dan Ye, David J. Tester, Ram K. Rohatgi, J. Martijn Bos, Michael J. Ackerman Source Type: research

Right Atrial Dual-loop Reentry Tachycardia after Cardiac Surgery: Prevalence, Electrophysiologic Characteristics and Ablation Outcomes
Right atrial dual-loop reentry tachycardia has been described in patients with open-heart surgery. However, the prevalence, electrophysiologic substrate and ablation outcomes have been poorly characterized. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jian-du Yang, Qi Sun, Xiao-gang Guo, Gong-bu Zhou, Xu Liu, Bin Luo, Hui-qiang Wei, Pasquale Santangeli, Jackson J. Liang, Jian Ma Source Type: research

Biomarkers to Non-Invasively Determine the Atrial Fibrillation Progression Phenotype: A Bridge to Individualized Ablative Therapy?
Finding the adequate therapy for patients with atrial fibrillation (AF) can often feel like a never-ending challenge. Although AF represents the most common age-related, progressive cardiac arrhythmia worldwide, there still is no curative therapy. Ablative therapy seemed promising, but many patients have recurrences or require multiple ablation procedures. Pulmonary vein isolation (PVI) is like flipping a coin, as single-procedure freedom from atrial arrhythmia at long-term follow-up is only ∼50% in the overall population. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Roeliene Starreveld, Natasja M.S. de Groot Source Type: research

The Loss of p21-Activated Kinase (Pak1) Promotes Atrial Arrhythmic Activity The Role of Pak1 in Atrial Arrhythmia
Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of excitation. Angiotensin II (AngII) has been implicated in initiation and maintenance of AF through changes in Ca2+ handling and production of reactive oxygen species (ROS). (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2018 Category: Cardiology Authors: Jaime DeSantiago, Dan J. Bare, Disha Varma, R.John Solaro, Rishi Arora, Kathrin Banach Source Type: research

Giant T-wave changes after termination of atrial fibrillation
A 67-year-old woman came to the emergency department because of palpitations, accompanied by chest pain and shortness of breath. This started 2 hours earlier during a heated discussion with her son who is a drug addict. The electrocardiogram (ECG) on admission is shown in Figure  1A. She did not have a cardiac history. No ECG was ever recorded in the past. She was not taking any medication. The troponin value was elevated. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2018 Category: Cardiology Authors: Hein J. Wellens Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research

Left atrial thrombus and dense spontaneous echocardiographic contrast in patients on continuous direct oral anticoagulant therapy undergoing catheter ablation of atrial fibrillation: Comparison of dabigatran, rivaroxaban, and apixaban
Left atrial thrombus (LAT) and dense spontaneous echocardiographic contrast (SEC) detected by transesophageal echocardiography (TEE) in patients on continuous direct oral anticoagulants (DOAC) therapy before catheter ablation of atrial fibrillation (AF) or atrial flutter (AFL) have been described. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2018 Category: Cardiology Authors: Michael Wu, James Gabriels, Mohammad Khan, Nada Shaban, Salvatore D'Amato, Christopher F. Liu, Steven M. Markowitz, James E. Ip, George Thomas, Parmanand Singh, Bruce Lerman, Apoor Patel, Jim W. Cheung Tags: Clinical Source Type: research

Dofetilide dose reductions and discontinuations in women compared with men
Compared with men, women have longer corrected QT (QTc) intervals, lower clearance of dofetilide, and higher rates of drug-induced torsades de pointes, but the dofetilide dosing algorithm is the same for men and women. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2018 Category: Cardiology Authors: Sean D. Pokorney, Debbie C. Yen, Kristen B. Campbell, Nancy M. Allen LaPointe, Shubin Sheng, Laine Thomas, Tristram D. Bahnson, James P. Daubert, Jonathan P. Picini, Kevin P. Jackson, Kevin L. Thomas, Sana M. Al-Khatib Tags: Featured Article Source Type: research

Sex, drugs, and funky rhythms
“It has only been possible to collect a few figures for normal women, but so many of these fall outside the range for normal men…” wrote Bazett (p 356) in his 1920 analysis of cardiac electrical activity.1 Despite the passage of nearly 100 years since the first recognition of sex-based differe nces in cardiac electrical activity, there have not been comprehensive investigations into the differences in responses of men and women to pharmacological intervention. This is despite the generally accepted fact that female sex is associated with a longer baseline heart rate–corrected QT (QTc) i nterval and...
Source: Heart Rhythm - April 1, 2018 Category: Cardiology Authors: Igor Vorobyov, Colleen E. Clancy Tags: Editorial Commentary Source Type: research

In Memoriam: Ralph Lazzara, MD
Ralph Lazzara passed away suddenly on January 16, 2018, after a period of declining health. He was preceded in death by his son Ralph and his wife Barbara. His two daughters, Melissa and Rosalie, and three grandchildren survive him. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2018 Category: Cardiology Authors: Edward J. Berbari, Warren M. Jackman, Dwight Reynolds, Benjamin J. Scherlag Tags: In Memoriam Source Type: research

Notable Papers
(Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2018 Category: Cardiology Source Type: research

Giant T-wave changes after termination of atrial fibrillation
A 67-year-old woman came to the emergency department because of palpitations, accompanied by chest pain and shortness of breath. This started 2 hours earlier during a heated discussion with her son who is a drug addict. The electrocardiogram (ECG) on admission is shown in Figure  1A. She did not have a cardiac history. No ECG was ever recorded in the past. She was not taking any medication. The troponin value was elevated. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Hein J. Wellens Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research

Left atrial thrombus and dense spontaneous echocardiographic contrast in patients on continuous direct oral anticoagulant therapy undergoing catheter ablation of atrial fibrillation: Comparison of dabigatran, rivaroxaban, and apixaban
Left atrial thrombus (LAT) and dense spontaneous echocardiographic contrast (SEC) detected by transesophageal echocardiography (TEE) in patients on continuous direct oral anticoagulants (DOAC) therapy before catheter ablation of atrial fibrillation (AF) or atrial flutter (AFL) have been described. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Michael Wu, James Gabriels, Mohammad Khan, Nada Shaban, Salvatore D'Amato, Christopher F. Liu, Steven M. Markowitz, James E. Ip, George Thomas, Parmanand Singh, Bruce Lerman, Apoor Patel, Jim W. Cheung Tags: Clinical Source Type: research

Dofetilide dose reductions and discontinuations in women compared with men
Compared with men, women have longer corrected QT (QTc) intervals, lower clearance of dofetilide, and higher rates of drug-induced torsades de pointes, but the dofetilide dosing algorithm is the same for men and women. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Sean D. Pokorney, Debbie C. Yen, Kristen B. Campbell, Nancy M. Allen LaPointe, Shubin Sheng, Laine Thomas, Tristram D. Bahnson, James P. Daubert, Jonathan P. Picini, Kevin P. Jackson, Kevin L. Thomas, Sana M. Al-Khatib Tags: Featured Article Source Type: research

Sex, drugs, and funky rhythms
“It has only been possible to collect a few figures for normal women, but so many of these fall outside the range for normal men…” wrote Bazett (p 356) in his 1920 analysis of cardiac electrical activity.1 Despite the passage of nearly 100 years since the first recognition of sex-based differe nces in cardiac electrical activity, there have not been comprehensive investigations into the differences in responses of men and women to pharmacological intervention. This is despite the generally accepted fact that female sex is associated with a longer baseline heart rate–corrected QT (QTc) i nterval and...
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Igor Vorobyov, Colleen E. Clancy Tags: Editorial Commentary Source Type: research

In Memoriam: Ralph Lazzara, MD
Ralph Lazzara passed away suddenly on January 16, 2018, after a period of declining health. He was preceded in death by his son Ralph and his wife Barbara. His two daughters, Melissa and Rosalie, and three grandchildren survive him. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Edward J. Berbari, Warren M. Jackman, Dwight Reynolds, Benjamin J. Scherlag Tags: In Memoriam Source Type: research

Notable Papers
(Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Source Type: research

EP News: Allied Professionals
Using data from the National Cardiovascular Data Registry (NCDR), Friedman et  al (Circulation 2018;[Epub ahead of print], PMID 29463509) sought to assess the use and safety of ventricular fibrillation (VF) conversion testing during subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation. The authors noted that VF conversion testing has a Class I indication , but there are reports of declining compliance with this testing. They used the registry data on all S-ICD implantations between September 28, 2012 (when the S-ICD was approved by the Food and Drug Administration), and April 1, 2016 (when VF ...
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Erica S. Zado Source Type: research

Role of NT-proANP and NT-proBNP in patients with atrial fibrillation: Association with atrial fibrillation progression phenotypes
Electroanatomic remodeling in atrial fibrillation (AF) leads to disease initiation and perpetuation. Although atrial natriuretic peptide (ANP) is specifically expressed in the atria and is involved in atrial remodeling, B-type natriuretic peptide (BNP) is associated with mortality and cardiovascular events in AF. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Petra B üttner, Katja Schumacher, Borislav Dinov, Samira Zeynalova, Philipp Sommer, Andreas Bollmann, Daniela Husser, Gerhard Hindricks, Jelena Kornej Source Type: research

Prognostic Value of Global Longitudinal Strain in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Mand J.H. Khidir, Rachid Abou, Dilek Yilmaz, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax Source Type: research

Erratum
In the article titled “Comparison of longevity and clinical outcomes of implantable cardioverter-defibrillator leads among manufacturers” by Satoshi Kawada, Nobuhiro Nishii, Yoshimasa Morimoto, Akihito Miyoshi, Motomi Tachibana, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Hiroshi Morita, Hiroshi Ito that pub lished in the October 2017 issue of Heart Rhythm journal (2017;14:1496-1503) the author would like to add to the Conflicts of Interest statement: Dr Hiroshi Morita and Nobuhiro Nishii are affiliated with the endowed department by Japan Medtronic Inc. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Tags: Erratum Source Type: research

Erratum
In the article titled “2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry” by Jonathan S. Steinberg, Niraj Varma, and Iwona Cygankiewicz, et al that published in the July 2017 issue of Heart Rhythm (2017;14:e55–e96), an author was inadvertently left off the author list. Dr. Mintu P. Turakhia (Stanford University) should be listed as the 22nd author. The authors regret this error. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Tags: Erratum Source Type: research

Role of NT-proANP and NT-proBNP in patients with atrial fibrillation: Association with atrial fibrillation progression phenotypes
Electroanatomic remodeling in atrial fibrillation (AF) leads to disease initiation and perpetuation. Although atrial natriuretic peptide (ANP) is specifically expressed in the atria and is involved in atrial remodeling, B-type natriuretic peptide (BNP) is associated with mortality and cardiovascular events in AF. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Petra B üttner, Katja Schumacher, Borislav Dinov, Samira Zeynalova, Philipp Sommer, Andreas Bollmann, Daniela Husser, Gerhard Hindricks, Jelena Kornej Source Type: research

EP News: Allied Professionals
Using data from the National Cardiovascular Data Registry (NCDR), Friedman et  al (Circulation 2018;[Epub ahead of print], PMID 29463509) sought to assess the use and safety of ventricular fibrillation (VF) conversion testing during subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation. The authors noted that VF conversion testing has a Class I indication , but there are reports of declining compliance with this testing. They used the registry data on all S-ICD implantations between September 28, 2012 (when the S-ICD was approved by the Food and Drug Administration), and April 1, 2016 (when VF ...
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Erica S. Zado Source Type: research

The role of NT-proANP and NT-proBNP in AF patients: Association with AF progression phenotypes
Electro-anatomical remodeling in atrial fibrillation (AF) leads to disease initiation and perpetuation. While atrial natriuretic peptide (ANP) is specifically expressed in the atria and is involved in atrial remodeling, B-type natriuretic peptide (BNP) is associated with mortality and cardiovascular events in AF. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Petra B üttner, Katja Schumacher, Borislav Dinov, Samira Zeynalova, Philipp Sommer, Andreas Bollmann, Daniela Husser, Gerhard Hindricks, Jelena Kornej Source Type: research

Prognostic Value of Global Longitudinal Strain in Heart Failure Patients Treated with Cardiac Resynchronization Therapy
Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Authors: Mand J.H. Khidir, Rachid Abou, Dilek Yilmaz, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax Source Type: research

Erratum
In the article titled “Comparison of longevity and clinical outcomes of implantable cardioverter-defibrillator leads among manufacturers” by Satoshi Kawada, Nobuhiro Nishii, Yoshimasa Morimoto, Akihito Miyoshi, Motomi Tachibana, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Hiroshi Morita, Hiroshi Ito that pub lished in the October 2017 issue of Heart Rhythm journal (2017;14:1496-1503) the author would like to add to the Conflicts of Interest statement: Dr Hiroshi Morita and Nobuhiro Nishii are affiliated with the endowed department by Japan Medtronic Inc. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Tags: Erratum Source Type: research

Erratum
In the article titled “2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry” by Jonathan S. Steinberg, Niraj Varma, and Iwona Cygankiewicz, et al that published in the July 2017 issue of Heart Rhythm (2017;14:e55–e96), an author was inadvertently left off the author list. Dr. Mintu P. Turakhia (Stanford University) should be listed as the 22nd author. The authors regret this error. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2018 Category: Cardiology Tags: Erratum Source Type: research

EP News: Heart Rhythm Case Reports
Our understanding of Wolff-Parkinson-White (WPW) syndrome has evolved significantly since its initial description a century ago, including the mechanisms that underlie the association with supraventricular tachycardia, atrial fibrillation, and sudden cardiac death. Although WPW syndrome is a frequently encountered congenital abnormality, incidence patterns for the most part are noninherited. Rare familial WPW syndrome has been associated with specific gene mutations in the PRKAG2 gene. Field et  al (DOI: https://doi.org/10.1016/j.hrcr.2018.01.013) presented an interesting case series of identical twins who developed p...
Source: Heart Rhythm - March 22, 2018 Category: Cardiology Authors: T. Jared Bunch Source Type: research

EP News: Basic and Translational
Cardiac rhythmicity strongly depends on cell Ca2+ handling, and prevalent cardiac diseases are causally associated with perturbations in intracellular Ca2+ handling. Mitochondria and mitochondrial Ca2+ transport proteins are important regulators of cardiac Ca2+ handling. Schweitzer et  al (JACC Basic Transl Sci 2017;2:737, PMID 29354781) evaluated the potential of pharmacological activation of mitochondrial Ca2+ uptake for the treatment of cardiac arrhythmia. They tested substances that enhance mitochondrial Ca2+ uptake in a murine model for ryanodine receptor 2 (RyR2)–mediate d catecholaminergic polymorphic ven...
Source: Heart Rhythm - March 22, 2018 Category: Cardiology Authors: Penelope A. Boyden Source Type: research

EP News: Clinical
Marrouche et  al (N Engl J Med 2018;378:417, PMID 29385358) randomized patients with atrial fibrillation (AF) with prior unsuccessful therapy with an antiarrhythmic drug to catheter ablation (179 patients) or medical therapy (rate or rhythm control) (184 patients). All the patients had New York Heart Associatio n class II, III, or IV heart failure; left ventricular ejection fraction ≤35%; and an implanted defibrillator. The primary end point was a composite of death or hospitalization for heart failure. (Source: Heart Rhythm)
Source: Heart Rhythm - March 22, 2018 Category: Cardiology Authors: N.A. Mark Estes Source Type: research

Copy number variations of SCN5A in Brugada syndrome
Loss-of-function mutations in SCN5A are associated in ∼20% of Brugada syndrome (BrS) patients. Copy number variations (CNVs) have been shown to be associated with several inherited arrhythmia syndromes. (Source: Heart Rhythm)
Source: Heart Rhythm - March 22, 2018 Category: Cardiology Authors: Keiko Sonoda, Seiko Ohno, Junichi Ozawa, Mamoru Hayano, Tetsuhisa Hattori, Atsushi Kobori, Mitsuhiko Yahata, Isao Aburadani, Seiichi Watanabe, Yuichi Matsumoto, Takeru Makiyama, Minoru Horie Source Type: research