Diagnostic value and prognostic implications of early cardiac magnetic resonance in survivors of out-of-hospital cardiac arrest
In patients who survived out-of-hospital cardiac arrest (OHCA), it is crucial to establish the underlying cause and its potential reversibility. (Source: Heart Rhythm)
Source: Heart Rhythm - March 14, 2018 Category: Cardiology Authors: Alessandro Zorzi, Angela Susana, Manuel De Lazzari, Federico Migliore, Giovanni Vescovo, Daniele Scarpa, Anna Baritussio, Giuseppe Tarantini, Luisa Cacciavillani, Benedetta Giorgi, Cristina Basso, Sabino Iliceto, Chiara Bucciarelli Ducci, Domenico Corrado Source Type: research

Diagnostic value and prognostic implications of early cardiac magnetic resonance in survivors of out of hospital cardiac arrest
In patients who survived out-of-hospital cardiac arrest (OHCA) it is crucial to establish the underlying cause and its potential reversibility. (Source: Heart Rhythm)
Source: Heart Rhythm - March 14, 2018 Category: Cardiology Authors: Alessandro Zorzi, Angela Susana, Manuel De Lazzari, Federico Migliore, Giovanni Vescovo, Daniele Scarpa, Anna Baritussio, Giuseppe Tarantini, Luisa Cacciavillani, Benedetta Giorgi, Cristina Basso, Sabino Iliceto, Chiara Bucciarelli Ducci, Domenico Corrado Source Type: research

Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction
Neuraxial modulation with cardiac sympathetic denervation (CSD) can potentially reduce burden of ventricular tachyarrhythmias (VT). However, despite catheter ablation and CSD, VT can recur in patients with cardiomyopathy and the role of vagal nerve stimulation (VNS) in this setting is unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Naoko Yamaguchi, Kentaro Yamakawa, Pradeep S. Rajendran, Tatsuo Takamiya, Marmar Vaseghi Source Type: research

Visualization of acute edema in the left atrial myocardium after radiofrequency ablation: Application of a novel high-resolution 3-dimensional magnetic resonance imaging sequence
Ablation-induced left atrial (LA) edema may result in procedural failure due to reversible pulmonary vein isolation. Conventional T2-weighted magnetic resonance edema imaging is limited by low spatial resolution. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Tarek Zghaib, Ashkan A. Malayeri, Esra G. Ipek, Mohammadali Habibi, Dong Huang, Muhammad A. Balouch, David A. Bluemke, Hugh Calkins, Saman Nazarian, Stefan L. Zimmerman Source Type: research

Role for electrocardiographic imaging in cardiac resynchronization therapy?
Heart failure (HF) is a highly prevalent progressive disease, with a high mortality rate. Up to 50% of deaths are sudden, mostly from ventricular tachyarrhythmias (VTs). The HF –VT relationship is reciprocal because arrhythmias contribute to cardiomyopathy through remodeling processes. Electrophysiologic (EP) abnormalities in HF involve multiple scales, from molecular modification of ion channels and alteration of cellular calcium cycling, to structural remodeling of car diac tissue. At the cellular scale, the changes can promote arrhythmia triggers in the form of delayed and early afterdepolarizations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Yoram Rudy Tags: Editorial Commentary Source Type: research

Anti-Arrhythmic Effects of Vagal Nerve Stimulation After Cardiac Sympathetic Denervation in the Setting of Chronic Myocardial Infarction
Neuraxial modulation with cardiac sympathetic denervation (CSD) can potentially reduce burden of ventricular tachy-arryhthmias (VT). Despite catheter ablation and CSD, however, VT can recur in patients with cardiomyopathy and the role of vagal nerve stimulation (VNS) in this setting is unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Naoko Yamaguchi, Kentaro Yamakawa, Pradeep S. Rajendran, Tatsuo Takamiya, Marmar Vaseghi Source Type: research

Visualization of Acute Edema in the Left Atrial Myocardium after Radiofrequency Ablation: Application of a Novel High-Resolution 3-Dimensional Magnetic Resonance Imaging Sequence
Ablation-induced left atrial (LA) edema may result in procedural failure due to reversible pulmonary vein (PV) isolation. Conventional T2-weighted magnetic resonance edema imaging is limited by low spatial resolution. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Tarek Zghaib, Ashkan A. Malayeri, Esra G. Ipek, Mohammadali Habibi, Dong Huang, Muhammad A. Balouch, David A. Bluemke, Hugh Calkins, Saman Nazarian, Stefan L. Zimmerman Source Type: research

Role for Electrocardiographic Imaging in Cardiac Resynchronization Therapy?
Heart failure (HF) is a highly-prevalent progressive disease, with high mortality rate. Up to 50% of deaths are sudden, mostly from ventricular tachyarrhythmias (VT). The HF –VT relationship is reciprocal, because arrhythmias contribute to cardiomyopathy through remodeling processes. Electrophysiological (EP) abnormalities in HF involve multiple scales, from molecular modification of ion-channels and alteration of cellular calcium cycling, to structural remodeling of cardiac tissue. At the cellular scale, the changes can promote arrhythmia triggers in the form of delayed and early afterdepolarizations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Yoram Rudy Source Type: research

Anti-Arrhythmic Effects of Vagal Nerve Stimulation After Cardiac Sympathetic Denervation in the Setting of Chronic Myocardial Infarction
Neuraxial modulation with cardiac sympathetic denervation (CSD) can potentially reduce burden of ventricular tachy-arryhthmias (VT). Despite catheter ablation and CSD, however, VT can recur in patients with cardiomyopathy and the role of vagal nerve stimulation (VNS) in this setting is unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 9, 2018 Category: Cardiology Authors: Naoko Yamaguchi, Kentaro Yamakawa, Pradeep S. Rajendran, Tatsuo Takamiya, Marmar Vaseghi Source Type: research

Approach to permanent His bundle pacing in challenging implants
Right ventricular apical pacing has been the cornerstone of bradycardia pacing for decades. It is well established that right ventricular pacing leads to ventricular dyssynchrony, reduced left ventricular function, and heart failure.1,2 Since the initial description of permanent His bundle pacing (HBP) by Deshmukh et  al in 2000,3 several investigators have demonstrated the clinical utility of HBP in patients with atrioventricular (AV) nodal block, infranodal AV block, and bundle branch block.4–7 Increasing interest in HBP has been hampered in part by challenges and limitations associated with a limited impla nt...
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Pugazhendhi Vijayaraman, Kenneth A. Ellenbogen Tags: Hands On Source Type: research

Left atrial appendage ligation and atrial fibrillation: A tool to “snare” greater success?
In 1998, Ha ïssaguerre et al1 published a seminal observational study describing pulmonary vein ectopic beats triggering atrial fibrillation. This landmark article ushered in a new era in the management of atrial fibrillation, and pulmonary vein isolation (PVI) rapidly became the basis for catheter ablation t herapy.2 Indeed, within the decade, catheter ablation for atrial fibrillation would become the single most common invasive procedure at many large medical centers managing cardiac arrhythmias in high-income nations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Sunil K. Sinha Tags: Editorial Commentary Source Type: research

Effect of dual-chamber minimal ventricular pacing on paroxysmal atrial fibrillation incidence in myotonic dystrophy type 1 patients: A prospective, randomized, single-blind, crossover study
Atrial fibrillation (AF) is a common finding in the myotonic dystrophy type 1 (DM1) population. Pacemakers (PMs) may facilitate the diagnosis and management of frequent subclinical asymptomatic AF episodes. (Source: Heart Rhythm)
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello, Gerardo Nigro Source Type: research

Left atrial appendage ligation and atrial fibrillation: A tool to “snare” greater success?
In 1998, Ha ïssaguerre et al1 published a seminal observational study describing pulmonary vein ectopic beats triggering atrial fibrillation. This landmark article ushered in a new era in the management of atrial fibrillation, and pulmonary vein isolation (PVI) rapidly became the basis for catheter ablation t herapy.2 Indeed, within the decade, catheter ablation for atrial fibrillation would become the single most common invasive procedure at many large medical centers managing cardiac arrhythmias in high-income nations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Sunil K. Sinha Tags: Editorial Commentary Source Type: research

Approach To Permanent His Bundle Pacing In Challenging Implants
Right ventricular apical pacing has been the cornerstone of bradycardia pacing for decades. It is well established that right ventricular pacing leads to ventricular dyssynchrony, reduced left ventricular function and heart failure.1,2 Since the initial description of permanent HBP by Deshmukh et al in 20003 several investigators have demonstrated the clinical utility of HBP in patients with AV nodal block, infranodal AV block and bundle branch block.4-7 Increasing interest in His bundle pacing has been hampered in part by challenges and limitations associated with a limited implantation tool set. (Source: Heart Rhythm)
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Pugazhendhi Vijayaraman, Kenneth A. Ellenbogen Source Type: research

Left Atrial Appendage Ligation & Atrial Fibrillation: A Tool To “Snare” Greater Success?
In 1998, Dr. Michel Ha ïssaguerre et al, published a seminal observational study describing pulmonary vein ectopic beats triggering atrial fibrillation1. This landmark paper ushered in a new era in the management of atrial fibrillation and pulmonary vein isolation (PVI) rapidly became the basis for catheter ablation ther apy2. Indeed, within the decade, catheter ablation for atrial fibrillation would become the single most common invasive procedure at many large medical centers managing cardiac arrhythmias in high income nations3. (Source: Heart Rhythm)
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Sunil K. Sinha Source Type: research

The effect of dual chamber minimal ventricular pacing on paroxysmal atrial fibrillation incidence in Myotonic Dystrophy type 1 patients: a prospective, randomized, single-blind, crossover study
Atrial fibrillation (AF) is a common finding in myotonic dystrophy type 1 (DM1) population. Pacemakers may facilitate the diagnosis and management of frequent subclinical asymptomatic AF episodes. (Source: Heart Rhythm)
Source: Heart Rhythm - March 7, 2018 Category: Cardiology Authors: Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello Eng, Gerardo Nigro Source Type: research

How to map and ablate parahisian ventricular arrhythmias
Ventricular tachycardia (VT) and premature ventricular contractions (PVCs) originating in the vicinity of the His-bundle region represent 3% –9% of all idiopathic ventricular arrhythmias (VAs).1,2 In addition, patients with cardiomyopathies and scar-related VT may exhibit septal arrhythmogenic substrate involving the parahisian region.3 Catheter ablation of these arrhythmias poses particular challenges because of the risk of inadverten t atrioventricular (AV) block, and a systematic approach is important to improve outcomes and minimize complications. (Source: Heart Rhythm)
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: Andres Enriquez, Carlos Tapias, Diego Rodriguez, Jackson Liang, Francis Marchlinski, Luis Saenz, Fermin Garcia Tags: Hands on Source Type: research

Should we consider the next implantable cardioverter-defibrillator trial in patients with acute  coronary syndrome and monomorphic ventricular tachycardia?
Episodes of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) observed during acute coronary syndrome (ACS) and acute myocardial infarction have always been of significant concerns. Recent data from cohorts with aggressive revascularization management of ACS indicated that VF increases in-hospital mortality but does not influence long-term mortality.1,2 The study of 3670 patients with acute myocardial infarction hospitalized in France in 20051 demonstrated that 116 (3%) patients developed VF that was associated with a 7-fold increase in in-hospital mortality but was not associated with increase in 5-y...
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: Wojciech Zareba Tags: Editorial Commentary Source Type: research

Mapping of atrial fibrillation: A test of faith
In the Leo Tolstoy's short story “Three Questions,” a king wished to understand 3 questions. These questions revolved around knowing the right time to do something, the right people to do it to, and how to make the right choice. The king offered a great reward to anyone in his kingdom who could answer these questions. Many lear ned men came and all gave different answers that did not satisfy the king. The king in disguise visited a wise hermit. The king found the hermit digging in his yard, and after asking the hermit his 3 questions received no answers. (Source: Heart Rhythm)
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: T. Jared Bunch Tags: Editorial Commentary Source Type: research

Should we consider the next implantable cardioverter-defibrillator trial in patients with acute  coronary syndrome and monomorphic ventricular tachycardia?
Episodes of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) observed during acute coronary syndrome (ACS) and acute myocardial infarction have always been of significant concerns. Recent data from cohorts with aggressive revascularization management of ACS indicated that VF increases in-hospital mortality but does not influence long-term mortality.1,2 The study of 3670 patients with acute myocardial infarction hospitalized in France in 20051 demonstrated that 3% of cases developed VF that was associated with a 7-fold increase in in-hospital mortality but was not associated with increase in 5-year su...
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: Wojciech Zareba Tags: Editorial Commentary Source Type: research

Mapping of atrial fibrillation: A test of faith
In the Leo Tolstoy's short story “Three Questions,” a king wished to understand 3 questions. These questions revolved around knowing the right time to do something, the right people to do it to, and how to make the right choice. The king offered a great reward to anyone in his kingdom who could answer these questions. Many lear ned men came and all gave different answers that did not satisfy the king. The king in disguise visited a wise hermit. The king found the hermit digging in his yard, and after asking the hermit his 3 questions received no answers. (Source: Heart Rhythm)
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: T. Jared Bunch Tags: Editorial Commentary Source Type: research

How to Map and Ablate Parahisian Ventricular Arrhythmias
Ventricular tachycardia (VT) and premature ventricular contractions (PVCs) originating in the vicinity of the His-bundle region represent 3-9% of all idiopathic ventricular arrhythmias (VAs)1,2. In addition, patients with cardiomyopathies and scar-related VT may exhibit septal arrhythmogenic substrate involving the parahisian region3. Catheter ablation of these arrhythmias poses particular challenges due to the risk of inadvertent atrioventricular (AV) block, and a systematic approach is important to improve outcomes and minimize complications. (Source: Heart Rhythm)
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: Andres Enriquez, Carlos Tapias, Diego Rodriguez, Jackson Liang, Francis Marchlinski, Luis Saenz, Fermin Garcia Source Type: research

Should we Consider the Next ICD Trial in the Acute Coronary Syndrome Patients with Monomorphic VT?
Episodes of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) observed during acute coronary syndromes (ACS) and acute myocardial infarction have always been of significant concerns. Recent data from cohorts with aggressive revascularization management of ACS indicated that VF increases in-hospital mortality but does not influence long-term mortality (1-2). The study of 3,670 acute myocardial infarction patients hospitalized in France in 2005 (1) demonstrated that 3% cases developed VF which was associated with a 7-fold increase in in-hospital mortality but was not associated with increase in a 5-year...
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: Wojciech Zareba Source Type: research

The Mapping of Atrial Fibrillation: A Test of Faith
In Leo Tolstoy ’s short story “Three Questions”, a king wished to understand three questions. These questions revolved around knowing the right time to do something, the right people to do it to, and how to make the right choice. The king offered a great reward to anyone in his kingdom who could answer these questions. Many learned men came and all gave different answers that did not satisfy the king. The king in disguise visited a wise hermit. The king found the hermit digging in his yard and after asking the hermit his three questions received no answers. (Source: Heart Rhythm)
Source: Heart Rhythm - March 6, 2018 Category: Cardiology Authors: T. Jared Bunch Source Type: research

Diagnosis and management of short QT syndrome
Establishing a definition of short QT syndrome (SQTS), including symptomatology and QT-interval duration, is still a work in progress. However, it is clear , that SQTS is a rare, life-threatening, inherited heart disease presenting as sudden cardiac death (SCD) or aborted SCD in 34% and a family history of SCD in 15%. Genetic testing is important in diagnosing the disease, but to date a causative mutation is found in (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Preben Bjerregaard Tags: Contemporary Review Source Type: research

Pulmonary vein activity does not predict the outcome of catheter ablation for persistent atrial fibrillation: A long-term multicenter prospective study
Pulmonary vein (PV) isolation (PVI) remains the cornerstone of catheter ablation (CA) in persistent atrial fibrillation (AF) (PeAF), although less successful than for paroxysmal AF. Whether rapid or fibrillatory (PV AF) PV firing may identify patients with PeAF more likely to benefit from a PV-based ablation approach is unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Sandeep Prabhu, Manish Kalla, Kah Y. Peck, Aleksandr Voskoboinik, Alex J.A. McLellan, Bupesh Pathik, Chrishan J. Nalliah, Geoff R. Wong, Hariharan Sugumar, Sonia M. Azzopardi, Geoffrey Lee, Liang-Han Ling, Jonathan M. Kalman, Peter M. Kistler Source Type: research

Association of regional epicardial right ventricular electrogram voltage amplitude and late gadolinium enhancement distribution on cardiac magnetic resonance in patients with arrhythmogenic right ventricular cardiomyopathy: Implications for ventricular tachycardia ablation
Criteria for identification of anatomic ventricular tachycardia substrates in arrhythmogenic right ventricular cardiomyopathy (ARVC) on late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) are unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Shuanglun Xie, Benoit Desjardins, Maciej Kubala, Jackson Liang, Jiandu Yang, Rob J. van der Geest, Robert Schaller, Michael Riley, David Callans, Erica Zado, Francis Marchlinski, Saman Nazarian Source Type: research

Amino acid –level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise
Due to rapid expansion of clinical genetic testing, an increasing number of genetic variants of undetermined significance and unclear diagnostic value are being identified in children. Variants found in genes associated with heritable channelopathies, such as long QT syndrome (LQTS), are particularly difficult to interpret given the risk of sudden cardiac death associated with pathologic mutations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Andrew P. Landstrom, Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim Source Type: research

Endocardial left ventricular pacing across the interventricular septum for cardiac resynchronization therapy: Clinical results of a pilot study
Cardiac resynchronization therapy (CRT) is an effective treatment for selected patients with heart failure, but it can be limited by the inability to place the left ventricular (LV) lead via the coronary sinus. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: James H.P. Gamble, Neil Herring, Matthew R. Ginks, Kim Rajappan, Yaver Bashir, Tim R. Betts Source Type: research

The diagnosis and management of short QT syndrome
Establishing a definition of short QT syndrome (SQTS), including symptomatology and QT-interval duration, is still a work in progress. However, it is clear , that SQTS is a rare, life-threatening, inherited heart disease presenting as sudden cardiac death (SCD) or aborted SCD in 34% and a family history of SCD in 15%. Genetic testing is important in diagnosing the disease, but to date a causative mutation is found in (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Preben Bjerregaard Tags: Contemporary Review Source Type: research

Endocardial left ventricular pacing across the interventricular septum for cardiac resynchronization therapy: Clinical results of a pilot study
Cardiac resynchronization therapy (CRT) is an effective treatment for selected patients with heart failure, but it can be limited by the inability to place the left ventricular (LV) lead via the coronary sinus. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: James H.P. Gamble, Neil Herring, Matthew R. Ginks, Kim Rajappan, Yaver Bashir, Tim R. Betts Source Type: research

Amino acid –level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise
Due to rapid expansion of clinical genetic testing, an increasing number of genetic variants of undetermined significance and unclear diagnostic value are being identified in children. Variants found in genes associated with heritable channelopathies, such as long QT syndrome (LQTS), are particularly difficult to interpret given the risk of sudden cardiac death associated with pathologic mutations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Andrew P. Landstrom, Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim Source Type: research

Pulmonary vein activity does not predict the outcome of catheter ablation for persistent atrial fibrillation: A long-term multicenter prospective study
Pulmonary vein (PV) isolation (PVI) remains the cornerstone of catheter ablation (CA) in persistent atrial fibrillation (AF) (PeAF), although less successful than for paroxysmal AF. Whether rapid or fibrillatory (PV AF) PV firing may identify patients with PeAF more likely to benefit from a PV-based ablation approach is unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Sandeep Prabhu, Manish Kalla, Kah Y. Peck, Aleksandr Voskoboinik, Alex J.A. McLellan, Bupesh Pathik, Chrishan J. Nalliah, Geoff R. Wong, Hariharan Sugumar, Sonia M. Azzopardi, Geoffrey Lee, Liang-Han Ling, Jonathan M. Kalman, Peter M. Kistler Source Type: research

Pulmonary vein activity does not predict outcome of catheter ablation for persistent atrial fibrillation – A long term multi-centre prospective study
Pulmonary vein isolation (PVI) remains the cornerstone of catheter ablation (CA) in persistent AF (PeAF) although less successful than for PAF. Whether rapid or fibrillatory (PVAF) PV firing may identify PeAF patients more likely to benefit from a PV based approach, is unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Sandeep Prabhu, Manish Kalla, Kah Y. Peck, Aleksandr Voskoboinik, Alex JA. McLellan, Bupesh Pathik, Chrishan J. Nalliah, Geoff R. Wong, Hariharan Sugumar, Sonia M. Azzopardi, Geoffrey Lee, Liang-Han Ling, Jonathan M. Kalman, Peter M. Kistler Source Type: research

Association of Regional Epicardial Right Ventricular Electrogram Voltage Amplitude and Late Gadolinium Enhancement Distribution on Cardiac Magnetic Resonance in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy: Implications for Ventricular Tachycardia Ablation
Criteria for identification of anatomic ventricular tachycardia (VT) substrates in arrhythmogenic right ventricular cardiomyopathy (ARVC) on late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) are unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Shuanglun Xie, Benoit Desjardins, Maciej Kubala, Jackson Liang, Jiandu Yang, Rob J. van der Geest, Robert Schaller, Michael Riley, David Callans, Erica Zado PAC, Francis Marchlinski, Saman Nazarian Source Type: research

Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise
Due to rapid expansion of clinical genetic testing, an increasing number of genetic variants of undetermined significance are being identified in children with unclear diagnostic value. Variants found in genes associated with heritable channelopathies, such as long QT syndrome (LQTS), are particularly difficult to interpret given the risk of sudden cardiac death associated with pathologic mutations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Andrew P. Landstrom, Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim Source Type: research

Endocardial Left Ventricular Pacing across the Inter-Ventricular Septum for Cardiac Resynchronization Therapy - Clinical Results of a pilot study
Cardiac Resynchronization Therapy (CRT) is an effective treatment for selected patients with heart failure, but can be limited by the inability to place the left ventricular (LV) lead via the coronary sinus. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: James H.P. Gamble, Neil Herring, Matthew R. Ginks, Kim Rajappan, Yaver Bashir, Tim R. Betts Source Type: research

The diagnosis and management of short QT syndrome
Establishing a definition of SQTS including symptomatology and QT interval duration is still a work in progress. It is clear, however, that SQTS is a rare, life-threatening, inherited heart disease presenting as SCD or aborted SCD in 34% and a family history of SCD in 15%. Genetic testing is important in diagnosing the disease, but so far with a causative mutation found in less than 25%. A benign variety of the disease has been observed in children with atrial fibrillation and a KCNH2-V141M mutation, and just recently a mutation in the cardiac Cl,HCO3- exchanger AE3 was found to cause SQTS. (Source: Heart Rhythm)
Source: Heart Rhythm - March 1, 2018 Category: Cardiology Authors: Preben Bjerregaard Source Type: research

A 66-year-old man with a wide QRS tachycardia
A 66-year-old man was admitted to hospital with dizziness, palpitations, and chest pain. His electrocardiogram (ECG) is shown in Figure  1A. Figure 1B shows his sinus rhythm ECG after cardioversion. His history revealed a myocardial infarction (MI) 8 months ago. He denied having had a similar episode of complaints as present on presentation. (Source: Heart Rhythm)
Source: Heart Rhythm - February 28, 2018 Category: Cardiology Authors: Hein J. Wellens Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research

Reviewer Thanks
(Source: Heart Rhythm)
Source: Heart Rhythm - February 28, 2018 Category: Cardiology Source Type: research

Remarkable Reviewers
(Source: Heart Rhythm)
Source: Heart Rhythm - February 28, 2018 Category: Cardiology Source Type: research

Safety and feasibility of leadless pacemaker in patients undergoing atrioventricular node ablation for atrial fibrillation
Atrioventricular node (AVN) ablation and permanent pacing is an established strategy for rate control in the management of symptomatic atrial fibrillation (AF). Leadless pacemakers (LPs) can overcome some of the short-term and long-term limitations of conventional transvenous pacemakers (CTPs). (Source: Heart Rhythm)
Source: Heart Rhythm - February 26, 2018 Category: Cardiology Authors: Bharath Yarlagadda, Mohit K. Turagam, Tawseef Dar, Pragna Jangam, Vaishnavi Veerapaneni, Donita Atkins, Sudharani Bommana, Paul Friedman, Abhishek J. Deshmukh, Rahul Doshi, Vivek Y. Reddy, Srinivas R. Dukkipati, Andrea Natale, Dhanunjaya Lakkireddy Source Type: research

Effect of ventricular pacing lead position on tricuspid regurgitation: A randomized prospective trial
Pacing lead –related tricuspid regurgitation (TR), a recognized complication of ventricular pacing lead implantation, may be affected by lead position or diameter. (Source: Heart Rhythm)
Source: Heart Rhythm - February 26, 2018 Category: Cardiology Authors: J. William Schleifer, Sorin V. Pislaru, Grace Lin, Brian D. Powell, Raul Espinosa, Celeste Koestler, Trena Thome, Lynn Polk, Zhuo Li, Samuel J. Asirvatham, Yong-Mei Cha Source Type: research

Safety and Feasibility of Leadless Pacemaker in Patients Undergoing Atrioventricular node Ablation for Atrial Fibrillation
Atrioventricular node (AV) ablation and permanent pacing is an established strategy for rate control in the management of symptomatic atrial fibrillation (AF). Leadless pacemakers (LP) can overcome some of the short-term and long-term limitations of conventional transvenous pacemakers (CTP). (Source: Heart Rhythm)
Source: Heart Rhythm - February 26, 2018 Category: Cardiology Authors: Bharath Yarlagadda, Mohit K. Turagam, Tawseef Dar, Pragna Jangam, Vaishnavi Veerapaneni, Donita Atkins, Sudharani Bommana, Paul Friedman, Abhishek J. Deshmukh, Rahul Doshi, Vivek Y. Reddy, Srinivas R. Dukkipati, Andrea Natale, Dhanunjaya Lakkireddy Source Type: research

Effect of Ventricular Pacing Lead Position on Tricuspid Regurgitation: A Randomized Prospective Trial
Pacing lead –related tricuspid regurgitation (TR), a recognized complication of ventricular pacing lead implantation, may be affected by lead position or diameter. (Source: Heart Rhythm)
Source: Heart Rhythm - February 26, 2018 Category: Cardiology Authors: J. William Schleifer, Sorin V. Pislaru, Grace Lin, Brian D. Powell, Raul Espinosa, Celeste Koestler, Trena Thome, Lynn Polk, Zhuo Li, Samuel J. Asirvatham, Yong-Mei Cha Source Type: research

EP News: Allied Professionals
The CASTLE-AF (Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation) trial by Marrouche et  al (N Engl J Med 2018;378:417–427, PMID 29385358) randomized patients with atrial fibrillation (AF), low left ventricular ejection fraction (LVEF), and heart failure (HF) symptoms to either ablation for AF or conventional medical therapy in the form of rate or rhythm control. All patients were o n guideline-directed therapy for HF that was adjusted and optimized during a 5-week run-up period to randomization. (Source: Heart Rhythm)
Source: Heart Rhythm - February 24, 2018 Category: Cardiology Authors: Erica S. Zado Tags: EP News —Section Editors: T. Jared Bunch, Penelope A. Boyden, N.A. Mark Estes III, Erica S. Zado Source Type: research

Is a little atrial fibrillation still too much?
Atrial fibrillation (AF) is most often viewed as a dichotomous variable, one that is either entirely present or absent. Guidelines support this perspective by recommending anticoagulation based on underlying stroke risk without regard to AF “type,” duration, or burden.1 The use of cardiac monitoring, however, has allowed us to quantify AF and associate outcomes with various arrhythmia characteristics.2,3 These types of studies have raised legitimate doubts as to whether the 30-second threshold used to define AF is associated with m eaningful consequences and have created equipoise for subclinical AF episodes la...
Source: Heart Rhythm - February 24, 2018 Category: Cardiology Authors: Rod Passman Tags: Editorial Commentary Source Type: research

EP News: Allied Professionals
The CASTLE-AF (Catheter Ablation versus Standard Conventional Therapy in Patients with Left Ventricular Dysfunction and Atrial Fibrillation) trial by Marrouche et  al (N Engl J Med 2018;378:417–427, PMID 29385358) randomized patients with atrial fibrillation (AF), low left ventricular ejection fraction (LVEF), and heart failure (HF) symptoms to either ablation for AF or conventional medical therapy in the form of rate or rhythm control. All patients were o n guideline-directed therapy for HF that was adjusted and optimized during a 5-week run-up period to randomization. (Source: Heart Rhythm)
Source: Heart Rhythm - February 24, 2018 Category: Cardiology Authors: Erica S. Zado Source Type: research

Is A Little Atrial Fibrillation Still Too Much?
Atrial fibrillation (AF) is most often viewed as a dichotomous variable, one that is either entirely present or absent. Guidelines support this perspective by recommending anticoagulation based on underlying stroke risk without regard to AF “type”, duration, or burden.1 The use of cardiac monitoring, however, has allowed us to quantify AF and associate outcomes with various arrhythmia characteristics.2, 3 These types of studies have raised legitimate doubts as to whether the 30 second threshold used to define AF is associated with meaningful consequences and have created equipoise for sub-clinical AF episodes l...
Source: Heart Rhythm - February 24, 2018 Category: Cardiology Authors: Rod Passman Source Type: research