The role of Marshall bundle epicardial connections in atrial tachycardias after atrial fibrillation ablation
Atrial tachycardias (ATs) are often seen in the context of atrial fibrillation (AF) ablation. (Source: Heart Rhythm)
Source: Heart Rhythm - May 21, 2019 Category: Cardiology Authors: Konstantinos Vlachos, Arnaud Denis, Masateru Takigawa, Takeshi Kitamura, Claire A. Martin, Antonio Frontera, Ruairidh Martin, George Bazoukis, Felix Bourier, Ghassen Cheniti, Josselin Duchateau, Nathaniel Thompson, Gregoire Massoullie, Anna Lam, Michael W Source Type: research

Detection of High Frequency Artifact as a Function of Pulse Generator Algorithms and Outer-Insulation Material
A high rate of malfunction, predominantly intermittent high frequency artifacts (HFAs), has been recently reported in Abbott Medical Tendril pacing leads. (Source: Heart Rhythm)
Source: Heart Rhythm - May 21, 2019 Category: Cardiology Authors: Ryohsuke Narui, Tomofumi Nakamura, Ikutaro Nakajima, Caleb A. Norton, Eun-jeong Kim, Benjamin B. Holmes, William G. Stevenson, Roy M. John, Christopher R. Ellis, George H. Crossley, Jay A. Montgomery Source Type: research

Why Low-Voltage Shock Impedance Measurements Fail to Reliably Detect Insulation Breaches in Transvenous Defibrillation Leads
Implantable-cardioverter defibrillators (ICDs) use low-voltage measures of shock impedance (LVSZ) to monitor integrity of leads. (Source: Heart Rhythm)
Source: Heart Rhythm - May 21, 2019 Category: Cardiology Authors: Charles D. Swerdlow, John E. Porterfield, Anil G. Kottam, Mark W. Kroll Source Type: research

Adaptive Cardiac Resynchronization Therapy is Associated with Decreased Risk of Incident Atrial Fibrillation Compared to Standard Biventricular Pacing: A Real-World Analysis of 37,450 Patients Followed by Remote Monitoring
The AdaptivCRTTM algorithm (aCRT) automatically adjusts AV delays each minute to achieve ventricular fusion through left ventricular (LV) or biventricular (BiV) pacing. aCRT is associated with superior clinical outcomes compared to standard BiV pacing, but the association of aCRT and subsequent atrial fibrillation (AF) in a real-world population has not been fully evaluated. (Source: Heart Rhythm)
Source: Heart Rhythm - May 15, 2019 Category: Cardiology Authors: Jonathan C. Hsu, David Birnie, Robert W. Stadler, Jeffrey Cerkvenik, Gregory K. Feld, Ulrika Birgersdotter-Green Source Type: research

2019 HRS/EHRA/APHRS/LAHRS focused update to 2015 expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing
The 2015 HRS/EHRA/APHRS/SOLAECE Expert Consensus Statement on Optimal Implantable Cardioverter-Defibrillator Programming and Testing provided guidance on bradycardia programming, tachycardia detection, tachycardia therapy, and defibrillation testing for implantable cardioverter-defibrillator (ICD) patient treatment. The 32 recommendations represented the consensus opinion of the writing group, graded by Class of Recommendation and Level of Evidence. In addition, Appendix B provided manufacturer-specific translations of these recommendations into clinical practice consistent with the recommendations within the parent docume...
Source: Heart Rhythm - May 15, 2019 Category: Cardiology Authors: Martin K. Stiles, Laurent Fauchier, Carlos A. Morillo, Bruce L. Wilkoff Source Type: research

Proarrhythmic Food for Thought
The author declares no conflict of interest (Source: Heart Rhythm)
Source: Heart Rhythm - May 14, 2019 Category: Cardiology Authors: James E. Tisdale Source Type: research

Cycle length criteria for His-bundle capture are capable of determining pacing types misclassified by output criteria
His-bundle pacing is currently defined according to the output criteria. However, potential nonselective His-bundle pacing (NSHBP) might be misclassified as right ventricular pacing by the output criteria. (Source: Heart Rhythm)
Source: Heart Rhythm - May 13, 2019 Category: Cardiology Authors: Yanchun Liang, Haibo Yu, Na Wang, Zhihao Liang, Baige Xu, Yang Gao, Yong-Mei Cha, Zulu Wang, Yaling Han Source Type: research

The cycle length criteria for His-bundle capture are capable of determining pacing types misclassified by the output criteria
His-bundle pacing is currently defined according to the output criteria. However, potential non-selective His bundle pacing (NSHBP) might be misclassified as right ventricular pacing by the output criteria. (Source: Heart Rhythm)
Source: Heart Rhythm - May 13, 2019 Category: Cardiology Authors: Yanchun Liang, Haibo Yu, Na Wang, Zhihao Liang, Baige Xu, Yang Gao, Yong-Mei Cha, Zulu Wang, Yaling Han Source Type: research

On-treatment comparison between corrective his bundle pacing and biventricular pacing for cardiac resynchronization: A secondary analysis of his-sync
The His-SYNC pilot trial was the first randomized comparison between His bundle pacing in lieu of an LV lead for cardiac resynchronization therapy (His-CRT) and biventricular pacing (BiV-CRT), but was limited by high rates of crossover. (Source: Heart Rhythm)
Source: Heart Rhythm - May 13, 2019 Category: Cardiology Authors: Gaurav A. Upadhyay, Pugazhendi Vijayaraman, Hemal M. Nayak, Nishant Verma, Gopi Dandamudi, Parikshit S. Sharma, Moeen Saleem, John Mandrola, Davide Genovese, Jess W. Oren, Faiz A. Subzposh, Zaid Aziz, Andrew Beaser, Dalise Shatz, Stephanie Besser, Roberto Source Type: research

Late-Breaking Clinical Trials Session IV: Innovations
(Source: Heart Rhythm)
Source: Heart Rhythm - May 11, 2019 Category: Cardiology Source Type: research

Ischemic ventricular tachycardia from below the posteromedial papillary muscle, a particular entity: Substrate characterization and challenges for catheter ablation
In patients with ischemic ventricular tachycardia (VT), substrate may be “protected” by the posteromedial papillary muscle (PMPM), explaining failure of endocardial-only ablation. (Source: Heart Rhythm)
Source: Heart Rhythm - May 11, 2019 Category: Cardiology Authors: Andres Enriquez, David Briceno, Carlos Tapias, Yasuhiro Shirai, Daniele Muser, Jackson Liang, Tatsuya Hayashi, Pasquale Santangeli, David Frankel, Gregory Supple, Robert Schaller, Jeffrey Arkles, Diego Rodriguez, David Callans, Francis Marchlinski, Luis S Source Type: research

Late Breaking Clinical Trials Session IV: Innovations
(Source: Heart Rhythm)
Source: Heart Rhythm - May 11, 2019 Category: Cardiology Source Type: research

Understanding Outcomes with the EMBLEM S-ICD in Primary Prevention Patients with Low EF Study (UNTOUCHED): Clinical characteristics and perioperative results
The subcutaneous implantable cardioverter-defibrillator (S-ICD) has shown favorable outcomes in large registries with broad inclusion criteria. The cohorts reported had less heart disease and fewer comorbidities than standard ICD populations. (Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Lucas V. Boersma, Mikhael F. El-Chami, Maria Grazia Bongiorni, Martin C. Burke, Reinoud E. Knops, Johan D. Aasbo, Pier D. Lambiase, Jean Claude Deharo, Andrea M. Russo, Jay Dinerman, Naushad Shaik, Craig S. Barr, Nathan Carter, Ursula Appl, Amy J. Brisben Source Type: research

Late-Breaking Clinical Trials Session II: New Data for Device Therapies
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Source: Heart Rhythm - May 10, 2019 Category: Cardiology Source Type: research

Late-Breaking Clinical Trials Session III: Late Breaking Science
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Source: Heart Rhythm - May 10, 2019 Category: Cardiology Source Type: research

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias
Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these pr...
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Edmond M. Cronin, Frank M. Bogun, Philippe Maury, Petr Peichl, Minglong Chen, Narayanan Namboodiri, Luis Aguinaga, Luiz Roberto Leite, Sana M. Al-Khatib, Elad Anter, Antonio Berruezo, David J. Callans, Mina K. Chung, Phillip Cuculich, Andre d ’Avila, Ba Source Type: research

2019 HRS/EHRA/APHRS/LAHRS Expert Consensus Statement on Catheter Ablation of Ventricular Arrhythmias: Executive Summary
Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for these pr...
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Edmond M. Cronin, Frank M. Bogun, Philippe Maury, Petr Peichl, Minglong Chen, Narayanan Namboodiri, Luis Aguinaga, Luiz Roberto Leite, Sana M. Al-Khatib, Elad Anter, Antonio Berruezo, David J. Callans, Mina K. Chung, Phillip Cuculich, Andre d ’Avila, Ba Source Type: research

Systematic review and meta-analysis of catheter ablation of ventricular tachycardia in ischemic heart disease
Patients with ischemic heart disease (IHD) are at risk for ventricular tachycardia (VT). Catheter ablation (CA) may reduce this risk. (Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Brandon K. Martinez, William L. Baker, Anna Konopka, Devon Giannelli, Craig I. Coleman, Jeffrey Kluger, Edmond M. Cronin Source Type: research

Late Breaking Clinical Trials Session II: New Data for Device Therapies
(Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Source Type: research

Late Breaking Clinical Trials Session III: Late Breaking Science
(Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Source Type: research

Digital Health: Present Conundrum, Future Hope Or Hype?
Henry Ford (Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Thomas F. Deering, Gerhard Hindricks, Nassir F. Marrouche Source Type: research

Understanding Outcomes with the S-ICD in Primary Prevention Patients with Low EF Study (UNTOUCHED): Clinical characteristics and perioperative results
The Subcutaneous implantable cardioverter-defibrillator (S-ICD) has shown favorable outcomes in large registries with broad inclusion criteria. The cohorts reported had less heart disease and fewer co-morbidities than standard ICD populations. (Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Lucas V. Boersma, Mikhael F. El-Chami, Maria Grazia Bongiorni, Martin C. Burke, Reinoud E. Knops, Johan D. Aasbo, Pier D. Lambiase, Jean Claude Deharo, Andrea M. Russo, Jay Dinerman, Naushad Shaik, Craig S. Barr, Nathan Carter, Ursula Appl, Amy J. Brisben Source Type: research

Five-year Outcomes in Cardiac Surgery Patients with Atrial Fibrillation Undergoing Concomitant Surgical Ablation Versus No Ablation. The Long-term Follow-up of the Prague-12 Study
The long-term effect of concomitant surgical ablation (SA) on clinical outcomes in unselected population of patients has not been sufficiently reported in randomized studies. (Source: Heart Rhythm)
Source: Heart Rhythm - May 10, 2019 Category: Cardiology Authors: Pavel Osmancik, Petr Budera, David Talavera, Jan Hlavicka, Dalibor Herman, Jiri Holy, Pavel Cervinka, Jiri Smid, Peter Hanak, Robert Hatala, Petr Widimsky Source Type: research

Late-Breaking Clinical Trials Session I
(Source: Heart Rhythm)
Source: Heart Rhythm - May 9, 2019 Category: Cardiology Source Type: research

2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy
Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloid and sarcoidosis, Chagas ’ disease and left ventricular noncompaction. The ACM phenotype overlaps with other cardiomyopathies, particularly dilated cardiomyopathy with arrhythmia presentation which may be associated with ventricular dilatation and/or impaire...
Source: Heart Rhythm - May 9, 2019 Category: Cardiology Authors: Jeffrey A. Towbin, William J. McKenna, Dominic J. Abrams, Michael J. Ackerman, Hugh Calkins, Francisco C.C. Darrieux, James P. Daubert, Christian de Chillou, Eugene C. DePasquale, Milind Y. Desai, N.A. Mark Estes, Wei Hua, Julia H. Indik, Jodie Ingles, Cy Source Type: research

Late Breaking Clinical Trials Session I
(Source: Heart Rhythm)
Source: Heart Rhythm - May 9, 2019 Category: Cardiology Source Type: research

HRS White Paper on interoperability of data from cardiac implantable electronic devices (CIEDs)
This HRS Needs Assessment is in the category of the Heart Rhythm Society (HRS) documents delineating a future direction of research, technology development, or health care policy and adheres to the following requirements set forth by the HRS: (Source: Heart Rhythm)
Source: Heart Rhythm - May 8, 2019 Category: Cardiology Authors: David J. Slotwiner, Robert L. Abraham, Sana M. Al-Khatib, H. Vernon Anderson, T. Jared Bunch, Martha G. Ferrara, Neal Lippman, Gerald A. Serwer, Paul R. Steiner, James E. Tcheng, Niraj Varma, Bruce L. Wilkoff Source Type: research

Transparent Sharing of Digital Health Data: A Call to Action
This HRS Needs Assessment is in the category of the Heart Rhythm Society (HRS) documents delineating a future direction of research, technology development, or health care policy and adheres to the following requirements set forth by the HRS: (Source: Heart Rhythm)
Source: Heart Rhythm - May 8, 2019 Category: Cardiology Authors: David J. Slotwiner, Khaldoun G. Tarakji, Sana M. Al-Khatib, Rod S. Passman, Leslie A. Saxon, Nicholas S. Peters, Debbe McCall, Mintu P. Turakhia, Jill Schaeffer, G. Stuart Mendenhall, Gerhard Hindricks, Sanjiv M. Narayan, Elizabeth E. Davenport, Nassir F. Source Type: research

HRS White Paper on Interoperability of Data from Cardiovascular Implantable Electronic Devices (CIEDs)
These revisions and clarifications will expand the capabilities of the IDCO profile and ISO/IEEE-11073 nomenclature1 making it less ambiguous to the clinicians, more specific for industry to implement thereby improving patient care, and expanding its use to more device and electrode types including leadless pacemakers, subcutaneous ICDs, and implantable loop recorders. (Source: Heart Rhythm)
Source: Heart Rhythm - May 8, 2019 Category: Cardiology Authors: David J. Slotwiner, Robert L. Abraham, Sana M. Al-Khatib, H. Vernon Anderson, T. Jared Bunch, Martha G. Ferrara, Neal Lippman, Gerald A. Serwer, Paul R. Steiner, James E. Tcheng, Niraj Varma, Bruce L. Wilkoff Source Type: research

Grapefruit Juice prolongs the QT Interval of Healthy Volunteers and Patients with Long QT syndrome
The list of medications linked to a drug-induced long QT syndrome (LQTS) is diverse. It is possible that food products too have QT-prolonging potential. (Source: Heart Rhythm)
Source: Heart Rhythm - May 7, 2019 Category: Cardiology Authors: Ehud Chorin, Aviram Hochstadt, Yoav Granot, Shafik Khoury, Arie Lorin Schwartz, Gilad Margolis, Rami Barashi, Dana Viskin, Eihab Ghantous, Michael Schnapper, Tal Mekori, Dana Fourey, Milton Ernesto Guevara-Valdivia, Manlio F. Marquez, David Zeltzer, Rapha Source Type: research

S-AB01-01 to S-AB36-06
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-PO01-001 to S-PO01-175
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-PO02-029 to S-PO02-244
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-PO03-029 to S-PO03-246
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-PO04-029 to S-PO04-246
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-PO05-029 to S-PO05-246
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Special Poster S-IA01-001 to S-BS03-10
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-PO06-001 to S-PO06-120
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

S-MP01-02 to S-SP06-06
(Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Author Index
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Subject Index
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Cover
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Title page
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Heart Rhythm Scientific Sessions Program Committee
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Mission Statement
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

Table of Contents
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Source: Heart Rhythm - May 1, 2019 Category: Cardiology Source Type: research

EP News: Case Reports
Ventricular tachycardia (VT) or ventricular fibrillation (VF) storm is a life-threatening condition that is often managed by antiarrhythmic drug therapies, catheter ablation, general anesthesia, and ventricular support devices. Radiotherapy for VT has shown early promise as a noninvasive therapy to reduce risk of recurrent VT. No data exist on the role of radiotherapy for VF storm. Scholz et  al (DOI: https://doi.org/10.1016/j.hrcr.2019.03.004) shared a case of a 53-year-old man who presented with VF storm after a recent presentation with anterior myocardial infarction. (Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Authors: T. Jared Bunch Tags: EP News Source Type: research

EP News: Clinical
Lemkes et  al (N Engl J Med 2019;380:1397, PMID 30883057) randomized 552 patients with cardiac arrest without ST-segment elevation myocardial infarction (STEMI) to immediate or delayed coronary angiography. The primary end point was survival at 90 days. Secondary end points included survival at 90 days with good cerebral performance, myocardial injury, duration of catecholamine support, shock, ventricular tachycardia, mechanical ventilation, major bleeding, kidney injury, need for renal replacement therapy, time to target temperature, and neurologic status at discharge from the intensive care unit. (Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Authors: N.A. Mark Estes Tags: EP News Source Type: research

EP News: Basic and Translational
Shafaattalab et  al (Proc Natl Acad Sci U S A 2019;116:6969, PMID 30886088) investigated the genetic pathogenesis of sudden unexpected death of infants (SUDI) by sequencing>70 genes from 191 autopsy-negative SUDI victims. A previously unknown variant in troponin I (TnI, TNNI1 R37C+/ −) was identified in 10 infants. The mutation was found in the fetal/neonatal paralog of TnI, a gene expressed in the heart up to the first 24 months of life. TNNI1 R37C mutation was functionally assessed in human reconstituted thin filaments (RTFs) using fluorometry. (Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Authors: Nipavan Chiamvimonvat Tags: EP News Source Type: research

EP News: Allied Professionals
In this multicenter center, the authors (Stevenson et  al. J Am Coll Cardiol 2019;73:1413-25, PMID: 30922472) sought to assess the efficacy and safety of a new ablation catheter that uses a 27-gauge needle that is inserted repeatedly into the myocardium to map and ablate ventricular arrhythmias (VA) including ventricular tachycardia (VT) and premature ventricular contractions (PVCs). They included 31 patients with VT (n=26) or very frequent (>20% burden) PVCs with decreased ejection fraction of (Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Authors: Erica S. Zado Tags: EP News Source Type: research