ECG-only Explainable Deep Learning Algorithm Predicts the Risk for Malignant Ventricular Arrhythmia in Phospholamban Cardiomyopathy
Phospholamban (PLN) p.(Arg14del) variant carriers are at risk of developing malignant ventricular arrhythmias (MVA). Accurate risk stratification allows for timely implantation of intracardiac defibrillators (ICD) and is currently performed using a multimodality prediction model. (Source: Heart Rhythm)
Source: Heart Rhythm - February 23, 2024 Category: Cardiology Authors: Rutger R. van de Leur, Remco de Brouwer, Hidde Bleijendaal, Tom E. Verstraelen, Belend Mahmoud, Ana Perez-Matos, Cathelijne Dickhoff, Bas A. Schoonderwoerd, Tjeerd Germans, Arjan Houweling, Paul A. van der Zwaag, Moniek GPJ. Cox, J. Peter van Tintelen, An Source Type: research
What Electrophysiologists Should Know about Cardiac Implantable Electronic Device Recalls
From 2003-2023, manufacturers recalled 500 cardiac implantable electronic device (CIED) products, including pulse generators, leads, and programmers.1 Manufacturers of CIEDs have a legal responsibility to protect the public health under laws administered by the Food and Drug Administration (FDA)2. A CIED recall is a method of removing or correcting marketed products that violate these laws because the products either are defective or present a risk of death or injury.3 (Source: Heart Rhythm)
Source: Heart Rhythm - February 23, 2024 Category: Cardiology Authors: Robert G. Hauser, Charles D. Swerdlow Source Type: research
Prevalence of frequent premature ventricular contractions and nonsustained ventricular tachycardia in older women screened for atrial fibrillation in the Women ’s Health Initiative
Frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT) have been associated with cardiovascular disease and mortality. Their prevalence, especially in ambulatory populations, is under-studied and limited by few female participants and the use of short-duration (24-48 hour) monitoring. (Source: Heart Rhythm)
Source: Heart Rhythm - February 23, 2024 Category: Cardiology Authors: Sofia E. Gomez, Joseph Larson, Mark A. Hlatky, Fatima Rodriguez, Matthew Wheeler, Philip Greenland, Michael LaMonte, Victor Froelicher, Marcia L. Stefanick, Robert Wallace, Charles Kooperberg, Lesley F. Tinker, Jenny Schoenberg, Elsayed Z. Soliman, Mara Z Source Type: research
Feasibility of carbon dioxide insufflation and impact on epicardial approach utilization for ventricular tachycardia ablation in a mid-volume referral center
Epicardial access is often crucial for successful ventricular tachycardia (VT) ablation, but it's often burdened by significant procedural risk. Intentional coronary vein exit and intrapericardial CO2 insufflation (EpiCO2) can facilitate subxiphoid pericardial access. (Source: Heart Rhythm)
Source: Heart Rhythm - February 23, 2024 Category: Cardiology Authors: Giulio Zucchelli, Matteo Parollo, Andrea Di Cori, Lorenzo Mazzocchetti, Luca Segreti, Gino Grifoni, Marco Torre, Sara Sbragi, Raffaele De Lucia, Valentina Barletta, Antonio Canu, Stefano Viani, Maria Grazia Bongiorni Source Type: research
Clinical outcomes of patients referred for left atrial appendage exclusion who did and did not undergo the procedure
Left arial appendage exclusion (LAAE) is an effective alternative to long-term anticoagulation in patients with atrial fibrillation (AF). Not all patients considered for LAAE undergo the procedure due to ineligibility, anatomical or medical constraints, and patient preference. (Source: Heart Rhythm)
Source: Heart Rhythm - February 23, 2024 Category: Cardiology Authors: Trisha Gupte, Mohammed Al-Sadawi, Tiffany Luke, Eryn K. Smith, Nimita Mehta, Jackson J. Liang, Aman Chugh, Fred Morady, Matthew A. Romano, Hakan Oral, Michael Ghannam Source Type: research
Diagnostic approach to the Pediatric Brugada Syndrome: A survey of international common practice
The Brugada Syndrome (BrS) is a rare inherited disorder predisposing patients to arrythmia and sudden cardiac death. Since its first description in 1992 1 much has been learned about its clinical characteristics, associated genetic changes, diagnostic strategies, and therapeutic options 2. A considerable number of patients are already symptomatic in infancy 2. For these early and often severe presentations assumptions from adult studies might not be valid. In 2014 a first comprehensive review of diagnostic and therapeutic strategies in the pediatric BrS was published 3. (Source: Heart Rhythm)
Source: Heart Rhythm - February 23, 2024 Category: Cardiology Authors: Christine Stratmann, Maria Cecilia Gonzalez Corcia Source Type: research
Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice
Diabetes mellitus (DM) is a major risk factor for atrial structural remodeling and atrial fibrillation (AF). Calpain activity is hypothesized to promote atrial remodeling and AF. (Source: Heart Rhythm)
Source: Heart Rhythm - February 21, 2024 Category: Cardiology Authors: Qing Wang, Jinxiang Yuan, Hua Shen, Qi Zhu, Biyi Chen, Jinxi Wang, Weizhong Zhu, Mark A. Yorek, Duane D. Hall, Zhinong Wang, Long-Sheng Song Source Type: research
Ventricular Arrhythmia Inducibility in Porcine Infarct Model after Stereotactic Body Radiation Therapy
Ventricular arrhythmia (VA) is the primary mechanism of sudden death in patients with structural heart disease. Cardiac stereotactic body radiation therapy (SBRT) delivered to the scar in the left ventricle (LV) significantly reduces the burden of VA (Source: Heart Rhythm)
Source: Heart Rhythm - February 21, 2024 Category: Cardiology Authors: Krishna Kancharla, Adam Olson, Siamak Salavatian, Yuki Kuwabara, Yuriy Martynyuk, Partha Dutta, Sathish Vasamsetti, Aman Mahajan, Kimberley Howard-Quijano, Samir Saba Source Type: research
Validation of the PRAETORIAN score in a large subcutaneous implantable cardioverter-defibrillator collective: Usefulness in clinical routine
To assess the risk of unsuccessful conversion of ventricular fibrillation during defibrillation testing (DFT) with the subcutaneous implantable cardioverter-defibrillator (S-ICD), the PRAETORIAN score has been proposed. (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Florian Doldi, Gerrit Frommeyer, Andreas L öher, Christian Ellermann, Julian Wolfes, Fatih Güner, Mathis Zerbst, Hauke Engelke, Dennis Korthals, Florian Reinke, Lars Eckardt, Kevin Willy Source Type: research
Predictor of A4 amplitude using preprocedural electrocardiography in patients with leadless pacemakers
Based on historical studies of leadless pacemakers (LPs), high atrioventricular synchrony (AVS) with mechanical sensing-based VDD pacing is largely influenced by A4 amplitude. A limited study investigated the predictors of A4 amplitude using clinical and echocardiographic parameters. (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Shunsuke Kawatani, Yasuhito Kotake, Aiko Takami, Kensuke Nakamura, Takuya Tomomori, Akihiro Okamura, Masaru Kato, Kazuhiro Yamamoto Source Type: research
Tropomyosin –troponin complex in inherited cardiomyopathies
The tropomyosin –troponin complex (TTC) regulates cardiac contractility by controlling cross-bridge attachments to actin filaments based on intracellular Ca2+ levels. TTC consists of tropomyosin (TPM), cardiac troponin-T (cTnT), cardiac troponin-I (cTnI), and cardiac troponin-C (cTnC). Pathogenic variants (mutati ons) in genes encoding these proteins (TPM1 [TPM], TNNT2 [cTnT], TNNI3 [cTnI], and TNNC1 [cTnC]) cause different cardiomyopathy types, including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Christian Krijger Ju árez, Vasco Sequeira, Malou van den Boogaard, Christiaan C. Veerman, Nicola J. Hoetjes, Edwin Poel, Michael W.T. Tanck, Ronald H. Lekanne Deprez, Alexa M.C. Vermeer, Jolanda van der Velden, Ahmad S. Amin Tags: Research Letter Source Type: research
To the Editor —The Role of Atrioventricular Delay in Determining Right Ventricular Function with Left Bundle Pacing
We read with great interest the article by Tian et al1 on the effects with left bundle branch pacing (LBBP) on right ventricular (RV) function. The authors are to be congratulated on their study, which adds to our understanding of LBBP. However, the authors did not report whether atrioventricular delay (AVD) was optimized for each patient. This is a key detail for interpreting these results. Previous experimental2 and simulation3 studies have shown that the effect of LBBP on RV activation is highly dependent on AVD, with AVD optimization allowing fusion between intrinsic RV and left ventricular (LV) paced activation, red...
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Marina Strocchi, Steven A. Niederer, Christopher A. Rinaldi Tags: Letters to the Editor Source Type: research
Reply to the Editor —The Role of Atrioventricular Delay in Determining Right Ventricular Function with Left Bundle Pacing
We thank Drs Strocchi, Niederer, and Rinaldi for their interest in our study1 and allowing us the opportunity to further explain our work. Strocchi et al issue a comment regarding our study, pointing out that we did not report whether atrioventricular delay (AVD) was optimized for each patient. We agree that this is an important detail. Left bundle branch pacing (LBBP) lead implantation was considered successful when a right bundle branch block (RBBB) paced QRS complex appeared, indicating that LBBP induced RBBB-like activation. (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Fangyan Tian, Ao Liu, Haiyan Chen, Xianhong Shu Tags: Letters to the Editor Source Type: research
The role of Atrioventricular Delay in Determining Right Ventricle Function with Left Bundle Pacing
We read with great interest the paper by Tian et al1 on the effects with left bundle branch pacing (LBBP) on RV function. The authors are to be congratulated on their study, which further adds to our understanding of LBBP. However, the authors did not report if the atrioventricular delay (AVD) was optimized for each patient. This is a key detail for interpreting these results. Previous experimental2 and simulation3 studies have shown that the effect of LBBP on RV activation is highly dependent on the AVD, with AVD optimization allowing fusion between intrinsic RV and LV paced activation, reducing the right bundle branch bl...
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Marina Strocchi, Steven A. Niederer, Christopher A. Rinaldi Source Type: research
Validation of the PRAETORIAN Score in a large S-ICD collective – usefulness in clinical routine
To assess the risk of unsuccessful conversion of ventricular fibrillation (VF) during defibrillation testing (DFT) with the subcutaneous implantable cardioverter defibrillator (S-ICD) the PRAETORIAN Score has been proposed. (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Florian Doldi, Gerrit Frommeyer, Andreas L öher, Christian Ellermann, Julian Wolfes, Fatih Güner, Mathis Zerbst, Hauke Engelke, Dennis Korthals, Florian Reinke, Lars Eckardt, Kevin Willy Source Type: research
