EP News: Pediatric and Congenital Electrophysiology
Chatterjee et  al (Eur Heart J 2020;41:2878–2890, PMID 32533187) sought to identify an additional biomarker for patients suspected of having Brugada syndrome (BrS). Normal ventricular myocardial proteins were solubilized and separated by isoelectric focusing and molecular weight on 2-dimensional gels and used to discover autoantibodies by plating with sera from patients with BrS and controls. Target genes were identified by mass spectrometry. Immunohistochemistry was performed on myocardium from patients with BrS vs controls. (Source: Heart Rhythm)
Source: Heart Rhythm - August 26, 2020 Category: Cardiology Authors: Thomas Paul Tags: EP News Source Type: research

Pediatric and Congenital Electrophysiology News
An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins (Source: Heart Rhythm)
Source: Heart Rhythm - August 26, 2020 Category: Cardiology Authors: Thomas Paul Source Type: research

Risk of arrhythmic events after alcohol septal ablation for hypertrophic cardiomyopathy using continuous implantable cardiac monitoring
Alcohol septal ablation (ASA) in patients with hypertrophic cardiomyopathy (HCM) can lead to heart rhythm disturbances including complete heart block (CHB) and atrial and ventricular arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - August 23, 2020 Category: Cardiology Authors: Peter A. Bleszynski, Ilan Goldenberg, Genaro Fernandez, Erik Howell, Arwa Younis, Anita Y. Chen, Scott McNitt, Jeffrey Bruckel, Fred Ling, Chris Cove, Mehmet K. Aktas Source Type: research

Risk of Arrhythmic Events Following Alcohol Septal Ablation for Hypertrophic Cardiomyopathy Using Continuous Implantable Cardiac Monitoring
Alcohol septal ablation (ASA) in hypertrophic cardiomyopathy (HCM) patients can lead to heart rhythm disturbances including complete heart block (CHB), atrial and ventricular arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - August 23, 2020 Category: Cardiology Authors: Peter A. Bleszynski, Ilan Goldenberg, Genaro Fernandez, Erik Howell, Arwa Younis, Anita Y. Chen, Scott McNitt, Jeffrey Bruckel, Fred Ling, Chris Cove, Mehmet K. Aktas Source Type: research

To the Editor — Fear does not avoid the danger!
We have read with much attention the article by Ananwattanasuk et  al,1 and their results are of the greatest importance. One key to success is the standardization of implantable cardioverter-defibrillator (ICD) programming, as previously shown in the EMPIRIC trial.2 In that perspective, the benefits of programming guidelines, even if partly based on expert conse nsus, are undeniable.3 One step further toward standardized programming may require to smooth the effects of the various algorithms of different manufacturers. (Source: Heart Rhythm)
Source: Heart Rhythm - August 17, 2020 Category: Cardiology Authors: Nicolas Clementy, Arnaud Bisson, Laurent Fauchier Tags: Letter to the Editor Source Type: research

Reply to the Editor — Fear Does Not Avoid the Danger
We thank Drs Clementy, Bisson, and Fauchier for their interest in our article and for sharing their experiences of the implantable cardioverter-defibrillator (ICD) programming. (Source: Heart Rhythm)
Source: Heart Rhythm - August 17, 2020 Category: Cardiology Authors: Tanyanan Tanawuttiwat, Teetouch Ananwattanasuk, Krit Jongnarangsin Source Type: research

Fear does not avoid the danger!
We have read with much attention the paper by Ananwattanasuk and colleagues, and their results are of the greatest importance [1]. One key to success is the standardization of ICD programming, as previously shown in the EMPIRIC trial [2]. In that perspective, the benefits of programming guidelines, even if partly based on expert consensus, are undeniable [3]. One step further towards standardized programming may require to smooth the effects of the various algorithms of the different manufacturers. (Source: Heart Rhythm)
Source: Heart Rhythm - August 17, 2020 Category: Cardiology Authors: Nicolas Clementy, Arnaud Bisson, Laurent Fauchier Source Type: research

Author ’s Reply to Fear Does Not Avoid the Danger
We thank Drs. Clementy, Bisson, and Fauchier for their interest in our article and for sharing their experiences on the implantable cardioverter-defibrillator (ICD) programming. (Source: Heart Rhythm)
Source: Heart Rhythm - August 17, 2020 Category: Cardiology Authors: Tanyanan Tanawuttiwat, Teetouch Ananwattanasuk, Krit Jongnarangsin Source Type: research

Unexpected high failure rate of a specific MicroPort/LivaNova/Sorin pacing lead
Pacing leads are the Achilles heel of pacemakers. Most manufacturers report a 3-year survival rate of>99% of their leads. We observed several failures of the Beflex ™/Vega™ leads (MicroPort, formerly Sorin/LivaNova). (Source: Heart Rhythm)
Source: Heart Rhythm - August 12, 2020 Category: Cardiology Authors: Andreas Haeberlin, Marie-Theres Anwander, Thomas Kueffer, Maximilien Tholl, Samuel Baldinger, Helge Servatius, Anna Lam, Florian Franzeck, Babken Asatryan, Adrian Zurbuchen, Hildegard Tanner, Tobias Reichlin, Laurent Roten, Fabian Noti Source Type: research

Primary prevention implantable cardioverter-defibrillators in hypertrophic cardiomyopathy —Are there predictors of appropriate therapy?
Identifying patients with hypertrophic cardiomyopathy (HCM) who warrant a primary prevention implantable cardioverter-defibrillator (ICD) is crucial. ICDs are effective in terminating life-threatening arrhythmias; however, ICDs carry risks of complications. (Source: Heart Rhythm)
Source: Heart Rhythm - August 11, 2020 Category: Cardiology Authors: Adaya Weissler-Snir, Paul Dorian, Harry Rakowski, Melanie Care, Danna Spears Source Type: research

Atrial Fibrillation Ablation in the 21st Century: Almost No Stroke Risk?
Atrial fibrillation ablation (AFabl) emerged at the end of the 20th century as an exciting alternative for physicians who were disappointed with antiarrhythmic drug outcomes1. However, numerous critics expressed skepticism at the long-term outcomes and benefits of the procedure and risks of serious complications2. (Source: Heart Rhythm)
Source: Heart Rhythm - August 11, 2020 Category: Cardiology Authors: Koonlawee Nademanee Source Type: research

Primary Prevention Implantable Cardioverter Defibrillators in Hypertrophic Cardiomyopathy – Are There Predictors of Appropriate Therapy?
Identifying hypertrophic cardiomyopathy (HCM) patients who warrant a primary-prevention implantable cardioverter defibrillator(ICD) is crucial. ICDs are effective in terminating life-threatening arrhythmias; however, ICDs carry risks of complications. (Source: Heart Rhythm)
Source: Heart Rhythm - August 11, 2020 Category: Cardiology Authors: Adaya Weissler-Snir, Paul Dorian, Harry Rakowski, Melanie Care, Danna Spears Source Type: research

Long or short postpacing interval response to ventricular tachycardia entrainment: What is the mechanism?
A 58-year-old man with nonischemic cardiomyopathy and an ejection fraction of 25% presented with ventricular tachycardia (VT) storm. Epicardial mapping revealed an inferolateral scar, and during tolerated VT with right bundle branch superior axis morphology with V3 transition (tachycardia cycle length [TCL] 325 ms), overdrive pacing was performed. What is the response to entrainment and why (Figure  1A)? (Source: Heart Rhythm)
Source: Heart Rhythm - August 10, 2020 Category: Cardiology Authors: Takuro Nishimura, Roderick Tung Tags: Unknown of the Month Source Type: research

Long or Short Post-Pacing Interval Response to VT Entrainment: What Is the Mechanism?
A 58 year old male with nonischemic cardiomyopathy and ejection fraction of 25% presented with VT storm. Epicardial mapping revealed an inferolateral scar and during tolerated VT with right bundle branch superior axis morphology with V3 transition (tachycardia cycle length [TCL] 325 ms), overdrive pacing was performed. What is the response to entrainment and why? (FIGURE 1A) (Source: Heart Rhythm)
Source: Heart Rhythm - August 10, 2020 Category: Cardiology Authors: Takuro Nishimura, Roderick Tung Source Type: research

EP News: Clinical
Andelius et  al (J Am Coll Card 2020;76:43, PMID 32616162) investigated arrival at the out-of-hospital cardiac arrest (OHCA) location of application (app)–dispatched citizen responders before the Emergency Medical Services (EMS) and the association with bystander cardiopulmonary resuscitation (CPR) and defib rillation. Citizen responders located within 1.1 miles from the OHCA location were dispatched to begin CPR or retrieve an automated external defibrillator. OHCA locations where at least 1 citizen responder arrived before EMS were compared with OHCA locations where EMS arrived first. (Source: Heart Rhythm)
Source: Heart Rhythm - August 9, 2020 Category: Cardiology Authors: N.A. Mark Estes Tags: EP News Source Type: research

EP News Clinical
August 2020 (Source: Heart Rhythm)
Source: Heart Rhythm - August 9, 2020 Category: Cardiology Authors: N. A. Mark Estes Source Type: research

EP News: Basic and Translational
In the current study, Ellinghaus and Severe Covid-19 GWAS Group (N Engl J Med. 2020; doi: 10.1056/NEJMoa2020283; PMID:32558485) used Genome wide association analysis (GWAS) to identify potential genetic factors involved in the development and severity of 2019 coronavirus disease (Covid-19). A total of 1,610 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the Covid-19 pandemic are included in the study compared to 2,205 control participants. (Source: Heart Rhythm)
Source: Heart Rhythm - August 9, 2020 Category: Cardiology Authors: Nipavan Chiamvimonvat Source Type: research

EP News: Allied Professionals
The authors (Lopez-Sainz et al. J Am Coll Cardiol 2020;76:186-97. PMID: 32646569) used data on patients from 27 European centers who have a variant of PRKAG2 gene to assess the clinical features and natural history of this abnormality. Previously, there were only reports with small numbers of patients with gene variants in PRKAG2 which causes a syndrome (PS) characterized by conduction disease, ventricular pre-excitation and hypertrophic cardiomyopathy (HCM). By pooling date from the 27 centers, 90 patients with a variant in PRKAG2 who were grouped as either affected (N=64) or unaffected (N=26) based on whether they had at...
Source: Heart Rhythm - August 9, 2020 Category: Cardiology Authors: Erica S. Zado Source Type: research

Optical capture and defibrillation in rats with monocrotaline-induced myocardial fibrosis 1 year after a single intravenous injection of adeno-associated virus channelrhodopsin-2
Optogenetics uses light to regulate cardiac rhythms and terminate malignant arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - August 7, 2020 Category: Cardiology Authors: Jianyi Li, Long Wang, Junmiao Luo, Haitao Li, Panpan Rao, Yue Cheng, Xi Wang, Congxin Huang Source Type: research

Global Electrical Heterogeneity Associated with Drug-Induced Torsades de Pointes
Drugs belonging to diverse therapeutic classes can prolong myocardial refractoriness or slow conduction. These drugs may be effective and well-tolerated, but the risk of sudden cardiac death from torsades de pointes (TdP) remains a major concern. The corrected QT interval has significant limitations when used for risk stratification. Measurement of GEH could help identify the substrate vulnerable to drug-induced ventricular arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - August 7, 2020 Category: Cardiology Authors: Hans F. Stabenau, Changyu Shen, Peter Zimetbaum, Alfred E. Buxton, Larisa G. Tereshchenko, Jonathan W. Waks Source Type: research

Optical capture and defibrillation in rats with monocrotaline-induced myocardial fibrosis one year after a single intravenous injection of adeno-associated virus-channelrhodopsin-2
Optogenetics uses light to regulate cardiac rhythms and terminate malignant arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - August 7, 2020 Category: Cardiology Authors: Jianyi Li, Long Wang, Junmiao Luo, Haitao Li, Panpan Rao, Yue Cheng, Xi Wang, Congxin Huang Source Type: research

Impact of preoperative electrophysiological intervention on occurrence of peri/postoperative supraventricular tachycardia following Fontan surgery
Little is known about the effects of preoperative electrophysiological study (EPS) and catheter ablation (CA) in Fontan surgery candidates with supraventricular tachycardia (SVT). (Source: Heart Rhythm)
Source: Heart Rhythm - August 7, 2020 Category: Cardiology Authors: Daiji Takeuchi, Keiko Toyohara, Yoshimichi Kudo, Tomomi Nishimura, Morio Shoda Source Type: research

EP News: Case Reports
Transcatheter aortic valve replacement (TAVR) is increasingly used as a first line option for significant aortic valve disease. Expansion of the transcatheter valve can impinge upon the aortic valve and His bundle and lead to high grade AV block and pacemaker need. As a consequence, defining risk factors for acute and long-term complete heart block is needed. A common finding after post-surgical aortic valve replacement is a junctional rhythm, its association with heart block after TAVR is not known. (Source: Heart Rhythm)
Source: Heart Rhythm - August 4, 2020 Category: Cardiology Authors: T. Jared Bunch Source Type: research

Premature Ventricular Complex Site of Origin and Ablation Outcomes in Patients with Prior Myocardial Infarction
Frequent premature ventricular complexes (PVCs) are common after a myocardial infarction (MI), but data on PVC ablation in this population is limited. (Source: Heart Rhythm)
Source: Heart Rhythm - August 3, 2020 Category: Cardiology Authors: Diego Penela, Cheryl Teres, Juan Fern ández-Armenta, Luis Aguinaga, Luis Tercedor, David Soto-Iglesias, Beatriz Jauregui, Augusto Ordóñez, Juan Acosta, Felipe Bisbal, Marta Aceña, Etelvino Silva, Alfredo Chauca, Francesco De Sensi, MD; Radu Vatasescu, Source Type: research

Simultaneous activation of the small conductance calcium-activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles
Concomitant apamin-sensitive small conductance calcium-activated potassium current (IKAS) activation and sodium current inhibition induce J-wave syndrome (JWS) in rabbit hearts. Sudden death in JWS occurs predominantly in men at night when parasympathetic tone is strong. (Source: Heart Rhythm)
Source: Heart Rhythm - August 2, 2020 Category: Cardiology Authors: Yu-Dong Fei, Mu Chen, Shuai Guo, Akira Ueoka, Zhenhui Chen, Michael Rubart-von der Lohe, Thomas H. Everett, Zhilin Qu, James N. Weiss, Peng-Sheng Chen Source Type: research

To the Editor — Costs and utilization of remote device monitoring in cardiology
We read with interest the article by Holtzman et  al1 that evaluates the utilization of and expenditure on remote monitoring (RM) of pacemakers and implantable cardioverter-defibrillators. (Source: Heart Rhythm)
Source: Heart Rhythm - August 2, 2020 Category: Cardiology Authors: Woon Senn Koh, Ali Kirresh, Mahmood Ahmad Tags: Letter to the Editor Source Type: research

Morbidity and mortality in patients precluded for transvenous pacemaker implantation: Experience with a leadless pacemaker
The Micra transcatheter pacemaker is a safe and effective alternative to transvenous permanent pacemakers (TV-PPMs). However, the safety profile and mortality outcomes of Micra implantation in patients deemed poor candidates for TV-PPM is incompletely understood. (Source: Heart Rhythm)
Source: Heart Rhythm - August 2, 2020 Category: Cardiology Authors: Aatish Garg, Jayanthi N. Koneru, Dedra H. Fagan, Kurt Stromberg, Santosh K. Padala, Mikhael F. El-Chami, Paul R. Roberts, Jonathan P. Piccini, Alan Cheng, Kenneth A. Ellenbogen Source Type: research

Simultaneous activation of the small conductance calcium activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles
Concomitant apamin-sensitive small conductance, calcium activated potassium current (IKAS) activation and INa inhibition induce J-wave syndrome (JWS) in rabbit hearts. Sudden death in JWS occurs predominantly in men at night, when parasympathetic tone is strong. (Source: Heart Rhythm)
Source: Heart Rhythm - August 2, 2020 Category: Cardiology Authors: Yu-Dong Fei, Mu Chen, Shuai Guo, Akira Ueoka, Zhenhui Chen, Michael Rubart-von der Lohe, Thomas H. Everett, Zhilin Qu, James N. Weiss, Peng-Sheng Chen Source Type: research

Costs and utilization of remote device monitoring in cardiology
Dear Editor, We read with interest Holtzman et al ’s1 article evaluating utilization and expenditure on remote monitoring (RM) of pacemakers and implantable cardioverter-defibrillators (ICD). (Source: Heart Rhythm)
Source: Heart Rhythm - August 2, 2020 Category: Cardiology Authors: Woon Senn Koh, Ali Kirresh, Mahmood Ahmad Source Type: research

Higher baseline cardiorespiratory fitness is associated with lower arrhythmia recurrence and death after atrial fibrillation ablation
Cardiorespiratory fitness (CRF) has been shown to correlate with incident atrial fibrillation (AF) and AF burden. In recent years there has been increasing recognition of the pivotal role of modifying risk factors before AF ablation. (Source: Heart Rhythm)
Source: Heart Rhythm - August 1, 2020 Category: Cardiology Authors: Eoin Donnellan, Oussama M. Wazni, Serge Harb, Mohamed Kanj, Walid I. Saliba, Wael A. Jaber Tags: Contemporary Review Source Type: research

Freedom from atrial fibrillation after catheter ablation: Survival of the fittest
Catheter ablation reduces symptom burden and improves quality of life in patients with atrial fibrillation (AF).1 However, long-term outcomes after ablation remain suboptimal, particularly in patients with persistent AF.2 Because risk factors for AF such as diabetes mellitus and obesity are often uncontrolled at the time of referral, electrophysiologists have become increasingly interested in the impact of risk factor assessment and modification before ablation. This interest has been emboldened by impressive reduction in AF recurrence after structured lifestyle modifications, exercise, and weight loss surgery in several s...
Source: Heart Rhythm - August 1, 2020 Category: Cardiology Authors: Eric Black-Maier, Jonathan P. Piccini Tags: Editorial Commentary Source Type: research

Reply to the Editor — Costs and Utilization of Remote Device Monitoring in Cardiology
We thank Drs Koh, Kirresh, and Ahmad for their interest in our article. Their letter raises several important points regarding technological advancement in remote monitoring of cardiac implantable electrical devices. (Source: Heart Rhythm)
Source: Heart Rhythm - July 31, 2020 Category: Cardiology Authors: Jessica N. Holtzman, Daniel B. Kramer Source Type: research

Authors ’ reply to Costs and utilization of remote device monitoring in cardiology
Relevant Disclosures: Dr. Kramer is supported by the Greenwall Faculty Scholars Program, and is a consultant to the Circulatory Systems Advisory Panel of the Food and Drug Administration. (Source: Heart Rhythm)
Source: Heart Rhythm - July 31, 2020 Category: Cardiology Authors: Jessica N. Holtzman, Daniel B. Kramer Source Type: research

Is Competitive Atrial Pacing a Possible Trigger for Atrial Fibrillation? Observations from the RATE Registry
A high incidence of asymptomatic atrial tachycardia and atrial fibrillation (AT/AF) has been recognized in patients with cardiac implantable devices (CIED). The clinical significance of these AT/AF episodes remains unclear. Some “device detected AT/AF” was previously shown to be triggered by competitive atrial pacing (CAP). (Source: Heart Rhythm)
Source: Heart Rhythm - July 28, 2020 Category: Cardiology Authors: Michael V. Orlov, Brian Olshansky, David G. Benditt, Gregory Kotler, Timothy McIntyre, Fujian Qu, Melanie Turkel, Maxim Gorev, Hermine Poghosyan, Albert L. Waldo Source Type: research

Progressive Implantable Cardioverter-Defibrillator Therapies for Ventricular Tachycardia: The Efficacy and Safety of Multiple Bursts, Ramps, and Low-Energy Shocks
The HRS/EHRA/APHRS/LAHRS expert consensus statement on optimal implantable cardioverter-defibrillator (ICD) programming recommends burst antitachycardia pacing (ATP) for treatment of ventricular tachycardia (VT) up to very high rates. The number of bursts is not specified and treatment by ramps or low-energy shocks are not recommended. (Source: Heart Rhythm)
Source: Heart Rhythm - July 28, 2020 Category: Cardiology Authors: Marc Strik, F Daniel Ramirez, Nicolas Welte, Thomas Bonnin, Saer Abu-Alrub, Romain Eschalier, Michel Ha ïssaguerre, Philippe Ritter, Sylvain Ploux, Pierre Bordachar Source Type: research

EP News: Quality Improvement and Outcomes
In this issue of Heart Rhythm, we continue this quarterly feature highlighting developments and advances in quality improvement in the delivery of heart rhythm care. The current issue focuses on quality improvement surrounding the challenges created for heart rhythm care during the coronavirus disease 2019 (COVID-19) pandemic. (Source: Heart Rhythm)
Source: Heart Rhythm - July 28, 2020 Category: Cardiology Authors: Jonathan P. Piccini, Anne Marie Smith Source Type: research

EP News: Basic and Translational
In the current article, Zheng et  al (Nat Rev Cardiol 2020;17:259–260, PMID 32139904) provide an up-to-date review of 2019 coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infects host cells using the host receptor angiotensin-converting enzyme 2 (AC E2). In patients with COVID-19, the incidence of cardiovascular involvement is high, although the specific mechanisms remain uncertain. The mechanism may be related to ACE2, which is expressed not only in the lungs but also in the cardiovascular system; therefore, ACE2-related signaling ...
Source: Heart Rhythm - July 28, 2020 Category: Cardiology Authors: Nipavan Chiamvimonvat Tags: EP News Source Type: research

The rationale for repurposing funny current inhibition for management of ventricular arrhythmia
Management of ventricular arrhythmia in structural heart disease is complicated by the toxicity of the limited antiarrhythmic options available. In others, pro-arrhythmia, deleterious hemodynamic, and noncardiac effects prevent practical use. This necessitates new thinking in therapeutic agents for ventricular arrhythmia in structural heart disease. Ivabradine, a funny current (If) inhibitor, has proven safety in heart failure, angina, and inappropriate sinus tachycardia. Though it is commonly known that funny channels are primarily expressed in the sinoatrial node, atrioventricular node, and conducting system of the ventr...
Source: Heart Rhythm - July 27, 2020 Category: Cardiology Authors: Praloy Chakraborty, Robert A. Rose, Krishnakumar Nair, Eugene Downar, K. Nanthakumar Source Type: research

Back to the future: Predicting sudden death in hypertrophic cardiomyopathy relying on individual risk markers and physician judgment without mathematical scoring
“…[C]linicians must respect the importance of their own thinking…and preserve the vitality of clinical reasoning while enhancing its scientific effectiveness.”Dr. Alvan Feinstein1974 (Source: Heart Rhythm)
Source: Heart Rhythm - July 24, 2020 Category: Cardiology Authors: Martin S. Maron, John Brush, Ethan J. Rowin, Barry J. Maron Tags: Viewpoint Source Type: research

Clinical Significance of Myocardial Scar in Patients With Frequent Premature Ventricular Complexes Undergoing Catheter Ablation
Frequent ventricular complexes (PVC) can result in PVC-induced cardiomyopathy (PICM). Scarring has been described in patients with frequent PVCs in the absence of apparent heart disease and in patients with known cardiomyopathy. (Source: Heart Rhythm)
Source: Heart Rhythm - July 24, 2020 Category: Cardiology Authors: Michael Ghannam, Miki Yokokawa, Jackson Liang, Hubert Cochet, Pierre Jais, Ghaith Sharaf Dabagh, Rakesh Latchamsetty, Krit Jongnarangsin, Fred Morady, Frank Bogun Source Type: research

Back to the Future: Predicting Sudden Death in Hypertrophic Cardiomyopathy Relyingon Individual Risk Markers and Physician Judgment Without Mathematical Scoring
“…clinicians must respect the importance of their own thinking…and preserve the vitality of clinical reasoning while enhancing its scientific effectiveness” (Source: Heart Rhythm)
Source: Heart Rhythm - July 24, 2020 Category: Cardiology Authors: Martin S. Maron, John Brush, Ethan J. Rowin, Barry J. Maron Source Type: research

Mind the gap: knowledge deficits in evaluating young sudden cardiac death
Sudden cardiac arrest affects around half a million people aged under 50 years old annually with a ninety percent mortality rate. Despite high patient numbers and clear clinical need to improve outcomes, many gaps exist in the evidence underpinning patients ’ management. Domains identifying the greatest barriers to conducting trials are the pre-hospital and forensic settings, who also provide care to the majority of patients. Addressing gaps in evidence along each point of the cardiac arrest trajectory is a key clinical priority. (Source: Heart Rhythm)
Source: Heart Rhythm - July 24, 2020 Category: Cardiology Authors: Elizabeth Paratz, Chris Semsarian, Andre La Gerche Source Type: research

Predictors of Atrial Mechanical Sensing and Atrioventricular Synchrony with a Leadless Ventricular Pacemaker: Results from the MARVEL 2 Study
The MARVEL 2 study assessed the efficacy of atrio-ventricular synchronous pacing with a Micra leadless pacemaker. Average AV synchrony (AVS) was 89.2%. Previously, low amplitude of the Micra-sensed atrial signal (A4) was observed to be a factor of low AVS. (Source: Heart Rhythm)
Source: Heart Rhythm - July 22, 2020 Category: Cardiology Authors: Christophe Garweg, Surinder Kaur Khelae, Clemens Steinwender, Joseph Yat Sun Chan, Philippe Ritter, Jens Brock Johansen, Venkata Sagi, Laurence M. Epstein, Jonathan P. Piccini, Mario Pascual, Lluis Mont, Rik Willems, Todd Sheldon, Vincent Splett, Kurt Str Source Type: research

Effect of QRS area reduction and myocardial scar on the hemodynamic response to cardiac resynchronization therapy
Vectorcardiographic QRS area (QRS area) predicts clinical outcomes after cardiac resynchronization therapy (CRT). Myocardial scar adversely affects clinical outcomes after CRT. (Source: Heart Rhythm)
Source: Heart Rhythm - July 22, 2020 Category: Cardiology Authors: Osita Okafor, Fraz Umar, Abbasin Zegard, Peter van Dam, Jamie Walton, Berthold Stegemann, Howard Marshall, Francisco Leyva Source Type: research

High-rate pacing guided by short-term variability of repolarization prevents imminent ventricular arrhythmias automatically by an internal cardioverter-defibrillator in the chronic atrioventricular block dog model
The anesthetized, complete chronic atrioventricular block (CAVB) dog model allows reproducible inducibility of torsades de pointes (TdP) arrhythmias due to ventricular remodeling and after a challenge with an IKr blocker. High-rate pacing (HRP) prevents ventricular arrhythmias but has long-term detrimental effects on cardiac function when applied continuously. Temporal dispersion of repolarization, quantified as short-term variability (STV), increases before ventricular arrhythmias and has been proposed as a marker to guide HRP. (Source: Heart Rhythm)
Source: Heart Rhythm - July 21, 2020 Category: Cardiology Authors: Agnieszka Smoczy ńska, Vera Loen, Alfonso Aranda, Henriëtte D.M. Beekman, Mathias Meine, Marc A. Vos Source Type: research

Corrigendum
In the article, “Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction” by Taisuke Ishikawa, et al, published in the May 2017 issue of Heart Rhythm (2017;14:717-724), the authors found errors in the abstract, text, table a nd figure legend with respect to the description of numerical data. The authors regret these errors, specifically, (Source: Heart Rhythm)
Source: Heart Rhythm - July 21, 2020 Category: Cardiology Tags: Corrigendum Source Type: research

High rate pacing guided by short-term variability of repolarization prevents imminent ventricular arrhythmias automatically by an internal cardioverter defibrillator in the chronic atrioventricular block dog model
The anesthetized, chronic complete atrioventricular block (CAVB) dog model allows reproducible inducibility of Torsade de Pointes (TdP) arrhythmias due to ventricular remodeling and after a challenge with an IKr-blocker. High rate pacing (HRP) prevents ventricular arrhythmias, but has long-term detrimental effects on cardiac function when applied continuously. Temporal dispersion of repolarization, quantified as short-term variability (STV), increases prior to ventricular arrhythmias and has been proposed as a marker to guide HRP. (Source: Heart Rhythm)
Source: Heart Rhythm - July 21, 2020 Category: Cardiology Authors: Agnieszka Smoczy ńska, Vera Loen, Alfonso Aranda, Henriëtte D.M. Beekman, Mathias Meine, Marc A. Vos Source Type: research

Sex-specific IKAS activation in rabbit ventricles with drug-induced QT prolongation
Female sex is a known risk factor for drug-induced long QT syndrome (diLQTS). We recently demonstrated a sex difference in apamin-sensitive small-conductance Ca2+-activated K+ (SK) current (IKAS) activation during β-adrenergic stimulation. (Source: Heart Rhythm)
Source: Heart Rhythm - July 20, 2020 Category: Cardiology Authors: Adonis Z. Wu, Mu Chen, Dechun Yin, Thomas H. Everett, Zhenhui Chen, Michael Rubart, James N. Weiss, Zhilin Qu, Peng-Sheng Chen Source Type: research

Left Ventricular Summit Arrhythmias with an Abrupt V3 Transition: Anatomy of the Aortic Interleaflet Triangle Vantage Point
While early precordial ECG characteristics are useful to differentiate left from right-sided outflow tract ventricular arrhythmia (OTVA), few patterns predict an origin from the septal margin of the LV summit (Source: Heart Rhythm)
Source: Heart Rhythm - July 20, 2020 Category: Cardiology Authors: Hongtao Liao, Wei Wei, Kevin S. Tanager, Frank Miele, Gaurav A. Upadhyay, Andrew D. Beaser, Zaid Aziz, Hemal M. Nayak, Cevher Ozcan, Takuro Nishimura, Ruhong Jiang, Dalise Shatz, Aliya N. Husain, Roderick Tung Source Type: research

Off-label dosing of non –vitamin K antagonist oral anticoagulants and clinical outcomes in Asian patients with atrial fibrillation
Off-label dosing non –vitamin K antagonist oral anticoagulants (NOACs) are commonly prescribed for Asian patients with atrial fibrillation (AF). (Source: Heart Rhythm)
Source: Heart Rhythm - July 19, 2020 Category: Cardiology Authors: Yi-Hsin Chan, Tze-Fan Chao, Shao-Wei Chen, Hsin-Fu Lee, Yung-Hsin Yeh, Ya-Chi Huang, Shang-Hung Chang, Chi-Tai Kuo, Gregory Y.H. Lip, Shih-Ann Chen Source Type: research