Susceptibility of atrial fibrillation in genetic architecture and heritability: A genome-wide association study in Taiwan
Atrial fibrillation (AF) is a common arrhythmia affecting ∼34 million people worldwide.1 Epidemiologic studies emphasize the heritable nature of AF.2 Hence, several recent studies evaluated the genetic susceptibility of AF by conventional genetic mapping approaches and genome-wide association studies. Many common single-nucleotide polymorphisms (SNPs) as sociated with AF have been identified.3,4 However, the genetic vulnerability to AF in the Taiwanese population remains unclear. In this single hospital–based study, the data from the Taiwan Precision Medicine Initiative were used. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Cheng-I Wu, I-Chieh Chen, Yun-Yu Chen, Yi-Ming Chen, Yenn-Jiang Lin, Yu-Chen Hsieh, Shih-Ann Chen Tags: Research Letter Source Type: research
Interference from lobe-and-disk left atrial appendage occluder affecting left superior pulmonary vein pulsed field ablation
Pulsed field ablation (PFA) employs high-voltage electroporation for tissue ablation, offering enhanced durability and minimized esophageal damage, thereby improving safety of pulmonary vein isolation.1 Electrical arcing, a possible complication of high-intensity electric field delivery, may occur when the current flows from 1 conductive point to another. The phenomenon is influenced by factors like electric field strength and tissue properties and may ultimately lead to significant temperature rise and tissue charring. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Charles Audiat, Domenico Giovanni Della Rocca, Carlo de Asmundis, Gian Battista Chierchia Source Type: research
Interference from Lobe-and-Disc Left Atrial Appendage Occluder Affecting Left Superior Pulmonary Vein Pulsed Field Ablation
Pulsed Field Ablation (PFA) employs high-voltage electroporation for tissue ablation, offering enhanced durability and minimized esophageal damage, thereby improving PVI safety (1). Electrical arcing is a possible complication of high-intensity electric field delivery, which may occur when the current flows from one conductive point to another. The phenomenon is influenced by factors like electric field strength and tissue properties and may ultimately lead to significant temperature rise and tissue charring. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Charles Audiat, Domenico Giovanni Della Rocca, Carlo de Asmundis, Gian Battista Chierchia Source Type: research
Inhibition of the potassium channel TASK-1 in human atria to reduce arrhythmogenesis
CoS (Schmidt C.) and FW have filed patent application on TASK-1-based gene therapy and pharmacotherapy of atrial arrhythmias. CoS received research funding from Boehringer Ingelheim. All other authors report no conflict of interest regarding the publication of this article. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Philipp Hegner, Manuel Schuh, Felix Wiedmann, Daniele Camboni, Christof Schmid, Lars Siegfried Maier, Constanze Schmidt, Stefan Wagner Source Type: research
Heart Rhythm Society ’s survey assessing same-day discharge after electrophysiology procedures and implementation in ambulatory surgical centers
With advances in technology and technique, catheter ablation has achieved increasing safety and efficacy in arrhythmia treatment. Simultaneously, innovations have been developed to expedite patient throughput and reduce cost – for example, same-day discharge (SDD) after atrial fibrillation (AF) ablation.1-2 These measures accelerated during the COVID-19 pandemic, with implementation of ablation procedures at ambulatory surgical centers (ASCs) in the United States.3-5 With cardiac rhythm device implantation procedures already being performed at ASCs, expanding ablation procedures to the ASC setting has garnered interest a...
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Christopher F. Liu, Jodie L. Hurwitz, Andrew D. Krahn, Kenneth A. Ellenbogen, David J. Slotwiner, Mark H. Schoenfeld, Frank Pelosi, Sumeet K. Mainigi, Adam E. Berman, Eric J. Rashba, Steven Hao, Molly Sachdev, Timothy R. Larsen, Shane Tsai, Lisa Miller, A Source Type: research
Catheter ablation of parahisian premature ventricular complexes in patients with and without cardiac scar
Ablation of premature ventricular complexes (PVCs) originating from the parahisian area is challenging. Late gadolinium enhanced cardiac magnetic resonance (LGE-CMR) scar may influence procedural outcomes; the impact of cardiac scar on parahisian PVCs has not been described. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Jamie Simpson, Mohamed Al-Sadawi, Amrish Deshmukh, Jackson J. Liang, Rakesh Latchamsetty, Thomas Crawford, Krit Jongnarangsin, Hakan Oral, Frank Bogun, Michael Ghannam Source Type: research
Accurate Detection of Lead Malfunction From ECG-derived Bipolar Pacing Stimulus Amplitude
One common mode of lead failure is insulation breach which may result in myopotential noise and device malfunction. “Pseudo-unipolarization” of bipolar pacing stimuli, as observed from a routine 12-lead ECG due to stimulus current leak has been observed with insulation breaches. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Michael S. Lloyd, Mary Pelling, Rand Ibrahim, Mikhael F. El-Chami, Shahriar Iravanian Source Type: research
Acute effects of Dantrolene on the mechanical performance of myopathic human hearts
Despite significant progress in pharmacotherapy, ventricular arrhythmia (VA) remains a challenge in heart failure (HF). Use of most conventional anti-arrhythmic drugs is limited by proarrhythmia and/or negative inotropic effects. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Praloy Chakraborty, Mahmoud M. Bokhari, St éphane Massé, Mohammed A. Azam, Patrick F.H. Lai, Timothy Liang, Daoyuan Si, Abhishek Bhaskaran, Sheila Riazi, Filio Billia, Kumaraswamy Nanthakumar Source Type: research
Association of Chronic Kidney Disease and End-Stage Renal Disease with Procedural Complications and Inpatient Outcomes of Leadless Pacemaker Implantations Across the United States
Leadless pacemakers have emerged as a promising alternative to transvenous pacemakers in patients with kidney disease. However, studies investigating leadless pacemaker outcomes and complications based on kidney dysfunction are limited. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Muhammad Zia Khan, Amanda Nguyen, Muhammad Usman Khan, Yasar Sattar, Waleed Alruwaili, Karthik Gonuguntla, Hafiz Muhammad Sohaib Hayat, Melody Mendez, Sameh Nassar, Zain Ul Abideen Asad, Siddharth Agarwal, Sameer Raina, Sudarshan Balla, Bao Nguyen, Dali F Source Type: research
Susceptibility of Atrial Fibrillation in Genetic Architecture and Heritability: A Genome-Wide Association Study in Taiwan
Atrial fibrillation (AF) is a common arrhythmia affecting ∼34 million people worldwide1. Epidemiological studies emphasize the heritable nature of AF2. Hence, several recent studies evaluated the genetic susceptibility of AF using conventional genetic mapping approaches and genome-wide association studies (GWASs). Many common single-nucleotide polymorphi sms (SNPs) have been identified to be associated with AF3,4. However, the genetic vulnerability to AF in the Taiwanese population remains unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - April 2, 2024 Category: Cardiology Authors: Cheng-I Wu, I-Chieh Chen, Yun-Yu Chen, Yi-Ming Chen, Yenn-Jiang Lin, Yu-Chen Hsieh, Shih-Ann Chen Source Type: research
To the Editor — Risk of atrial arrhythmias in arrhythmogenic right ventricular cardiomyopathy patients undergoing ventricular tachycardia ablation
The objective of this study was to determine the type, prevalence, outcome, and risk correlates of atrial arrhythmias in arrhythmogenic right ventricular cardiomyopathy in patients undergoing ventricular tachycardia ablation. The risk score for typical atrial flutter was determined from univariate logistic regression analysis. They then found that the risk score for typical flutter included age>40 years, ≥moderate right ventricular dysfunction, ≥moderate tricuspid regurgitation, ≥moderate right atrial dilation, and right ventricular volume>250 mL, with score>4 identifying 50% prevalence of typical flutter. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Yun Cheng, Qinggang Zhang Source Type: research
Reply to the Editor — Heart transplant, CIED implant, and mortality
We reported longer survival in orthotopic heart transplant patients receiving cardiac implantable electronic devices (CIEDs), noting an early separation of survival curves that “suggest other confounding factors at play.” Dr Wimmer and colleagues note this reflects inherent lead time bias due to time between transplantation and device placement. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Zain Gowani, Michael R. Gold Source Type: research
Regarding the risk of atrial arrhythmias in arrhythmogenic right ventricular cardiomyopathy patients undergoing ventricular tachycardia ablation
The objective of this study was to determine the type, prevalence, outcome, and risk correlates of atrial arrhythmias (AAs) in arrhythmogenic right ventricular cardiomyopathy (ARVC) in patients undergoing ventricular tachycardia (VT) ablation. The risk score for typi cal atrial flutter was determined from univariate logistic regression analysis, then they found that the risk score for typical flutter included age>40 years, ≥moderate right ventricular dysfunction, ≥moderate tricuspid regurgitation, ≥moderate right atrial dilation, and right ventricular volume>250 cc, with score>4 identifying 50% prevalence of typical ...
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Yun Cheng, Qinggang Zhang Source Type: research
Modernizing cardiovascular medicine board certification: Leveraging innovation and strengthening continuous competency and professional growth
Achieving and maintaining clinical competence in the practice of cardiovascular medicine is fundamental to providing appropriate, patient-centric, high-value health care and is part of the ethical and professional duties of all physicians in their responsibility to patients and the public. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Jodie L. Hurwitz, B. Hadley Wilson, Joseph C. Wu, James C. Fang, George D. Dangas Tags: Editorial Source Type: research
Author ’s Reply to Heart Transplant, CIED Implant and Mortality
We reported longer survival in orthotopic heart transplant patients receiving CIEDs, noting an early separation of survival curves which “suggest other confounding factors at play”. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Zain Gowani, Michael R. Gold Source Type: research
