2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy
Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloid and sarcoidosis, Chagas ’ disease and left ventricular noncompaction. The ACM phenotype overlaps with other cardiomyopathies, particularly dilated cardiomyopathy with arrhythmia presentation which may be associated with ventricular dilatation and/or impaire...
Source: Heart Rhythm - May 8, 2019 Category: Cardiology Authors: Jeffrey A. Towbin, William J. McKenna, Dominic J. Abrams, Michael J. Ackerman, Hugh Calkins, Francisco C.C. Darrieux, James P. Daubert, Christian de Chillou, Eugene C. DePasquale, Milind Y. Desai, N.A. Mark Estes, Wei Hua, Julia H. Indik, Jodie Ingles, Cy Source Type: research

Late Breaking Clinical Trials Session I
(Source: Heart Rhythm)
Source: Heart Rhythm - May 8, 2019 Category: Cardiology Source Type: research

HRS White Paper on interoperability of data from cardiac implantable electronic devices (CIEDs)
This HRS Needs Assessment is in the category of the Heart Rhythm Society (HRS) documents delineating a future direction of research, technology development, or health care policy and adheres to the following requirements set forth by the HRS: (Source: Heart Rhythm)
Source: Heart Rhythm - May 7, 2019 Category: Cardiology Authors: David J. Slotwiner, Robert L. Abraham, Sana M. Al-Khatib, H. Vernon Anderson, T. Jared Bunch, Martha G. Ferrara, Neal Lippman, Gerald A. Serwer, Paul R. Steiner, James E. Tcheng, Niraj Varma, Bruce L. Wilkoff Source Type: research

Transparent Sharing of Digital Health Data: A Call to Action
This HRS Needs Assessment is in the category of the Heart Rhythm Society (HRS) documents delineating a future direction of research, technology development, or health care policy and adheres to the following requirements set forth by the HRS: (Source: Heart Rhythm)
Source: Heart Rhythm - May 7, 2019 Category: Cardiology Authors: David J. Slotwiner, Khaldoun G. Tarakji, Sana M. Al-Khatib, Rod S. Passman, Leslie A. Saxon, Nicholas S. Peters, Debbe McCall, Mintu P. Turakhia, Jill Schaeffer, G. Stuart Mendenhall, Gerhard Hindricks, Sanjiv M. Narayan, Elizabeth E. Davenport, Nassir F. Source Type: research

HRS White Paper on Interoperability of Data from Cardiovascular Implantable Electronic Devices (CIEDs)
These revisions and clarifications will expand the capabilities of the IDCO profile and ISO/IEEE-11073 nomenclature1 making it less ambiguous to the clinicians, more specific for industry to implement thereby improving patient care, and expanding its use to more device and electrode types including leadless pacemakers, subcutaneous ICDs, and implantable loop recorders. (Source: Heart Rhythm)
Source: Heart Rhythm - May 7, 2019 Category: Cardiology Authors: David J. Slotwiner, Robert L. Abraham, Sana M. Al-Khatib, H. Vernon Anderson, T. Jared Bunch, Martha G. Ferrara, Neal Lippman, Gerald A. Serwer, Paul R. Steiner, James E. Tcheng, Niraj Varma, Bruce L. Wilkoff Source Type: research

Grapefruit Juice prolongs the QT Interval of Healthy Volunteers and Patients with Long QT syndrome
The list of medications linked to a drug-induced long QT syndrome (LQTS) is diverse. It is possible that food products too have QT-prolonging potential. (Source: Heart Rhythm)
Source: Heart Rhythm - May 6, 2019 Category: Cardiology Authors: Ehud Chorin, Aviram Hochstadt, Yoav Granot, Shafik Khoury, Arie Lorin Schwartz, Gilad Margolis, Rami Barashi, Dana Viskin, Eihab Ghantous, Michael Schnapper, Tal Mekori, Dana Fourey, Milton Ernesto Guevara-Valdivia, Manlio F. Marquez, David Zeltzer, Rapha Source Type: research

S-AB01-01 to S-AB36-06
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-PO01-001 to S-PO01-175
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-PO02-029 to S-PO02-244
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-PO03-029 to S-PO03-246
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-PO04-029 to S-PO04-246
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-PO05-029 to S-PO05-246
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Special Poster S-IA01-001 to S-BS03-10
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-PO06-001 to S-PO06-120
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

S-MP01-02 to S-SP06-06
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Author Index
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Subject Index
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Cover
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Title page
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Heart Rhythm Scientific Sessions Program Committee
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Mission Statement
(Source: Heart Rhythm)
Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

Table of Contents
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Source: Heart Rhythm - April 30, 2019 Category: Cardiology Source Type: research

EP News: Case Reports
Ventricular tachycardia (VT) or ventricular fibrillation (VF) storm is a life-threatening condition that is often managed by antiarrhythmic drug therapies, catheter ablation, general anesthesia, and ventricular support devices. Radiotherapy for VT has shown early promise as a noninvasive therapy to reduce risk of recurrent VT. No data exist on the role of radiotherapy for VF storm. Scholz et  al (DOI: https://doi.org/10.1016/j.hrcr.2019.03.004) shared a case of a 53-year-old man who presented with VF storm after a recent presentation with anterior myocardial infarction. (Source: Heart Rhythm)
Source: Heart Rhythm - April 29, 2019 Category: Cardiology Authors: T. Jared Bunch Tags: EP News Source Type: research

EP News: Clinical
Lemkes et  al (N Engl J Med 2019;380:1397, PMID 30883057) randomized 552 patients with cardiac arrest without ST-segment elevation myocardial infarction (STEMI) to immediate or delayed coronary angiography. The primary end point was survival at 90 days. Secondary end points included survival at 90 days with good cerebral performance, myocardial injury, duration of catecholamine support, shock, ventricular tachycardia, mechanical ventilation, major bleeding, kidney injury, need for renal replacement therapy, time to target temperature, and neurologic status at discharge from the intensive care unit. (Source: Heart Rhythm)
Source: Heart Rhythm - April 29, 2019 Category: Cardiology Authors: N.A. Mark Estes Tags: EP News Source Type: research

EP News: Basic and Translational
Shafaattalab et  al (Proc Natl Acad Sci U S A 2019;116:6969, PMID 30886088) investigated the genetic pathogenesis of sudden unexpected death of infants (SUDI) by sequencing>70 genes from 191 autopsy-negative SUDI victims. A previously unknown variant in troponin I (TnI, TNNI1 R37C+/ −) was identified in 10 infants. The mutation was found in the fetal/neonatal paralog of TnI, a gene expressed in the heart up to the first 24 months of life. TNNI1 R37C mutation was functionally assessed in human reconstituted thin filaments (RTFs) using fluorometry. (Source: Heart Rhythm)
Source: Heart Rhythm - April 29, 2019 Category: Cardiology Authors: Nipavan Chiamvimonvat Tags: EP News Source Type: research

EP News: Allied Professionals
In this multicenter center, the authors (Stevenson et  al. J Am Coll Cardiol 2019;73:1413-25, PMID: 30922472) sought to assess the efficacy and safety of a new ablation catheter that uses a 27-gauge needle that is inserted repeatedly into the myocardium to map and ablate ventricular arrhythmias (VA) including ventricular tachycardia (VT) and premature ventricular contractions (PVCs). They included 31 patients with VT (n=26) or very frequent (>20% burden) PVCs with decreased ejection fraction of (Source: Heart Rhythm)
Source: Heart Rhythm - April 29, 2019 Category: Cardiology Authors: Erica S. Zado Tags: EP News Source Type: research

Incidence of myopotential induction in subcutaneous implantable cardioverter-defibrillator patients: Is the oversensing issue really solved?
The subcutaneous implantable cardioverter-defibrillator (S-ICD) has established its role in the prevention of sudden cardiac death in a defined population. Inappropriate shocks and device malfunction in S-ICD therapy may be caused by myopotential (MP) oversensing. (Source: Heart Rhythm)
Source: Heart Rhythm - April 28, 2019 Category: Cardiology Authors: Jan-Hendrik van den Bruck, Arian Sultan, Tobias Plenge, Katharina Seuthe, Tim M ödder, Christos Iliadis, Daniel Stern, Tatjana Blankenheim, Daniel Steven, Jakob Lüker Source Type: research

Permanent left bundle branch area pacing for atrioventricular block: Feasibility, safety, and acute effect
Left bundle branch area pacing (LBBAP), a new pacing approach, lacks adequate evaluation. (Source: Heart Rhythm)
Source: Heart Rhythm - April 28, 2019 Category: Cardiology Authors: Xiaofei Li, Hui Li, Wentao Ma, Xiaohui Ning, Erpeng Liang, Kunjing Pang, Yan Yao, Wei Hua, Shu Zhang, Xiaohan Fan Source Type: research

Permanent left bundle branch area pacing for atrioventricular block: feasibility, safety and acute effect
Left bundle branch area pacing (LBBAP), a new pacing approach, lacks adequate evaluation. (Source: Heart Rhythm)
Source: Heart Rhythm - April 28, 2019 Category: Cardiology Authors: Xiaofei Li, Hui Li, Wentao Ma, Xiaohui Ning, Erpeng Liang, Kunjing Pang, Yan Yao, Wei Hua, Shu Zhang, Xiaohan Fan Source Type: research

Incidence of myopotential induction in Subcutaneous Implantable Cardioverter Defibrillator patients – Is the oversensing issue really solved?
The subcutaneous ICD (S-ICD) has established its role in the prevention of sudden cardiac death in a defined population. Inappropriate shocks and device malfunction in S-ICD therapy may be caused by myopotential (MP) oversensing. (Source: Heart Rhythm)
Source: Heart Rhythm - April 28, 2019 Category: Cardiology Authors: Jan-Hendrik van den Bruck, Arian Sultan, Tobias Plenge, Katharina Seuthe, Tim M ödder, Christos Iliadis, Daniel Stern, Tatjana Blankenheim, none, Daniel Steven, Jakob Lüker Source Type: research

Radiofrequency ablation of the cavotricuspid isthmus for management of atrial flutter in patients with congenital heart disease after tricuspid valve surgery: A single Center experience
Typical atrial flutter involving the cavotricuspid isthmus (CTI) is the most common reentrant arrhythmia in congenital heart disease (CHD) and ablation is effective in its management. However, CHD patients often require surgical interventions on their tricuspid valve that utilize prosthetic material making CTI ablation technically challenging. (Source: Heart Rhythm)
Source: Heart Rhythm - April 28, 2019 Category: Cardiology Authors: Danesh K. Kella, Omar Z. Yasin, Ameesh M. Isath, Christopher J. McLeod, Bryan Canon, Samuel J. Asirvatham, Philip L. Wackel Source Type: research

New Insights on Ablation of Idiopathic Ventricular Arrhythmias Arising From the Right Ventricular Outflow tract
Soon after the recognition that radiofrequency energy is a safe and effective energy source for catheter ablation of cardiac arrhythmias, Morady and colleagues reported 100% efficacy for RF ablation of idiopathic VT arising in the right ventricular outflow tract.1 One of the next major milestones in perfection of catheter ablation of idiopathic ventricular arrhythmias was the identification of the aortic cusps as an important site of origin of idiopathic ventricular arrhythmias with a LBBB inferior axis that could not be ablated from the RVOT. (Source: Heart Rhythm)
Source: Heart Rhythm - April 28, 2019 Category: Cardiology Authors: Sunjeet Sidhu, Hugh Calkins Source Type: research

A young man with a narrow and a wide QRS tachycardia
Figure  1 shows electrocardiograms (ECGs) of a 22-year-old man with a history of palpitations. He was known at the emergency department because of a 2-year history of occasional episodes of a rapid heart rhythm. The ECGs recorded at those times, one shown in Figure 1B, always revealed a narrow QRS tachyc ardia with alternating R-R intervals of 280 and 320 ms. Each QRS complex is followed by a P wave. Those tachycardias were terminated by intravenous adenosine. The sinus rhythm ECG outside tachycardia is shown in Figure 1A. (Source: Heart Rhythm)
Source: Heart Rhythm - April 26, 2019 Category: Cardiology Authors: Hein J. Wellens Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research

Prevalence of atrial fibrillation and association with clinical, sociocultural, and ancestral correlates among Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos
Hispanics/Latinos represent the largest ethnic minority group in the United States. Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States. (Source: Heart Rhythm)
Source: Heart Rhythm - April 26, 2019 Category: Cardiology Authors: Jered D. Linares, Larry R. Jackson, Farah Z. Dawood, Katrina Swett, Emelia J. Benjamin, Neil Schneiderman, Elsayed Z. Soliman, Jianwen Cai, Alvaro Alonso, Sylvia Wassertheil-Smoller, Gregory A. Talavera, James P. Daubert, Martha L. Daviglus, Carlos J. Rod Tags: Clinical Source Type: research

HRS 40th anniversary viewpoints: Fifty years of clinical cardiac arrhythmology –Reflections from a Dutchman on an exciting journey
My interest in cardiology started in the United States. After finishing my medical studies at Leiden University in the Netherlands, I went in 1960 for a rotating internship to Mercy Hospital in Baltimore. There I met Dr Marriott, one of the attending cardiologists, who always invited the interns to attend his reading of electrocardiograms (ECGs). Soon, I was fascinated by the way he analyzed and explained the tracings, emphasizing the simplicities rather than the complexities of the tracing and discussing all important ECG patterns known at that time. (Source: Heart Rhythm)
Source: Heart Rhythm - April 26, 2019 Category: Cardiology Authors: Hein J. Wellens Tags: Viewpoint Source Type: research

Heart Rhythm Society —40th anniversary: A history of success
Half a century ago, under the innovative direction of Dirk Durrer in Amsterdam and Philippe Coumel in Paris, the field of invasive cardiac electrophysiology was born. Approximately 10 years later, in 1980, the North American Society of Pacing and Electrophysiology (NASPE), the progenitor of the Heart Rhythm Society (HRS), was founded. This year HRS, which has served as the leading global home to cardiac electrophysiology professionals, celebrates its 40th anniversary. Readers are referred to an earlier publication, created at the time of our 25th anniversary by Dr Seymour Furman, one of our founders and the first historian...
Source: Heart Rhythm - April 26, 2019 Category: Cardiology Authors: Thomas F. Deering, Igor R. Efimov Tags: Editorial Source Type: research

Troubleshooting and programming considerations for His bundle pacing
Interest in permanent His bundle pacing as a means of both preventing pacing-induced cardiomyopathy and providing physiological resynchronization by normalization of His-Purkinje activation is steadily growing. However, there are differences in atrioventricular timing cycles, sensing, and tissue capture that distinguish His bundle pacing from right ventricular pacing, and hence it is of utmost importance to bear these differences in mind when implanting a His pacing lead and programming the His pacing system. (Source: Heart Rhythm)
Source: Heart Rhythm - April 26, 2019 Category: Cardiology Authors: Daniel L. Lustgarten, Parikshit S. Sharma, Pugazhendhi Vijayaraman Tags: Featured Article Source Type: research

Risk factors for Lethal Arrhythmic Events in Children and Adolescents with Hypertrophic Cardiomyopathy and an Implantable Defibrillator: An International Multi-Center Study
Predictors of risk for lethal arrhythmic events (LAE) is poorly understood and may differ from adults in children with hypertrophic cardiomyopathy (HCM). (Source: Heart Rhythm)
Source: Heart Rhythm - April 22, 2019 Category: Cardiology Authors: Seshadri Balaji, Michael P. DiLorenzo, Frank A. Fish, Susan P. Etheridge, Peter F. Aziz, Mark W. Russell, Svjetlana Tisma, Andreas Pflaumer, Narayanswami Sreeram, Peter Kubus, Ian H. Law, Michal J. Kantoch, Naomi J. Kertesz, Margaret Strieper, Christopher Source Type: research

Mastering the Art of Epicardial Access in Cardiac Electrophysiology
Access to the epicardial space is fundamental to several cardiac procedures. Whilst traditional indications include catheter ablation of ventricular arrhythmias and accessory pathways, novel indications include left atrial appendage occlusion, esophageal protection, mapping and ablation during atrial fibrillation procedures, implantation of epicardial pacing leads, and phrenic nerve displacement to facilitate safe ablation of arrhythmias. Accessing the epicardial space safely is a major challenge requiring intimate knowledge of cardiac anatomy, extensive training and expertise. (Source: Heart Rhythm)
Source: Heart Rhythm - April 19, 2019 Category: Cardiology Authors: Jorge Romero, Kalayanam Shivkumar, Luigi Di Biase, Ricardo Avendano, Robert D. Anderson, Andrea Natale, Saurabh Kumar Source Type: research

Fluctuations in premature ventricular contraction burden can affect medical assessment and management
Frequent premature ventricular contractions (PVCs) can cause disabling symptoms and decrease left ventricular ejection fraction. PVC burden, typically quantified by a 24-hour monitor, is one of the factors that determines the clinical management of PVCs. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Andin H. Mullis, Karam Ayoub, Jignesh Shah, Muhammad Butt, John Suffredini, Melissa Czarapata, Brian Delisle, Gbolahan O. Ogunbayo, Yousef Darrat, Claude S. Elayi Source Type: research

Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model
Noninvasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricular (LV) ablative radiation treatment on global LV function and volumes are unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Stephan Hohmann, Amanda J. Deisher, Atsushi Suzuki, Hiroki Konishi, Maryam E. Rettmann, Kenneth W. Merrell, Jon J. Kruse, Laura K. Newman, Kay D. Parker, Kristi H. Monahan, Robert L. Foote, Michael G. Herman, Douglas L. Packer Source Type: research

Cardiac resynchronization therapy using pacemakers vs defibrillators in patients with nonischemic cardiomyopathy: The United States experience from 2007 to 2014
The impact of implantable defibrillator therapy on outcomes of patients with nonischemic cardiomyopathy (NICM) who receive a cardiac resynchronization therapy (CRT) device is controversial. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Samir Saba, Terence McLaughlin, Meiqi He, Andrew Althouse, Suresh Mulukutla, Inmaculada Hernandez Source Type: research

Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome
Commercial genetic testing for long QT syndrome (LQTS) has rapidly expanded, but the inability to accurately predict whether a rare variant is pathogenic has limited its clinical benefit. Novel missense variants are routinely reported as variant of unknown significance (VUS) and cannot be used to screen family members at risk for sudden cardiac death. Better approaches to determine the pathogenicity of VUS are needed. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Nikhil V. Chavali, Dmytro O. Kryshtal, Shan S. Parikh, Lili Wang, Andrew M. Glazer, Daniel J. Blackwell, Brett M. Kroncke, Moore Benjamin Shoemaker, Bjorn C. Knollmann Source Type: research

Conduction Patterns of Idiopathic Arrhythmias from the Endocardium and Epicardium of Outflow Tracts: New Insights with Non-Invasive Electroanatomic Mapping
Idiopathic arrhythmias commonly arise from the septal right ventricular outflow tract (sRVOT), sinuses of Valsalva (SoV) and great cardiac vein (GCV). Predicting exact site of origin is important for preparation for catheter ablation. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Stavros E. Mountantonakis, Aditi S. Vaishnav, Jeremy D. Jacobson, Neil E. Bernstein, Kabir Bhasin, Kristie M. Coleman, Nicholas T. Skipitaris Source Type: research

Cardiac Resynchronization Therapy Using Pacemakers versus Defibrillators in Patients with Non-Ischemic Cardiomyopathy: The United States Experience from 2007 to 2014
The impact of implantable defibrillator therapy on outcomes of patients with non-ischemic cardiomyopathy (NICM) who receive a cardiac resynchronization therapy (CRT) device is controversial. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Samir Saba, Terence McLaughlin, Meiqi He, Andrew Althouse, Suresh Mulukutla, Inmaculada Hernandez Source Type: research

Insights from atrial surface activation throughout atrial tachycardia cycle length: A new mapping tool
A novel ‘LUMIPOINT’-software in the Rhythmia system displays a histogram of activated area over the entire AT cycle length (CL) with a normalized score. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Masateru Takigawa, Claire A. Martin, Nicolas Derval, Arnaud Denis, Konstantinos Vlachos, Takeshi Kitamura, Antonio Frontera, Ruairidh Martin, Ghassen Cheniti, Anna Lam, Felix Bourier, Nathaniel Thompson, Michel Wolf, Gregoire Massoullie, William Escande, Source Type: research

Left Ventricular Function After Non-Invasive Cardiac Ablation Using Proton Beam Therapy In A Porcine Model
Non-invasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricle (LV) ablative radiation treatment on global LV function and volumes are unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Stephan Hohmann, Amanda J. Deisher, Atsushi Suzuki, Hiroki Konishi, Maryam E. Rettmann, Kenneth W. Merrell, Jon J. Kruse, Laura K. Newman, Kay D. Parker, Kristi H. Monahan, Robert L. Foote, Michael G. Herman, Douglas L. Packer Source Type: research

The patient-independent human iPSC model – a new tool for rapid determination of genetic variant pathogenicity in long QT syndrome
Commercial genetic testing for Long QT Syndrome (LQTS) has rapidly expanded, but the inability to accurately predict whether a rare variant is pathogenic has limited its clinical benefit. Novel missense variants are routinely reported as “Variant of Unknown Significance (VUS)” and cannot be used to screen family members at-risk for sudden cardiac death. Better approaches to determine pathogenicity of VUS are needed. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Nikhil V. Chavali, Dmytro O. Kryshtal, Shan S. Parikh, Lili Wang, Andrew M. Glazer, Daniel J. Blackwell, Brett M. Kroncke, Moore Benjamin Shoemaker, Bjorn C. Knollmann Source Type: research

Fluctuations in premature ventricular contraction burden can impact medical assessment and management
Frequent premature ventricular contractions (PVCs) can cause disabling symptoms and decrease left ventricle ejection fraction. The PVC burden, typically quantified by a 24-hour monitor, is one of the factors that determines the clinical management of PVCs. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2019 Category: Cardiology Authors: Andin H. Mullis, Karam Ayoub, Jignesh Shah, Muhammad Butt, John Suffredini, Melissa Czarapata, Brian Delisle, Gbolahan O. Ogunbayo, Yousef Darrat, Claude S. Elayi Source Type: research

Idiopathic ventricular fibrillation with repetitive activity inducible within the distal Purkinje system
Ventricular ectopy mostly originating from the distal Purkinje system, are observed in approximately 30% of idiopathic ventricular fibrillation (VF)1-5. These ectopy have commonly short coupling R-on-T intervals. However the Purkinje triggers are often transient, only present during short arrhythmic periods, thus preventing the recognition of this condition and its treatment. Here, we report two cases of idiopathic VF in which altered electrophysiological properties and inducible repetitive activity were demonstrated in the peripheral Purkinje system in the absence of clinical short-coupled ectopy. (Source: Heart Rhythm)
Source: Heart Rhythm - April 9, 2019 Category: Cardiology Authors: Michel Haissaguerre, Ghassen Cheniti, William Escande, Alexandre Zhao, M élèze Hocini, Olivier Bernus Source Type: research