Catheter ablation of ventricular arrhythmias originating from the junction of the pulmonary sinus cusp via a nonreversed U curve approach
Ventricular arrhythmias (VAs) can originate from the pulmonary sinus cusp, and reversed U curve ablation has been highly efficient treatment. (Source: Heart Rhythm)
Source: Heart Rhythm - April 4, 2019 Category: Cardiology Authors: Xiaonan Dong, Qi Sun, Min Tang, Shu Zhang Source Type: research

Ibrutinib promotes atrial fibrillation by inducing structural remodeling and calcium dysregulation in the atrium
Ibrutinib is a novel anti-tumor drug that targets Bruton ’s tyrosine kinase (BTK) for the treatment of chronic lymphocytic leukemia. Atrial fibrillation (AF) occurs in 5—9% of patients during treatment, but the underlying mechanisms remain unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - April 4, 2019 Category: Cardiology Authors: Le Jiang, Linling Li, Yanfei Ruan, Song Zuo, Xiaoyan Wu, Qianqian zhao, Yanwei Xing, Xin Zhao, Shijun Xia, Rong Bai, Xin Du, Nian Liu, ChangSheng Ma Source Type: research

Catheter Ablation of Ventricular Arrhythmias Originating From the Junction of Pulmonary Sinus Cusp Via A Nonreversed U Curve Approach
Ventricular arrhythmias (VAs) could be originated from the pulmonary sinus cusp (PSC) and the reversed U curve ablation was highly efficient. (Source: Heart Rhythm)
Source: Heart Rhythm - April 4, 2019 Category: Cardiology Authors: Xiaonan Dong, Qi Sun, Min Tang, Shu Zhang Source Type: research

Regulation of the TRPC1 channel by endothelin-1 in human atrial myocytes
Our recent study demonstrated that the nonselective cation current mediated by the transient receptor potential channel 1 (TRPC1) channel is activated by endothelin-1 (ET-1) in human atrial myocytes; however, the related signal molecules involved are unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Kai Zhang, Wei-Yin Wu, Gang Li, Yan-Hui Zhang, Yong Sun, Feng Qiu, Qian Yang, Guo-Sheng Xiao, Gui-Rong Li, Yan Wang Source Type: research

Reply to the Editor — Patients with atrial fibrillation with hypertrophic cardiomyopathy: Do we need new stroke risk stratification?
We thank Joung et  al for their interest in our work.1 In our study, patients with nonvalvular atrial fibrillation (NVAF) with hypertrophic cardiomyopathy (HCM) had a higher risk of stroke than did patients with NVAF without HCM in all generations and all CHA2DS2-VASc score groups. As shown in the study by Jung et  al,2 stroke risk in patients with NVAF with HCM without any other stroke risk factor was higher than that in patients with NVAF with a CHA2DS2-VASc score of 2. We agree with their results, and all patients with NVAF with HCM should receive anticoagulation. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Toyonobu Tsuda, Akihiro Nomura, Kenshi Hayashi Source Type: research

To the Editor — Augmenting speed of conduction to improve CRT
We read with great interest the article by Yagishita et  al,1 which documents the correlation of the S-QRS interval (left ventricular pacing stimulus to QRS onset) with response to cardiac resynchronization therapy (CRT). It appears that slowed local conduction in the left ventricle (possibly from local scar formation) is associated with impaired respon ses. The advice is to search to avoid using left ventricular lead implantation site positions giving rise to long such intervals. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Morton M. Mower Tags: Letter to the Editor Source Type: research

Reply to the Editor — Augmenting speed of conduction to improve CRT
We appreciate the constructive comments on our article. It has been reported that scar pacing should be avoided in order to obtain a better cardiac resynchronization therapy (CRT) response.1 In addition, we concluded that a left ventricular (LV) pacing site with a long S-QRS interval, which may reflect local conduction disturbance due to diseased myocardium, should be avoided. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Daigo Yagishita, Morio Shoda, Yoshimi Yagishita, Koichiro Ejima, Nobuhisa Hagiwara Source Type: research

To the Editor — Patients with atrial fibrillation with hypertrophic cardiomyopathy: Do we need new stroke risk stratification?
Because of high thromboembolic risk, lifelong oral anticoagulation is recommended in all patients with nonvalvular atrial fibrillation (NVAF) with hypertrophic cardiomyopathy (HCM).1 –3 We read with great interest the article by Tsuda et al,4 who rightly emphasized the importance of HCM in thromboembolism in patients with AF. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Boyoung Joung, Gregory Y.H. Lip Tags: Letter to the Editor Source Type: research

Author's reply to Atrial fibrillation patients with hypertrophic cardiomyopathy: Do we need new stroke risk stratification?
We thank Dr. Joung and colleagues for their interests in our work.1 In our study, patients with non-valvular atrial fibrillation (NVAF) with hypertrophic cardiomyopathy (HCM) had a higher risk of stroke than NVAF patients without HCM in all generations and all CHA2DS2-VASc score groups. As shown in the study of Jung et al.,2 the stroke risk in NVAF with HCM without any other stroke risk factor was greater than that in NVAF with a CHA2DS2-VASc score of 2. We agree with their results, and all NVAF patients with HCM should receive anticoagulation. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Toyonobu Tsuda, Akihiro Nomura, Kenshi Hayashi Source Type: research

How to Use the 12-lead ECG to Predict the Site of Origin of Idiopathic Ventricular Arrhythmias
Idiopathic ventricular arrhythmias (VAs) may arise from anywhere in the heart and the majority of them can be effectively treated with catheter ablation. The 12-lead electrocardiogram (ECG) is the initial mapping tool to predict the most likely site of origin and is valuable to choose the appropriate ablation strategy. Crucial to ECG interpretation is understanding the attitudinal orientation of the heart within the chest and the relationship between the different cardiac structures. In this review, we provide a stepwise anatomical approach for localization of idiopathic VAs based on sequential analysis of most relevant EC...
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Andres Enriquez, Adrian Baranchuk, David Briceno, Luis Saenz, Fermin Garcia Source Type: research

Regulation of TRPC1 channel by endothelin-1 in human atrial myocytes
Our recent study demonstrated that the non-selective cation current mediated by TRPC1 channel is activated by endothelin-1 (ET-1) in human atrial myocytes; however, the related signal molecules involved are unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Kai Zhang, Wei-Yin Wu, Gang Li, Yan-Hui Zhang, Yong Sun, Feng Qiu, Qian Yang, Guo-Sheng Xiao, Gui-Rong Li, Yan Wang Source Type: research

Author ’s reply to Augmenting speed of conduction to improve CRT
We appreciate the constructive comments on our article. It has been reported that scar pacing should be avoided in order to obtain a better cardiac resynchronization therapy (CRT) response1). Additionally, we also concluded that a left ventricular (LV) pacing site with a long S-QRS interval, which may reflect a local conduction disturbance due to diseased myocardium, should be avoided. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Daigo Yagishita, Morio Shoda, Yoshimi Yagishita, Koichiro Ejima, Nobuhisa Hagiwara Source Type: research

Augmenting Speed of Conduction to Improve CRT
We read with great interest the above paper documenting correlation of the S-QRS interval (LV pacing stimulus to QRS onset) with response to CRT. It appears that slowed local conduction in the left ventricle (possibly from local scar formation) is associated with impaired responses. The advice is to search to avoid using left ventricular lead implantation sites positions giving rise to long such intervals. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Morton M. Mower Source Type: research

Atrial fibrillation patients with hypertrophic cardiomyopathy: Do we need new stroke risk stratification?
Due to very high thromboembolic risk, life-long oral anticoagulation is recommended in all hypertrophic cardiomyopathy (HCM) patients with non-valvular atrial fibrillation (NVAF).1-3 We read with great interest the paper by Tsuda et al.4 who rightly emphasized the importance of HCM on thromboembolism in patients with AF. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Boyoung Joung, Gregory Y.H. Lip Source Type: research

The Heart Rhythm Society/American College of Physicians Atrial Fibrillation Screening and Education Initiative
The prevalence of both atrial fibrillation (AF) and stroke is increasing. Stroke is common in AF and can have devastating consequences, especially when AF is unrecognized, and anticoagulation is not initiated. (Source: Heart Rhythm)
Source: Heart Rhythm - April 3, 2019 Category: Cardiology Authors: Lynda E. Rosenfeld, Alpesh Navin Amin, Jonathan C. Hsu, Asa Oxner, Mellanie True Hills, David S. Frankel Source Type: research

Ten-year ablation outcomes of patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation
Pulmonary vein isolation (PVI) is commonly performed in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (PAF). However, the very long-term follow-up result is limited. (Source: Heart Rhythm)
Source: Heart Rhythm - March 31, 2019 Category: Cardiology Authors: Wen-Han Cheng, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Yuan Hung, Fa-Po Chung, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Tseng-Ying Tsai, Shin-Huei Liu, Shih-Ann Chen Tags: Clinical Source Type: research

Ten-year Ablation Outcomes of Patients With Paroxysmal Atrial Fibrillation Receiving Pulmonary Vein Isolation
Pulmonary vein isolation (PVI) is commonly performed in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (PAF). However, the very long-term follow-up result is limited. (Source: Heart Rhythm)
Source: Heart Rhythm - March 31, 2019 Category: Cardiology Authors: Wen-Han Cheng, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Yuan Hung, Fa-Po Chung, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Tseng-Ying Tsai, Shin-Huei Liu, Shih-Ann Chen Source Type: research

Epicardial injection of nanoformulated calcium into cardiac ganglionic plexi suppresses autonomic nerve activity and postoperative atrial fibrillation
Imbalanced activation of the cardiac autonomic nervous system triggers postoperative atrial fibrillation (POAF). Neuronal calcium overload induces apoptosis. We hypothesize that epicardial injection of timed-release nanoformulated CaCl2 (nCaCl2) into left atrial ganglionic plexi (GP) modulates autonomic function and suppresses POAF. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2019 Category: Cardiology Authors: Michael P. O ’Quinn, Kenneth J. Dormer, Jose F. Huizar, Kytai T. Nguyen, Karoly Kaszala, Adam Sima, Kenneth A. Ellenbogen, Alex Y. Tan Tags: Experimental Source Type: research

A slow irregular rhythm in a 65-year-old woman
A 65-year-old woman was referred by her family physician to the outpatient clinic because of a slow irregular pulse. Since 1 month she suffered from lightheadedness and fatigue. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2019 Category: Cardiology Authors: Hein J. Wellens Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research

HRS 40th anniversary viewpoints: Reflections on a career in arrhythmia surgery
Those of you who are following Editor-in-Chief Dr Chen ’s series of invited Viewpoint vignettes in celebration of the 40th anniversary of the Heart Rhythm Society will recognize that the title of my invited contribution to this celebratory series, “Reflections on a Career in Arrhythmia Surgery,” is a wordplay on the title of my friend Mel Scheinma n’s recent contribution, “Reflections on a Career in Academic Medicine.” This singular form of flattery—imitation—intentionally signifies the deep admiration I have for my electrophysiology colleagues with whom I have worked on a da...
Source: Heart Rhythm - March 28, 2019 Category: Cardiology Authors: James L. Cox Tags: Viewpoint Source Type: research

In utero exposure to nicotine abolishes the postnatal response of the cardiac sodium current to isoproterenol in newborn rabbit atrium
In utero exposure to tobacco smoke is associated with sudden infant death syndrome (SIDS) and cardiac arrhythmias in newborns. The arrhythmogenic mechanisms seem linked to alterations of the cardiac sodium current (INa). We previously reported that in utero exposure to nicotine delays the postnatal development of the heart sinoatrial node in rabbits and altered expression of the sodium channels NaV1.5 and NaV1.1 in the atrium surrounding it. These channels react differently to sympathetic stimulation. (Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2019 Category: Cardiology Authors: Michael Biet, Anh Tuan Ton, Jean-Francois Delabre, Nathalie Morin, Robert Dumaine Tags: Featured Article Source Type: research

Notable Papers
(Source: Heart Rhythm)
Source: Heart Rhythm - March 28, 2019 Category: Cardiology Source Type: research

ECG-based cardiac screening programs: Legal, ethical, and logistical considerations
Screening asymptomatic people with a resting electrocardiogram (ECG) has been theorized to detect latent cardiovascular disease. However, resting ECG screening is not recommended for numerous populations, such as asymptomatic middle-age (sedentary) people, because it is not sufficiently sensitive to detect coronary artery disease. Although the issues raised in this article are common to all screening programs, this review focuses on 2 distinct programs: (1) screening elite athletes for conditions associated with sudden cardiac death (SCD); and (2) screening people age ≥65 years for atrial fibrillation (AF). (Source: Heart Rhythm)
Source: Heart Rhythm - March 27, 2019 Category: Cardiology Authors: Jessica J. Orchard, Lis Neubeck, John W. Orchard, Rajesh Puranik, Hariharan Raju, Ben Freedman, Andre La Gerche, Christopher Semsarian Tags: Contemporary Review Source Type: research

Outcomes of His-bundle pacing upgrade after long-term right ventricular pacing and/or pacing-induced cardiomyopathy: Insights into disease progression
His-bundle pacing (HBP) is a physiological alternative to right ventricular pacing (RVP). The outcomes of HBP in patients with longstanding atrioventricular block (AVB) and RVP are unknown (Source: Heart Rhythm)
Source: Heart Rhythm - March 27, 2019 Category: Cardiology Authors: Pugazhendhi Vijayaraman, Bengt Herweg, Gopi Dandamudi, Suneet Mittal, Advay G. Bhatt, Lina Marcantoni, Angela Naperkowski, Parikshit S. Sharma, Francesco Zanon Source Type: research

ECG-based Cardiac Screening Programs: Legal, Ethical and Logistical Considerations
Screening asymptomatic people with a resting electrocardiogram (ECG) has been theorised to detect latent cardiovascular disease. However, resting ECG screening is not recommended for numerous populations, such as asymptomatic middle-aged (sedentary) people, as it is not sufficiently sensitive to detect coronary artery disease. While the issues raised in this article are largely common to all screening programs, this review focuses on two distinct programs: (1) screening elite athletes for conditions associated with sudden cardiac death (SCD); and (2) screening people aged ≥65 years for atrial fibrillation (AF). (Source: Heart Rhythm)
Source: Heart Rhythm - March 27, 2019 Category: Cardiology Authors: Jessica J. Orchard, Lis Neubeck, John W. Orchard, Rajesh Puranik, Hariharan Raju, Ben Freedman, Andre La Gerche, Christopher Semsarian Source Type: research

Outcomes Of His Bundle Pacing Upgrade After Long-term Right Ventricular Pacing And / Or Pacing-Induced Cardiomyopathy: Insights Into Disease Progression
His bundle pacing (HBP) is a physiologic alternative to right ventricular pacing (RVP). The outcomes of HBP in patients with longstanding atrioventricular block (AVB) and RVP are unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - March 27, 2019 Category: Cardiology Authors: Pugazhendhi Vijayaraman, Bengt Herweg, Gopi Dandamudi, Suneet Mittal, Advay G. Bhatt, Lina Marcantoni, Angela Naperkowski, Parikshit S. Sharma, Francesco Zanon Source Type: research

Pacing in proximity to scar during cardiac resynchronization therapy increases local dispersion of repolarization and susceptibility to ventricular arrhythmogenesis.
Cardiac resynchronization therapy (CRT) increases the risk of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy (ICM) when the left ventricular (LV) epicardial lead is implanted in proximity to scar. (Source: Heart Rhythm)
Source: Heart Rhythm - March 27, 2019 Category: Cardiology Authors: Caroline Mendonca Costa, Aurel Neic, Eric Kerfoot, Bradley Porter, Benjamin Sieniewicz, Justin Gould, Baldeep Sidhu, Zhong Chen, Gernot Plank, Christopher A. Rinaldi, Martin J. Bishop, Steven A. Niederer Source Type: research

Cryoballoon pulmonary vein ablation and left atrial appendage closure combined procedure: A long-term follow-up analysis
The combined left atrial appendage closure (LAAC) and cryoenergy pulmonary vein isolation (PVI) procedure has been proven safe and effective in managing stroke in patients with nonvalvular atrial fibrillation (AF), although most data refer to procedures performed using radiofrequency as the main energy source. (Source: Heart Rhythm)
Source: Heart Rhythm - March 26, 2019 Category: Cardiology Authors: Gaetano Fassini, Alessio Gasperetti, Gianpiero Italiano, Stefania Riva, Massimo Moltrasio, Antonio Dello Russo, Michela Casella, Anna Maltagliati, Fabrizio Tundo, Benedetta Majocchi, Luca Arioli, Ghaliah Al-Mohani, Gianluca Pontone, Mauro Pepi, Claudio To Source Type: research

EP News: Allied Professionals
In this single-center retrospective study, El-Am et  al (J Am Coll Cardiol 2019;79:589, PMID 30732713) sought to assess procedural outcomes related to direct current cardioversion (CV) in patients with cardiac amyloidosis (CA). In addition to atrial arrhythmias such as atrial fibrillation (AF), atrial flutter (AFL), and atrial tachycardia (AT), pati ents with CA are predisposed to conduction disease, heart failure, intracardiac thrombi, and sudden death. All patients with CA referred for CV over a 12-year period were included and matched in a 2:1 ratio for type of arrhythmia (AF, AFL, or AT), age, sex, and date of CV ...
Source: Heart Rhythm - March 26, 2019 Category: Cardiology Authors: Erica S. Zado Tags: EP News Source Type: research

Systematic review of biological therapies for atrial fibrillation
Biological therapies that increase or suppress the expression of transcripts underlying atrial fibrillation (AF) progression are increasingly being explored to create novel treatment paradigms beyond simply suppressing or destroying tissue. To date, there has been no systematic overview of the pre-clinical evidence exploring manipulation of fundamental biological principles in the treatment of AF. As such, the objective of this study was to establish the effect of biological approaches used in the treatment of AF within large and small animals. (Source: Heart Rhythm)
Source: Heart Rhythm - March 26, 2019 Category: Cardiology Authors: Callum McRae, Anshul Kapoor, Pushpinder Kanda, Benjamin Hibbert, Darryl R. Davis Source Type: research

Cryoballoon Pulmonary Vein Ablation and Left Atrial Appendage Closure Combined Procedure: a long term follow up analysis Cryoablation with Concomitant Left Atrial Appendage Closure
combined left atrial appendage closure (LAAC) and cryo-energy pulmonary vein isolation (PVI) procedure has been proven safe and effective in managing stroke in patients with non-valvular atrial fibrillation (AF), although most data refer to procedures performed using radiofrequency (RF) as main energy source. (Source: Heart Rhythm)
Source: Heart Rhythm - March 26, 2019 Category: Cardiology Authors: Gaetano Fassini, Alessio Gasperetti, Gianpiero Italiano, Stefania Riva, Massimo Moltrasio, Antonio Dello Russo, Michela Casella, Anna Maltagliati, Fabrizio Tundo, Benedetta Majocchi, Luca Arioli, Ghaliah Al-Mohani, Gianluca Pontone, Mauro Pepi, Claudio To Source Type: research

Comparison of the Arrhythmogenic Substrate between Men and Women with Nonischemic Cardiomyopathy
Outcomes of ventricular tachycardia (VT) ablation in structural heart disease have been reported to differ by sex. Whether this is due to differences in the underlying arrhythmogenic substrates among patients with nonischemic cardiomyopathy (NICM) remains unclear. (Source: Heart Rhythm)
Source: Heart Rhythm - March 26, 2019 Category: Cardiology Authors: Ling Kuo, Yasuhiro Shirai, Daniele Muser, Jackson J. Liang, Simon A. Castro, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, David Lin, Saman Nazarian, Sanjay Dixit, David J. Callans, Francis E. Marchlinski, David S. Frankel Source Type: research

EP News: Clinical
van Rein et  al (Circulation 2019;139:775, PMID 30586754) evaluated bleeding rates in a comprehensive national database of patients with atrial fibrillation (AF) who were 50 years and older. Treatments included vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs), platelet inhibitors, and combinati ons of antithrombotic drugs. Major bleeding was defined as bleeding requiring hospitalization or causing death. Overall, 272,315 patients with AF were followed for 1,373,131 patient-years (PYs); 31,459 major bleeds occurred for an incidence rate (IR) of 2.3 per 100 PYs. (Source: Heart Rhythm)
Source: Heart Rhythm - March 22, 2019 Category: Cardiology Authors: N.A. Mark Estes Tags: EP News Source Type: research

EP News: Case Reports
Congenital short QT syndrome is a cardiac channelopathy with mutations identified in the KCNH2, KCNJ2, and KCNQ1 genes. The syndrome is associated with atrial and ventricular arrhythmias and typically manifests early with sudden death or aborted cardiac arrest. During an electrophysiology study, induction of ventricular fibrillation (VF) can be seen in the majority of patients and they display unique susceptibility to mechanical stimuli. Farag and Atallah (DOI: https://doi.org/10.1016/j.hrcr.2018.11.015) shared a case of a 7-year-old boy with short QT syndrome and recurrent VF despite flecainide and amiodarone. (Source: Heart Rhythm)
Source: Heart Rhythm - March 21, 2019 Category: Cardiology Authors: T. Jared Bunch Tags: EP News Source Type: research

EP News: Basic and Translational
Muscle-specific mitsugumin 53 (MG53) is a muscle-specific tripartite motif family member in the heart and participates in membrane repair by recruiting vesicles to the site of injury. Liu  et al (Circulation February 14, 2019; https://doi.org/10.1161/CIRCULATIONAHA.118.029413, PMID 30760025) investigated the functional roles of cardiac MG53 in the regulation of KChIP2 (a K+ channel interacting protein), transient outward K+ current (Ito,f), and the arrhythmogenic potential in cardi ac hypertrophy using genetic ablation of MG53 in a mouse model. (Source: Heart Rhythm)
Source: Heart Rhythm - March 21, 2019 Category: Cardiology Authors: Nipavan Chiamvimonvat Tags: EP News Source Type: research

Algorithm-Based Reduction of Inappropriate Defibrillator Shock: Results of the Inappropriate Shock Reduction wIth PARAD+ Rhythm DiScrimination –Implantable Cardioverter Defibrillator Study
Inappropriate shocks (IS) continue to have a major negative impact on patients implanted with defibrillators. (Source: Heart Rhythm)
Source: Heart Rhythm - March 21, 2019 Category: Cardiology Authors: Ricardo Ruiz-Granell, Emilio Vincenzo Dovellini, Antoine Dompnier, Dr Koroush Khalighi, Enrique Garc ía-Campo, Audrey Olivier, Aina Barcelo, Philippe Ritter Source Type: research

Relation of IGF-1 and IGFBP-3 with prevalent and incident atrial fibrillation in a population-based study
Insulin-like growth factor 1 (IGF-1) and its main binding protein IGFBP-3 have been related to several cardiovascular diseases. The relationship with atrial fibrillation (AF) is largely unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - March 21, 2019 Category: Cardiology Authors: Mathias Busch, Anne Kr üger, Stefan Gross, Till Ittermann, Nele Friedrich, Matthias Nauck, Marcus Dörr, Stephan B. Felix Source Type: research

Patterns of Amiodarone-Induced Thyroid Dysfunction in Infants and Children
Heart Rhythm Society guidelines recommend obtaining thyroid function tests (TFTs) at amiodarone initiation and every six months thereafter in adults, with no specific pediatric recommendations. Untreated hypothyroidism in young children negatively affects brain development and somatic growth, yet the optimal screening frequency for pediatric patients remains unclear and limited data exists on pediatric amiodarone-induced thyroid dysfunction. (Source: Heart Rhythm)
Source: Heart Rhythm - March 19, 2019 Category: Cardiology Authors: Ana Creo, Heather Anderson, Bryan Cannon, Aida Lteif, Seema Kumar, Peter Tebben, Anoop Mohamed Iqbal, Akhila Ramakrishna, Siobhan Pittock Source Type: research

Risk Factors and Localization of Silent Cerebral Infarction in Patients with Atrial Fibrillation
It is important to identify the risk factors and localization of silent cerebral infarction (SCI), especially in younger patients with atrial fibrillation (AF). (Source: Heart Rhythm)
Source: Heart Rhythm - March 17, 2019 Category: Cardiology Authors: Keita Miki, Makoto Nakano, Kentaro Aizawa, Yuhi Hasebe, Yoshitaka Kimura, Susumu Morosawa, Toshiaki Akashi, Yohei Morishita, Satoshi Miyata, Koji Fukuda, Hiroaki Shimokawa Source Type: research

Alternative left ventricular pacing approaches for optimal cardiac resynchronization therapy
Cardiac resynchronization therapy (CRT) improves mortality, morbidity, and quality of life in selected heart failure patients with severe left ventricular (LV) ejection fraction impairment. However, between 20% and 40% of device recipients do not benefit clinically from CRT. Indeed, some anatomic and technical difficulties are related to the coronary venous implantation site via the coronary sinus (CS). Additionally, electrical constraints have been described, and CS does not always correspond to the optimal LV lead position. (Source: Heart Rhythm)
Source: Heart Rhythm - March 14, 2019 Category: Cardiology Authors: Vincent Galand, Jagmeet P. Singh, Christophe Leclercq Tags: Contemporary Review Source Type: research

Alternative left ventricular pacing approaches for an optimal cardiac resynchronization therapy
Cardiac resynchronization therapy (CRT) improves mortality, morbidity and quality of life in selected heart failure patients with severe left ventricular ejection fraction impairment. However, between 20% and 40% of device recipients do not benefit clinically from CRT. Indeed, some anatomical and technical difficulties are related to the coronary venous implantation site via the coronary sinus (CS). Additionally, electrical constraints have been described and CS does not always correspond to the optimal LV lead position. (Source: Heart Rhythm)
Source: Heart Rhythm - March 14, 2019 Category: Cardiology Authors: Vincent Galand, Jagmeet P. Singh, Christophe Leclercq Source Type: research

The rationale for isolation of the left atrial pulmonary venous component to control atrial fibrillation: a review article
Catheter ablation of persistent atrial fibrillation is an evolving field. In this review, we discuss the rationale for the isolation of the pulmonary venous component of the left atrium to control atrial fibrillation. The review describes the embryological origin of this component and makes the important distinction between the true posterior wall and the pulmonary venous component, which forms the dome of the left atrium. Studies that have examined the role of left atrial posterior wall isolation in AF ablation have loosely referred to the pulmonary venous component as the posterior wall. (Source: Heart Rhythm)
Source: Heart Rhythm - March 14, 2019 Category: Cardiology Authors: Ahmed I. Elbatran, Robert H. Anderson, Shumpei Mori, Magdi M. Saba Source Type: research

To the Editor — Mediterranean diet and wine intake could improve atrial function in patients with atrial fibrillation
This study found that regular moderate alcohol consumption, but not mild consumption, is an important modifiable risk factor for atrial fibrillation. (Source: Heart Rhythm)
Source: Heart Rhythm - March 12, 2019 Category: Cardiology Authors: Anna Vittoria Mattioli, Alberto Farinetti, Roberta Gelmini Tags: Letter to the Editor Source Type: research

Reply to the Editor — Mediterranean diet and wine intake could improve atrial function in patients with atrial fibrillation
We agree with Mattioli et  al1 that the Mediterranean diet appears to be beneficial for primary and secondary prevention of rhythm disorders. Observational studies demonstrate a lower risk of incident atrial fibrillation (AF) and higher rates of spontaneous conversion to sinus rhythm.2 Wine “in moderation” is one of the numerous components of this diet, which incorporates fruit, vegetables, moderate fish intake, olive oil, and avoidance of saturated fat, processed dairy, and meat. It remains unclear as to which components (eg, vitamins and omega-3 polyunsaturated fatty acids) are providing potential anti-i...
Source: Heart Rhythm - March 12, 2019 Category: Cardiology Authors: Aleksandr Voskoboinik, Peter M. Kistler Tags: Letter to the Editor Source Type: research

Mediterranean Diet and wine intake could improve atrial function in patients with atrial fibrillation
This study found that regular moderate alcohol consumption, but not mild consumption, is an important modifiable risk factor for atrial fibrillation (AF). (Source: Heart Rhythm)
Source: Heart Rhythm - March 12, 2019 Category: Cardiology Authors: Anna Vittoria Mattioli, Alberto Farinetti, Roberta Gelmini Source Type: research

Author's reply to Mediterranean Diet and wine intake could improve atrial function in patients with atrial fibrillation
We agree with Mattioli et al1 that the Mediterranean diet appears to be beneficial for primary and secondary prevention of rhythm disorders. Observational studies demonstrate a lower risk of incident AF and higher rates of spontaneous conversion to sinus rhythm2. Wine ‘in moderation’ is one of numerous components of this diet, which incorporates fruit, vegetables, moderate fish intake, olive oil and avoidance of saturated fat, processed dairy and meat. It remains unclear as to which components (e.g. (Source: Heart Rhythm)
Source: Heart Rhythm - March 12, 2019 Category: Cardiology Authors: Aleksandr Voskoboinik, Peter M. Kistler Source Type: research

Iatrogenic Aortic Regurgitation after Radiofrequency Ablation of Idiopathic Ventricular Arrhythmias Originating from the Aortic Valvular Region
Radiofrequency ablation at the aortic root has the potential risk of aortic regurgitation (AR). (Source: Heart Rhythm)
Source: Heart Rhythm - March 12, 2019 Category: Cardiology Authors: Yasutoshi Shinoda, Yuki Komatsu, Yukio Sekiguchi, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda Source Type: research

Mean entropy predicts implantable cardioverter-defibrillator therapy using cardiac magnetic resonance texture analysis of scar heterogeneity
Risk stratification of ventricular arrhythmia (VA) remains complex in both ischemic and non-ischemic populations. (Source: Heart Rhythm)
Source: Heart Rhythm - March 4, 2019 Category: Cardiology Authors: Justin Gould, Bradley Porter, Simon Claridge, Zhong Chen, Benjamin.J. Sieniewicz, Baldeep.S. Sidhu, Steven Niederer, Martin.J. Bishop, Francis Murgatroyd, Balaji Ganeshan, Gerald Carr-White, Reza Razavi, Amedeo Chiribiri, Christopher.A. Rinaldi Source Type: research

Minimally invasive percutaneous epicardial placement of a prototype miniature pacemaker with a leadlet under direct visualization: A feasibility study in an infant porcine model
Pacemaker implantation in infants is limited to epicardial lead placement and an abdominal generator pocket. We propose a minimally invasive solution using a prototype miniature pacemaker with a steroid-eluting leadlet that can affix against the epicardium under thoracoscopy. (Source: Heart Rhythm)
Source: Heart Rhythm - February 28, 2019 Category: Cardiology Authors: Rohan N. Kumthekar, Justin D. Opfermann, Paige Mass, Bradley C. Clark, Jeffrey P. Moak, Elizabeth D. Sherwin, Teresa Whitman, Mark Marshall, Charles I. Berul Source Type: research

Increased risk of late pacemaker implantation after ablation for atrioventricular nodal reentry tachycardia. A 10-year follow up of a nationwide cohort
Catheter ablation of the slow pathway is standard treatment for atrioventricular nodal reentry tachycardia (AVNRT), with a well-described, low risk for periprocedural atrioventricular block. Less is known about the risk of pacemaker implantation late after ablation. (Source: Heart Rhythm)
Source: Heart Rhythm - February 28, 2019 Category: Cardiology Authors: Milos Kesek, Daniel Lindmark, Amir Rashid, Steen M. Jensen Source Type: research