Top Stories: Mitochondrial origin of inherited cardiac arrhythmias
Mitochondria control cardiac function by regulating adenosine triphosphate synthesis, reactive oxygen species (ROS) generation, intracellular calcium (Ca2+), and the cellular redox state. Yet, their role in the pathophysiology of arrhythmias remains massively underappreciated. In this Top Stories article, we shed light on this issue by focusing on recent advances in our understanding of mechanisms by which mitochondria act as central mediators of inherited arrhythmic disorders.
Source: Heart Rhythm - Category: Cardiology Authors: Fadi G. Akar, Christoph Maack Tags: Top Stories Source Type: research