Polyacetylenes from Saposhnikovia divaricata and their anticancer activity
Fitoterapia. 2024 Feb 29:105876. doi: 10.1016/j.fitote.2024.105876. Online ahead of print.ABSTRACTNine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhib...
Source: Fitoterapia - March 2, 2024 Category: Biochemistry Authors: Yan Sun Yan Liu Peng Jiang Si-Yi Wang Juan Pan Wei Guan Yu-Xuan Wang Hai-Xue Kuang Yan-Hong Wang Bing-You Yang Source Type: research
Secondary metabolites isolated from Trichoderma hamatum b-3 and their fungicidal activity
Fitoterapia. 2024 Feb 29:105880. doi: 10.1016/j.fitote.2024.105880. Online ahead of print.ABSTRACTAn undescribed trichodenone derivative (1), a bisabolane analog (2), along with two new diketopiperazines (3) and (4) were isolated from Trichoderma hamatum b-3. The structures of the new findings were established through comprehensive analyses of spectral evidences in HRESIMS, 1D and 2D NMR, Maffey's analysis as well as comparisons of ECD. The absolute configuration of 2 was unambiguously confirmed by NMR, ECD calculation and Mo2(AcO)4 induced circular dichroism. Compounds 1-4 were tested for their fungicidal effects against ...
Source: Fitoterapia - March 2, 2024 Category: Biochemistry Authors: Li Huang Meng-Dan Liu Yi-Wen Hu Li-Juan Chen Yun Deng Yu-Cheng Gu Qiang Bian Da-Le Guo Guang-Zhi Wang Source Type: research
Polyacetylenes from Saposhnikovia divaricata and their anticancer activity
Fitoterapia. 2024 Feb 29:105876. doi: 10.1016/j.fitote.2024.105876. Online ahead of print.ABSTRACTNine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhib...
Source: Fitoterapia - March 2, 2024 Category: Biochemistry Authors: Yan Sun Yan Liu Peng Jiang Si-Yi Wang Juan Pan Wei Guan Yu-Xuan Wang Hai-Xue Kuang Yan-Hong Wang Bing-You Yang Source Type: research
Comparative analysis of chemical profiles, antioxidant, antibacterial, and anticancer effects of essential oils of two Thymus species from Montenegro
Fitoterapia. 2024 Feb 28:105871. doi: 10.1016/j.fitote.2024.105871. Online ahead of print.ABSTRACTThe essential oils of Thymus vulgaris (TVEO) and Thymus serpyllum (TSEO) show different biological activities. The aim of the study was to evaluate the biological activities of TVEO and TSEO from Montenegro. The main components of TVEO were p-cymene (29.52%), thymol (22.8%) and linalool (4.73%) while the main components of TSEO were p-cymene (19.04%), geraniol (11,09%), linalool (9.16%), geranyl acetate (6.49%) and borneol (5.24%). Antioxidant activity determined via DPPH for TVEO was 4.49 and FRAP 1130.27, while for TSEO it w...
Source: Fitoterapia - March 1, 2024 Category: Biochemistry Authors: Kenan Preljevi ć Ivana Pa šić Milorad Vlaovi ć Ivana Z Mati ć Sla đana Krivokapić Nina Petrovi ć Tatjana Stanojkovi ć Vladimir Živković Svetlana Perovi ć Source Type: research
Comparative analysis of chemical profiles, antioxidant, antibacterial, and anticancer effects of essential oils of two Thymus species from Montenegro
Fitoterapia. 2024 Feb 28:105871. doi: 10.1016/j.fitote.2024.105871. Online ahead of print.ABSTRACTThe essential oils of Thymus vulgaris (TVEO) and Thymus serpyllum (TSEO) show different biological activities. The aim of the study was to evaluate the biological activities of TVEO and TSEO from Montenegro. The main components of TVEO were p-cymene (29.52%), thymol (22.8%) and linalool (4.73%) while the main components of TSEO were p-cymene (19.04%), geraniol (11,09%), linalool (9.16%), geranyl acetate (6.49%) and borneol (5.24%). Antioxidant activity determined via DPPH for TVEO was 4.49 and FRAP 1130.27, while for TSEO it w...
Source: Fitoterapia - March 1, 2024 Category: Biochemistry Authors: Kenan Preljevi ć Ivana Pa šić Milorad Vlaovi ć Ivana Z Mati ć Sla đana Krivokapić Nina Petrovi ć Tatjana Stanojkovi ć Vladimir Živković Svetlana Perovi ć Source Type: research
The mechanistic role of curcumin on matrix metalloproteinases in osteoarthritis
Fitoterapia. 2024 Feb 27:105870. doi: 10.1016/j.fitote.2024.105870. Online ahead of print.ABSTRACTA systematic mechanistic review was performed to determine mechanistic evidence for curcumin on pro-inflammatory matrix metalloproteinases and Osteoarthritis to understand the underlying pathophysiology, and to evaluate available human intervention evidence to inform clinical decision making. The systematic literature search was performed in 3 tranches (reviews, mechanistic, intervention studies) using PubMed, with no date limitations and using specific search terms. 65 out of 393 screened papers were accepted based on detaile...
Source: Fitoterapia - February 29, 2024 Category: Biochemistry Authors: Jennifer Swallow Karin Seidler Michelle Barrow Source Type: research
The mechanistic role of curcumin on matrix metalloproteinases in osteoarthritis
Fitoterapia. 2024 Feb 27:105870. doi: 10.1016/j.fitote.2024.105870. Online ahead of print.ABSTRACTA systematic mechanistic review was performed to determine mechanistic evidence for curcumin on pro-inflammatory matrix metalloproteinases and Osteoarthritis to understand the underlying pathophysiology, and to evaluate available human intervention evidence to inform clinical decision making. The systematic literature search was performed in 3 tranches (reviews, mechanistic, intervention studies) using PubMed, with no date limitations and using specific search terms. 65 out of 393 screened papers were accepted based on detaile...
Source: Fitoterapia - February 29, 2024 Category: Biochemistry Authors: Jennifer Swallow Karin Seidler Michelle Barrow Source Type: research
Anti-breast cancer activity of the essential oil from grapefruit mint (Mentha suaveolens × piperita)
Fitoterapia. 2024 Feb 26:105875. doi: 10.1016/j.fitote.2024.105875. Online ahead of print.ABSTRACTGrapefruit mint (Mentha suaveolens × piperita) is a hybrid, perennial, and aromatic plant widely cultivated all over the world and used in the food, cosmetics, and pharmaceutical industries mostly for its valuable essential oil. Herein, we evaluated the anticancer activity of the grapefruit mint essential oil, cultivated in Iran. For the chemical composition analysis of essential oil, GC-MS was used. MTT assay was utilized for assessing the cytotoxic activity of the essential oil. The type of cell death was determined by anne...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Zohreh Jahanafrooz Mir Mohammad Hossein Mousavi Soghra Akbarzadeh Maedeh Hemmatzadeh Filippo Maggi Mohammad Reza Morshedloo Source Type: research
Seco-nortriterpenoids from Cirsium setosum and their anti-inflammatory activity
Fitoterapia. 2024 Feb 26:105879. doi: 10.1016/j.fitote.2024.105879. Online ahead of print.ABSTRACTFive unusual seco-nortriterpenoids, 3β-hydroxy-20,21-seco-30-nortaraxastan-20,21-dioic acid (1), 3β-hydroxy-20,21-seco-30-nortaraxastan-20-oic-21-oate (2), 3β-hydroxy-20-oxo-21,22-seco-30-nortaraxastan-22-oic acid (3), 3β-hydroxy-19-oxo-20,21-seco-29,30-nortaraxastan-21-oic acid (4) and 3β-hydroxy-19-oxo-20,21-seco-19-norlupan-21-oic acid (5) were isolated and elucidated from the anti-inflammatory activity fraction of the ethanol extract of Cirsium setosum. The structures of these compounds were established through spectr...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Qing-Jiang Xu Jia-Chen Liu Cheng-Jin Huang Xin Wang Xiao-Ya Shang Source Type: research
Dauferulins A-L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities
Fitoterapia. 2024 Feb 28;174:105877. doi: 10.1016/j.fitote.2024.105877. Online ahead of print.ABSTRACTPhytochemical study on the roots of a medicinal plant Ferula communis L. (Apiaceae) resulted in the isolation of 20 sesquiterpenes including 12 previously undescribed compounds, dauferulins A-L (1-12). The detailed spectroscopic analysis revealed 1-12 to be daucane-type sesquiterpenes with a p-methoxybenzoyloxy group at C-6. The absolute configurations of 1-12 were deduced by analysis of the ECD spectra. Dauferulins A-L (1-12), known sesquiterpenes (13-20), and analogues (14a-14l) derived from 6-O-p-methoxybenzoyl-10α-ang...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Yuki Yoshino Masaki Imanishi Licht Miyamoto Daisuke Tsuji Reiko Akagi Koichiro Tsuchiya Yoshiki Kashiwada Naonobu Tanaka Source Type: research
Synthesis, biological evaluation and docking studies of N-substituted resveratrol derivatives
Fitoterapia. 2024 Feb 26:105872. doi: 10.1016/j.fitote.2024.105872. Online ahead of print.ABSTRACTA total of 19 resveratrol derivatives, including 12 imines and 7 amines, were synthesized, among which compounds 1, 5, 6, 7', 11', and 13 are new compounds. The anti-inflammatory and antitumor activities of these compounds were evaluated in vitro. The results revealed that compounds 1, 6, 8', 12, and 12' exhibited significant inhibitory effects (> 50%) on NO production at the concentration of 10 μM and their NO production inhibitory activities have a significant concentration-dependent ability. Additionally, compounds 8' a...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Haoyu Wu Liying Liu Mingxiang Song Xiaorong Yin Mengqing Chen Guangyao Lv Feng Zhao Xiaofeng Mou Source Type: research
Chemodiverse monoterpene indole alkaloids from Kopsia teoi, inhibitory potential against α-amylase, and their molecular docking studies
Fitoterapia. 2024 Feb 28;174:105873. doi: 10.1016/j.fitote.2024.105873. Online ahead of print.ABSTRACTDiabetes mellitus stands as a metabolic ailment marked by heightened blood glucose levels due to inadequate insulin secretion. The primary aims of this investigative inquiry encompassed the isolation of phytochemical components from the bark of Kopsia teoi, followed by the assessment of their α-amylase inhibition. The phytochemical composition of the K. teoi culminated in the discovery of a pair of new indole alkaloids; which are 16-epi-deacetylakuammiline N(4)-methylene chloride (akuammiline) (1), and N(1)-methoxycarbony...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Muhammad Tahir Muhammad Mehdi A Beniddir Lacksany Phongphane Mohamad Hafizi Abu Bakar Mohd Hazwan Hussin Khalijah Awang Marc Litaudon Unang Supratman Mohamad Nurul Azmi Source Type: research
New clerodane diterpenoids from Callicarpa pseudorubella and their antitumor proliferative activity
Fitoterapia. 2024 Feb 26:105878. doi: 10.1016/j.fitote.2024.105878. Online ahead of print.ABSTRACTSix previously undescribed clerodane diterpenes, cardorubellas A-F (1-6), along with seven known ones (7-13), were isolated from the aerial parts of Callicarpa pseudorubella. Their chemical structures were established by analysis of 1D and 2D NMR, HR-ESI-MS, X-ray diffraction, and electronic circular dichroism (ECD) data. Notably, cardorubella B (2) represented the first examples of naturally occurring succinic anhydride-containing clerodane diterpenes derivatives. The anti-proliferative activities of these compounds were asse...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Xing Zhao Zhaopeng Zheng Chao Chen Huan Wang Hanfei Liu Jinyu Li Sun Chao Huayong Lou Weidong Pan Source Type: research
Five new sesquiterpenoids isolated from Dictamnus dasycarpus Turcz
Fitoterapia. 2024 Feb 26:105874. doi: 10.1016/j.fitote.2024.105874. Online ahead of print.ABSTRACTFive new sesquiterpenoids, dictamtrinorguaianols E and F (1-2), and dictameudesmnosides F, G, and H (3-5), along with seven known sesquiterpenoids (6-12) were isolated from Dictamnus dasycarpus Turcz. The structures of all new compounds were characterized by spectroscopic methods, including UV, IR, HR-ESI-MS, and 1D and 2D NMR. The In-vitro anti-proliferative activities of all the compounds against two human cancer cell lines (SW982 and A549) were evaluated by CCK-8 assay. Compounds 1 and 4 showed medium anti-proliferative act...
Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Ye Sun Yan Liu Si-Yi Wang Xu Yang Jia-Tong Wu Juan Pan Zhi-Chao Hao Wei Guan Adnan-Mohammed Algradi Zhen-Peng Xu Yuan-Yuan Zhou Shao-Wa Lv Hai-Xue Kuang Bing-You Yang Source Type: research
Phenolics and flavonoids from Polygonum posumbu and comparision of flavonoid compounds content in different tissues (leaves, stems and roots)
Fitoterapia. 2024 Feb 24:105864. doi: 10.1016/j.fitote.2024.105864. Online ahead of print.ABSTRACTThe growing global need for antioxidative phenolics and flavonoids for maintenance of human health resulted into search of new sustainable unexplored medicinal plants used by the traditional healers for various ailments. Many synthetic based products of phenolics and flavonoids have been used, however the demand of eco-friendly, natural herbal based products are increasing. As a result, the current study aims to explore traditional potential of Polygonum posumbu related to its phenolics and flavonoids. Optimization of extracti...
Source: Fitoterapia - February 26, 2024 Category: Biochemistry Authors: Premi Devi Pukhrambam Khomdram Khedashwori Devi Chingoileima Maibam Roseeta Devi Mutum Moirangthem Lakshmipriyari Devi Sudripta Das Source Type: research
