Secondary metabolites isolated from Trichoderma hamatum b-3 and their fungicidal activity

Fitoterapia. 2024 Feb 29:105880. doi: 10.1016/j.fitote.2024.105880. Online ahead of print.ABSTRACTAn undescribed trichodenone derivative (1), a bisabolane analog (2), along with two new diketopiperazines (3) and (4) were isolated from Trichoderma hamatum b-3. The structures of the new findings were established through comprehensive analyses of spectral evidences in HRESIMS, 1D and 2D NMR, Maffey's analysis as well as comparisons of ECD. The absolute configuration of 2 was unambiguously confirmed by NMR, ECD calculation and Mo2(AcO)4 induced circular dichroism. Compounds 1-4 were tested for their fungicidal effects against eight crop pathogenic fungi, among which 1 showed 51% inhibition against Sclerotinia sclerotiorum at a concentration of 50 μg/mL.PMID:38431026 | DOI:10.1016/j.fitote.2024.105880

Source: Fitoterapia - March 2, 2024 Category: Biochemistry Authors: Li Huang Meng-Dan Liu Yi-Wen Hu Li-Juan Chen Yun Deng Yu-Cheng Gu Qiang Bian Da-Le Guo Guang-Zhi Wang Source Type: research