Transcriptome analysis of the mechanism of endophytic fungus CHS3 promoting saikosaponin d synthesis in Bupleurum scorzonerifolium Willd. suspension cells
In conclusion, CHS3 could promote the accumulation of SSd in BSS cells, and the molecular mechanism was related to its ability to regulate the MVA pathway, the calcium signaling pathway, and the AMPK signaling pathway by upregulating the expressions of ANT, CypD, CaM, AMPK, AATC, HMGS, HMGR, MVK, MVD, SS, and SE.PMID:38128620 | DOI:10.1016/j.fitote.2023.105778 (Source: Fitoterapia)
Source: Fitoterapia - December 21, 2023 Category: Biochemistry Authors: Yupeng Cheng Yuanzhen Liu Xinhong Li Guangjie Liu Zhongmeng Li Bo Liu Ning Gao Source Type: research
Inhibitory effects against SARSCoV-2 main protease (M < sup > pro < /sup > ) of biflavonoids and benzophenones from the fruit of Platonia insignis
Fitoterapia. 2023 Dec 19:105784. doi: 10.1016/j.fitote.2023.105784. Online ahead of print.ABSTRACTThe SARS-CoV-2 mutation and the limitation of the approved drug against COVID-19 are still a challenge in many country healthcare systems and need to be affronted despite the set of vaccines to prevent this viral infection. To contribute to the identification of new antiviral agents, the present study focused on natural products from an edible fruit with potential inhibitory effects against the SARS-CoV-2 main protease (Mpro). First, LC-ESIMS analysis of Platonia insignis fruits was performed and showed the presence of biflavo...
Source: Fitoterapia - December 21, 2023 Category: Biochemistry Authors: Monalisa A Moreira Costa Nat ália F de Sousa Carime L Mansur Pontes Marcus T Scotti Francisco F de Assis Antonio L Braga Louis P Sandjo Source Type: research
Untargeted metabolomics-based molecular networking for chemical characterization of selected Apiaceae fruit extracts in relation to their antioxidant and anti-cellulite potentials
Fitoterapia. 2023 Dec 19:105782. doi: 10.1016/j.fitote.2023.105782. Online ahead of print.ABSTRACTStress, obesity, hormonal changes, and aging have been connected to cellulite aggravation resulting in skin dimpled appearance, a very common painless skin disorder with a female preponderance. Several Apiaceae plants have been traditionally used for cosmetic applications. However, their screening for anti-cellulite potential has not been deeply investigated. In this work, UPLC-HRMS/MS coupled with molecular networking was employed to glean a holistic overview of the chemodiversity of the metabolome of nine Apiaceae fruits. Ad...
Source: Fitoterapia - December 21, 2023 Category: Biochemistry Authors: Nesrine M Hegazi Mohamed A Salem Hamada H Saad Nora M Aborehab Mahitab H El Bishbishy Shahira M Ezzat Source Type: research
Anthraquinones from the roots of Morinda scabrida Craib exhibit antiproliferative activity against A549 lung cancer cells and antitubulin polymerization
Fitoterapia. 2023 Dec 19:105781. doi: 10.1016/j.fitote.2023.105781. Online ahead of print.ABSTRACTSix anthraquinones were isolated from Morinda scabrida Craib, an unexplored species of Morinda found in the tropical forest of Thailand. All six anthraquinones showed cytotoxicity against A549 lung cancer cells, with the most active compound, nordamnacanthal (MS01), exhibiting the IC50 value of 16.3 ± 2.5 μM. The cytotoxic effect was dose-dependent and led to cell morphological changes characteristic of apoptosis. In addition, flow cytometric analysis showed dose-dependent apoptosis induction and the G2/M phase cell cycle ar...
Source: Fitoterapia - December 21, 2023 Category: Biochemistry Authors: Sorachai Sae-Lim Lukana Ngiwsara Kriengsak Lirdprapamongkol Thamrongjet Puttamuk Sutida Maneeanakekul Poomsith Thangsan Withsakorn Sangsuwan Jisnuson Svasti Pitak Chuawong Source Type: research
Transcriptome analysis of the mechanism of endophytic fungus CHS3 promoting saikosaponin d synthesis in Bupleurum scorzonerifolium Willd. suspension cells
In conclusion, CHS3 could promote the accumulation of SSd in BSS cells, and the molecular mechanism was related to its ability to regulate the MVA pathway, the calcium signaling pathway, and the AMPK signaling pathway by upregulating the expressions of ANT, CypD, CaM, AMPK, AATC, HMGS, HMGR, MVK, MVD, SS, and SE.PMID:38128620 | DOI:10.1016/j.fitote.2023.105778 (Source: Fitoterapia)
Source: Fitoterapia - December 21, 2023 Category: Biochemistry Authors: Yupeng Cheng Yuanzhen Liu Xinhong Li Guangjie Liu Zhongmeng Li Bo Liu Ning Gao Source Type: research
