Underutilized fruit lasoda (Cordia myxa L.): Review on bioactive compounds, antioxidant potentiality and applications in health bioactivities and food
Fitoterapia. 2024 Mar 9:105898. doi: 10.1016/j.fitote.2024.105898. Online ahead of print.ABSTRACTUnderutilized fruits are thought to be nutrient and antioxidant gold mines. Despite their high nutritive value, therapeutic properties, and ability to grow in adverse soil and climatic conditions, they have received little attention. However, these underutilized fruits are an important component of traditional foods, particularly in arid and semiarid regions of Rajasthan. Lasoda (Cordia myxa) contains numerous phytochemicals that contribute to its antioxidant potential, including tannins, flavonoids, phenolic acids, xanthones, ...
Source: Fitoterapia - March 11, 2024 Category: Biochemistry Authors: Yamini Tak Mahesh Kumar Samota Nirmal Kumar Meena Gurpreet Kaur M C Jain Rajendra Kumar Manpreet Kaur Ryszard Amarowicz Source Type: research
Salty treatment increased bioactive compounds accumulation during agarwood development in Aquilaria sinensis trees
This study provided a 2D-TLC-EDA-LC-MS/MS method for bioactive compounds screen and qualification of agarwood. Based on this method, non-conventional methods were found to accelerate the accumulation of some bioactive PECs in A. sinensis trees.PMID:38467281 | DOI:10.1016/j.fitote.2024.105901 (Source: Fitoterapia)
Source: Fitoterapia - March 11, 2024 Category: Biochemistry Authors: Tingting Yan Ningnan Zhang Zhou Hong Yuan Chen Gaiyun Li Source Type: research
Underutilized fruit lasoda (Cordia myxa L.): Review on bioactive compounds, antioxidant potentiality and applications in health bioactivities and food
Fitoterapia. 2024 Mar 9:105898. doi: 10.1016/j.fitote.2024.105898. Online ahead of print.ABSTRACTUnderutilized fruits are thought to be nutrient and antioxidant gold mines. Despite their high nutritive value, therapeutic properties, and ability to grow in adverse soil and climatic conditions, they have received little attention. However, these underutilized fruits are an important component of traditional foods, particularly in arid and semiarid regions of Rajasthan. Lasoda (Cordia myxa) contains numerous phytochemicals that contribute to its antioxidant potential, including tannins, flavonoids, phenolic acids, xanthones, ...
Source: Fitoterapia - March 11, 2024 Category: Biochemistry Authors: Yamini Tak Mahesh Kumar Samota Nirmal Kumar Meena Gurpreet Kaur M C Jain Rajendra Kumar Manpreet Kaur Ryszard Amarowicz Source Type: research
Salty treatment increased bioactive compounds accumulation during agarwood development in Aquilaria sinensis trees
This study provided a 2D-TLC-EDA-LC-MS/MS method for bioactive compounds screen and qualification of agarwood. Based on this method, non-conventional methods were found to accelerate the accumulation of some bioactive PECs in A. sinensis trees.PMID:38467281 | DOI:10.1016/j.fitote.2024.105901 (Source: Fitoterapia)
Source: Fitoterapia - March 11, 2024 Category: Biochemistry Authors: Tingting Yan Ningnan Zhang Zhou Hong Yuan Chen Gaiyun Li Source Type: research
Anti-hemostatic, antithrombotic, and chemical profiles of a curly-leaf variety of Petroselinum crispum (Apiaceae), a food and medicinal aromatic herb
We report here the in vitro, in vivo, and ex vivo anti-hemostatic and antithrombotic activities of a parsley curly-leaf variety. Aqueous extracts of aerial parts (PCC-AP), stems (PCC-S), and leaves (PCC-L) showed significant in vitro antiplatelet activity. PCC-AP extract exhibited the highest activity (IC50 2.92 mg/mL) when using ADP and collagen as agonists. All extracts also presented in vitro anticoagulant activity (APTT and PT) and anti-thrombogenic activity. PCC-S was the most active, with more significant interference in the factors of the intrinsic coagulation pathway. The oral administration of PCC-AP extract in ra...
Source: Fitoterapia - March 10, 2024 Category: Biochemistry Authors: Alessandra Lyra Guedes Livia Marques Casanova Mariana Neubarth Coelho Fl ávia Serra Frattani S ônia Soares Costa Russolina Benedeta Zingali Source Type: research
Anti-hemostatic, antithrombotic, and chemical profiles of a curly-leaf variety of Petroselinum crispum (Apiaceae), a food and medicinal aromatic herb
We report here the in vitro, in vivo, and ex vivo anti-hemostatic and antithrombotic activities of a parsley curly-leaf variety. Aqueous extracts of aerial parts (PCC-AP), stems (PCC-S), and leaves (PCC-L) showed significant in vitro antiplatelet activity. PCC-AP extract exhibited the highest activity (IC50 2.92 mg/mL) when using ADP and collagen as agonists. All extracts also presented in vitro anticoagulant activity (APTT and PT) and anti-thrombogenic activity. PCC-S was the most active, with more significant interference in the factors of the intrinsic coagulation pathway. The oral administration of PCC-AP extract in ra...
Source: Fitoterapia - March 10, 2024 Category: Biochemistry Authors: Alessandra Lyra Guedes Livia Marques Casanova Mariana Neubarth Coelho Fl ávia Serra Frattani S ônia Soares Costa Russolina Benedeta Zingali Source Type: research
Targeted isolation, identification, and antioxidant evaluation of aromatic polyketides from a plant-derived fungus Ophiobolus cirsii LZU-1509
Fitoterapia. 2024 Mar 7:105884. doi: 10.1016/j.fitote.2024.105884. Online ahead of print.ABSTRACTThere are >350 species of the Ophiobolus genus, which is not yet very well-known and lacks research reports on secondary metabolites. Three new 3,4-benzofuran polyketides 1-3, a new 3,4-benzofuran polyketide racemate 4, two new pairs of polyketide enantiomers (±)-5 and (±)-7, two new acetophenone derivatives 6 and 8, and three novel 1,4-dioxane aromatic polyketides 9-11, were isolated from a fungus Ophiobolus cirsii LZU-1509 derived from an important medicinal and economic crop Anaphalis lactea. The isolation was guided by...
Source: Fitoterapia - March 9, 2024 Category: Biochemistry Authors: Zhen-Qing Yu Hao Ren Xiao-Wei Guo Ge-Ge Yang Jia Wu Jun-Min Xi Xin-Yu Xiang Jianguo Fang Quan-Xiang Wu Source Type: research
Protective effect of phenylpropionamides in the seed of Cannabis Sativa L. on Parkinson's disease through autophagy
In this study, the seeds of Cannabis sativa L. were extracted under reflux with 60% EtOH-H2O, and the 60% EtOH-H2O elution fraction was identified as PHS with the UPLC-QTOF-MS. The 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-induced PD model in C57BL/6 J mice was used for behavioral and pharmacodynamic experiments. Behavioral symptoms were improved, Nissl-stained and TH-positive neurons in the substantia nigra were significantly increased in PHS-treated MPTP-induced PD model mice. Compared with the model group, PHS treatment reduced the expression level of α-syn, and the expression of TH increased significantly b...
Source: Fitoterapia - March 8, 2024 Category: Biochemistry Authors: Yi-Kai Jiang Meng-Meng Li Si-Yi Wang Zhi-Chao Hao Xin Meng Hai-Xue Kuang Bing-You Yang Yan Liu Source Type: research
Protective effect of phenylpropionamides in the seed of Cannabis Sativa L. on Parkinson's disease through autophagy
In this study, the seeds of Cannabis sativa L. were extracted under reflux with 60% EtOH-H2O, and the 60% EtOH-H2O elution fraction was identified as PHS with the UPLC-QTOF-MS. The 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-induced PD model in C57BL/6 J mice was used for behavioral and pharmacodynamic experiments. Behavioral symptoms were improved, Nissl-stained and TH-positive neurons in the substantia nigra were significantly increased in PHS-treated MPTP-induced PD model mice. Compared with the model group, PHS treatment reduced the expression level of α-syn, and the expression of TH increased significantly b...
Source: Fitoterapia - March 8, 2024 Category: Biochemistry Authors: Yi-Kai Jiang Meng-Meng Li Si-Yi Wang Zhi-Chao Hao Xin Meng Hai-Xue Kuang Bing-You Yang Yan Liu Source Type: research
Structurally diverse phthalides from fibrous roots of Ligusticum chuanxiong Hort. and their biological activities
Fitoterapia. 2024 Mar 5:105882. doi: 10.1016/j.fitote.2024.105882. Online ahead of print.ABSTRACTFalonolide A (1) and B (2), two novel polyyne hybrid phthalides resulting from unprecedented carbon skeleton polymerized by Z-ligustilide and falcarindiol, along with six new related phthalides (3-8), were isolated from Ligusticum chuanxiong Hort. Their structures were elucidated by spectroscopic analysis, computer-assisted structure elucidation (CASE) analysis, DP4+ probability analysis and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for 1-8 was proposed, and the production mechanism of 2...
Source: Fitoterapia - March 7, 2024 Category: Biochemistry Authors: Yu-Zhu Tan Hong-Ling Yan Yun-Yun Liu Yong-Ming Yan Li Wang Ji-Xu Qiao Jing Wu Yin Tian Cheng Peng Source Type: research
Structurally diverse phthalides from fibrous roots of Ligusticum chuanxiong Hort. and their biological activities
Fitoterapia. 2024 Mar 5:105882. doi: 10.1016/j.fitote.2024.105882. Online ahead of print.ABSTRACTFalonolide A (1) and B (2), two novel polyyne hybrid phthalides resulting from unprecedented carbon skeleton polymerized by Z-ligustilide and falcarindiol, along with six new related phthalides (3-8), were isolated from Ligusticum chuanxiong Hort. Their structures were elucidated by spectroscopic analysis, computer-assisted structure elucidation (CASE) analysis, DP4+ probability analysis and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway for 1-8 was proposed, and the production mechanism of 2...
Source: Fitoterapia - March 7, 2024 Category: Biochemistry Authors: Yu-Zhu Tan Hong-Ling Yan Yun-Yun Liu Yong-Ming Yan Li Wang Ji-Xu Qiao Jing Wu Yin Tian Cheng Peng Source Type: research
Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata
Fitoterapia. 2024 Mar 2:105881. doi: 10.1016/j.fitote.2024.105881. Online ahead of print.ABSTRACTTwo previously undescribed cholestanol saponins, parpetiosides F - G (1-2), and six known analogs (3-8) were isolated from the rhizomes of Paris fargesii var. petiolata. Their structures were elucidated by extensive spectroscopic data analysis and chemical methods. Compound 1 was a rare 6/6/6/5/5 fused-rings cholestanol saponin with disaccharide moiety linked at C-26 of aglycone which was hardly seen in genus Paris. All of these compounds were discovered in this plant for the first time. In addition, the cytotoxicities of sapon...
Source: Fitoterapia - March 4, 2024 Category: Biochemistry Authors: Yun-Yuan Tian Lin-Lin Bi Wen-Wen Chen Shu-Xian Zheng Yu Cao Yan-Hua Xie Hai-Feng Tang Yun-Yang Lu Si-Wang Wang Source Type: research
Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata
Fitoterapia. 2024 Mar 2:105881. doi: 10.1016/j.fitote.2024.105881. Online ahead of print.ABSTRACTTwo previously undescribed cholestanol saponins, parpetiosides F - G (1-2), and six known analogs (3-8) were isolated from the rhizomes of Paris fargesii var. petiolata. Their structures were elucidated by extensive spectroscopic data analysis and chemical methods. Compound 1 was a rare 6/6/6/5/5 fused-rings cholestanol saponin with disaccharide moiety linked at C-26 of aglycone which was hardly seen in genus Paris. All of these compounds were discovered in this plant for the first time. In addition, the cytotoxicities of sapon...
Source: Fitoterapia - March 4, 2024 Category: Biochemistry Authors: Yun-Yuan Tian Lin-Lin Bi Wen-Wen Chen Shu-Xian Zheng Yu Cao Yan-Hua Xie Hai-Feng Tang Yun-Yang Lu Si-Wang Wang Source Type: research
Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata
Fitoterapia. 2024 Mar 2:105881. doi: 10.1016/j.fitote.2024.105881. Online ahead of print.ABSTRACTTwo previously undescribed cholestanol saponins, parpetiosides F - G (1-2), and six known analogs (3-8) were isolated from the rhizomes of Paris fargesii var. petiolata. Their structures were elucidated by extensive spectroscopic data analysis and chemical methods. Compound 1 was a rare 6/6/6/5/5 fused-rings cholestanol saponin with disaccharide moiety linked at C-26 of aglycone which was hardly seen in genus Paris. All of these compounds were discovered in this plant for the first time. In addition, the cytotoxicities of sapon...
Source: Fitoterapia - March 4, 2024 Category: Biochemistry Authors: Yun-Yuan Tian Lin-Lin Bi Wen-Wen Chen Shu-Xian Zheng Yu Cao Yan-Hua Xie Hai-Feng Tang Yun-Yang Lu Si-Wang Wang Source Type: research
Secondary metabolites isolated from Trichoderma hamatum b-3 and their fungicidal activity
Fitoterapia. 2024 Feb 29:105880. doi: 10.1016/j.fitote.2024.105880. Online ahead of print.ABSTRACTAn undescribed trichodenone derivative (1), a bisabolane analog (2), along with two new diketopiperazines (3) and (4) were isolated from Trichoderma hamatum b-3. The structures of the new findings were established through comprehensive analyses of spectral evidences in HRESIMS, 1D and 2D NMR, Maffey's analysis as well as comparisons of ECD. The absolute configuration of 2 was unambiguously confirmed by NMR, ECD calculation and Mo2(AcO)4 induced circular dichroism. Compounds 1-4 were tested for their fungicidal effects against ...
Source: Fitoterapia - March 2, 2024 Category: Biochemistry Authors: Li Huang Meng-Dan Liu Yi-Wen Hu Li-Juan Chen Yun Deng Yu-Cheng Gu Qiang Bian Da-Le Guo Guang-Zhi Wang Source Type: research
