MS/MS-based molecular networking discovery of sesquiterpenes from Carpesium abrotanoides L. with their cytotoxic and acetylcholinesterase inhibitory activity
Fitoterapia. 2024 Apr 1:105947. doi: 10.1016/j.fitote.2024.105947. Online ahead of print.ABSTRACTEmploying an MS/MS-based molecular networking-guided strategy, three new eudesmane-type sesquiterpenes (1-3) and one undescribed pseudoguaianolide sesquiterpene (8), along with four known eudesmane-type sesquiterpene lactones (4-7) were extracted and purified from the herbs of Carpesium abrotanoides L. Structural elucidation encompassed comprehensive spectroscopic analysis, NMR calculations, DP4+ analysis, and ECD calculations. The cytotoxicity activity of all isolates was evaluated against two human hepatoma carcinoma cells (H...
Source: Fitoterapia - April 3, 2024 Category: Biochemistry Authors: Xin Zhang Mei-Juan Han Xiao-Yu Han Jian-Huan Jia Rui-Yan Lu Guo-Dong Yao Yu-Yang Liu Ming Bai Shao-Jiang Song Source Type: research
Toonanoronoids A-E, five new limonoids from Toona ciliate var. yunnanensis
Fitoterapia. 2024 Mar 31:105938. doi: 10.1016/j.fitote.2024.105938. Online ahead of print.ABSTRACTFive new B-seco-limonoids, namely toonanoronoids A-E (1-5), in conjunction with three previously reported compounds, were isolated from the EtOAc extract of the twigs and leaves of Toona ciliata var. yunnanensis. Their structures were elucidated through comprehensive spectroscopic and X-ray crystallographic analysis. The cytotoxic activities of new compounds against five human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) were screened, Compounds 4 and 5 exerted inhibition toward two tumor cell lines (HL-60, SW-4...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Wei-Hua Wang Wei Yang Jin-Run Dong Fa-Zhong Yang Xiao-Tao Chen Si-Da Xie Xiao-Qin Yang Ping Zhao Guo-Lei Zhu Source Type: research
Analysis of bitter compounds in traditional preparations of Gentiana purpurea L
Fitoterapia. 2024 Mar 31:105932. doi: 10.1016/j.fitote.2024.105932. Online ahead of print.ABSTRACTRoots of Gentiana purpurea are known to have an intense bitter taste due to its high content of secoiridoids. In folk medicine roots have commonly been prepared as water decoctions, soaked in ethanol, or boiled with milk, wine, or beer. The aim of this study was to explore how various historical preparation methods influence yields of major bitter compounds in G. purpurea. HPLC-DAD analysis revealed that maceration with 40% and 70% ethanol, boiling with acetic acid (3 and 6%), vinegar and raw milk gave the highest extraction y...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: H åvard Hoel Hugo J de Boer Anneleen Kool Helle Wangensteen Source Type: research
Biological activity of essential oils from Ferulago angulata and Ferula assa-foetida against food-related microorganisms (antimicrobial) and Ephestia kuehniella as a storage Pest (insecticidal); an in vitro and in silico study
Fitoterapia. 2024 Mar 31:105937. doi: 10.1016/j.fitote.2024.105937. Online ahead of print.ABSTRACTMisuse of synthetic pesticides and antimicrobials in agriculture and the food industry has resulted in food contamination, promoting resistant pests and pathogen strains and hazards for humanity and the environment. Therefore, ever-increasing concern about synthetic chemicals has stimulated interest in eco-friendly compounds. Ferulago angulata (Schltdl.) Boiss. and Ferula assa-foetida L., as medicinal species with restricted natural distribution and unknown biological potential, aimed at investigation of their essential oil (E...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Mohammad Hamidian Amin Salehi Reza Naghiha Mohsen Movahhedi Dehnavi Hojjatollah Mohammadi Maryamossadat Nejad Mirfathi Malahat Mojarab-Mahboubkar Oya Azizi Source Type: research
Bioguided isolation, identification and bioactivity evaluation of anti-fatigue constituents from Schizophyllum commune
This study aims to clarify the specific anti-fatigue components of Schizophyllum commune (S.commune) and analyze its potential anti-fatigue mechanism. The main anti-fatigue active ingredient of S.commune was locked in n-butanol extract (SPE-n) by activity evaluation. Twelve compounds were identified by high performance liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS). The anti-fatigue effect of morusin is the most predominant among these 12 ingredients. The determination of biochemical indices showed that morusin could increase liver glycogen reserves, improve the activity of antioxidant enzymes i...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Hao Chen Qianzhen Wu Kaili Xuan Wenqiang Guo Kunfeng Zhang Yuanyuan Wang Zhenzhen Dai Rong Sheng Huaqi He Yuzhe Huang Yan Chen Source Type: research
Toonanoronoids A-E, five new limonoids from Toona ciliate var. yunnanensis
Fitoterapia. 2024 Mar 31:105938. doi: 10.1016/j.fitote.2024.105938. Online ahead of print.ABSTRACTFive new B-seco-limonoids, namely toonanoronoids A-E (1-5), in conjunction with three previously reported compounds, were isolated from the EtOAc extract of the twigs and leaves of Toona ciliata var. yunnanensis. Their structures were elucidated through comprehensive spectroscopic and X-ray crystallographic analysis. The cytotoxic activities of new compounds against five human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) were screened, Compounds 4 and 5 exerted inhibition toward two tumor cell lines (HL-60, SW-4...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Wei-Hua Wang Wei Yang Jin-Run Dong Fa-Zhong Yang Xiao-Tao Chen Si-Da Xie Xiao-Qin Yang Ping Zhao Guo-Lei Zhu Source Type: research
Analysis of bitter compounds in traditional preparations of Gentiana purpurea L
Fitoterapia. 2024 Mar 31:105932. doi: 10.1016/j.fitote.2024.105932. Online ahead of print.ABSTRACTRoots of Gentiana purpurea are known to have an intense bitter taste due to its high content of secoiridoids. In folk medicine roots have commonly been prepared as water decoctions, soaked in ethanol, or boiled with milk, wine, or beer. The aim of this study was to explore how various historical preparation methods influence yields of major bitter compounds in G. purpurea. HPLC-DAD analysis revealed that maceration with 40% and 70% ethanol, boiling with acetic acid (3 and 6%), vinegar and raw milk gave the highest extraction y...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: H åvard Hoel Hugo J de Boer Anneleen Kool Helle Wangensteen Source Type: research
Biological activity of essential oils from Ferulago angulata and Ferula assa-foetida against food-related microorganisms (antimicrobial) and Ephestia kuehniella as a storage Pest (insecticidal); an in vitro and in silico study
Fitoterapia. 2024 Mar 31:105937. doi: 10.1016/j.fitote.2024.105937. Online ahead of print.ABSTRACTMisuse of synthetic pesticides and antimicrobials in agriculture and the food industry has resulted in food contamination, promoting resistant pests and pathogen strains and hazards for humanity and the environment. Therefore, ever-increasing concern about synthetic chemicals has stimulated interest in eco-friendly compounds. Ferulago angulata (Schltdl.) Boiss. and Ferula assa-foetida L., as medicinal species with restricted natural distribution and unknown biological potential, aimed at investigation of their essential oil (E...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Mohammad Hamidian Amin Salehi Reza Naghiha Mohsen Movahhedi Dehnavi Hojjatollah Mohammadi Maryamossadat Nejad Mirfathi Malahat Mojarab-Mahboubkar Oya Azizi Source Type: research
Bioguided isolation, identification and bioactivity evaluation of anti-fatigue constituents from Schizophyllum commune
This study aims to clarify the specific anti-fatigue components of Schizophyllum commune (S.commune) and analyze its potential anti-fatigue mechanism. The main anti-fatigue active ingredient of S.commune was locked in n-butanol extract (SPE-n) by activity evaluation. Twelve compounds were identified by high performance liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS). The anti-fatigue effect of morusin is the most predominant among these 12 ingredients. The determination of biochemical indices showed that morusin could increase liver glycogen reserves, improve the activity of antioxidant enzymes i...
Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Hao Chen Qianzhen Wu Kaili Xuan Wenqiang Guo Kunfeng Zhang Yuanyuan Wang Zhenzhen Dai Rong Sheng Huaqi He Yuzhe Huang Yan Chen Source Type: research
QSAR prediction, synthesis, anticancer evaluation, and mechanistic investigations of novel sophoridine derivatives as topoisomerase I inhibitors
This study provides valuable insights into the design and synthesis of N-substituted sophoridine derivatives with anticancer activity.PMID:38561052 | DOI:10.1016/j.fitote.2024.105921 (Source: Fitoterapia)
Source: Fitoterapia - April 1, 2024 Category: Biochemistry Authors: Lin Zhu Yongle Yu Youfu Ma Yenong Shi Jamal Alzobair Hammad Kowah Lisheng Wang Mingqing Yuan Xu Liu Source Type: research
Two new quinoline alkaloid with neuroprotective activities from Xylaria longipes
Fitoterapia. 2024 Mar 28:105930. doi: 10.1016/j.fitote.2024.105930. Online ahead of print.ABSTRACTTwo new quinoline alkaloids with an α, β-unsaturated amide side chain, xylarinines A and B (1 and 2), were isolated from the ethyl acetate extracts of Xylaria longipes solid fermentation. The structures of these were primarily determined though NMR and HRESIMS data analysis. The absolute configuration of compound 1 was assigned using experimental and calculated ECD data. The neuroprotective effects of compounds 1 and 2 against glutamate-induced damage in PC12 cells were evaluated in vitro bioassay. The results demonstrated t...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Tao-Hai Liu Xia Xu Lan-Qing Li Yu-Fen Tan Si-Qian Zhou Shao Liu Hong-Ping Long Wen-Xuan Wang Jing Li Ji-Kai Liu Source Type: research
Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein
Fitoterapia. 2024 Mar 28:105923. doi: 10.1016/j.fitote.2024.105923. Online ahead of print.ABSTRACTCervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages of this tumor. Therefore, the therapeutic strategies based on biologically active substances from plants are needed to develop for the treatment of cervical cancer. The aim of the present study was to assess in vivo toxicity, hematological and biochemical blood parameters in Wistar rats fed R...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Soumia Moujane Ismail Bouadid Aziz Bouymajane Filali Zegzouti Younes Mohamed Benlyas Bouachrine Mohammed Francesco Cacciola Roberto Lagan à Vinci Alessia Tropea Luigi Mondello Ammar B Altemimi Mohamed Eddouks Benaissa Moualij Source Type: research
Natural products - Dawn of keloid treatment
Fitoterapia. 2024 Mar 28;175:105918. doi: 10.1016/j.fitote.2024.105918. Online ahead of print.ABSTRACTKeloids are prevalent pathological scars, often leading to cosmetic deformities and hindering joint mobility.They cause discomfort, including burning and itching, while gradually expanding and potentially posing a risk of cancer.Developing effective drugs and treatments for keloids has been a persistent challenge in the medical field. Natural products are an important source of innovative drugs and a breakthrough for many knotty disease.Herein, keywords of "natural, plant, compound, extract" were combined with "keloid" and...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Zongzhou Song Wenquan Li Qingying He Xin Xie Xurui Wang Jing Guo Source Type: research
Two new quinoline alkaloid with neuroprotective activities from Xylaria longipes
Fitoterapia. 2024 Mar 28:105930. doi: 10.1016/j.fitote.2024.105930. Online ahead of print.ABSTRACTTwo new quinoline alkaloids with an α, β-unsaturated amide side chain, xylarinines A and B (1 and 2), were isolated from the ethyl acetate extracts of Xylaria longipes solid fermentation. The structures of these were primarily determined though NMR and HRESIMS data analysis. The absolute configuration of compound 1 was assigned using experimental and calculated ECD data. The neuroprotective effects of compounds 1 and 2 against glutamate-induced damage in PC12 cells were evaluated in vitro bioassay. The results demonstrated t...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Tao-Hai Liu Xia Xu Lan-Qing Li Yu-Fen Tan Si-Qian Zhou Shao Liu Hong-Ping Long Wen-Xuan Wang Jing Li Ji-Kai Liu Source Type: research
Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein
Fitoterapia. 2024 Mar 28:105923. doi: 10.1016/j.fitote.2024.105923. Online ahead of print.ABSTRACTCervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages of this tumor. Therefore, the therapeutic strategies based on biologically active substances from plants are needed to develop for the treatment of cervical cancer. The aim of the present study was to assess in vivo toxicity, hematological and biochemical blood parameters in Wistar rats fed R...
Source: Fitoterapia - March 30, 2024 Category: Biochemistry Authors: Soumia Moujane Ismail Bouadid Aziz Bouymajane Filali Zegzouti Younes Mohamed Benlyas Bouachrine Mohammed Francesco Cacciola Roberto Lagan à Vinci Alessia Tropea Luigi Mondello Ammar B Altemimi Mohamed Eddouks Benaissa Moualij Source Type: research
