Phenolics and flavonoids from Polygonum posumbu and comparision of flavonoid compounds content in different tissues (leaves, stems and roots)
Fitoterapia. 2024 Feb 24:105864. doi: 10.1016/j.fitote.2024.105864. Online ahead of print.ABSTRACTThe growing global need for antioxidative phenolics and flavonoids for maintenance of human health resulted into search of new sustainable unexplored medicinal plants used by the traditional healers for various ailments. Many synthetic based products of phenolics and flavonoids have been used, however the demand of eco-friendly, natural herbal based products are increasing. As a result, the current study aims to explore traditional potential of Polygonum posumbu related to its phenolics and flavonoids. Optimization of extracti...
Source: Fitoterapia - February 26, 2024 Category: Biochemistry Authors: Premi Devi Pukhrambam Khomdram Khedashwori Devi Chingoileima Maibam Roseeta Devi Mutum Moirangthem Lakshmipriyari Devi Sudripta Das Source Type: research
Phenolics and flavonoids from Polygonum posumbu and comparision of flavonoid compounds content in different tissues (leaves, stems and roots)
Fitoterapia. 2024 Feb 24:105864. doi: 10.1016/j.fitote.2024.105864. Online ahead of print.ABSTRACTThe growing global need for antioxidative phenolics and flavonoids for maintenance of human health resulted into search of new sustainable unexplored medicinal plants used by the traditional healers for various ailments. Many synthetic based products of phenolics and flavonoids have been used, however the demand of eco-friendly, natural herbal based products are increasing. As a result, the current study aims to explore traditional potential of Polygonum posumbu related to its phenolics and flavonoids. Optimization of extracti...
Source: Fitoterapia - February 26, 2024 Category: Biochemistry Authors: Premi Devi Pukhrambam Khomdram Khedashwori Devi Chingoileima Maibam Roseeta Devi Mutum Moirangthem Lakshmipriyari Devi Sudripta Das Source Type: research
Design, synthesis and biological evaluation of bakuchiol derivatives as multi-target agents for the treatment of Alzheimer's disease
Fitoterapia. 2024 Feb 19:105867. doi: 10.1016/j.fitote.2024.105867. Online ahead of print.ABSTRACTThe concept of multi-target-directed ligands offers fresh perspectives for the creation of brand-new Alzheimer's disease medications. To explore their potential as multi-targeted anti-Alzheimer's drugs, eighteen new bakuchiol derivatives were designed, synthesized, and evaluated. The structures of the new compounds were elucidated by IR, NMR, and HRMS. Eighteen compounds were assayed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in vitro using Ellman's method. It was shown that most of the compounds inhibit...
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Xiao-Qing Zhang Yan-Nan Xiang Tian Qin Jing-Pei Zou Qian-Wen Guo Shu-Tong Han Zhao-Yuan Zhang Wei-Wei Liu Gang Ding Jing-Quan Dong Da-Hua Shi Source Type: research
Characterization, multivariate analysis and bioactivity evaluation of coumarins in the bark of Fraxinus mandshurica
This study established an identification and evaluation method applicable to plants of different origins, which provides a strong reference for quality control, origin evaluation and clinical application of traditional medicinal plants.PMID:38382892 | DOI:10.1016/j.fitote.2024.105865 (Source: Fitoterapia)
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Jianjin Guo Jing Gao Yan Guo Lu Bai Chi-Tang Ho Naisheng Bai Source Type: research
Design, synthesis and biological evaluation of bakuchiol derivatives as multi-target agents for the treatment of Alzheimer's disease
Fitoterapia. 2024 Feb 19:105867. doi: 10.1016/j.fitote.2024.105867. Online ahead of print.ABSTRACTThe concept of multi-target-directed ligands offers fresh perspectives for the creation of brand-new Alzheimer's disease medications. To explore their potential as multi-targeted anti-Alzheimer's drugs, eighteen new bakuchiol derivatives were designed, synthesized, and evaluated. The structures of the new compounds were elucidated by IR, NMR, and HRMS. Eighteen compounds were assayed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in vitro using Ellman's method. It was shown that most of the compounds inhibit...
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Xiao-Qing Zhang Yan-Nan Xiang Tian Qin Jing-Pei Zou Qian-Wen Guo Shu-Tong Han Zhao-Yuan Zhang Wei-Wei Liu Gang Ding Jing-Quan Dong Da-Hua Shi Source Type: research
Characterization, multivariate analysis and bioactivity evaluation of coumarins in the bark of Fraxinus mandshurica
This study established an identification and evaluation method applicable to plants of different origins, which provides a strong reference for quality control, origin evaluation and clinical application of traditional medicinal plants.PMID:38382892 | DOI:10.1016/j.fitote.2024.105865 (Source: Fitoterapia)
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Jianjin Guo Jing Gao Yan Guo Lu Bai Chi-Tang Ho Naisheng Bai Source Type: research
Design, synthesis and biological evaluation of bakuchiol derivatives as multi-target agents for the treatment of Alzheimer's disease
Fitoterapia. 2024 Feb 19:105867. doi: 10.1016/j.fitote.2024.105867. Online ahead of print.ABSTRACTThe concept of multi-target-directed ligands offers fresh perspectives for the creation of brand-new Alzheimer's disease medications. To explore their potential as multi-targeted anti-Alzheimer's drugs, eighteen new bakuchiol derivatives were designed, synthesized, and evaluated. The structures of the new compounds were elucidated by IR, NMR, and HRMS. Eighteen compounds were assayed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in vitro using Ellman's method. It was shown that most of the compounds inhibit...
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Xiao-Qing Zhang Yan-Nan Xiang Tian Qin Jing-Pei Zou Qian-Wen Guo Shu-Tong Han Zhao-Yuan Zhang Wei-Wei Liu Gang Ding Jing-Quan Dong Da-Hua Shi Source Type: research
Characterization, multivariate analysis and bioactivity evaluation of coumarins in the bark of Fraxinus mandshurica
This study established an identification and evaluation method applicable to plants of different origins, which provides a strong reference for quality control, origin evaluation and clinical application of traditional medicinal plants.PMID:38382892 | DOI:10.1016/j.fitote.2024.105865 (Source: Fitoterapia)
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Jianjin Guo Jing Gao Yan Guo Lu Bai Chi-Tang Ho Naisheng Bai Source Type: research
Design, synthesis and biological evaluation of bakuchiol derivatives as multi-target agents for the treatment of Alzheimer's disease
Fitoterapia. 2024 Feb 19:105867. doi: 10.1016/j.fitote.2024.105867. Online ahead of print.ABSTRACTThe concept of multi-target-directed ligands offers fresh perspectives for the creation of brand-new Alzheimer's disease medications. To explore their potential as multi-targeted anti-Alzheimer's drugs, eighteen new bakuchiol derivatives were designed, synthesized, and evaluated. The structures of the new compounds were elucidated by IR, NMR, and HRMS. Eighteen compounds were assayed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in vitro using Ellman's method. It was shown that most of the compounds inhibit...
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Xiao-Qing Zhang Yan-Nan Xiang Tian Qin Jing-Pei Zou Qian-Wen Guo Shu-Tong Han Zhao-Yuan Zhang Wei-Wei Liu Gang Ding Jing-Quan Dong Da-Hua Shi Source Type: research
Characterization, multivariate analysis and bioactivity evaluation of coumarins in the bark of Fraxinus mandshurica
This study established an identification and evaluation method applicable to plants of different origins, which provides a strong reference for quality control, origin evaluation and clinical application of traditional medicinal plants.PMID:38382892 | DOI:10.1016/j.fitote.2024.105865 (Source: Fitoterapia)
Source: Fitoterapia - February 21, 2024 Category: Biochemistry Authors: Jianjin Guo Jing Gao Yan Guo Lu Bai Chi-Tang Ho Naisheng Bai Source Type: research
Discovery of sesquiterpene from Youngia japonica with antitumor effect
Fitoterapia. 2024 Feb 18:105869. doi: 10.1016/j.fitote.2024.105869. Online ahead of print.ABSTRACTFourteen sesquiterpenes, including one undescribed sesquiterpene lactone, were isolated from Youngia japonica, and their structures were identified by NMR, HRESIMS, ECD and calculated ECD. Cytotoxic activities of all isolates against A549, HeLa, and 4 T1 cell lines were detected by CCK8 assay. Among them, 2 showed obvious cytotoxic activity against A549 cells. Subsequently, the production of ROS, and apoptosis of A549 cells treated with 2 were evaluated. The result showed that 2 distinctly increased the ROS level, and induced ...
Source: Fitoterapia - February 20, 2024 Category: Biochemistry Authors: Xian-Sheng Ye Kuan Lin Xiao-Qing Tao Jin-Ting Shang Yu-Ran Gui Shu-Xiu Zhu Yi-Yuan Xia Hai-Feng Chen Bin-Lian Sun Wei Liu Xi-Ji Shu Source Type: research
Four unreported aporphine alkaloids with antifungal activities from Artabotrys hexapetalus
In this study, the extract from Artabotrys hexapetalus showed strong antifungal activity against phytopathogenic fungi in vitro. Four unreported aporphine alkaloids, hexapetalusine A-D (1-4), were isolated from stems and roots of Artabotrys hexapetalus (L.f.) Bhandari, along with six known aporphine alkaloids (5-10). Their chemical structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1-3 were determined using single-crystal X-ray diffractions and ECD calculations. Hexapetalusine A-C (1-3) were special amidic isomers. Additionally, all isolated compounds were evaluated for their ant...
Source: Fitoterapia - February 20, 2024 Category: Biochemistry Authors: Pei Zhao Zhiyin Yu Jian-Ping Huang Li Wang Sheng-Xiong Huang Jing Yang Source Type: research
Abietane diterpenoids with anti-neuroinflammation activity from Rosmarinus officinalis
Fitoterapia. 2024 Feb 18;174:105866. doi: 10.1016/j.fitote.2024.105866. Online ahead of print.ABSTRACTA total of 12 abietane diterpenoids were isolated and identified from Rosmarinus officinalis in which 6 ones were undescribed compounds. Their structures were illuminated by the HRESIMS, NMR, and ECD methods and named as rosmarinusin Q-V (1-6). It worthy mentioned that rosmarinusin Q was a novel abietane diterpenoid with 6/6/5 skeleton whose C ring was an α,β-unsaturated five-element ketone. All the compounds and four compounds (13-16) reported in our previous paper were evaluated their anti-neuroinflammatory activities ...
Source: Fitoterapia - February 20, 2024 Category: Biochemistry Authors: Tang Zhou Ji Wang Zhiqi Lin Hongbo Zhu Weiyan Hu Rongping Zhang Xinglong Chen Source Type: research
Discovery of sesquiterpene from Youngia japonica with antitumor effect
Fitoterapia. 2024 Feb 18:105869. doi: 10.1016/j.fitote.2024.105869. Online ahead of print.ABSTRACTFourteen sesquiterpenes, including one undescribed sesquiterpene lactone, were isolated from Youngia japonica, and their structures were identified by NMR, HRESIMS, ECD and calculated ECD. Cytotoxic activities of all isolates against A549, HeLa, and 4 T1 cell lines were detected by CCK8 assay. Among them, 2 showed obvious cytotoxic activity against A549 cells. Subsequently, the production of ROS, and apoptosis of A549 cells treated with 2 were evaluated. The result showed that 2 distinctly increased the ROS level, and induced ...
Source: Fitoterapia - February 20, 2024 Category: Biochemistry Authors: Xian-Sheng Ye Kuan Lin Xiao-Qing Tao Jin-Ting Shang Yu-Ran Gui Shu-Xiu Zhu Yi-Yuan Xia Hai-Feng Chen Bin-Lian Sun Wei Liu Xi-Ji Shu Source Type: research
Four unreported aporphine alkaloids with antifungal activities from Artabotrys hexapetalus
In this study, the extract from Artabotrys hexapetalus showed strong antifungal activity against phytopathogenic fungi in vitro. Four unreported aporphine alkaloids, hexapetalusine A-D (1-4), were isolated from stems and roots of Artabotrys hexapetalus (L.f.) Bhandari, along with six known aporphine alkaloids (5-10). Their chemical structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1-3 were determined using single-crystal X-ray diffractions and ECD calculations. Hexapetalusine A-C (1-3) were special amidic isomers. Additionally, all isolated compounds were evaluated for their ant...
Source: Fitoterapia - February 20, 2024 Category: Biochemistry Authors: Pei Zhao Zhiyin Yu Jian-Ping Huang Li Wang Sheng-Xiong Huang Jing Yang Source Type: research
