Phytochemical analysis, antioxidant and ALR2 inhibitory activity of Sorbus torminalis (L.) fruits at different maturity stages
Fitoterapia. 2024 Feb 17:105863. doi: 10.1016/j.fitote.2024.105863. Online ahead of print.ABSTRACTThirty four compounds were identified in Sorbus torminalis (L.) fruit extracts of different maturity types by means of LC-DAD-MS (ESI+) fragmentation analysis. Both immature and mature fruits were rich in flavonoid glycosides esterified with hydroxycinnamic, phenolic and dicarboxylic acids along with benzoic, phenylpropanoic and cinnamoyl quinic acid derivatives with many of them being detected for the first time in Sorbus species and in literature. Extracts and fractions were tested for their antioxidant activity (DPPH, chemi...
Source: Fitoterapia - February 19, 2024 Category: Biochemistry Authors: Karakousi Christina-Vasiliki Beilektsidou Xanthippi Theano Samara Kokkalou Eugene Source Type: research
Elucidating the therapeutic mechanism of Hengqing II decoction in Alzheimer's disease using network pharmacology and molecular docking techniques
CONCLUSION: Hengqing II decoction exerted therapeutic effects on AD through multi-component, multi-target, and multi-pathway regulation, and its action mechanisms were related to oxidative stress, neuroinflammation, autophagy, and other pathways. Our research laid the data foundation for further exploration of action mechanism and clarification of clinical positioning and provided new ideas and clues in TCM formula research.PMID:38367649 | DOI:10.1016/j.fitote.2024.105860 (Source: Fitoterapia)
Source: Fitoterapia - February 17, 2024 Category: Biochemistry Authors: Yajing Wang Jiahui Jiang Shuyu Chen Qian Chen Xiaojing Yan Xiaozhong Shen Source Type: research
Elucidating the therapeutic mechanism of Hengqing II decoction in Alzheimer's disease using network pharmacology and molecular docking techniques
CONCLUSION: Hengqing II decoction exerted therapeutic effects on AD through multi-component, multi-target, and multi-pathway regulation, and its action mechanisms were related to oxidative stress, neuroinflammation, autophagy, and other pathways. Our research laid the data foundation for further exploration of action mechanism and clarification of clinical positioning and provided new ideas and clues in TCM formula research.PMID:38367649 | DOI:10.1016/j.fitote.2024.105860 (Source: Fitoterapia)
Source: Fitoterapia - February 17, 2024 Category: Biochemistry Authors: Yajing Wang Jiahui Jiang Shuyu Chen Qian Chen Xiaojing Yan Xiaozhong Shen Source Type: research
An outlook on the versatility of plant saponins: A review
This article examines and discusses the structure and properties of plant saponins with high yield of saponin concentrations and their exploitable applications. This highlights the potential of saponins as ethical substitutes for traditional synthetic surfactants and pharmacological agents, with favorable effects on the economy and environment. For this purpose, studies on the relevant capabilities, structure, and yield of selected plants were thoroughly examined. Studies on the possible uses of the selected saponins have also been conducted. This in-depth analysis highlights the potential of saponins as workable and ethic...
Source: Fitoterapia - February 16, 2024 Category: Biochemistry Authors: Annu Jolly Youl Hour Young-Chul Lee Source Type: research
An outlook on the versatility of plant saponins: A review
This article examines and discusses the structure and properties of plant saponins with high yield of saponin concentrations and their exploitable applications. This highlights the potential of saponins as ethical substitutes for traditional synthetic surfactants and pharmacological agents, with favorable effects on the economy and environment. For this purpose, studies on the relevant capabilities, structure, and yield of selected plants were thoroughly examined. Studies on the possible uses of the selected saponins have also been conducted. This in-depth analysis highlights the potential of saponins as workable and ethic...
Source: Fitoterapia - February 16, 2024 Category: Biochemistry Authors: Annu Jolly Youl Hour Young-Chul Lee Source Type: research
Lagerstroemia macrocarpa extract inhibits Th2-mediated STAT6 signaling pathway in human keratinocytes
In this study, we examined physiological functions as a key material to develop cosmeceuticals using extracts of Lagerstroemia macrocarpa Wall. Ex Kurz (L. macrocarpa). Initially, the L. macrocarpa extract was treated by different concentration and antioxidant assay (DPPH and ABTS) were performed to measure free radical scavenging ability. In the cytotoxicity experiment, the extract was treated into human epidermal keratinocytes with different concentrations to measure cytotoxicity. We found that the extract induces differentiation markers such as keratin (KRT)1, KRT2, KRT9, KRT10 in keratinocytes. Furthermore, the extract...
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Gayeon Seo Hoyong Hyun Minju Jeong Yukyung Park Jeongmin Cho Thet Thet Mar Win Thant Zaw Win Jinhyup Paik Alfan D Arbianto Jung-Hee Kim Jongmin Ahn Dongwon Kim Source Type: research
Integrated analysis and separation of 5-lipoxygenase inhibitors from triterpenes of Poria cocos using bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking and target-based multiple complex networks
In this study, based on the β-Amyloid deposition hypothesis of AD, an integrated analysis was conducted to screen and separation 5-lipoxygenase (5-LOX) inhibitors from triterpenoids of P. cocos and investigate the anti-AD mechanisms, containing bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking, and multiple complex networks. Five triterpenoids were identified as potential 5-LOX inhibitors, including Tumulosic acid, Polyporenic acid C, 3-Epi-dehydrotumulosic acid, Pachymic acid and Dehydrotrametenolic acid. Five potential 5-LOX inhibitors were screened by ultrafiltration affinity assay in P. cocos. The molecul...
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Tong Wu Wanchao Hou Sainan Li Chunming Liu Yuchi Zhang Source Type: research
Antiulcer activity of Mauritia flexuosa L.f. (Arecaceae) pulp oil: An edible Amazonian species with functional properties
This study aimed to evaluate the gastroprotective and antiulcer effects of buriti oil and its possible mechanisms of action. Buriti oil reduced the ulcerative area and lipid peroxidation induced by ethanol. The gastroprotective activity of buriti oil partially depends on nitric oxide and sulfhydryl compounds. In acetic acid-induced gastric ulcers, buriti oil accelerated healing and stimulated the formation of new gastric glands. These results demonstrated the potential of buriti oil as a functional ingredient to promote health benefits in the gastrointestinal tract.PMID:38354821 | DOI:10.1016/j.fitote.2024.105857 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Maria de F átima Rodrigues Jos é Wellinton da Silva Jucielma Silva de Lima B árbara de Azevedo Ramos Silvania Tavares Paz Diego Lomonaco Davila Zampieri Rafael Matos Ximenes Source Type: research
Effect of Polygonatum sibiricum saponins on gut microbiota of mice with ulcerative colitis
This study confirmed that Polygonatum sibiricum saponins play a therapeutic and palliative role in ulcerative colitis by regulating the microbiome balance.PMID:38354822 | DOI:10.1016/j.fitote.2024.105855 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Rong Cao Xinyi Fang Ziyi Li Sijia Li Qinqi Guo Yangyang Chai Source Type: research
Characterization of four new cycloartane triterpenoids from Swietenia macrophylla and their angiotensin-I-converting enzyme inhibitory activity
In this study, four new (1-4) and one known (5) cycloartane triterpenoids were isolated from the leaves of Swietenia macrophylla by chromatographic techniques and identified by their spectroscopic data and a comprehensive comparison of published data. The triterpenoids were evaluated for their ACE inhibitory potential using in vitro inhibition assays and in silico methods. The inhibition assay and enzyme kinetics results showed that the most active triterpenoid, compound 4, inhibited ACE in a mixed-type manner with an IC50 value of 57.7 ± 6.07 μM. Computer simulations revealed that compound 4 reduces the catalytic effici...
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Bongani Sicelo Dlamini Chiy-Rong Chen Ya-Lin Chang Pei-Hsuan Ho Chia-Ho Chao Chi-I Chang Source Type: research
Humulus lupulus aqueous extract and hydrolate as a potential ingredient for cosmetics: Chemical characterization and in vitro antimicrobial, cytotoxicity, antioxidant, and anti-inflammatory assessment
CONCLUSION: The studied H. lupulus aqueous extracts and hydrolates revealed that FH stands out as the most promising bioactive source for cosmetic formulations. However, future research addressing antimicrobial activity is necessary to confirm its potential incorporation into dermatological and cosmetic formulations.PMID:38354824 | DOI:10.1016/j.fitote.2024.105861 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Jo ão Valente Rita Palmeira-de-Oliveira Liliana Guiomar C átia Vaz Joana Rolo Carlos Gaspar Ana Sofia Oliveira D ébora Caramelo Luiza Breitenfeld Jos é Carlos Gonçalves Fernanda Delgado Jos é Martinez-de-Oliveira Ana Palmeira-de-Oliveira Source Type: research
Lagerstroemia macrocarpa extract inhibits Th2-mediated STAT6 signaling pathway in human keratinocytes
In this study, we examined physiological functions as a key material to develop cosmeceuticals using extracts of Lagerstroemia macrocarpa Wall. Ex Kurz (L. macrocarpa). Initially, the L. macrocarpa extract was treated by different concentration and antioxidant assay (DPPH and ABTS) were performed to measure free radical scavenging ability. In the cytotoxicity experiment, the extract was treated into human epidermal keratinocytes with different concentrations to measure cytotoxicity. We found that the extract induces differentiation markers such as keratin (KRT)1, KRT2, KRT9, KRT10 in keratinocytes. Furthermore, the extract...
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Gayeon Seo Hoyong Hyun Minju Jeong Yukyung Park Jeongmin Cho Thet Thet Mar Win Thant Zaw Win Jinhyup Paik Alfan D Arbianto Jung-Hee Kim Jongmin Ahn Dongwon Kim Source Type: research
Integrated analysis and separation of 5-lipoxygenase inhibitors from triterpenes of Poria cocos using bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking and target-based multiple complex networks
In this study, based on the β-Amyloid deposition hypothesis of AD, an integrated analysis was conducted to screen and separation 5-lipoxygenase (5-LOX) inhibitors from triterpenoids of P. cocos and investigate the anti-AD mechanisms, containing bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking, and multiple complex networks. Five triterpenoids were identified as potential 5-LOX inhibitors, including Tumulosic acid, Polyporenic acid C, 3-Epi-dehydrotumulosic acid, Pachymic acid and Dehydrotrametenolic acid. Five potential 5-LOX inhibitors were screened by ultrafiltration affinity assay in P. cocos. The molecul...
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Tong Wu Wanchao Hou Sainan Li Chunming Liu Yuchi Zhang Source Type: research
Antiulcer activity of Mauritia flexuosa L.f. (Arecaceae) pulp oil: An edible Amazonian species with functional properties
This study aimed to evaluate the gastroprotective and antiulcer effects of buriti oil and its possible mechanisms of action. Buriti oil reduced the ulcerative area and lipid peroxidation induced by ethanol. The gastroprotective activity of buriti oil partially depends on nitric oxide and sulfhydryl compounds. In acetic acid-induced gastric ulcers, buriti oil accelerated healing and stimulated the formation of new gastric glands. These results demonstrated the potential of buriti oil as a functional ingredient to promote health benefits in the gastrointestinal tract.PMID:38354821 | DOI:10.1016/j.fitote.2024.105857 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Maria de F átima Rodrigues Jos é Wellinton da Silva Jucielma Silva de Lima B árbara de Azevedo Ramos Silvania Tavares Paz Diego Lomonaco Davila Zampieri Rafael Matos Ximenes Source Type: research
Effect of Polygonatum sibiricum saponins on gut microbiota of mice with ulcerative colitis
This study confirmed that Polygonatum sibiricum saponins play a therapeutic and palliative role in ulcerative colitis by regulating the microbiome balance.PMID:38354822 | DOI:10.1016/j.fitote.2024.105855 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Rong Cao Xinyi Fang Ziyi Li Sijia Li Qinqi Guo Yangyang Chai Source Type: research
