Five new compounds from the stems of Ephedra equisetina
Fitoterapia. 2024 Mar 11;175:105907. doi: 10.1016/j.fitote.2024.105907. Online ahead of print.ABSTRACTFive new compounds were identified from the stems of Ephedra equisetina Bunge. Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectrum and HRESIMS analyses. The absolute configuration of compound 2 was proved by comparing their experimental and calculated ECD spectrum. The vitro bioactive assay of all compounds suggested that compound 1, 3, 4, 5 and 6 may have potential anti-asthmatic activities.PMID:38479617 | DOI:10.1016/j.fitote.2024.105907 (Source: Fitoterapia)
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Siqi Tao Denghui Zhu Qimei Tie Yuanyuan Wu Jingke Zhang Xiaoke Zheng Weisheng Feng Source Type: research
Cymbopogon schoenanthus (L) extract ameliorates high fat diet-induced obesity and dyslipidemia via reducing expression of lipogenic and thermogenic proteins
This study was conducted to evaluate the anti-obesity potential of Cymbopogon schoenanthus methanolic extract (CS) in rats. Fifty male Wistar rats of six to eight weeks old, 100-120 g body weight (BW) were randomly assigned into 5 groups (n = 10): The control group was fed a basal diet. CS-group was supplied with basal diet and orally given CS (200 mg/kg BW) for 12 weeks. HFD-group was fed a high-fat diet (HFD) for 18 weeks. HFD + CS-group was fed on HFD and CS HFD then CS-group was fed HFD for 12 weeks then shifted to basal diet and CS for another 6 weeks. Phytochemical analysis of CS indicated the presence of various ter...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Asmaa Elebishehy Mohamed M Ahmed Badr Aldahmash Mostafa Abdelgaber Mohamed Aya A Shetaia Shaden A M Khalifa Mabrouk Attia Abd Eldaim Hesham R El-Seedi Nermeen Yosri Source Type: research
Three new indole alkaloid derivatives from Fissistigma oldhamii Levl. and their anti-inflammatory effects
Fitoterapia. 2024 Mar 11;175:105910. doi: 10.1016/j.fitote.2024.105910. Online ahead of print.ABSTRACTThree new indole alkaloid derivatives, fissindoalkas A-C (1-3) together with one known biogenetically related polysubstituted indole alkaloid (4) were isolated from the roots of Fissistigma oldhamii (Hemsl.) Merr. The structures of compounds 1-4 were elucidated using comprehensive spectroscopic methods. The inhibitory activities of compounds 1-4 against nitric oxide (NO) production induced by lipopolysaccharide (LPS) were evaluated in vitro using mouse macrophage RAW264.7 cells. Compounds 2 and 3 showed potent inhibitory a...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: De-Cai Dai Xue-Feng Xu Hao Yan Yu Zhang Source Type: research
Undescribed (2-7')-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production
Fitoterapia. 2024 Mar 11:105903. doi: 10.1016/j.fitote.2024.105903. Online ahead of print.ABSTRACTA phytochemical study of the aerial parts of Piper mutabile C. DC. revealed seven undescribed compounds [two (2-7')-neolignans and five polyoxygenated cyclohexene glycosides] and six known propenylcatechol derivatives. The chemical structures of the isolated compounds were elucidated by extensive HR-ESI-MS and NMR analyses, as well as comparison with the literature. The absolute configurations of the (2-7')-neolignans were confirmed by GIAO 13C NMR calculations with a sorted training set strategy and TD-DFT calculation ECD spe...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Phan Van Kiem Nguyen Xuan Nhiem Nguyen Huy Hoang Ngo Anh Bang Pham Hai Yen Do Thi Trang Duong Thi Dung Nguyen Thi Cuc Phan Thi Thanh Huong Bui Huu Tai Source Type: research
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis
Fitoterapia. 2024 Mar 11;175:105908. doi: 10.1016/j.fitote.2024.105908. Online ahead of print.ABSTRACTThree undescribed sesquiterpenes, designed as pichinenoid A-C (1-3), along with nine known ones (4-12) were isolated from the stems and leaves of Picrasma chinensis. The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally, compounds 1 and 2 are descending sesquiterpenes, while pichinenoid C (3) is a rare sesquiterpene beari...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Xian-Zhe Fan Jia-Qi Song Xin-Yi Shi Jin-Fang Zhou Rui-Juan Yuan Ting Liu Xiang-Qian Kong Ya-Si Huang Li-Jun Zhang Hai-Bing Liao Source Type: research
Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006
Fitoterapia. 2024 Mar 11;175:105906. doi: 10.1016/j.fitote.2024.105906. Online ahead of print.ABSTRACTNine metabolites, including three undescribed alkaloids pyripyropenes VW (1-2), penicioxa A (4), two previously reported pyripyropene A (3), oxaline (5), three grisephenone-type xanthone derivatives (6-8), and a diphenyl ether derivative 4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone (9), were isolated from cultures of the mangrove-derived fungus Penicillium robsamsonii HNNU0006. Their structures were determined by spectroscopic analysis, ECD calculations, together with DP4+ probability analysis....
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Jing-Wen Wang Yi-Yi Liu Guang-Ying Chen Cai-Juan Zheng Xu-Hua Nong Source Type: research
Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity
Fitoterapia. 2024 Mar 11:105909. doi: 10.1016/j.fitote.2024.105909. Online ahead of print.ABSTRACTArtemdubosides A-E (1-5), the first examples of natural polyacetylenes substituted by 6'-O-crotonyl β-glucopyranoside, and artemdubosides F-G (6-7) that were two unusual polyacetylenes featuring a 6'-O-acetyl β-glucopyranoside moiety, were isolated from Artemisia dubia var. subdigitata. Their structures were elucidated based on the spectral data including HRESIMS, UV, IR, 1D and 2D NMR, and ECD calculations. Antihepatoma assay suggested that compound 1 exhibited activity against HepG2, Huh7, and SK-Hep-1 cells with inhibitor...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Yang Ke-Xin Ma Yun-Bao Li Tian-Ze Wang Meng-Fei Li Feng-Jiao Chen Ji-Jun Source Type: research
Six unprecedented 2-(2-phenethyl)chromone dimers from agarwood of Aquilaria filaria
Fitoterapia. 2024 Mar 11:105905. doi: 10.1016/j.fitote.2024.105905. Online ahead of print.ABSTRACTSix new dimeric 2-(2-phenylethyl)chromones (1-6) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1-6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone via a single ether bond, and the linkage site (C5-O-C8'') of compound 2 is extremely rare. A variety of spectroscopic methods were used to ascertain their structures, including extensive 1D and 2D NMR spectroscopic analysis,...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Yuan Wei Wen-Hua Dong Wei Li Jun Zeng Hui-Qin Chen Sheng-Zhuo Huang Li Yang Wen-Li Mei Ya-Li Wang Zhi-Yong Guo Hao-Fu Dai Hao Wang Source Type: research
Five new compounds from the stems of Ephedra equisetina
Fitoterapia. 2024 Mar 11:105907. doi: 10.1016/j.fitote.2024.105907. Online ahead of print.ABSTRACTFive new compounds were identified from the stems of Ephedra equisetina Bunge. Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectrum and HRESIMS analyses. The absolute configuration of compound 2 was proved by comparing their experimental and calculated ECD spectrum. The vitro bioactive assay of all compounds suggested that compound 1, 3, 4, 5 and 6 may have potential anti-asthmatic activities.PMID:38479617 | DOI:10.1016/j.fitote.2024.105907 (Source: Fitoterapia)
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Siqi Tao Denghui Zhu Qimei Tie Yuanyuan Wu Jingke Zhang Xiaoke Zheng Weisheng Feng Source Type: research
Cymbopogon schoenanthus (L) extract ameliorates high fat diet-induced obesity and dyslipidemia via reducing expression of lipogenic and thermogenic proteins
This study was conducted to evaluate the anti-obesity potential of Cymbopogon schoenanthus methanolic extract (CS) in rats. Fifty male Wistar rats of six to eight weeks-old, 100-120 g body weight (BW) was randomly assigned into 5 groups (n = 10): Control group was fed basal diet. CS-group was supplied with basal diet and orally given CS (200 mg/kg BW) for 12 weeks. HFD-group was fed a high fat diet (HFD) for 18 weeks. HFD + CS-group was fed on HFD and CS. HFD then CS-group was fed HFD for 12 weeks then shifted to basal diet and CS for another 6 weeks. Phytochemical analysis of CS indicated the presence of various terpenes ...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Asmaa Elebishehy Mohamed M Ahmed Badr Aldahmash Mostafa Abdelgaber Mohamed Aya A Shetaia Shaden A M Khalifa Mabrouk Attia Abd Eldaim Hesham R El-Seedi Nermeen Yosri Source Type: research
Three new indole alkaloid derivatives from Fissistigma oldhamii Levl. and their anti-inflammatory effects
Fitoterapia. 2024 Mar 11:105910. doi: 10.1016/j.fitote.2024.105910. Online ahead of print.ABSTRACTThree new indole alkaloid derivatives, fissindoalkas A-C (1-3) together with one known biogenetically related polysubstituted indole alkaloid (4) were isolated from the roots of Fissistigma oldhamii (Hemsl.) Merr. The structures of compounds 1-4 were elucidated using comprehensive spectroscopic methods. The inhibitory activities of compounds 1-4 against nitric oxide (NO) production induced by lipopolysaccharide (LPS) were evaluated in vitro using mouse macrophage RAW264.7 cells. Compounds 2 and 3 showed potent inhibitory activ...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: De-Cai Dai Xue-Feng Xu Hao Yan Yu Zhang Source Type: research
Undescribed (2-7')-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production
Fitoterapia. 2024 Mar 11:105903. doi: 10.1016/j.fitote.2024.105903. Online ahead of print.ABSTRACTA phytochemical study of the aerial parts of Piper mutabile C. DC. revealed seven undescribed compounds [two (2-7')-neolignans and five polyoxygenated cyclohexene glycosides] and six known propenylcatechol derivatives. The chemical structures of the isolated compounds were elucidated by extensive HR-ESI-MS and NMR analyses, as well as comparison with the literature. The absolute configurations of the (2-7')-neolignans were confirmed by GIAO 13C NMR calculations with a sorted training set strategy and TD-DFT calculation ECD spe...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Phan Van Kiem Nguyen Xuan Nhiem Nguyen Huy Hoang Ngo Anh Bang Pham Hai Yen Do Thi Trang Duong Thi Dung Nguyen Thi Cuc Phan Thi Thanh Huong Bui Huu Tai Source Type: research
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis
Fitoterapia. 2024 Mar 11:105908. doi: 10.1016/j.fitote.2024.105908. Online ahead of print.ABSTRACTThree undescribed sesquiterpenes, designed as pichinenoid A-C (1-3), along with nine known ones (4-12) were isolated from the stems and leaves of Picrasma chinensis. The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally, compounds 1 and 2 are descending sesquiterpenes, while pichinenoid C (3) is a rare sesquiterpene bearing a...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Xian-Zhe Fan Jia-Qi Song Xin-Yi Shi Jin-Fang Zhou Rui-Juan Yuan Ting Liu Xiang-Qian Kong Ya-Si Huang Li-Jun Zhang Hai-Bing Liao Source Type: research
Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006
Fitoterapia. 2024 Mar 11;175:105906. doi: 10.1016/j.fitote.2024.105906. Online ahead of print.ABSTRACTNine metabolites, including three undescribed alkaloids pyripyropenes VW (1-2), penicioxa A (4), two previously reported pyripyropene A (3), oxaline (5), three grisephenone-type xanthone derivatives (6-8), and a diphenyl ether derivative 4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone (9), were isolated from cultures of the mangrove-derived fungus Penicillium robsamsonii HNNU0006. Their structures were determined by spectroscopic analysis, ECD calculations, together with DP4+ probability analysis....
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Jing-Wen Wang Yi-Yi Liu Guang-Ying Chen Cai-Juan Zheng Xu-Hua Nong Source Type: research
Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity
Fitoterapia. 2024 Mar 11:105909. doi: 10.1016/j.fitote.2024.105909. Online ahead of print.ABSTRACTArtemdubosides A-E (1-5), the first examples of natural polyacetylenes substituted by 6'-O-crotonyl β-glucopyranoside, and artemdubosides F-G (6-7) that were two unusual polyacetylenes featuring a 6'-O-acetyl β-glucopyranoside moiety, were isolated from Artemisia dubia var. subdigitata. Their structures were elucidated based on the spectral data including HRESIMS, UV, IR, 1D and 2D NMR, and ECD calculations. Antihepatoma assay suggested that compound 1 exhibited activity against HepG2, Huh7, and SK-Hep-1 cells with inhibitor...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Yang Ke-Xin Ma Yun-Bao Li Tian-Ze Wang Meng-Fei Li Feng-Jiao Chen Ji-Jun Source Type: research
