Research on the antipruritic active ingredients of Mikania micrantha
This study indicated that the main antipruritic active ingredients of Mikania micrantha are β-caryophyllene and humulene.PMID:38286314 | DOI:10.1016/j.fitote.2024.105837 (Source: Fitoterapia)
Source: Fitoterapia - January 29, 2024 Category: Biochemistry Authors: Qianqian Cheng Bin Lyu Jingweng Hu Zhiqiang Zhang Yusheng Huang Zhenhua Wang Source Type: research
Citrisorbicillinol, an undescribed hybrid sorbicillinoid with osteogenic activity from Penicillium citrinum ZY-2
Fitoterapia. 2024 Mar;173:105836. doi: 10.1016/j.fitote.2024.105836. Epub 2024 Jan 28.ABSTRACTCitrisorbicillinol (1), along with six other known compounds (2-7), was isolated from an endphyte Penicillium citrinum ZY-2 of Plantago asiatica L. Citrisorbicillinol (1) was characterized as a skeletally unprecedented hybrid sorbicillinoid, and its unique framework is likely formed by intermolecular [4 + 2] cycloaddition between intermediates derived from citrinin and sorbicillinoid biosynthetic gene clusters. Compounds 1 and 2 demonstrated to promote osteoblastic differentiation in MC3T3-E1 cells, and to be osteogenic in the pre...
Source: Fitoterapia - January 29, 2024 Category: Biochemistry Authors: Ying Zhang Jing Zhang Qi Du Xue Ming Wu Yong Chen Ren Xiang Tan Source Type: research
Phytochemistry and pharmacological activities of five species of Bauhinia genus: A review
In conclusion, the pharmacological potential of Bauhinia plants show promise with various leads such as insulin-like protein, roseoside, bauhiniastatin, and melibiose binding lectin. However, further investigations are required to address existing gaps and advance them towards product development. This review will lay the groundwork for future research initiatives aimed at fully realizing the therapeutic potential of Bauhinia plants.PMID:38286316 | DOI:10.1016/j.fitote.2024.105830 (Source: Fitoterapia)
Source: Fitoterapia - January 29, 2024 Category: Biochemistry Authors: Divya Gudavalli Komal Pandey Venkata Gopal Ede Dakshata Sable Ashwini S Ghagare Abhijeet S Kate Source Type: research
UPLC-Q-TOF/MS based metabolite profiling and quality marker constituents screening of root, stem and rhizome extracts of Ilex asprella
CONCLUSION: A sensitive and rapid strategy was established to evaluate the differences on secondary metabolites of different parts of IA for the first time, and this study may contribute to the quality evaluation of medicinal herbs and provide theoretically data support for further analysis of different parts of IA.PMID:38280682 | DOI:10.1016/j.fitote.2024.105832 (Source: Fitoterapia)
Source: Fitoterapia - January 27, 2024 Category: Biochemistry Authors: Lulu Wang Zhechen Fan Siyi Ma Shiyu Wu Chi Ma Huawu Zeng Xike Xu Qing Ma Ji Ye Source Type: research
New cassane-type alkaloids and diterpenoids from the pericarps of Caesalpinia bonduc
Fitoterapia. 2024 Mar;173:105834. doi: 10.1016/j.fitote.2024.105834. Epub 2024 Jan 26.ABSTRACTThe phytochemical investigation of the pericarps of Caesalpinia bonduc led to the isolation and identification of five new cassane-type alkaloids: caesalminines C - G (1-5) and six new diterpenoids: caesalbonducin K - P (6-11), along with seven known compounds (12-18). Compounds 1-5 were identified as a group of rare alkaloids possessing a tetracyclic cassane-type diterpenoid skeleton with a lactam D-ring instead of a typical furan or lactone moiety. The structures of 1-11 were elucidated on the basis of 1D and 2D NMR including HS...
Source: Fitoterapia - January 27, 2024 Category: Biochemistry Authors: Shuai-Jie Yan Si-Yang Huang Jia-Shuo Xing Yang-Rui Cai Ye-Ping Ruan Pan-Pan Zhang Source Type: research
Advanced quality assessment of Sanshishi (Gardenia jasminoides Ellis) and Kampo medicines using a monoclonal antibody against geniposide
This study developed such a method by first synthesizing GE-bovine serum albumin conjugates to function as immunizing agents in mice. This led to the production of a monoclonal antibody (mAb 3A6) against GE from the fusion of splenocytes from immunized mice with myeloma cells (P3U1), resulting in a hybridoma that produces mAb 3A6. Thereafter, we developed a mAb 3A6-based indirect competitive enzyme-linked immunosorbent assay (icELISA). The icELISA exhibited satisfactory sensitivity (0.391-12.5 μg/ml) and repeatability (coefficients of variation <10%). The accuracy of this method was validated through a spike-recovery a...
Source: Fitoterapia - January 26, 2024 Category: Biochemistry Authors: Kanta Noguchi Daisuke Imahori Riko Nishiura Poomraphie Nuntawong Waraporn Putalun Hiroyuki Tanaka Satoshi Morimoto Seiichi Sakamoto Source Type: research
Ginseng (Panax ginseng) leaf extract modulates the expression of heme oxygenase-1 to attenuate osteoclast differentiation
In this study, we evaluated the potential effects of ginseng leaf extract (GLE) on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in RAW264.7 macrophage cells. Tartrate-resistant acid phosphatase (TRAP) staining revealed that GLE had significant anti-osteoclastogenic activity. GLE significantly reduced mRNA levels of osteoclast differentiation markers including TRAP, nuclear factor of activated T cell cytoplasmic 1, and cathepsin K. It also suppressed the production of reactive oxygen species (ROS) and secretion of high mobility group box-1 (HMGB1) in RANKL-treated RAW264.7 cells...
Source: Fitoterapia - January 26, 2024 Category: Biochemistry Authors: Hyuk Gyoon Lee Jinwoo Hur Jun Pil Won Han Geuk Seo Source Type: research
Aspercitrininone A, novel antibacterial polyketide featuring unusual spiral skeleton from Aspergillus cristatus
Fitoterapia. 2024 Mar;173:105827. doi: 10.1016/j.fitote.2024.105827. Epub 2024 Jan 23.ABSTRACTAspercitrininone A (1), a novel polyketide featuring an unprecedented tetracyclic 6/6/6/5 spiral skeleton, was obtained from the rice fermentation cultures of the fungus Aspergillus cristatus together with five known compounds (2-6). Their structures were determined by HRESIMS data, 1D and 2D NMR spectroscopic analysis, and electronic circular dichroism (ECD) calculations. Aspercitrininone A was revealed as a new type of C/D cycle spiral structure and an unusual addition product of o-quinoid form citrinin with 2-methylterrefuranon...
Source: Fitoterapia - January 24, 2024 Category: Biochemistry Authors: Tian-Xiao Li Hong-Hui Dong Lei Xing Li He Rong-Ya Zhang Deng-Yin Shao Yu-Xiang Dai Dong-Liang Li Chun-Ping Xu Source Type: research
Two new 2-(2-phenylethyl)chromone derivatives and two sesquiterpenes from agarwood of Aquilaria sinensis with anti-inflammatory activity
Fitoterapia. 2024 Mar;173:105824. doi: 10.1016/j.fitote.2024.105824. Epub 2024 Jan 19.ABSTRACTTwo new 2-(2-phenylethyl)chromones (1-2), two new sesquiterpenes (12-13), and twelve known compounds (3-11, 14-16) were isolated from agarwood of Aquilaria sinensis. These structures were confirmed by HRESIMS, 1D and 2D NMR spectra. The absolute configurations of two new sesquiterpenes were determined by comparing the experimental and calculated ECD spectra. Among them, 7,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (2) was the first time found that the hydroxyl groups at both C-7/C-8 in agarwood. And Aseudesm B (13), the ald...
Source: Fitoterapia - January 20, 2024 Category: Biochemistry Authors: Bin Hu Shu-Jing Ling Xia Liu Jia-Bo Huang Hui Cui Zhong-Xiang Zhao Source Type: research
Secondary metabolites from Scindapsus officinalis (Roxb.) Schott. with in vitro antidiabetic activities
Fitoterapia. 2024 Mar;173:105822. doi: 10.1016/j.fitote.2024.105822. Epub 2024 Jan 13.ABSTRACTOne new phenolic cyclobutantetraol ester united chromone glycoside (1), one new amide (2), and three new phenyl ethanol glycosides (3-5) were obtained from the water extract of Scindapsus officinalis (Roxb.) Schott, in which compound 1 was the first reported structure incorporating the phenolic cyclobutantetraol ester and chromone via the glucose phenolic metabolites in nature. Structures of the isolated compounds, including absolute configurations, were elucidated according to the analysis of HRESIMS, NMR, ECD and BLYP/6-31G* geo...
Source: Fitoterapia - January 15, 2024 Category: Biochemistry Authors: Lei Zhao Yan Wang Zhenqiang Wang Tong Niu Jinqian Yu Tao Yue Source Type: research
Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii
Fitoterapia. 2024 Mar;173:105826. doi: 10.1016/j.fitote.2024.105826. Epub 2024 Jan 12.ABSTRACTFive undescribed lignans, cleiseberharnins A-D (1-4), cleiseberharside A (5) were isolated from the fruits of Cleistanthus eberhartii (Phyllanthaceae), together with six known aryltetralin lignans, cleistantoxin (6), picroburseranin (7), neocleistantoxin (8), 7-hydroxypicropolygamain (9), cleisindoside D (10), and cleisindoside A (11). Their structures and relative configurations were established by analysis of HRESIMS and NMR data, and quantum chemical calculations of JH,H coupling constants. The absolute configurations of 1-5 we...
Source: Fitoterapia - January 14, 2024 Category: Biochemistry Authors: Lam Hong Nguyen Thi Hue Nguyen Viet Hung Tran Marc Litaudon Van Thanh Nguyen Thi Mai Huong Doan Van Cuong Pham Source Type: research
Effect of the Pulsatilla decoction n-butanol extract on vulvovaginal candidiasis caused by Candida glabrata and on its virulence factors
In this study, the experimenter conducted in vitro and in vivo experiments to explore the effects of BEPD on the virulence factors of C. glabrata, as well as its efficacy, with a focus on possible immunological mechanism in VVC caused by C. glabrata. The contents of Anemoside B4, Epiberberine, Berberine, Aesculin, Aesculetin, Phellodendrine and Jatrorrhizine in BEPD, detected by high-performance liquid chromatography, were 31,736.64, 13,529.66, 105,143.72, 19,406.20, 4952.67, 10,317.03, 2489.93 μg/g, respectively. In vitro experiments indicated that BEPD moderately inhibited the growth of C. glabrata, its adhesion, and bi...
Source: Fitoterapia - January 14, 2024 Category: Biochemistry Authors: Jiaping Zhang Xiaojuan Jiang Gaoxiang Shi Hao Zhang Kaifan Hu Daqiang Wu Jing Shao Tingting Liu Tianming Wang Changzhong Wang Source Type: research
A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract
In this study, we specifically focused on the crude methanolic leaf extract of Byrsonima coccolobifolia, investigating its antifungal potential against human pathogenic fungi and its antiviral activity against COVID-19. Through the use of high-performance liquid chromatography coupled with electrospray ionization ion trap tandem mass spectrometry, direct infusion electrospray ionization ion trap tandem mass spectrometry, and chromatographic dereplication procedures, we identified galloyl quinic acid derivatives, catechin derivatives, proanthocyanidins, and flavonoid glycosides. The broth dilution assay revealed that the me...
Source: Fitoterapia - January 11, 2024 Category: Biochemistry Authors: Clenilson Martins Rodrigues Charlyana Carvalho Bento Carolina Borsoi Moraes Cecilia Gomes Rafaella Sayuri Ioshino Lucio H Freitas-Junior Cristina de Castro Spadari Kelly Ishida Wagner Vilegas Juliana Cajado Souza Carvalho Marcelo Jos é Pena Ferreira Virg Source Type: research
Euphzycopins A - D, macrocyclic diterpenoids with potential anti-inflammatory activity from Euphorbia Helioscopia
Fitoterapia. 2024 Mar;173:105821. doi: 10.1016/j.fitote.2024.105821. Epub 2024 Jan 9.ABSTRACTFour new diterpenoids (1-4) and four known diterpenoids (5-8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome wit...
Source: Fitoterapia - January 11, 2024 Category: Biochemistry Authors: Xiong Qiu Yu Zhang Yao-Jun Xu Zhong-Dan Liang Xiao-Chang Dai Wei-Lie Xiao Xing-Jie Zhang Xiao-Li Li Source Type: research
Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities
Fitoterapia. 2024 Mar;173:105813. doi: 10.1016/j.fitote.2023.105813. Epub 2024 Jan 4.ABSTRACTThree new formyl phloroglucinol meroterpenoids, eumaidials A-C (1-3), were isolated from the leaves of Eucalyptus globulus subsp. maidenii, along with ten known analogues (4-13). Their chemical structures were determined by various spectral data and electronic circular dichroism calculations. Eumaidial A (1) is the first β-caryophyllene-based formyl phloroglucinol meroterpenoids from the genus Eucalyptus. Compounds 1-4 and 10 exhibited ATP-citrate lyase inhibitory activities, and compounds 2 and 3 suppressed the hepatocyte lipogen...
Source: Fitoterapia - January 6, 2024 Category: Biochemistry Authors: Zhu Hu Yi-Nan Liu Mei-Hua Yu Ai-Jun Hou Jing-Ya Li Ying-Xia Li Chun Lei Source Type: research
