Secondary metabolites from Scindapsus officinalis (Roxb.) Schott. with in vitro antidiabetic activities

Fitoterapia. 2024 Mar;173:105822. doi: 10.1016/j.fitote.2024.105822. Epub 2024 Jan 13.ABSTRACTOne new phenolic cyclobutantetraol ester united chromone glycoside (1), one new amide (2), and three new phenyl ethanol glycosides (3-5) were obtained from the water extract of Scindapsus officinalis (Roxb.) Schott, in which compound 1 was the first reported structure incorporating the phenolic cyclobutantetraol ester and chromone via the glucose phenolic metabolites in nature. Structures of the isolated compounds, including absolute configurations, were elucidated according to the analysis of HRESIMS, NMR, ECD and BLYP/6-31G* geometry optimization calculations of 13C NMR data. All isolates (1-5) were evaluated for the antidiabetic activity by the insulin resistance (IR) model and anti-inflammatory activity against NO production in vitro. Compounds 1-3 showed strong antidiabetic activities, greatly promoting the glucose consumption in the insulin resistance HepG2 cells compared with the model group, however, 1-5 showed weak anti-inflammatory activities.PMID:38224899 | DOI:10.1016/j.fitote.2024.105822

Source: Fitoterapia - January 15, 2024 Category: Biochemistry Authors: Lei Zhao Yan Wang Zhenqiang Wang Tong Niu Jinqian Yu Tao Yue Source Type: research