Toonanoronoids A-E, five new limonoids from Toona ciliate var. yunnanensis

Fitoterapia. 2024 Mar 31:105938. doi: 10.1016/j.fitote.2024.105938. Online ahead of print.ABSTRACTFive new B-seco-limonoids, namely toonanoronoids A-E (1-5), in conjunction with three previously reported compounds, were isolated from the EtOAc extract of the twigs and leaves of Toona ciliata var. yunnanensis. Their structures were elucidated through comprehensive spectroscopic and X-ray crystallographic analysis. The cytotoxic activities of new compounds against five human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) were screened, Compounds 4 and 5 exerted inhibition toward two tumor cell lines (HL-60, SW-480) with IC50 values between 1.7 and 5.9 μM.PMID:38565379 | DOI:10.1016/j.fitote.2024.105938

Source: Fitoterapia - April 2, 2024 Category: Biochemistry Authors: Wei-Hua Wang Wei Yang Jin-Run Dong Fa-Zhong Yang Xiao-Tao Chen Si-Da Xie Xiao-Qin Yang Ping Zhao Guo-Lei Zhu Source Type: research