Polyacetylenes from Saposhnikovia divaricata and their anticancer activity

Fitoterapia. 2024 Feb 29:105876. doi: 10.1016/j.fitote.2024.105876. Online ahead of print.ABSTRACTNine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC50 value of 11.66 μM against HEPG2.PMID:38431027 | DOI:10.1016/j.fitote.2024.105876
Source: Fitoterapia - Category: Biochemistry Authors: Source Type: research