Dauferulins A-L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities

Fitoterapia. 2024 Feb 28;174:105877. doi: 10.1016/j.fitote.2024.105877. Online ahead of print.ABSTRACTPhytochemical study on the roots of a medicinal plant Ferula communis L. (Apiaceae) resulted in the isolation of 20 sesquiterpenes including 12 previously undescribed compounds, dauferulins A-L (1-12). The detailed spectroscopic analysis revealed 1-12 to be daucane-type sesquiterpenes with a p-methoxybenzoyloxy group at C-6. The absolute configurations of 1-12 were deduced by analysis of the ECD spectra. Dauferulins A-L (1-12), known sesquiterpenes (13-20), and analogues (14a-14l) derived from 6-O-p-methoxybenzoyl-10α-angeloyloxy-jeaschkeanadiol (14) were evaluated for their effects on AMPK phosphorylation in human hepatoma HepG2 cells as well as inhibitory activities against erastin-induced ferroptosis on human hepatoma Hep3B cells and IL-1β production from LPS-treated murine microglial cells.PMID:38417680 | DOI:10.1016/j.fitote.2024.105877

Source: Fitoterapia - February 28, 2024 Category: Biochemistry Authors: Yuki Yoshino Masaki Imanishi Licht Miyamoto Daisuke Tsuji Reiko Akagi Koichiro Tsuchiya Yoshiki Kashiwada Naonobu Tanaka Source Type: research