European Journal of Cancer Prevention 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial
We report here an exploratory analysis in which serum IGF-I, IGF-II, IGF binding protein (BP)-2 and IGFBP-3 were measured at baseline and 6 months of postintervention. A total of 133 men were randomized (34% of eligible men approached) and 130 had follow-up IGF peptides (98%). In intention-to-treat analyses, there was only weak evidence that lycopene or green tea influenced some aspects of serum IGF-I, IGF-II, IGFBP-2 or IGFBP-3. In men randomized to lycopene supplements, IGFBP-2 was nonsignificantly (50.9 ng/ml; 95% confidence interval: −51.2–152.9, P = 0.3) higher in comparison to placebo, whereas in men randomized t...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Paper Source Type: research
Preventing physician distress: burnout syndrome, a sneaky disease
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research
Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?
Novel pharmacological therapies are in development for cancer, ranging from conventional chemotherapeutic drugs to molecular targeted drugs, antibody-based drugs, and immune checkpoint inhibitors, which are developed using new technologies. However, the increasing cost of new drug development is increasing the costs of national healthcare and putting pressure on government finances worldwide. Under these circumstances, drug repositioning (i.e. discovering novel effects of existing drugs, thereby allowing their use to treat other diseases) has become a major focus because of reliability and cost reduction. It is becoming in...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Review Article: Lifestyle Source Type: research
The association between birth order and childhood brain tumors: a systematic review and meta-analysis
The incidence of childhood brain tumors (CBT) has increased worldwide, likely resulting from the improvements of early diagnostics. We conducted a systematic review and meta-analysis to clarify the association between birth order and CBT. We followed established guidelines to systematically search Ovid Medline, PubMed, and the Cochrane Library for English language studies, published before March 2018. Quality assessment was performed using the Newcastle–Ottawa Scale. Meta-analysis provided pooled risk estimates and their 95% confidence intervals (CIs) for birth order and CBT. We identified 16 case–control studies with ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Pediatric Cancer Source Type: research
Increasing melanoma incidence in the elderly in North-East Hungary: is this a more serious problem than we thought?
There is a great need for efficient and cost-effective melanoma screening, but this is not yet solved. Epidemiological studies on trends in melanoma incidence by tumour thickness, anatomical site and demographical data can help to improve public health efforts regarding earlier melanoma diagnosis. We aimed to study the trends in the incidence and characteristics of patients and their melanoma in North-East Hungary from 2000 to 2014. Data were obtained from a university hospital-based registry. A total of 1509 cutaneous invasive melanomas of 1464 patients were included in the study. A moderate but significant increase in in...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Skin Cancer Source Type: research
Integration rates of human papilloma virus genome in a molecular survey on cervical specimens among Iranian patients
In this study, we aim to investigate HPV infection in different cytological and pathological stages by different molecular methods, and then the viral genome integration of HPV-16 and -18 is determined by a specific real-time PCR method. The study included women who underwent liquid-based cytology. HPV PCR was conducted by MY09/11 universal primers, HPV genotyping was performed by INNO-LiPA HPV genotyping assay, and the viral genome status was defined by two real-time PCR assays. The statistics were calculated by SPSS v.22 software. In 1668 women included in the study with mean age±std. deviation of 35.6±0.7, HPV was det...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research
Immigration, screening, and cervical cancer incidence: an application of Age–Period–Cohort analysis
Cervical cancer (CC) control is based on the implementation of effective screening programs. In the coming years, human papilloma virus vaccination coverage will contribute considerably toward cancer prevention. In Italy, where an organized screening program has been implemented, immigration from low/middle-income countries with a high prevalence of human papilloma virus infections has increased steadily over the last decades. To assess the impact of screening efforts in counteracting background changes, we analyzed the incidence trends of cervical intraepithelial neoplasia grade 3 carcinomas in situ (CIS) and invasive CC ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research
Polymorphisms in DNA repair genes in lung cancer patients living in a coal-mining region
Air pollutants and ionizing radiation are well-known carcinogens involved in the pathogenesis of lung cancer, and residents of coal-mining regions are exposed routinely to these agents. Polymorphisms in DNA repair genes may be associated with an increased risk of malignant transformation. We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Lung Cancer Source Type: research
Awareness of breast cancer incidence and risk factors among healthy women in Germany: an update after 10 years
This study investigated changes in women’s risk factor awareness between 2004 and 2016. Results from a 2004 survey of 2107 healthy women were compared with new data obtained using the same questionnaire in 2016, with 866 participants indicating their knowledge and perceptions regarding breast cancer incidence, risk factors, risk perceptions, and levels of concern. Logistic regression models assessed the influence of time point (2004 vs. 2016) on correct recognition of risk factors such as age at first childbirth, childlessness, lack of breastfeeding, hormone replacement therapy (HRT), and family history. Regression model...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research
Systematic analysis of breast atypical hyperplasia-associated hub genes and pathways based on text mining
The purpose of this study was to describe breast atypical hyperplasia (BAH)-related gene expression and to systematically analyze the functions, pathways, and networks of BAH-related hub genes. On the basis of natural language processing, gene data for BAH were extracted from the PubMed database using text mining. The enriched Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways were obtained using DAVID (http://david.abcc.ncifcrf.gov/). A protein–protein interaction network was constructed using the STRING database. Hub genes were identified as genes that interact with at least 10 other genes within ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research
Lifestyle behaviours and health measures of women at increased risk of breast cancer taking chemoprevention
Women at increased breast cancer (BC) risk are eligible for chemoprevention. Healthy lifestyles are potentially important for these women to improve efficacy and minimise side effects of chemoprevention and reduce the risk of BC and other lifestyle-related conditions. We investigated whether women taking chemoprevention adhere to healthy lifestyle recommendations, how their lifestyle risk factors and health measures compare to women in the general population, and whether these change whilst taking chemoprevention. Lifestyle risk factors and health measures in 136 premenopausal women taking tamoxifen for prevention of BC (T...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research
Factors associated with locoregional and metastatic breast cancer at diagnosis in a Southern Portuguese registry in the period 2005–2012
Breast cancer (BC) is the most frequent malignancy in Portuguese women, and more than half of the registered cases live in the south of the country. The main of this study was to characterize patients with locoregional and metastatic incident BC living in the Southern Portuguese and Madeira regions in 2005–2012 according to demographic, clinical and contextual characteristics. Additionally it aimns to find the associations and relative influences of these factors with locoregional or metastatic disease at diagnosis. After a descriptive approach, binary logistic regression models were used to estimate factors related to t...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research
Topical application of a dual PI3K/mTOR inhibitor prevents anal carcinogenesis in a human papillomavirus mouse model of anal cancer
In this study, we investigate the effect of the local, topical application of a BEZ235 on tumor-free survival, histopathology, PI3K/mTOR, and autophagy. The rationale for investigating a topical formulation is the localized nature of anal dysplasia/cancer and the goal for creating a clinically translatable formulation to decrease anal carcinogenesis. In this study, HPV transgenic mice were given no treatment, topical BEZ235, topical 7,12 dimethylbenz[a]anthracene (DMBA) (carcinogen), or both topical DMBA + BEZ235. Mice were assessed for tumor development and treatment-related toxicities. Tissue was evaluated for histology,...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research
Supplementation of p-coumaric acid exhibits chemopreventive effect via induction of Nrf2 in a short-term preclinical model of colon cancer
Suppression of colorectal cancer by means of chemoprevention is gaining great attention owing to promising outcomes with less adverse effects in preclinical and clinical trials. The present study aims to explore the mechanism of chemoprevention by p-coumaric acid (p-CA) in a short-term preclinical model of colon cancer. 1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2 and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation. Apoptosis induction ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research
A colorectal cancer diet quality index is inversely associated with colorectal cancer in the Malmö diet and cancer study
The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. The aim of the present study was to examine the association between an a priori constructed dietary index and incident CRC and between intake of processed meat, fiber, and dairy products and CRC. In the Malmö Diet and Cancer study cohort, 923 cases of CRC were identified, during 502 136 person-years of ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research
