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Association of poor mental health and skin cancer development: a cross-sectional study of adults in the United States
The relationship between mental health and skin cancer is poorly characterized. This cross-sectional study used 2016 Behavioral Risk Factor Surveillance System data to evaluate the association between mental health problems and skin cancer development. Multivariate logistic regression analyses were performed to calculate adjusted odds ratio (aOR) for skin cancer development by mental health problems, adjusting for potentially confounding demographic and lifestyle factors. Odds of skin cancer were significantly higher in those with mental health problems problems [aOR 1.24, 95% confidence interval (CI) 1.17–1.31, P  (So...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Skin cancer Source Type: research

Constitutional variants in POT1, TERF2IP, and ACD genes in patients with melanoma in the Polish population
Evaluation of the prevalence of POT1, ACD, and TERF2IP mutations among Polish melanoma patients. A cohort of 60 patients from melanoma-prone families, 1500 unselected cases and 1500 controls were genotyped. Methodology included Sanger sequencing, in-silico software predilection, and TaqMan assays. We identified three nonsynonymous variants: POT1 c.903 G>T; TERF2IP c.970 A>G; and ACD c.1544 T>C and a splice site variant ACD c.645 G>A. The c.903 G>T was predicted to be pathogenic according to PolyPhen-2, benign according to Mutation Taster, PROVEAN, AGVGD, and SIFT. The c.645 G>A was defined as disease caused by Mutation Tas...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Skin cancer Source Type: research

Effectiveness of the cervical cancer prevention programme: a case-control mortality audit in Lithuania
In conclusion, participation in screening has been effective in reducing cervical cancer mortality in Lithuania. The study shows poor screening attendance, emphasizing the importance of greater efforts at the national level to improve the effectiveness of the screening. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Gynecological cancer Source Type: research

Cesarean delivery may be protective against neoplasms of the uterine cervix in women of childbearing age
Parity has been reported as a risk factor for cervical cancer. However, no study has investigated the risk of neoplasms of the uterine cervix according to the delivery type. We carried out a retrospective cohort study using nationwide data from the Korean Health Insurance Review and Assessment Database to investigate whether cesarean delivery might be associated with less development of neoplasms of the uterine cervix than a vaginal delivery in women of childbearing age. Women aged 20–44 years, who had undergone vaginal or cesarean deliveries in 2009 were included as subjects. Two individual datasets for carcinoma in s...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Gynecological cancer Source Type: research

Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China
This study aimed to investigate the associations between total and subclasses of flavonoid and breast cancer risk among Chinese population. This case-control study recruited 1522 eligible breast cancer cases and 1547 frequency-matched control subjects from June 2007 to July 2018 in Guangdong, China. Dietary intake was obtained by face-to-face interview using a validated food frequency questionnaire. Odds ratios and 95% confidence intervals were calculated by multivariable logistic regression models. After adjusting for potential confounders, inverse associations were observed between total flavonoids, anthocyanidins, proan...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Breast cancer Source Type: research

Outcomes and cost of lung cancer patients treated surgically or medically in Catalunya: cost–benefit implications for lung cancer screening programs
Lung cancer screening programs with computed tomography of the chest reduce mortality by more than 20%. Yet, they have not been implemented widely because of logistic and cost implications. Here, we sought to: (1) use real-life data to compare the outcomes and cost of lung cancer patients with treated medically or surgically in our region and (2) from this data, estimate the cost–benefit ratio of a lung cancer screening program (CRIBAR) soon to be deployed in our region (Catalunya, Spain). We accessed the Catalan Health Surveillance System (CHSS) and analysed data of all patients with a first diagnosis of lung cancer bet...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

HASPIN kinase inhibitor CHR-6494 suppresses intestinal polyp development, cachexia, and hypogonadism in Apcmin/+ mice
In this study, we examined whether HASPIN inhibitor CHR-6494 suppresses cancer progression in ApcMin/+ mice, a familial colon tumor disease model. Mice were treated by intraperitoneal injection of CHR-6494 for 50 days. Following the treatment period, intestinal polyps were counted and testosterone and spermatogenesis levels were observed. Intraperitoneal administration of CHR-6494 significantly inhibited intestinal polyp development and recovered body weight in ApcMin/+ mice. Although spermatogenesis was inhibited with increasing age in ApcMin/+ mice, CHR-6494 significantly improved blood testosterone levels and spermatoge...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Problem-solving in technology-rich environments and cancer screening in later life
This study examined the association between problem-solving skills in the technology-rich environment and cancer screening in later life. Using 2012/2014 Program for International Assessment of Adult Competencies data, binary logistic regressions with survey weights were used to estimate the association between problem-solving skills in the technology-rich environment and four cancer screening behaviors among the corresponding target populations aged between 45 and 74 years old (n = 1374 for cervical screening; n = 1373 for breast screening; n = 1166 for prostate screening; n = 2563 for colon screening). Results showed tha...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Paper: Sctreening Source Type: research

A systematic review on the mechanisms of malignant transformation of oral submucous fibrosis
Oral submucous fibrosis (OSMF), the most commonly encountered potentially premalignant oral epithelial lesion, is a chronic disorder associated with areca nut chewing. It has a relatively high potential for malignant transformation resulting into oral squamous cell carcinoma (OSCC), the most common oral malignancy with high mortality rate. Paymaster first described the malignant potential of OSMF in 1956, the rate of which had been estimated to be 7–13%. The pathogenesis of OSMF in itself is quite varied, and hence, its transformation to malignancy is also open to many varied mechanisms. The early diagnosis and sequentia...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Short Paper: Head & Neck cancer Source Type: research

Are anti-inflammatory foods associated with a protective effect for cutaneous melanoma?
In conclusion, the only anti-inflammatory food item that was consistently associated with a protective effect for cutaneous was coffee in particular caffeinated coffee. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Short Paper: Skin cancer Source Type: research

National organization of uterine cervical cancer screening and social inequality in France
Some of the inequality in uterine cervical cancer (UCC) screening uptake are due to the socioeconomic deprivation of women. A national organized screening programme has proven to be effective in increasing the uptake, but may increase socioeconomic inequality. Therefore, we compared inequality in uptake of UCC screening between two French departments, one of which is experimenting an organized screening programme. We used reimbursement data from the main French health insurance scheme to compare screening rates in the municipalities of the two departments over a three-year period. The experimental department had higher scr...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Gynecological cancer Source Type: research

Trends in prevalence in human papillomavirus types and their association with cervical dysplasia: an analysis on 15 138 women over 20 years
To investigate trends in prevalence of various human papillomavirus types in order to assess the unmet clinical needs for women affected by human papillomavirus-related disease. Data of consecutive 15 138 patients undergoing human papillomavirus DNA testing from 1998 to 2018 were retrospectively identified. Human papillomavirus types were classified at high-risk according to the classification of the International Agency for Research on Cancer. The International Agency for Research on Cancer included seven human papillomavirus types covered by nine-valent vaccine and five not yet covered by any available vaccines. Overall,...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Gynecological cancer Source Type: research

Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study
In conclusion, these results suggest that the gradual implementation of low-dose computed tomography lung screening program could lead to a remarkable decrease in lung cancer mortality and a remarkable stage shift in the trend over time in this hospital-based cohort. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Lung cancer Source Type: research

Effect of vitamin D receptor polymorphisms on plasma oxidative stress and apoptotic biomarkers among breast cancer survivors supplemented vitamin D3
We investigated whether plasma oxidative stress and apoptotic biomarkers were associated with the VDR polymorphisms in breast cancer survivors supplemented with vitamin D3. Two hundred fourteen breast cancer survivors received 4000 IU of vitamin D3 daily for 12 weeks. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was associated with the selected VDR single nucleotide polymorphisms executing by ‘association’ function in the R package ‘SNPassoc’. Linear regression analyses adjusted for age, BMI and on-study plasma 25(OH)D changes indicated that the aa gen...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Breast cancer Source Type: research

Age at last birth and risk of developing breast cancer: a meta-analysis
Conclusion This meta-analysis suggested that ALB was positively associated with the risk of breast cancer. The risk of developing breast cancer increased gradually with the ALB for women. Our findings may have implications for family planning. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Breast cancer Source Type: research