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Duodenal neoplasms of gastric phenotype: reports of two cases and a brief review of literature
Duodenal neoplasms of gastric phenotype are uncommon epithelial neoplasms. Pyloric gland adenomas should be recognized as neoplasms with risk for transformation into invasive adenocarcinoma (Choi et al. 2018). Here we report the case histories of two male patients, who presented with duodenal polypoid lesion. Endoscopic polypectomy and endoscopic submucosal dissection were carried out, respectively. Histopathologically, both polyps showed features of neoplasms of gastric phenotype. The clinical and endoscopic features, pathologic features, immunophenotype, molecular pathogenesis, clinical management and prognosis of the tw...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

Prophylactic effects of secretion metabolites of dairy lactobacilli through downregulation of ErbB-2 and ErbB-3 genes on colon cancer cells
Colon cancer is one of the most prevalent cancers, and intestinal microbial community plays a pivotal role in colorectal tumor genesis. Probiotics as live microorganisms may be able to exert an anticancer effect in colon cancer. The aim of this study was to isolate and identify Lactobacillus spp. from traditional dairy products with probiotic properties and to investigate their anticancer effects through ErbB-2 and ErbB-3 gene expression in colon cancer cells. The isolated lactobacilli from yogurt and cheese samples were molecularly identified by blasting of 16–23s rDNA region PCR sequenced products. The probiotic proper...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

Phytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions
This review summarizes the current evidence on the potential role of phytol, a microbial metabolite of chlorophyl A, and its metabolites, phytanic and pristanic acids, in carcinogenesis. Primary food sources in Western diets are the nut skin for phytol and lipids in dairy, beef and fish for its metabolites. Phytol and its metabolites gained interest as dietary compounds for cancer prevention because, as natural ligands of peroxisome proliferator-activated receptor-α and -γ and retinoid X receptor, phytol and its metabolites have provided some evidence in cell culture studies and limited evidence in animal models of anti-...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Review Article: Carcinogenesis Source Type: research

Evaluation of recent evidence on the solubility of beryllium compounds and cancer risk
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Opinion: Carcinogenesis Source Type: research

Fertility drugs and cutaneous melanoma risk: a French prospective cohort study
Cutaneous melanoma has been suspected to be influenced by female sex hormones. A review of the literature in 2018 indicated that fertility drug (FD) use was associated with increased melanoma risk among parous women only. However, most studies so far were based on a retrospective design and the current evidence is unclear. We sought to prospectively investigate the associations between FD use and melanoma risk in women. E3N is a prospective cohort of 98 995 French women aged 40–65 years at inclusion in 1990. Information on use of FDs, including duration and time of administration, was assessed through self-administered q...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Short Paper: Skin Cancer Source Type: research

Exploring the long noncoding RNAs-based biomarkers and pathogenesis of malignant transformation from dysplasia to oral squamous cell carcinoma by bioinformatics method
Long noncoding RNAs (lncRNAs) play an important role in many biological processes and carcinogenesis. We aimed to explore lncRNA-based pathogenesis, diagnostic biomarkers, and predictive factors of malignant transformation from dysplasia to oral squamous cell carcinoma (OSCC). Microarray data of GSE30784 consisting of 167 OSCC, 17 dysplasia, and 45 normal oral tissues were downloaded from the GEO database. The differentially expressed genes (DEGs) and lncRNAs between the three samples were identified using R, followed by lncRNA-mRNA coexpression and coregulation network analysis for the prediction of lncRNA target genes. G...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Head & Neck Cancer Source Type: research

Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis
Conclusions: Circ_PTN acted as a sponge of miR-122 and upregulated miR-122 target SOX6, thus promoting carcinogenesis of glioma cells. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Nervous System Cancer Source Type: research

A roadmap for a comprehensive control of cervical cancer in Poland: integration of available solutions into current practice in primary and secondary prevention
In Poland, cervical cancer incidence and mortality still remain considerably higher than in Western European countries or North America. Recent data indicate decreasing trends in women younger than 60 years and stable trends in older women. In this article, we identified obstacles in primary and secondary prevention of cervical cancer in Poland. We analysed local legislation, management structure and organization of cervical cancer prevention in Poland and reviewed solutions available and implemented in other European countries. The main weaknesses include: (i) very low coverage of organized screening; concurrent unregiste...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Review Article: Nervous System Cancer Source Type: research

Human papillomavirus vaccination in immigrants and descendants of immigrants in Denmark
Conclusion HPV vaccination uptake varied by country and region. Most immigrants had lower uptake than native Danes, and in most groups, this was not fully explained by socioeconomic differences. Patterns in descendants were mixed. Interventions to increase uptake should be tailored to specific groups of immigrants/descendants. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Prevalence of positive screening test results and agreement between cytology and human papillomavirus testing in primary cervical cancer screening in North-Western Romania
Using data from a pilot study conducted in North-Western Romania, we aimed to estimate the prevalence of abnormal cytology and positive high-risk human papillomavirus (hr-HPV) test results in an ethnically diverse screening population and to assess the agreement between cytology and hr-HPV testing to evaluate the feasibility of integrating the latter as a primary test in the national cervical cancer screening program. The cross-sectional pilot study included Roma women, other ethnic minorities, and women in rural remote areas. Samples were taken for liquid-based cytology and hr-HPV testing (Hybrid Capture 2 DNA test) by a ...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Is leisure time sitting associated with mortality rates among men diagnosed with localized prostate cancer?
Conclusions No significant association between leisure time sitting and mortality rates among men diagnosed with localized prostate cancer was seen. This study does not support an association between leisure time sitting per se; however, being physically active may have beneficial effects on survival among men diagnosed with localized prostate cancer. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Urological Cancer Source Type: research

Colorectal cancer risk factors in asymptomatic Chilean population: a survey of international collaboration between Japan and Chile
In Chile, the mortality from colorectal cancer has been on the rise. A national screening program based on a fecal immunochemical test was started in 2012 as an international collaboration with Japan. This case-control study was designed to identify the risk factors for colorectal cancer, with a goal of increasing the participation rate for colorectal cancer screening. In accordance with the Strengthening the Reporting of Observational Studies in Epidemiology guidelines, we conducted a case-control study from 2012 to 2017; 23 845 asymptomatic participants were enrolled in the study. Participants who were fecal immunochemic...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Do socioeconomic factors play a role in nonadherence to follow-up colonoscopy after a positive faecal immunochemical test in the Flemish colorectal cancer screening programme?
Conclusion Adherence to follow-up colonoscopy after a positive FIT differs according to sociodemographic variables. Additional research is needed to explore reasons for nonadherence to colonoscopy and tackle barriers by exploring interventions to increase colonoscopy follow-up adherence after a positive FIT in the Flemish colorectal cancer screening programme. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Fluid intake and clinicopathological characteristics of bladder cancer: the West Midlands Bladder Cancer Prognosis Programme
Objective Between 10 and 20% of bladder cancer patients who are diagnosed with nonmuscle-invasive bladder cancer will progress to muscle-invasive disease. Risk of progression depends on several factors at diagnosis including age, tumour stage, grade, size and number, and the presence or absence of carcinoma in situ. Fluid intake may be related to these factors. Methods Data of 1123 participants from the West Midlands Bladder Cancer Prognosis Programme were used. Data collection was via a semistructured questionnaire, and case report forms were used to collect clinicopathological data. Fluid intake was measured for six...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Exploring the potential carcinogenic role of arsenic in gallbladder cancer
Gallbladder cancer (GBC) is an aggressive malignancy, associated with dismal outcomes. Although several risk factors including age, sex, and gallstones have been postulated, epidemiologic determinants of the disease remain largely uncovered. Moreover, the implication of environmental toxicants as possible risk factors is increasingly suspected. Arsenic (As), an established human carcinogen, is a natural contaminant of groundwater and has a geographic distribution similar to GBC incidence. This, combined with As metabolites being partially excreted in bile, raised the hypothesis that As may represent a carcinogenic hazard f...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research