European Journal of Cancer Prevention 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Negative correlation of high serum bilirubin with cancer development in adults without hepatobiliary disease
This study aimed to evaluate whether serum bilirubin levels were associated with cancer development in a population without liver disease.
Methods
A retrospective longitudinal study was performed by including participants who underwent a health checkup at St. Luke’s International Hospital in Tokyo from 2005 to 2019. We excluded those with liver diseases or prior history of cancer at baseline. All participants were classified into four groups according to their total bilirubin (T-Bil) level: very low ( (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research
Association between plasma prostaglandin E2 level and colorectal cancer
This study was designed as a case-control study including 60 CRC patients and 120 cancer-free controls. A sensitive empirical method, precolumn derivatization HPLC, was used to determine plasma PGE2 levels. The TaqMan SNP Genotyping Assay was used for the genotyping of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms. Multivariate logistic regression analysis suggested that 1 log10(PGE2) increase would result in a 3.64-fold increase in the risk of CRC. Moreover, subjects with log10(PGE2) level in the 75th percentile had a significantly higher risk of CRC than those with log10(PGE2) levels in the 25th percentile ...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research
KIT and PDGFRa mutational patterns in Sardinian patients with gastrointestinal stromal tumors
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of the gastrointestinal tract. We provide in the present article the molecular characterization of a series of primary GISTs in a cohort of Sardinian patients (Italy), with the aim to describe the patterns of KIT and PDGFRa mutations and the corresponding clinical features. Ninety-nine Sardinian patients with histologically-proven diagnosis of GIST were included in the study. Medical records and pathology reports were used to assess the demographic and clinical features of the patients and the disease at the time of the diagnosis. Formalin-fixe...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research
Dietary nutrient patterns and the risk of colorectal cancer and colorectal adenomas: a case-control study
Although the association between food patterns and the risk of colorectal cancer (CRC) and colorectal adenomas (CRA) has been explored previously, a distinct paucity of studies has evaluated the association of nutrient pattern and the risk of CRC and CRA as precursors of CRC. Thus, the purpose of this case-control study was to investigate nutrient patterns and their relationship with CRC and CRA in Iran. Two hundred forty hospital control, 129 newly diagnosed CRC and 130 newly diagnosed CRA patients were asked about their dietary intakes using validated questionnaires. To define the major nutrient patterns, principal compo...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research
Dietary total antioxidant capacity and colorectal cancer and colorectal adenomatous polyps: a case-control study
Colorectal cancer (CRC) is the third most common and the third most deadly cancer worldwide. In Iran, CRC is the third and fifth most common cancer in females and males, respectively. Chronic oxidative stress has been implicated in the development of CRC and its precursor, colorectal adenomatous polyps (CAP). While there were a few studies that suggested a favorable role of individuals antioxidants on the CRC risk, the total antioxidant capacity (TAC) of diet has been less investigated. Consequently, the aim of this study is to investigate the association of TAC with the odds of CRC and CAP. This is a case-control study. T...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research
Tinospora cordifolia and arabinogalactan exert chemopreventive action during benzo(a)pyrene-induced pulmonary carcinogenesis: studies on ultrastructural, molecular, and biochemical alterations
The aim of the present study was to unveil the chemopreventive potentials of aqueous Tinospora cordifolia stem extract and its active component viz. Arabinogalactan against Benzo(a)pyrene-induced pulmonary carcinogenesis. Animals were divided into six groups: (I) Control, (II) aqueous Tinospora cordifolia (200 mg/kg b.wt, p.o.), (III) arabinogalactan (7.5 mg/kg b.wt, p.o.), (IV) benzo(a)pyrene (50 mg/kg b.wt, i.p.) at second and fourth week of study, (V) benzo(a)pyrene + aqueous Tinospora cordifolia, and (VI) benzo(a)pyrene + arabinogalactan. The benzo(a)pyrene treatment resulted in severe alterations in the cellular arran...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Lung cancer Source Type: research
Comparative analysis of three data mining techniques in diagnosis of lung cancer
There is a lot of abnormal information in the development of lung cancer, and how to extract useful knowledge is urgent from massive information. Data mining technology has become a popular tool for medical classification and prediction. However, each technology has its advantage and disadvantage, and several data mining methods will be applied to conduct the in-depth analysis step by step. And the prediction results of different models are compared. A total of 180 lung cancer patients and 243 lung benign individuals were collected from the First Affiliated Hospital of Zhengzhou University from October 2014 to March 2016, ...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Lung cancer Source Type: research
Cancer mortality and predictions for 2020 in selected Australasian countries, Russia and Ukraine
Conclusion
Predicted cancer rates were lower than in the European Union and the USA, even though falls started later and were less marked. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Epidemiology Source Type: research
High mobility group A protein-2 as a tumor cancer diagnostic and prognostic marker: a systematic review and meta-analysis
High mobility group A protein-2 (HMGA2) is an architectural transcription factor that binds to the A/T-rich DNA minor groove and is responsible for regulating transcriptional activity of multiple genes indirectly through chromatin change and assembling enhanceosome. HMGA2 is overexpressed in multiple tumor types, suggesting its involvement in cancer initiation and progression, thus, making it an ideal candidate for cancer diagnostic and prognostic. We performed a systematic review to examine the role of HMGA2 as a universal tumor cancer diagnostic and prognostic marker. We used Reporting Recommendations for Tumor Marker Pr...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Carcinogenesis Source Type: research
SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer
Cancer is an unpleasant, painful disease. It is one of the most devastating diseases worldwide diminishing many lives. Many genetic and epigenetic changes occur before cancer develops. Mutation in SETD2 gene is one such example. RNA splicing, DNA damage repair, DNA methylation and histone methylation are some of the biological processes mediated by SETD2. SETD2 (histone H3 lysine 36 methyltransferase) is a frequently mutated gene in different types of cancer. Loss of SETD2 is associated with worse prognosis and aggressive phenotypes. Histone modification is one of the epigenetic regulation having a significant effect on ge...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Carcinogenesis Source Type: research
New information flows for cancer registries: testing the use of laboratory data in the province of Reggio Emilia, Italy
Conclusions
Although the laboratory information system’s contribution to the completeness of Cancer Registry incident cases was modest, it is useful to add laboratory data to routine cancer registry information flows due to the increasing use of molecular characterisation and to the phenomenon of dehospitalisation. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Cancer Registries Source Type: research
The quality of cancer registries data has to become ‘liquid’
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Cancer Registries Source Type: research
Infections and the development of childhood acute lymphoblastic leukemia: a population-based study
An infectious trigger for childhood acute lymphoblastic leukemia is hypothesized and we assessed the association between the rate, type, and critical exposure period for infections and the development of acute lymphoblastic leukemia. We conducted a matched case-control study using administrative databases to evaluate the association between the rate of infections and childhood acute lymphoblastic leukemia diagnosed between the ages of 2–14 years from Ontario, Canada and we used a validated approach to measure infections. In 1600 cases of acute lymphoblastic leukemia, and 16 000 matched cancer-free controls aged 2–14 ye...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Hematological cancers Source Type: research
Association between variant alleles of major histocompatibility complex class II regulatory genes and nasopharyngeal carcinoma susceptibility
Major histocompatibility complex (MHC) class II regulatory genes play a paramount role in immune response that can exert a predominant influence on clinical outcome of Epstein–Barr virus infection consistently assumed as the main pathogenetic factor for nasopharyngeal carcinoma. To elucidate the relationship between allelic variants of MHC class II regulatory genes and susceptibility to nasopharyngeal carcinoma, a total of 28 polymorphic loci at MHC class II regulatory genes, involving CIITA, CREB1, RFX family genes (RFX5, RFXAP, and RFXANK), and NFY family genes (NFYA, NFYB, and NFYC), were genotyped by multiplex SNaPsh...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Head & Neck cancers Source Type: research
Epstein–Barr virus molecular epidemiology and variants identification in head and neck squamous cell carcinoma
Epstein-Barr virus (EBV) is known as one of the most widespread oncogenic viruses. Head and neck squamous cell carcinoma (HNSCC) is triggered by various risk factors. The aim of the present study was to determine the EBV infection rate, genotyping and variants frequency in HNSCC patients. In this cross-sectional study, 156 patients with HNSCC were enrolled. Formalin fixed paraffin embedded (FFPE) tissue samples were selected from hospitals affiliated to Iran University of Medical Sciences, Tehran, Iran. The EBV EBNA-3C, EBNA-1 and LMP-1 genes were amplified by PCR and then analyzed and confirmed by nucleotide sequencing. C...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Head & Neck cancers Source Type: research
