Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial
We report here an exploratory analysis in which serum IGF-I, IGF-II, IGF binding protein (BP)-2 and IGFBP-3 were measured at baseline and 6 months of postintervention. A total of 133 men were randomized (34% of eligible men approached) and 130 had follow-up IGF peptides (98%). In intention-to-treat analyses, there was only weak evidence that lycopene or green tea influenced some aspects of serum IGF-I, IGF-II, IGFBP-2 or IGFBP-3. In men randomized to lycopene supplements, IGFBP-2 was nonsignificantly (50.9 ng/ml; 95% confidence interval: −51.2–152.9, P = 0.3) higher in comparison to placebo, whereas in men rand...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Paper Source Type: research

Preventing physician distress: burnout syndrome, a sneaky disease
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?
Novel pharmacological therapies are in development for cancer, ranging from conventional chemotherapeutic drugs to molecular targeted drugs, antibody-based drugs, and immune checkpoint inhibitors, which are developed using new technologies. However, the increasing cost of new drug development is increasing the costs of national healthcare and putting pressure on government finances worldwide. Under these circumstances, drug repositioning (i.e. discovering novel effects of existing drugs, thereby allowing their use to treat other diseases) has become a major focus because of reliability and cost reduction. It is becoming in...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Review Article: Lifestyle Source Type: research

The association between birth order and childhood brain tumors: a systematic review and meta-analysis
The incidence of childhood brain tumors (CBT) has increased worldwide, likely resulting from the improvements of early diagnostics. We conducted a systematic review and meta-analysis to clarify the association between birth order and CBT. We followed established guidelines to systematically search Ovid Medline, PubMed, and the Cochrane Library for English language studies, published before March 2018. Quality assessment was performed using the Newcastle–Ottawa Scale. Meta-analysis provided pooled risk estimates and their 95% confidence intervals (CIs) for birth order and CBT. We identified 16 case–control studi...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Pediatric Cancer Source Type: research

Increasing melanoma incidence in the elderly in North-East Hungary: is this a more serious problem than we thought?
There is a great need for efficient and cost-effective melanoma screening, but this is not yet solved. Epidemiological studies on trends in melanoma incidence by tumour thickness, anatomical site and demographical data can help to improve public health efforts regarding earlier melanoma diagnosis. We aimed to study the trends in the incidence and characteristics of patients and their melanoma in North-East Hungary from 2000 to 2014. Data were obtained from a university hospital-based registry. A total of 1509 cutaneous invasive melanomas of 1464 patients were included in the study. A moderate but significant increase in in...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Skin Cancer Source Type: research

Integration rates of human papilloma virus genome in a molecular survey on cervical specimens among Iranian patients
In this study, we aim to investigate HPV infection in different cytological and pathological stages by different molecular methods, and then the viral genome integration of HPV-16 and -18 is determined by a specific real-time PCR method. The study included women who underwent liquid-based cytology. HPV PCR was conducted by MY09/11 universal primers, HPV genotyping was performed by INNO-LiPA HPV genotyping assay, and the viral genome status was defined by two real-time PCR assays. The statistics were calculated by SPSS v.22 software. In 1668 women included in the study with mean age±std. deviation of 35.6±0.7,...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Immigration, screening, and cervical cancer incidence: an application of Age–Period–Cohort analysis
Cervical cancer (CC) control is based on the implementation of effective screening programs. In the coming years, human papilloma virus vaccination coverage will contribute considerably toward cancer prevention. In Italy, where an organized screening program has been implemented, immigration from low/middle-income countries with a high prevalence of human papilloma virus infections has increased steadily over the last decades. To assess the impact of screening efforts in counteracting background changes, we analyzed the incidence trends of cervical intraepithelial neoplasia grade 3 carcinomas in situ (CIS) and invasive CC ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Polymorphisms in DNA repair genes in lung cancer patients living in a coal-mining region
Air pollutants and ionizing radiation are well-known carcinogens involved in the pathogenesis of lung cancer, and residents of coal-mining regions are exposed routinely to these agents. Polymorphisms in DNA repair genes may be associated with an increased risk of malignant transformation. We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Lung Cancer Source Type: research

Awareness of breast cancer incidence and risk factors among healthy women in Germany: an update after 10 years
This study investigated changes in women’s risk factor awareness between 2004 and 2016. Results from a 2004 survey of 2107 healthy women were compared with new data obtained using the same questionnaire in 2016, with 866 participants indicating their knowledge and perceptions regarding breast cancer incidence, risk factors, risk perceptions, and levels of concern. Logistic regression models assessed the influence of time point (2004 vs. 2016) on correct recognition of risk factors such as age at first childbirth, childlessness, lack of breastfeeding, hormone replacement therapy (HRT), and family history. Regression m...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Systematic analysis of breast atypical hyperplasia-associated hub genes and pathways based on text mining
The purpose of this study was to describe breast atypical hyperplasia (BAH)-related gene expression and to systematically analyze the functions, pathways, and networks of BAH-related hub genes. On the basis of natural language processing, gene data for BAH were extracted from the PubMed database using text mining. The enriched Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways were obtained using DAVID (http://david.abcc.ncifcrf.gov/). A protein–protein interaction network was constructed using the STRING database. Hub genes were identified as genes that interact with at least 10 other genes wit...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Lifestyle behaviours and health measures of women at increased risk of breast cancer taking chemoprevention
Women at increased breast cancer (BC) risk are eligible for chemoprevention. Healthy lifestyles are potentially important for these women to improve efficacy and minimise side effects of chemoprevention and reduce the risk of BC and other lifestyle-related conditions. We investigated whether women taking chemoprevention adhere to healthy lifestyle recommendations, how their lifestyle risk factors and health measures compare to women in the general population, and whether these change whilst taking chemoprevention. Lifestyle risk factors and health measures in 136 premenopausal women taking tamoxifen for prevention of BC (T...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Factors associated with locoregional and metastatic breast cancer at diagnosis in a Southern Portuguese registry in the period 2005–2012
Breast cancer (BC) is the most frequent malignancy in Portuguese women, and more than half of the registered cases live in the south of the country. The main of this study was to characterize patients with locoregional and metastatic incident BC living in the Southern Portuguese and Madeira regions in 2005–2012 according to demographic, clinical and contextual characteristics. Additionally it aimns to find the associations and relative influences of these factors with locoregional or metastatic disease at diagnosis. After a descriptive approach, binary logistic regression models were used to estimate factors related ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Topical application of a dual PI3K/mTOR inhibitor prevents anal carcinogenesis in a human papillomavirus mouse model of anal cancer
In this study, we investigate the effect of the local, topical application of a BEZ235 on tumor-free survival, histopathology, PI3K/mTOR, and autophagy. The rationale for investigating a topical formulation is the localized nature of anal dysplasia/cancer and the goal for creating a clinically translatable formulation to decrease anal carcinogenesis. In this study, HPV transgenic mice were given no treatment, topical BEZ235, topical 7,12 dimethylbenz[a]anthracene (DMBA) (carcinogen), or both topical DMBA + BEZ235. Mice were assessed for tumor development and treatment-related toxicities. Tissue was evaluated for histology,...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Supplementation of p-coumaric acid exhibits chemopreventive effect via induction of Nrf2 in a short-term preclinical model of colon cancer
Suppression of colorectal cancer by means of chemoprevention is gaining great attention owing to promising outcomes with less adverse effects in preclinical and clinical trials. The present study aims to explore the mechanism of chemoprevention by p-coumaric acid (p-CA) in a short-term preclinical model of colon cancer. 1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2 and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation. Apoptosis induction ...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

A colorectal cancer diet quality index is inversely associated with colorectal cancer in the Malmö diet and cancer study
The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. The aim of the present study was to examine the association between an a priori constructed dietary index and incident CRC and between intake of processed meat, fiber, and dairy products and CRC. In the Malmö Diet and Cancer study cohort, 923 cases of CRC were identified, during 502 136 person-years...
Source: European Journal of Cancer Prevention - October 4, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

BRCA test: what is the correct timing for surgery?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Who will benefit from colorectal cancer prevention measures?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Protection of cancer in patients with neurodegenerative diseases
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Response to the author: invitation to cancer screening: putting the car before the horse?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Invitation to cancer screening: putting the car before the horse?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Reply to the letter from Beuy Joob and Viroj Wiwanitkit
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Uptake of breast and cervical cancer screening in four Gulf Cooperation Council countries
In Gulf Cooperation Council States, there is limited information on national levels of mammography and Pap smear screening uptake. The aim of this study is to provide a baseline for national estimates for mammography and Pap smear screening and to explore associations between screening uptake and socioeconomic factors. The nationally representative World Health Survey Plus, implemented in 2008/2009 in Kuwait, Oman, Saudi Arabia and United Arab Emirates (UAE), was used. Uptake of mammography and Pap smear was estimated for each country, followed by the examination of associations between screening and a range of socioeconom...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Screening Source Type: research

Occupational and environmental exposure to polychlorinated biphenyls and risk of non-Hodgkin lymphoma: a systematic review and meta-analysis of epidemiology studies
We carryied out a meta-analysis of studies on exposure to polychlorinated biphenyls (PCBs) and risk of non-Hodgkin lymphoma (NHL). Through a systematic search of the literature, we identified relative risks (RRs) for PCB exposure and NHL risk in 30 populations (10 occupational exposure, seven high environmental exposure, 13 without special exposure). We performed random effects meta-analyses for exposure to all PCBs, specific PCB congeners and risk of all NHL and NHL subtypes. The meta-RR for studies of occupational exposure, high environmental exposure, and no special exposure were 0.94 [95% confidence interval (CI): 0.84...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Lifestyle Source Type: research

Nomogram-based prediction of cervical dysplasia persistence/recurrence
The widespread introduction of screening methods allow to identify cervical dysplasia before having invasive cancer. The risk of developing cervical dysplasia persistence/ recurrence following conization represent a major health issue. Although several studies tried to identify predictors for cervical dysplasia persistence/recurrence, no previous study has been conducted to develop a risk calculator. The current study aimed to identify predictors of cervical dysplasia persistence/recurrence among women undergoing primary conization. We aimed to build nomograms estimating the risk of developing cervical dysplasia recurrence...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Review Article: Gynecological Cancer Source Type: research

The effect of NSAIDs exposure on breast cancer risk in female patients with autoimmune diseases
Both breast cancer and autoimmune diseases (ADs) are predominant in women. NSAIDs are common medications for AD. Evidence on the association between NSAIDs use and breast cancer risk is controversial. We investigated the association between NSAIDs exposure and breast cancer risk in female patients with AD. AD patients older than 18 years of age were enrolled from Taiwan Longitudinal Health Insurance Database 2005. The NSAID users were defined as AD patients who had ever taken NSAIDs for at least 3 months between 2000 and 2009. All individuals were followed from the date of first diagnosis of AD to the end of 2013 to evalua...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Cruciferous vegetable intake and colorectal cancer risk: Japan public health center-based prospective study
We aimed to assess the association between cruciferous vegetable intake and colorectal cancer (CRC) development among Japanese adults aged between 45 and 74 years in the Japan Public Health Center-based Prospective Study. During 1 325 853 person-years of follow-up, 2612 CRC cases were identified. The association of cruciferous vegetable intake with CRC risk was assessed using a Cox proportional hazard regression model to compute hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. No significant association was observed between the highest cruciferous vegetable intake quartile (compar...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Colorectal cancer screening in hospitalized patients: results from the Nationwide Inpatient Sample
This study aims to determine estimates and predictors of inpatient CRC screening during hospitalization in the USA. This nationwide population-based study utilized data from the National Inpatient Sample database from 2005 to 2014 to examine rates of CRC screening among hospitalized patients. There were 6470 inpatient CRC screening nationwide from 129 645 394 inpatient hospitalizations. Multivariable analysis showed that higher rates of inpatient CRC screening were associated with: females compared to males [odds ratio (OR): 0.87; 95% confidence interval (CI): 0.78–0.97]; 50–59 years age group compared to 70&nd...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Gastric cancer: epidemiology, biology, and prevention: a mini review
The objective of this article is to review the epidemiology and biology of gastric cancer risk. This literature review explores the biological, clinical, and environmental factors that influence the rates of this disease and discuss the different intervention methods that may not only increase the awareness of gastric cancer but also increase screening in efforts to reduce the risk of gastric cancer. Helicobacter pylori infection is the primary risk factor for gastric cancer. Additional risk factors include geographical location, age, sex, smoking, socioeconomic status, dietary intake, and genetics. Primary and secondary p...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Review Article: Gastrointestinal Cancer Source Type: research

Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project)
Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case–control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% conf...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model
Multicomponent therapy has gained interest for its potential to synergize and subsequently lower the effective dose of each constituent required to reduce colon cancer risk. We have previously showed that rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk. In the present study, we quantified the dose-dependent synergistic properties of dietary n-3 polyunsaturated fatty acids (PUFA) and curcumin (Cur) to promote targeted apoptotic deletion of damaged colonic Lgr5+ stem cells. For this purpose, both heterogeneous bulk colonocytes and Lgr5+ stem cells were i...
Source: European Journal of Cancer Prevention - September 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Vinegar production and cancer risk
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Folate intake and risk of esophageal cancer
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

The risk for childhood malignancies in the offspring of mothers with previous gestational diabetes mellitus: a population-based cohort study
The hyperglycemic intrauterine environment has been shown to have long-term effects on offspring. We aimed to evaluate its effect on the long-term risk of childhood malignancies. This was a population-based cohort analysis comparing the risk for long-term childhood malignancies (≤18 years) in children born to mothers with and without gestational diabetes mellitus (GDM). Childhood malignancies were diagnosed by physicians and recorded in hospital medical files according to predefined codes based on ICD-9. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center. Children to mothers with pre-GDM, w...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Registration Source Type: research

Cancer incidence in Mozambique in 2015–2016: data from the Maputo Central Hospital Cancer Registry
There is scarce information on cancer incidence in Mozambique. We aimed to describe cancer incidence data from the Cancer Registry of the Maputo Central Hospital (MCH) in 2015–2016, for Maputo City dwellers, and to compare the incidence rates with those observed in 1956–1961. Cancers with incidence data in 2015–2016 were identified by the Cancer Registry of the MCH. Crude and age-standardized incident rates (ASIR, per 100 000) – direct method, world standard population – were computed for Maputo City, under the assumption that most cancer cases among this population were identified at t...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Registration Source Type: research

Trace of survivin in cancer
Survivin is one of the most cancer-specific proteins overexpressed in almost all malignancies, but is nearly undetectable in most normal tissues in adults. Functionally, as a member of the inhibitor of apoptosis family, survivin has been shown to inhibit apoptosis and increase proliferation. The antiapoptotic function of survivin seems to be related to its ability to inhibit caspases directly or indirectly. Furthermore, the role of survivin in cell cycle division control is related to its role in the chromosomal passenger complex. Consistent with its determining role in these processes, survivin plays a crucial role in can...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Review Article: Carcinogenesis Source Type: research

The intervention mechanism of folic acid for benzo(a)pyrene toxic effects in vitro and in vivo
In conclusion, the mechanisms by which this effect is mediated were not entirely elucidated by our study, possibly because folic acid antagonizes the toxic effects of BaP by upregulating the levels of excision repair cross complementation group 1, xeroderma pigmentosum group A, and xeroderma pigmentosum group C gene expression to improve the rate of DNA repair, in turn accelerating the speed of repair for DNA damage caused by BaP. Meanwhile, folic acid could restrain BaP-induced cyclinD1 protein expression, which could help cells return to their normal cell cycle. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Carcinogenesis Source Type: research

Race and renal cell carcinoma stage at diagnosis: an analysis of the Surveillance, Epidemiology, and End Results data
In conclusion, blacks were less likely to be diagnosed at a later stage RCC than Whites regardless of cancer histology. This racial disparity may exist over time during the study period. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Urologic Cancer Source Type: research

Persistent organic pollutants, pesticides, and the risk of thyroid cancer: systematic review and meta-analysis
Previous epidemiological studies have reported persistent organic pollutants (POPs) and some nonpersistent pesticides and the risk of thyroid cancer. The aim of this study was to assess the association between exposure to POPs, pesticides, and thyroid cancer by carrying out a meta-analysis. Literature searches were performed using PubMed, Embase, and reference lists of relevant articles. Summary risk estimates for thyroid cancer were calculated using fixed-effects and random-effects models. In addition, several subgroup and sensitivity analyses were carried out. Fifteen studies were reviewed, and eight studies were include...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Head & Neck Cancer Source Type: research

Cervical cancer screening uptake in women aged between 15 and 64 years in Mozambique
Cervical cancer is the most common cancer in Mozambique, reflecting the high prevalence of both human papillomavirus and HIV infections. A national screening program for cervical cancer was started in 2009, using the visual inspection with acetic acid and cryotherapy, targeting women aged 30–55 years. We aimed to estimate the self-reported prevalence and determinants of cervical cancer screening uptake in Mozambique. A cross-sectional study of a representative sample of the women aged 15–64 years (n=1888) was carried out in 2014/2015 following the WHO-Stepwise Approach to Chronic Disease Risk Factor Surveillanc...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Changes in health behaviours and body mass index after a breast cancer diagnosis: results from a prospective cohort study
The aim of the study was to describe changes in health behaviours and BMI after breast cancer diagnosis, depicting the potential influence of sociodemographic, clinical and psychological characteristics. A total of 428 breast cancer patients were prospectively followed for 3 years, since diagnosis. At the end of follow-up, women were classified regarding their adherence to recommendations for cancer prevention, prediagnosis and after 3 years, including not smoking, alcohol consumption up to one drink per day, intake of at least five portions per day of fruits and/or vegetables, physical activity and body mass index (BMI) l...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Long-term sleep habits and the risk of breast cancer among Chinese women: a case–control study
Previous observational studies have inconsistently suggested that poor sleep is a novel risk factor for breast cancer (BC). However, these studies mainly focused on sleep duration; other sleep domains were rarely reported. The aim of this study was to evaluate the association of a broad range of sleep domains with the risk of BC incidence. We used a community-based 1 : 1 individual matched case–control design that included 401 female patients with incident BC and 401 age-matched and area-matched female controls in Jiujiang, China. Long-term sleep habits were assessed comprehensively using a validated 17...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research

Genetic polymorphism of catechol-O-methyltransferase modulates the association of green tea consumption and lung cancer
Tea polyphenols are strong antioxidants, which can be rapidly O-methylated by catechol-O-methyltransferase (COMT). Thus, it is possible that the genetic polymorphism of COMT can modulate the association of green tea consumption and lung cancer. Here, we designed a case–control study to evaluate the combined effect of green tea consumption and COMT genotypes on the risk of lung cancer. A total of 237 lung cancer patients and 474 healthy controls were recruited. Questionnaires were administered to obtain demographic data, smoking status, green tea consumption, fruits and vegetables intake, exposure to cooking fumes, an...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Lung Cancer Source Type: research

Metformin for lung cancer prevention and improved survival: a novel approach
This study focuses on assessing metformin association with lung cancer as reported in the literature. Recent studies and reviews investigating metformin effects on lung cancer incidence and patient survival are critically and systematically discussed. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Review Article: Lung Cancer Source Type: research

Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk
The association between red meat intake and colorectal cancer (CRC) may be modulated by genetic polymorphisms of cytochrome P450 2E1 (CYP2E1), a key enzyme in the metabolism of nitrosamines, and peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involved in adipogenesis and lipid and glucose metabolism. We conducted a case–control study of 971 patients with CRC and 658 controls who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. Participants were asked about red meat intake by using a validated food frequency questionnaire. Polymorphisms of CYP2E1 (...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors
Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. The aim of this study was to describe the association of adult and childhood sociodemographic factors with the seroprevalence of H. pylori, and with CagA and VacA antigen-specific seropositivity among H. pylori-seropositive individuals in the Spanish adult population. Serum antibody reactivity to H. pylori proteins was evaluated using multiplex serology in 2555 population-based controls enrolled in the MCC-Spai...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Red meat and processed meat intake and risk of colorectal cancer: a population-based case–control study
To examine the association between red meat subtypes intake and risk of colorectal cancer (CRC) among Jewish and Arabs populations in a unique Mediterranean environment. The Molecular Epidemiology of Colorectal Cancer study (n=10 026) is a prospective population-based case–control study in northern Israel. Participants were interviewed in-person about their dietary intake and lifestyle using a questionnaire that included a food-frequency questionnaire. Red meat consumption in Israel was found to be especially low in the Jewish population (1.29±1.45 servings/week), but higher in Arabs (3.0±1.98 se...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Consumption of garlic and its interactions with tobacco smoking and alcohol drinking on esophageal cancer in a Chinese population
Garlic consumption has been associated inversely with esophageal cancer (EC); however, its interactions with tobacco smoking and alcohol consumption have never been evaluated in an epidemiological study. We evaluated the potential interactions between garlic intake and tobacco smoking as well as alcohol consumption in a population-based case–control study with 2969 incident EC cases and 8019 healthy controls. Epidemiologic data were collected by face-to-face interviews using a questionnaire. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated and additive and multiplicative interactions were ...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Dietary and serum vitamins A and E and colorectal cancer risk in Chinese population: a case–control study
The effect of vitamin A (VA) and vitamin E (VE) on colorectal cancer (CRC) risk is controversial. The aim of this study is to examine the association between serum concentrations and dietary intakes of VA and VE and the risk of CRC in Guangdong, China. A total of 535 cases and 552 sex and age-matched (5-year interval) controls were recruited during July 2010 to September 2014. Dietary information was assessed by face-to-face interviews using a validated food frequency questionnaire. Concentrations of VA and VE were measured by high-performance liquid chromatography. Multivariable logistic regression was used to estimate th...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Association of family history of tumors with clinicopathological characteristics and prognosis of colorectal cancer
To investigate the association of family history of malignant tumors with clinicopathological characteristics of colorectal cancer, and its effects on prognosis. We conducted a retrospective review of pathological and follow-up data of patients with colorectal cancer treated in our hospital from January 2010 to December 2015. Of 870 patients undergoing surgery, 737 received follow-up (84.7%). Among them, 192 (26.1%) were family history of malignant neoplasm-positive [MN-FH (+)] and 545 (73.9%) were family history of malignant neoplasm-negative [MN-FH (–)]. MN-FH (+) patients had earlier disease onset, smaller tumor d...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research

Risk factors for extrahepatic cholangiocarcinoma: a case–control study in China
To investigate risk factors for extrahepatic cholangiocarcinoma (ECC) in China. A total of 200 ECC cases and 200 matched control were included in the study. The presence of cigarette smoking, alcohol drinking, choledocholithiasis, primary sclerosing cholangitis, liver fluke infection (Clonorchis sinensis), diabetes mellitus, was investigated through clinical records. Blood from all cases was tested for hepatitis B surface antigen. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Compared with controls, ECC patients had a higher prevalence of cigarette smoking (61.0 v...
Source: European Journal of Cancer Prevention - July 1, 2019 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research