Reply to: Comment to: The association of metabolic syndrome and its components with serum prostate-specific antigen levels
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Should the cervical dysplasia (CIN2+) recurrence nomogram be used for HPV vaccination triage after conization?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

The impact of hot fluid food on esophageal squamous cell carcinoma might be underestimated
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

All-trans retinoic acid suppressed GES-1 cell proliferation induced by exosomes from patients with precancerous lesions by arresting the cell cycle in S-phase
We aimed to detect the expression of specific LncRNAs in exosomes isolated from the serum of patients with precancerous lesions and to study the effect of these serum exosomes on the activity of GES-1 cells in patients with precancerous lesions, as well as the activity of all-trans retinoic acid on GES-1 cells with or without the exosomes. Exosomes were extracted from the serum of patients with precancerous lesions and normal controls. Based on our previous sequencing results, quantitative real time-PCR was used to detect differentially expressed LncRNAs. Exosomes from the serum of patients with precancerous lesions were c...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Carcinogenesis Source Type: research

Diagnosis methods and treatment strategy for primary thyroid lymphoma: a retrospective analysis of 41 cases in China
In this study, we retrospectively analyzed PTL patients to determine their clinical, ultrasound and histological features. Forty-one PTL cases were analyzed. The pathological results of all cases were B-cell-derived non-Hodgkin’s lymphoma. In these patients, 12 were mucosa-associated lymphoid tissue lymphomas, and 24 were diffuse large B-cell lymphomas. Through the analysis of the clinical, ultrasonographic and histological features of 41 patients with PTL, and the discussion of treatment strategies, we support that middle-aged women with a history of Hashimoto’s thyroiditis should pay more attention to the pos...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Head & Neck cancer Source Type: research

Suicide risk among prostate cancer patients before and after the implementation of prostate-specific antigen-based prostate screening in Lithuania in 2006
Despite good prognosis, increased suicide rates are reported for prostate cancer. The aim of this study was to assess the risk of suicide among prostate cancer patients before and after the start of nation-wide prostate-specific antigen (PSA)-based screening programme. Prostate cancer cases diagnosed between 2000 and 2011 were identified from the population-based Lithuanian Cancer Registry and analysis was conducted in 2018. Analysis was stratified by period of diagnosis, age, Gleason score, extent of disease, and time since diagnosis. Standardized mortality ratios (SMRs) were used to assess suicide risk. SMRs were calcula...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Urological cancer Source Type: research

Knowledge, awareness, and practices of cervical cancer, its risk factors, screening, and prevention among women in Karachi, Pakistan
Conclusion Majority of women in our study belonged to a higher socioeconomic class and were mostly educated but their knowledge and practices regarding prevention and screening of cervical cancer were poor. This reflects that the knowledge levels as a whole would be considerably lower in the city’s general population. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gynecological cancer Source Type: research

The association between hypertension and colorectal cancer: a meta-analysis of observational studies
The relationship between hypertension and risk of colorectal cancer (CRC) is unclear. This meta-analysis aims to explore the association between them. Six databases were searched for studies published before August 2019. The pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated to estimate the association between the hypertension and CRC risk. A total of 2841 potentially relevant articles were obtained, and 25 studies with a pooled 1.95 million participants were finally included in the meta-analysis. These results suggested a positive association between hypertension and risk of CRC with a pooled RR ...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

CCL20 mediates the anti-tumor effect of vitamin D3 in p38MAPK/NF-κB signaling in colitis-associated carcinogenesis
Vitamin D3 is beneficial in ameliorating or preventing inflammation and carcinogenesis. CCL20 is a potential therapeutic target in carcinogenesis, which mediates the protective effect of vitamin D or vitamin D analogue in autoimmune and cancer diseases. Here we aim to evaluate whether vitamin D3 plays a protective role in colitis-associated colorectal cancer (CAC) by affecting CCL20 and the molecular mechanism. Administration of azoxymethane (AOM) followed with dextran sulfate sodium (DSS) was used to simulate CAC in mouse. After 5-day DSS treatment, vitamin D3 supplementation was for 9 weeks at 60 IU/g/w. We found that di...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Negative correlation of high serum bilirubin with cancer development in adults without hepatobiliary disease
This study aimed to evaluate whether serum bilirubin levels were associated with cancer development in a population without liver disease. Methods A retrospective longitudinal study was performed by including participants who underwent a health checkup at St. Luke’s International Hospital in Tokyo from 2005 to 2019. We excluded those with liver diseases or prior history of cancer at baseline. All participants were classified into four groups according to their total bilirubin (T-Bil) level: very low ( (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Association between plasma prostaglandin E2 level and colorectal cancer
This study was designed as a case-control study including 60 CRC patients and 120 cancer-free controls. A sensitive empirical method, precolumn derivatization HPLC, was used to determine plasma PGE2 levels. The TaqMan SNP Genotyping Assay was used for the genotyping of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms. Multivariate logistic regression analysis suggested that 1 log10(PGE2) increase would result in a 3.64-fold increase in the risk of CRC. Moreover, subjects with log10(PGE2) level in the 75th percentile had a significantly higher risk of CRC than those with log10(PGE2) levels in the 25th percentile ...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

KIT and PDGFRa mutational patterns in Sardinian patients with gastrointestinal stromal tumors
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of the gastrointestinal tract. We provide in the present article the molecular characterization of a series of primary GISTs in a cohort of Sardinian patients (Italy), with the aim to describe the patterns of KIT and PDGFRa mutations and the corresponding clinical features. Ninety-nine Sardinian patients with histologically-proven diagnosis of GIST were included in the study. Medical records and pathology reports were used to assess the demographic and clinical features of the patients and the disease at the time of the diagnosis. Formalin-fixe...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Dietary nutrient patterns and the risk of colorectal cancer and colorectal adenomas: a case-control study
Although the association between food patterns and the risk of colorectal cancer (CRC) and colorectal adenomas (CRA) has been explored previously, a distinct paucity of studies has evaluated the association of nutrient pattern and the risk of CRC and CRA as precursors of CRC. Thus, the purpose of this case-control study was to investigate nutrient patterns and their relationship with CRC and CRA in Iran. Two hundred forty hospital control, 129 newly diagnosed CRC and 130 newly diagnosed CRA patients were asked about their dietary intakes using validated questionnaires. To define the major nutrient patterns, principal compo...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Dietary total antioxidant capacity and colorectal cancer and colorectal adenomatous polyps: a case-control study
Colorectal cancer (CRC) is the third most common and the third most deadly cancer worldwide. In Iran, CRC is the third and fifth most common cancer in females and males, respectively. Chronic oxidative stress has been implicated in the development of CRC and its precursor, colorectal adenomatous polyps (CAP). While there were a few studies that suggested a favorable role of individuals antioxidants on the CRC risk, the total antioxidant capacity (TAC) of diet has been less investigated. Consequently, the aim of this study is to investigate the association of TAC with the odds of CRC and CAP. This is a case-control study. T...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Tinospora cordifolia and arabinogalactan exert chemopreventive action during benzo(a)pyrene-induced pulmonary carcinogenesis: studies on ultrastructural, molecular, and biochemical alterations
The aim of the present study was to unveil the chemopreventive potentials of aqueous Tinospora cordifolia stem extract and its active component viz. Arabinogalactan against Benzo(a)pyrene-induced pulmonary carcinogenesis. Animals were divided into six groups: (I) Control, (II) aqueous Tinospora cordifolia (200 mg/kg b.wt, p.o.), (III) arabinogalactan (7.5 mg/kg b.wt, p.o.), (IV) benzo(a)pyrene (50 mg/kg b.wt, i.p.) at second and fourth week of study, (V) benzo(a)pyrene + aqueous Tinospora cordifolia, and (VI) benzo(a)pyrene + arabinogalactan. The benzo(a)pyrene treatment resulted in severe alterations in the cellular arran...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

Comparative analysis of three data mining techniques in diagnosis of lung cancer
There is a lot of abnormal information in the development of lung cancer, and how to extract useful knowledge is urgent from massive information. Data mining technology has become a popular tool for medical classification and prediction. However, each technology has its advantage and disadvantage, and several data mining methods will be applied to conduct the in-depth analysis step by step. And the prediction results of different models are compared. A total of 180 lung cancer patients and 243 lung benign individuals were collected from the First Affiliated Hospital of Zhengzhou University from October 2014 to March 2016, ...
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

Cancer mortality and predictions for 2020 in selected Australasian countries, Russia and Ukraine
Conclusion Predicted cancer rates were lower than in the European Union and the USA, even though falls started later and were less marked. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - December 14, 2020 Category: Cancer & Oncology Tags: Epidemiology Source Type: research

High mobility group A protein-2 as a tumor cancer diagnostic and prognostic marker: a systematic review and meta-analysis
High mobility group A protein-2 (HMGA2) is an architectural transcription factor that binds to the A/T-rich DNA minor groove and is responsible for regulating transcriptional activity of multiple genes indirectly through chromatin change and assembling enhanceosome. HMGA2 is overexpressed in multiple tumor types, suggesting its involvement in cancer initiation and progression, thus, making it an ideal candidate for cancer diagnostic and prognostic. We performed a systematic review to examine the role of HMGA2 as a universal tumor cancer diagnostic and prognostic marker. We used Reporting Recommendations for Tumor Marker Pr...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Carcinogenesis Source Type: research

SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer
Cancer is an unpleasant, painful disease. It is one of the most devastating diseases worldwide diminishing many lives. Many genetic and epigenetic changes occur before cancer develops. Mutation in SETD2 gene is one such example. RNA splicing, DNA damage repair, DNA methylation and histone methylation are some of the biological processes mediated by SETD2. SETD2 (histone H3 lysine 36 methyltransferase) is a frequently mutated gene in different types of cancer. Loss of SETD2 is associated with worse prognosis and aggressive phenotypes. Histone modification is one of the epigenetic regulation having a significant effect on ge...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Carcinogenesis Source Type: research

New information flows for cancer registries: testing the use of laboratory data in the province of Reggio Emilia, Italy
Conclusions Although the laboratory information system’s contribution to the completeness of Cancer Registry incident cases was modest, it is useful to add laboratory data to routine cancer registry information flows due to the increasing use of molecular characterisation and to the phenomenon of dehospitalisation. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Cancer Registries Source Type: research

The quality of cancer registries data has to become ‘liquid’
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Cancer Registries Source Type: research

Infections and the development of childhood acute lymphoblastic leukemia: a population-based study
An infectious trigger for childhood acute lymphoblastic leukemia is hypothesized and we assessed the association between the rate, type, and critical exposure period for infections and the development of acute lymphoblastic leukemia. We conducted a matched case-control study using administrative databases to evaluate the association between the rate of infections and childhood acute lymphoblastic leukemia diagnosed between the ages of 2–14 years from Ontario, Canada and we used a validated approach to measure infections. In 1600 cases of acute lymphoblastic leukemia, and 16 000 matched cancer-free controls aged 2&nda...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Hematological cancers Source Type: research

Association between variant alleles of major histocompatibility complex class II regulatory genes and nasopharyngeal carcinoma susceptibility
Major histocompatibility complex (MHC) class II regulatory genes play a paramount role in immune response that can exert a predominant influence on clinical outcome of Epstein–Barr virus infection consistently assumed as the main pathogenetic factor for nasopharyngeal carcinoma. To elucidate the relationship between allelic variants of MHC class II regulatory genes and susceptibility to nasopharyngeal carcinoma, a total of 28 polymorphic loci at MHC class II regulatory genes, involving CIITA, CREB1, RFX family genes (RFX5, RFXAP, and RFXANK), and NFY family genes (NFYA, NFYB, and NFYC), were genotyped by multiplex SN...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Head & Neck cancers Source Type: research

Epstein–Barr virus molecular epidemiology and variants identification in head and neck squamous cell carcinoma
Epstein-Barr virus (EBV) is known as one of the most widespread oncogenic viruses. Head and neck squamous cell carcinoma (HNSCC) is triggered by various risk factors. The aim of the present study was to determine the EBV infection rate, genotyping and variants frequency in HNSCC patients. In this cross-sectional study, 156 patients with HNSCC were enrolled. Formalin fixed paraffin embedded (FFPE) tissue samples were selected from hospitals affiliated to Iran University of Medical Sciences, Tehran, Iran. The EBV EBNA-3C, EBNA-1 and LMP-1 genes were amplified by PCR and then analyzed and confirmed by nucleotide sequencing. C...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Head & Neck cancers Source Type: research

Association of poor mental health and skin cancer development: a cross-sectional study of adults in the United States
The relationship between mental health and skin cancer is poorly characterized. This cross-sectional study used 2016 Behavioral Risk Factor Surveillance System data to evaluate the association between mental health problems and skin cancer development. Multivariate logistic regression analyses were performed to calculate adjusted odds ratio (aOR) for skin cancer development by mental health problems, adjusting for potentially confounding demographic and lifestyle factors. Odds of skin cancer were significantly higher in those with mental health problems problems [aOR 1.24, 95% confidence interval (CI) 1.17–1.31, P&th...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Skin cancer Source Type: research

Constitutional variants in POT1, TERF2IP, and ACD genes in patients with melanoma in the Polish population
Evaluation of the prevalence of POT1, ACD, and TERF2IP mutations among Polish melanoma patients. A cohort of 60 patients from melanoma-prone families, 1500 unselected cases and 1500 controls were genotyped. Methodology included Sanger sequencing, in-silico software predilection, and TaqMan assays. We identified three nonsynonymous variants: POT1 c.903 G>T; TERF2IP c.970 A>G; and ACD c.1544 T>C and a splice site variant ACD c.645 G>A. The c.903 G>T was predicted to be pathogenic according to PolyPhen-2, benign according to Mutation Taster, PROVEAN, AGVGD, and SIFT. The c.645 G>A was defined as disease caus...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Skin cancer Source Type: research

Effectiveness of the cervical cancer prevention programme: a case-control mortality audit in Lithuania
In conclusion, participation in screening has been effective in reducing cervical cancer mortality in Lithuania. The study shows poor screening attendance, emphasizing the importance of greater efforts at the national level to improve the effectiveness of the screening. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Gynecological cancer Source Type: research

Cesarean delivery may be protective against neoplasms of the uterine cervix in women of childbearing age
Parity has been reported as a risk factor for cervical cancer. However, no study has investigated the risk of neoplasms of the uterine cervix according to the delivery type. We carried out a retrospective cohort study using nationwide data from the Korean Health Insurance Review and Assessment Database to investigate whether cesarean delivery might be associated with less development of neoplasms of the uterine cervix than a vaginal delivery in women of childbearing age. Women aged 20–44 years, who had undergone vaginal or cesarean deliveries in 2009 were included as subjects. Two individual datasets for carci...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Gynecological cancer Source Type: research

Association between flavonoids, flavonoid subclasses intake and breast cancer risk: a case-control study in China
This study aimed to investigate the associations between total and subclasses of flavonoid and breast cancer risk among Chinese population. This case-control study recruited 1522 eligible breast cancer cases and 1547 frequency-matched control subjects from June 2007 to July 2018 in Guangdong, China. Dietary intake was obtained by face-to-face interview using a validated food frequency questionnaire. Odds ratios and 95% confidence intervals were calculated by multivariable logistic regression models. After adjusting for potential confounders, inverse associations were observed between total flavonoids, anthocyanidins, proan...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Breast cancer Source Type: research

Outcomes and cost of lung cancer patients treated surgically or medically in Catalunya: cost–benefit implications for lung cancer screening programs
Lung cancer screening programs with computed tomography of the chest reduce mortality by more than 20%. Yet, they have not been implemented widely because of logistic and cost implications. Here, we sought to: (1) use real-life data to compare the outcomes and cost of lung cancer patients with treated medically or surgically in our region and (2) from this data, estimate the cost–benefit ratio of a lung cancer screening program (CRIBAR) soon to be deployed in our region (Catalunya, Spain). We accessed the Catalan Health Surveillance System (CHSS) and analysed data of all patients with a first diagnosis of lung cancer...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

HASPIN kinase inhibitor CHR-6494 suppresses intestinal polyp development, cachexia, and hypogonadism in Apcmin/+ mice
In this study, we examined whether HASPIN inhibitor CHR-6494 suppresses cancer progression in ApcMin/+ mice, a familial colon tumor disease model. Mice were treated by intraperitoneal injection of CHR-6494 for 50 days. Following the treatment period, intestinal polyps were counted and testosterone and spermatogenesis levels were observed. Intraperitoneal administration of CHR-6494 significantly inhibited intestinal polyp development and recovered body weight in ApcMin/+ mice. Although spermatogenesis was inhibited with increasing age in ApcMin/+ mice, CHR-6494 significantly improved blood testosterone levels and spermatoge...
Source: European Journal of Cancer Prevention - October 7, 2020 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Problem-solving in technology-rich environments and cancer screening in later life
This study examined the association between problem-solving skills in the technology-rich environment and cancer screening in later life. Using 2012/2014 Program for International Assessment of Adult Competencies data, binary logistic regressions with survey weights were used to estimate the association between problem-solving skills in the technology-rich environment and four cancer screening behaviors among the corresponding target populations aged between 45 and 74 years old (n = 1374 for cervical screening; n = 1373 for breast screening; n = 1166 for prostate screening; n = 2563 for colon screening). Results showed tha...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Paper: Sctreening Source Type: research

A systematic review on the mechanisms of malignant transformation of oral submucous fibrosis
Oral submucous fibrosis (OSMF), the most commonly encountered potentially premalignant oral epithelial lesion, is a chronic disorder associated with areca nut chewing. It has a relatively high potential for malignant transformation resulting into oral squamous cell carcinoma (OSCC), the most common oral malignancy with high mortality rate. Paymaster first described the malignant potential of OSMF in 1956, the rate of which had been estimated to be 7–13%. The pathogenesis of OSMF in itself is quite varied, and hence, its transformation to malignancy is also open to many varied mechanisms. The early diagnosis and seque...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Short Paper: Head & Neck cancer Source Type: research

Are anti-inflammatory foods associated with a protective effect for cutaneous melanoma?
In conclusion, the only anti-inflammatory food item that was consistently associated with a protective effect for cutaneous was coffee in particular caffeinated coffee. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Short Paper: Skin cancer Source Type: research

National organization of uterine cervical cancer screening and social inequality in France
Some of the inequality in uterine cervical cancer (UCC) screening uptake are due to the socioeconomic deprivation of women. A national organized screening programme has proven to be effective in increasing the uptake, but may increase socioeconomic inequality. Therefore, we compared inequality in uptake of UCC screening between two French departments, one of which is experimenting an organized screening programme. We used reimbursement data from the main French health insurance scheme to compare screening rates in the municipalities of the two departments over a three-year period. The experimental department had higher scr...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Gynecological cancer Source Type: research

Trends in prevalence in human papillomavirus types and their association with cervical dysplasia: an analysis on 15 138 women over 20 years
To investigate trends in prevalence of various human papillomavirus types in order to assess the unmet clinical needs for women affected by human papillomavirus-related disease. Data of consecutive 15 138 patients undergoing human papillomavirus DNA testing from 1998 to 2018 were retrospectively identified. Human papillomavirus types were classified at high-risk according to the classification of the International Agency for Research on Cancer. The International Agency for Research on Cancer included seven human papillomavirus types covered by nine-valent vaccine and five not yet covered by any available vaccines. Overall,...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Gynecological cancer Source Type: research

Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study
In conclusion, these results suggest that the gradual implementation of low-dose computed tomography lung screening program could lead to a remarkable decrease in lung cancer mortality and a remarkable stage shift in the trend over time in this hospital-based cohort. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Lung cancer Source Type: research

Effect of vitamin D receptor polymorphisms on plasma oxidative stress and apoptotic biomarkers among breast cancer survivors supplemented vitamin D3
We investigated whether plasma oxidative stress and apoptotic biomarkers were associated with the VDR polymorphisms in breast cancer survivors supplemented with vitamin D3. Two hundred fourteen breast cancer survivors received 4000 IU of vitamin D3 daily for 12 weeks. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was associated with the selected VDR single nucleotide polymorphisms executing by ‘association’ function in the R package ‘SNPassoc’. Linear regression analyses adjusted for age, BMI and on-study plasma 25(OH)D changes indicated...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Breast cancer Source Type: research

Age at last birth and risk of developing breast cancer: a meta-analysis
Conclusion This meta-analysis suggested that ALB was positively associated with the risk of breast cancer. The risk of developing breast cancer increased gradually with the ALB for women. Our findings may have implications for family planning. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles: Breast cancer Source Type: research

Evolving perspectives on stool testing for colorectal cancer: a qualitative systematic review
Conclusion This systematic review focuses on addressing and understanding the perception of FIT from first-hand accounts. Since its inception, FIT screening has increased colorectal cancer screening uptake due to its increased reliability and the simplicity of the test. However, there is a need to increase the uptake of FIT kits through increasing accessibility of the screening process and considering the holistic patient experience. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4)
Background The association among gallbladder disease, cholecystectomy, and pancreatic cancer is unclear. Moreover, time interval between gallbladder disease or cholecystectomy and pancreatic cancer diagnosis is not considered in most previous studies. Aim To quantify the association among gallbladder disease, cholecystectomy, and pancreatic cancer, considering time since first diagnosis of gallbladder disease or cholecystectomy. Methods We used data from nine case-control studies within the Pancreatic Cancer Case-Control Consortium, including 5760 cases of adenocarcinoma of the exocrine pancreas and 8437 controls. ...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

How do international gastric cancer prevention guidelines influence clinical practice globally?
Clinical guidelines recommend particular approaches, including ‘screen-and-treat’ strategy for Helicobacter pylori, to prevent gastric cancer. However, little of this is implemented in clinical practice. The aim of the study was to identify barriers to implementation of international guidelines. A web-based questionnaire distributed globally to specialists in the field. Altogether 886 responses from 75 countries were received. Of the responders, 570 (64%) were men of mean age 47 years. There were 606 gastroenterologists and 65 epidemiologists among the responders. Altogether, 79.8% of the responders disagreed t...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Years of life lost due to malignant neoplasms of the digestive system in Poland during 10 years of socioeconomic transformation
The aim of the study was to analyse years of life lost due to selected malignant neoplasms of the digestive system (colorectum, stomach, and pancreas) in Poland, a post-communist country in Central Europe, according to socioeconomic variables: sex, age, level of education, marital status, working status, and place of residence. The study included a dataset comprising death certificates of Polish citizens from 2002 (N = 359 486) and 2011 (N = 375 501). The data on deaths caused by malignant neoplasms of the digestive system, that is, coded as C15-C26 according to International Statistical Classification of Dis...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Tea drinking and the risk of esophageal cancer: focus on tea type and drinking temperature
This study is to determine the association between tea drinking and esophageal squamous cell carcinoma focusing on drinking temperature and tea types. A population-based case-control study was conducted in a high esophageal squamous cell carcinoma risk area in China. A total of 942 incident esophageal squamous cell carcinoma cases with historical confirmation and 942 age- and sex- individually matched community controls were recruited from the study area. Trained interviewers using a structured questionnaire collected detailed information on tea drinking, diet, smoking and alcohol drinking habits. Habitual tea drinking tem...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Progress in cancer mortality, incidence, and survival: a global overview
Cancer mortality has declined over the last three decades in most high-income countries reflecting improvements in cancer prevention, diagnosis, and management. However, there are persisting and substantial differences in mortality, incidence, and survival worldwide. In order to provide an up-to-date overview of trends in mortality, incidence, and survival, we retrieved data from high-quality, population-based cancer registries for all cancers and 10 selected cancer sites in six high-income countries and the European Union. We computed age-standardized (world standard population) mortality and incidence rates, and applied ...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Headline Source Type: research

Why is COVID-19 virus so deadly for cancer patients?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Transcriptomic analysis reveals that heat shock protein 90α is a potential diagnostic and prognostic biomarker for cancer
In conclusion, we demonstrated that high HSP90AA1 expression was ubiquitous in cancer and that HSP90AA1 was a potential diagnostic and prognostic biomarker for hepatocellular carcinoma. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Early detection Source Type: research

The reduction of CA 125 serum levels in BRCA 1/2 mutation carriers after risk-reducing salpingo-oophorectomy is only partially associated with surgery: a prospective cohort, other biomarker controlled, study
Objectives A significant reduction in CA 125 postoperative serum levels was observed after risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers. In contrast to previous studies, where control groups were absent, we conducted a prospective study including also a screening only group (RSSO refusal) and a group having previously undergone RRSO. Methods Consecutive BRCA1 and BRCA2 mutation carriers, not hysterectomised,>35 years old and with completed childbearing, were recruited. Some women had previously undergone RRSO (previous RRSO group). The others, who had either chosen RRSO (actual RRSO group) o...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

HPV vaccine acceptance and hesitancy – lessons learned during 8 years of regional HPV prophylaxis program in Wroclaw, Poland
In 2019, the WHO has announced that it will intensify efforts to eliminate cervical cancer worldwide by increasing coverage of the HPV (Human Papillomavirus) vaccine. Finding reasons for low HPV vaccine coverage and looking for solutions to address the problem should be the priorities for public health. The municipality of Wroclaw (Poland) attempted to meet the challenge earlier by introducing a Prophylaxis Program against HPV in 2010. The core of the program are educational meetings at schools and free vaccinations offered at GP offices. After five successful years (vaccination coverage>80% fully vaccinated), vaccinati...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

Factors associated with cervical intraepithelial neoplasia (CIN2/CIN3), early stage and advanced stage of cervical cancer diagnosis in the Brazilian Amazonian region
To understand the impact of demographic, behavioral and contextual factors on cervical cancer, we examined the profile of women classified according to cervical cancer staging [precursor lesions cervical intraephitelial neoplasia (CIN2/CIN3), early- and advanced-stage cancer]. Patients were identified in the main oncological reference hospital in Pará State, Brazil, from 2013 through 2015. Adjusted prevalence ratios and their respective 95% confidence intervals were estimated using Poisson regression with robust variance. The study included 172 cases of CIN2/CIN3 lesions, 158 of early stage and 552 of advanced stage...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research