Problem-solving in technology-rich environments and cancer screening in later life
This study examined the association between problem-solving skills in the technology-rich environment and cancer screening in later life. Using 2012/2014 Program for International Assessment of Adult Competencies data, binary logistic regressions with survey weights were used to estimate the association between problem-solving skills in the technology-rich environment and four cancer screening behaviors among the corresponding target populations aged between 45 and 74 years old (n = 1374 for cervical screening; n = 1373 for breast screening; n = 1166 for prostate screening; n = 2563 for colon screening). Results showed tha...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Research Paper: Sctreening Source Type: research

A systematic review on the mechanisms of malignant transformation of oral submucous fibrosis
Oral submucous fibrosis (OSMF), the most commonly encountered potentially premalignant oral epithelial lesion, is a chronic disorder associated with areca nut chewing. It has a relatively high potential for malignant transformation resulting into oral squamous cell carcinoma (OSCC), the most common oral malignancy with high mortality rate. Paymaster first described the malignant potential of OSMF in 1956, the rate of which had been estimated to be 7–13%. The pathogenesis of OSMF in itself is quite varied, and hence, its transformation to malignancy is also open to many varied mechanisms. The early diagnosis and seque...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Short Paper: Head & Neck cancer Source Type: research

Are anti-inflammatory foods associated with a protective effect for cutaneous melanoma?
In conclusion, the only anti-inflammatory food item that was consistently associated with a protective effect for cutaneous was coffee in particular caffeinated coffee. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Short Paper: Skin cancer Source Type: research

National organization of uterine cervical cancer screening and social inequality in France
Some of the inequality in uterine cervical cancer (UCC) screening uptake are due to the socioeconomic deprivation of women. A national organized screening programme has proven to be effective in increasing the uptake, but may increase socioeconomic inequality. Therefore, we compared inequality in uptake of UCC screening between two French departments, one of which is experimenting an organized screening programme. We used reimbursement data from the main French health insurance scheme to compare screening rates in the municipalities of the two departments over a three-year period. The experimental department had higher scr...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Review Articles: Gynecological cancer Source Type: research

Trends in prevalence in human papillomavirus types and their association with cervical dysplasia: an analysis on 15 138 women over 20 years
To investigate trends in prevalence of various human papillomavirus types in order to assess the unmet clinical needs for women affected by human papillomavirus-related disease. Data of consecutive 15 138 patients undergoing human papillomavirus DNA testing from 1998 to 2018 were retrospectively identified. Human papillomavirus types were classified at high-risk according to the classification of the International Agency for Research on Cancer. The International Agency for Research on Cancer included seven human papillomavirus types covered by nine-valent vaccine and five not yet covered by any available vaccines. Overall,...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Review Articles: Gynecological cancer Source Type: research

Prognostic effect of implementation of the mass low-dose computed tomography lung cancer screening program: a hospital-based cohort study
In conclusion, these results suggest that the gradual implementation of low-dose computed tomography lung screening program could lead to a remarkable decrease in lung cancer mortality and a remarkable stage shift in the trend over time in this hospital-based cohort. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Review Articles: Lung cancer Source Type: research

Effect of vitamin D receptor polymorphisms on plasma oxidative stress and apoptotic biomarkers among breast cancer survivors supplemented vitamin D3
We investigated whether plasma oxidative stress and apoptotic biomarkers were associated with the VDR polymorphisms in breast cancer survivors supplemented with vitamin D3. Two hundred fourteen breast cancer survivors received 4000 IU of vitamin D3 daily for 12 weeks. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was associated with the selected VDR single nucleotide polymorphisms executing by ‘association’ function in the R package ‘SNPassoc’. Linear regression analyses adjusted for age, BMI and on-study plasma 25(OH)D changes indicated...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Review Articles: Breast cancer Source Type: research

Age at last birth and risk of developing breast cancer: a meta-analysis
Conclusion This meta-analysis suggested that ALB was positively associated with the risk of breast cancer. The risk of developing breast cancer increased gradually with the ALB for women. Our findings may have implications for family planning. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Review Articles: Breast cancer Source Type: research

Evolving perspectives on stool testing for colorectal cancer: a qualitative systematic review
Conclusion This systematic review focuses on addressing and understanding the perception of FIT from first-hand accounts. Since its inception, FIT screening has increased colorectal cancer screening uptake due to its increased reliability and the simplicity of the test. However, there is a need to increase the uptake of FIT kits through increasing accessibility of the screening process and considering the holistic patient experience. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4)
Background The association among gallbladder disease, cholecystectomy, and pancreatic cancer is unclear. Moreover, time interval between gallbladder disease or cholecystectomy and pancreatic cancer diagnosis is not considered in most previous studies. Aim To quantify the association among gallbladder disease, cholecystectomy, and pancreatic cancer, considering time since first diagnosis of gallbladder disease or cholecystectomy. Methods We used data from nine case-control studies within the Pancreatic Cancer Case-Control Consortium, including 5760 cases of adenocarcinoma of the exocrine pancreas and 8437 controls. ...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

How do international gastric cancer prevention guidelines influence clinical practice globally?
Clinical guidelines recommend particular approaches, including ‘screen-and-treat’ strategy for Helicobacter pylori, to prevent gastric cancer. However, little of this is implemented in clinical practice. The aim of the study was to identify barriers to implementation of international guidelines. A web-based questionnaire distributed globally to specialists in the field. Altogether 886 responses from 75 countries were received. Of the responders, 570 (64%) were men of mean age 47 years. There were 606 gastroenterologists and 65 epidemiologists among the responders. Altogether, 79.8% of the responders disagreed t...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Years of life lost due to malignant neoplasms of the digestive system in Poland during 10 years of socioeconomic transformation
The aim of the study was to analyse years of life lost due to selected malignant neoplasms of the digestive system (colorectum, stomach, and pancreas) in Poland, a post-communist country in Central Europe, according to socioeconomic variables: sex, age, level of education, marital status, working status, and place of residence. The study included a dataset comprising death certificates of Polish citizens from 2002 (N = 359 486) and 2011 (N = 375 501). The data on deaths caused by malignant neoplasms of the digestive system, that is, coded as C15-C26 according to International Statistical Classification of Dis...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Tea drinking and the risk of esophageal cancer: focus on tea type and drinking temperature
This study is to determine the association between tea drinking and esophageal squamous cell carcinoma focusing on drinking temperature and tea types. A population-based case-control study was conducted in a high esophageal squamous cell carcinoma risk area in China. A total of 942 incident esophageal squamous cell carcinoma cases with historical confirmation and 942 age- and sex- individually matched community controls were recruited from the study area. Trained interviewers using a structured questionnaire collected detailed information on tea drinking, diet, smoking and alcohol drinking habits. Habitual tea drinking tem...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Progress in cancer mortality, incidence, and survival: a global overview
Cancer mortality has declined over the last three decades in most high-income countries reflecting improvements in cancer prevention, diagnosis, and management. However, there are persisting and substantial differences in mortality, incidence, and survival worldwide. In order to provide an up-to-date overview of trends in mortality, incidence, and survival, we retrieved data from high-quality, population-based cancer registries for all cancers and 10 selected cancer sites in six high-income countries and the European Union. We computed age-standardized (world standard population) mortality and incidence rates, and applied ...
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Research Articles: Headline Source Type: research

Why is COVID-19 virus so deadly for cancer patients?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Transcriptomic analysis reveals that heat shock protein 90α is a potential diagnostic and prognostic biomarker for cancer
In conclusion, we demonstrated that high HSP90AA1 expression was ubiquitous in cancer and that HSP90AA1 was a potential diagnostic and prognostic biomarker for hepatocellular carcinoma. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Early detection Source Type: research

The reduction of CA 125 serum levels in BRCA 1/2 mutation carriers after risk-reducing salpingo-oophorectomy is only partially associated with surgery: a prospective cohort, other biomarker controlled, study
Objectives A significant reduction in CA 125 postoperative serum levels was observed after risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers. In contrast to previous studies, where control groups were absent, we conducted a prospective study including also a screening only group (RSSO refusal) and a group having previously undergone RRSO. Methods Consecutive BRCA1 and BRCA2 mutation carriers, not hysterectomised,>35 years old and with completed childbearing, were recruited. Some women had previously undergone RRSO (previous RRSO group). The others, who had either chosen RRSO (actual RRSO group) o...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

HPV vaccine acceptance and hesitancy – lessons learned during 8 years of regional HPV prophylaxis program in Wroclaw, Poland
In 2019, the WHO has announced that it will intensify efforts to eliminate cervical cancer worldwide by increasing coverage of the HPV (Human Papillomavirus) vaccine. Finding reasons for low HPV vaccine coverage and looking for solutions to address the problem should be the priorities for public health. The municipality of Wroclaw (Poland) attempted to meet the challenge earlier by introducing a Prophylaxis Program against HPV in 2010. The core of the program are educational meetings at schools and free vaccinations offered at GP offices. After five successful years (vaccination coverage>80% fully vaccinated), vaccinati...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

Factors associated with cervical intraepithelial neoplasia (CIN2/CIN3), early stage and advanced stage of cervical cancer diagnosis in the Brazilian Amazonian region
To understand the impact of demographic, behavioral and contextual factors on cervical cancer, we examined the profile of women classified according to cervical cancer staging [precursor lesions cervical intraephitelial neoplasia (CIN2/CIN3), early- and advanced-stage cancer]. Patients were identified in the main oncological reference hospital in Pará State, Brazil, from 2013 through 2015. Adjusted prevalence ratios and their respective 95% confidence intervals were estimated using Poisson regression with robust variance. The study included 172 cases of CIN2/CIN3 lesions, 158 of early stage and 552 of advanced stage...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

Drug consumption and melanocytic nevi: correlation between oral contraceptives or hormone replacement therapy and a high melanocytic nevi count
The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk. Aims of the study were to evaluate a possible association between the above-mentioned drugs and features such as number and atypia of melanocytic nevi in long-term users. We retrospectively looked at pharmacological, clinical and dermoscopic records of 1321 patients that attended our unit for routine mole check between January 2013 and January 2018. Patients were divided into two groups...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Skin cancer Source Type: research

Association of rs8444 polymorphism in the LASS2 3′-UTR and bladder cancer risk in Chinese population
The aim of the present study was to explore the correlations between single nucleotide polymorphisms in LASS2 gene 3′-untranslated regions and bladder cancer risk in Chinese population. We first performed PCR and sequence for LASS2-3′-UTR in 105 bladder cancer patients and 100 control subjects. Next, multivariate logistic regression analysis was used to determine the relationship between single nucleotide polymorphisms frequency and susceptibility of bladder cancer, and clinical features in 105 cases. In addition, survival curves and Cox Regression analysis were used to investigate the effect of single nucleoti...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Urological cancer Source Type: research

Recent developments and advances in secondary prevention of lung cancer
Lung cancer prevention may include primary prevention strategies, such as corrections of working conditions and life style – primarily smoking cessation – as well as secondary prevention strategies, aiming at early detection that allows better survival rates and limited resections. This review summarizes recent developments and advances in secondary prevention, focusing on recent technological tools for an effective early diagnosis. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Lung cancer Source Type: research

The diagnostic efficiency of seven autoantibodies in lung cancer
This study aimed to evaluate the diagnostic efficacy of seven autoantibodies in all lung cancer, lung adenocarcinoma, lung squamous cell carcinoma and early-stage lung cancer patients. ELISA testing of a seven autoantibody panel was performed on 386 lung cancer patients and 238 normal controls. The sensitivity and specificity of each autoantibody were analyzed using the receiver operating characteristic curve analysis. The diagnostic efficacy of a combination of these seven autoantibodies was evaluated by binary logistic regression. The results indicated that six of the seven autoantibodies (p53, SOX2, GAGE7, GBU4-5, MAGEA...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Lung cancer Source Type: research

Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis
The recent interest in beta-blockers as possible agents for drug repurposing in oncology arises from many pre-clinical and epidemiologic studies suggesting a possible clinically relevant antitumour effect. In lung cancer, given the contradictory results obtained, it is crucial to further study its effects. A systematic review of the literature was planned to evaluate a possible beneficial effect of beta-blocker on overall survival in lung cancer patients. Medline and Embase databases were searched from inception until 1 May 2018 to identify published studies that assessed the effect beta-blocker use on overall survival in ...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Lung cancer Source Type: research

Hormone replacement therapy: revisiting the risk of breast cancer
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Breast cancer Source Type: research

The conversion factor for predicting adenoma detection rate from polyp detection rate varies according to colonoscopy indication and patient sex
The adenoma detection rate (ADR) is the primary quality indicator for colonoscopies. The polyp detection rate (PDR) is available from administrative data and does not depend on histology verification. The correlation between PDR and ADR and the ADR/PDR conversion factor in preventive colonoscopies were evaluated. In the prospective study, asymptomatic individuals aged 45–75 years with preventive colonoscopy in 2012–2016 were included. Spearman’s correlation coefficient was used to assess PDR/ADR for each endoscopist. Conversion factor predicting ADR from PDR was obtained by linear regression and subsequen...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Colorectal cancer Source Type: research

Positive effect of metformin treatment in colorectal cancer patients with type 2 diabetes: national cohort study
We aimed to estimate colorectal cancer risk in patients with type 2 diabetes mellitus (T2DM) using metformin. Patients with colorectal cancer and diabetes from 2000 to 2012 were identified form Lithuanian Cancer Registry and the National Health Insurance Fund database. Standardized incidence ratios (SIRs) for colorectal cancers as a ratio of observed number of cancer cases in people with diabetes to the expected number of cancer cases in the underlying general population was calculated. We analysed 111 109 patients with diabetes. Overall, 1213 colorectal cancers were observed versus 954.91 expected within a period o...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Colorectal cancer Source Type: research

Universal screening to identify Lynch syndrome: two years of experience in a Northern Italian Center
This study demonstrates that the IHC approach for both MMR deficiency and V600E BRAF mutation detections is the most efficient approach for Lynch syndrome screening in the Italian population. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Colorectal cancer Source Type: research

Reply to: Comment to: Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Risk of cancer in individuals with alcohol and drug use disorders: a registry-based study in Reggio Emilia, Italy
Aims of this population-based cohort study was to compare the overall and site-specific cancer incidence in individuals with alcohol or drug use disorders with incidence of the general population, and to estimate excess cancer risk in a subgroup of individuals who have hepatitis C virus or HIV infection. The study included 4373 residents of Reggio Emilia province diagnosed with alcohol or drug use disorders during the period from 1 January 1985 to 31 December 2014. All newly diagnosed cancers registered from 1 January 1996 to 31 December 2014 were taken into account to calculate the standardised incidence ratio (SIR) of ca...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Lifestyle Source Type: research

Cervical cancer screening and Pap test non-adherence risk factors in systemic sclerosis patients
Systemic sclerosis is a rare autoimmune disorder that potentially affects nearly every organ of the body. Malignancies are one of the most common non-systemic sclerosis related cause of mortality. There are controversial findings regarding the cervical cancer rate among these patients, but prolonged immunosuppressive medication makes them more susceptible to cervical cancer. In the present study, we have aimed to investigate the cervical cancer screening result and the Pap test non-adherence risk factors among systemic sclerosis patients. This cross-sectional study was conducted on 100 systemic sclerosis patients. The clin...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

Associations of telomerase reverse transcriptase rs10069690 and rs2736100 polymorphisms with papillary thyroid carcinoma
Papillary thyroid carcinoma is one of the most common endocrine malignancies. Telomerase reverse transcriptase rs10069690 and rs2736100 polymorphisms have been studied in thyroid carcinomas with different ethnicity, but the results were inconsistent. Therefore, we evaluated the relationship between rs10069690 and rs2736100 polymorphisms and papillary thyroid carcinoma risk and furtherly investigated the associations of these polymorphisms with stimulated thyroglobulin (sTg) positivity and adverse reactions of 131I treatment in papillary thyroid carcinoma. Four hundred thirty-six papillary thyroid carcinoma patients and 345...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Head & Neck cancer Source Type: research

Prostate cancer awareness and screening practice among Kenyan men
Despite globally increased awareness and widespread availability of screening tools, little is known about prostate cancer (PCa) awareness and screening practices in Kenya. To assess PCa awareness and screening practice among Kenyan men (age: 15–54 years), a cross-sectional study was carried out using Kenya Demographic Health Survey (KDHS 2014) data. A subsample of 12 803 men was taken and analyzed using SPSS version 22. Overall, 7926 (61.9%) men were aware of PCa. Three hundred eleven (3.9%) men who were aware of PCa reported ever screening for PCa. A strong association was found by crude and adjusted logistic regre...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Prostate cancer Source Type: research

Prostate cancer screening in Portugal: prevalence and perception of potential benefits and adverse effects
Conclusions: Almost half of the men between 40 and 79 years old declared that they have been screened for prostate cancer. Nearly one-third of the participants considered that reassurance of a negative result was the main potential benefit of screening, whereas most failed to identify the most frequent adverse effects. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Prostate cancer Source Type: research

Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure
This study aimed to recognize potential lung cancer biomarkers using induced sputum noninvasively collected from the lungs of individuals in risk of contracting lung cancer. Study groups composed of current and former smokers, who either were significantly asbestos exposed, had lung cancer, or were unexposed and asymptomatic. Screening of potential biomarkers was performed with 52, and five differentially abundant proteins, peroxiredoxin 2 (PRDX2), thioredoxin (TXN), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), extracellular matrix protein 1 (ECM1), and protein S100 A8 (S100A8), were chosen to undergo validation, for ...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Lung cancer Source Type: research

Hormonal and reproductive factors and reduction in the risk of colorectal cancer
Females differ from males in incidence and clinical characteristics of colorectal cancer. Understanding the differences can lead to development of preventive approaches. To identify reproductive factors currently associated with the risk of colorectal cancer. Consecutively diagnosed female colorectal cancer cases and randomly chosen colorectal cancer-free controls matched on age/ethnicity/primary care clinic within the molecular epidemiology of colorectal cancer study, a population-based case-control study in Northern Israel, were included. A total of 2867 female cases and 2333 controls participated in this analysis. Parti...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

The relationship between the index of nutritional quality and the risk of colorectal cancer and adenoma : a case-control study
Conclusion: This study showed that individuals who have a healthier diet, high in calcium, vitamin C, riboflavin, folate and fiber and food groups like fruits, vegetables and whole-grain and less in sweets and red or process meats are at a lower risk of colorectal cancer and CRA than those with unhealthy and poor diet. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

The effect of a gastric second primary cancer on the survival of patients with a previous cancer history
In conclusion, cancer patients with a gastric SPC have a nearly two-fold higher risk of death over 10 years than those with a corresponding FPC only. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

Duodenal neoplasms of gastric phenotype: reports of two cases and a brief review of literature
Duodenal neoplasms of gastric phenotype are uncommon epithelial neoplasms. Pyloric gland adenomas should be recognized as neoplasms with risk for transformation into invasive adenocarcinoma (Choi et al. 2018). Here we report the case histories of two male patients, who presented with duodenal polypoid lesion. Endoscopic polypectomy and endoscopic submucosal dissection were carried out, respectively. Histopathologically, both polyps showed features of neoplasms of gastric phenotype. The clinical and endoscopic features, pathologic features, immunophenotype, molecular pathogenesis, clinical management and prognosis of the tw...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

Prophylactic effects of secretion metabolites of dairy lactobacilli through downregulation of ErbB-2 and ErbB-3 genes on colon cancer cells
Colon cancer is one of the most prevalent cancers, and intestinal microbial community plays a pivotal role in colorectal tumor genesis. Probiotics as live microorganisms may be able to exert an anticancer effect in colon cancer. The aim of this study was to isolate and identify Lactobacillus spp. from traditional dairy products with probiotic properties and to investigate their anticancer effects through ErbB-2 and ErbB-3 gene expression in colon cancer cells. The isolated lactobacilli from yogurt and cheese samples were molecularly identified by blasting of 16–23s rDNA region PCR sequenced products. The probiotic pr...
Source: European Journal of Cancer Prevention - April 29, 2020 Category: Cancer & Oncology Tags: Research paper: Gastrointestintal cancer Source Type: research

Phytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions
This review summarizes the current evidence on the potential role of phytol, a microbial metabolite of chlorophyl A, and its metabolites, phytanic and pristanic acids, in carcinogenesis. Primary food sources in Western diets are the nut skin for phytol and lipids in dairy, beef and fish for its metabolites. Phytol and its metabolites gained interest as dietary compounds for cancer prevention because, as natural ligands of peroxisome proliferator-activated receptor-α and -γ and retinoid X receptor, phytol and its metabolites have provided some evidence in cell culture studies and limited evidence in animal model...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Review Article: Carcinogenesis Source Type: research

Evaluation of recent evidence on the solubility of beryllium compounds and cancer risk
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Opinion: Carcinogenesis Source Type: research

Fertility drugs and cutaneous melanoma risk: a French prospective cohort study
Cutaneous melanoma has been suspected to be influenced by female sex hormones. A review of the literature in 2018 indicated that fertility drug (FD) use was associated with increased melanoma risk among parous women only. However, most studies so far were based on a retrospective design and the current evidence is unclear. We sought to prospectively investigate the associations between FD use and melanoma risk in women. E3N is a prospective cohort of 98 995 French women aged 40–65 years at inclusion in 1990. Information on use of FDs, including duration and time of administration, was assessed through self-administer...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Short Paper: Skin Cancer Source Type: research

Exploring the long noncoding RNAs-based biomarkers and pathogenesis of malignant transformation from dysplasia to oral squamous cell carcinoma by bioinformatics method
Long noncoding RNAs (lncRNAs) play an important role in many biological processes and carcinogenesis. We aimed to explore lncRNA-based pathogenesis, diagnostic biomarkers, and predictive factors of malignant transformation from dysplasia to oral squamous cell carcinoma (OSCC). Microarray data of GSE30784 consisting of 167 OSCC, 17 dysplasia, and 45 normal oral tissues were downloaded from the GEO database. The differentially expressed genes (DEGs) and lncRNAs between the three samples were identified using R, followed by lncRNA-mRNA coexpression and coregulation network analysis for the prediction of lncRNA target genes. G...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Head & Neck Cancer Source Type: research

Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis
Conclusions: Circ_PTN acted as a sponge of miR-122 and upregulated miR-122 target SOX6, thus promoting carcinogenesis of glioma cells. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Nervous System Cancer Source Type: research

A roadmap for a comprehensive control of cervical cancer in Poland: integration of available solutions into current practice in primary and secondary prevention
In Poland, cervical cancer incidence and mortality still remain considerably higher than in Western European countries or North America. Recent data indicate decreasing trends in women younger than 60 years and stable trends in older women. In this article, we identified obstacles in primary and secondary prevention of cervical cancer in Poland. We analysed local legislation, management structure and organization of cervical cancer prevention in Poland and reviewed solutions available and implemented in other European countries. The main weaknesses include: (i) very low coverage of organized screening; concurrent unregiste...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Review Article: Nervous System Cancer Source Type: research

Human papillomavirus vaccination in immigrants and descendants of immigrants in Denmark
Conclusion HPV vaccination uptake varied by country and region. Most immigrants had lower uptake than native Danes, and in most groups, this was not fully explained by socioeconomic differences. Patterns in descendants were mixed. Interventions to increase uptake should be tailored to specific groups of immigrants/descendants. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Prevalence of positive screening test results and agreement between cytology and human papillomavirus testing in primary cervical cancer screening in North-Western Romania
Using data from a pilot study conducted in North-Western Romania, we aimed to estimate the prevalence of abnormal cytology and positive high-risk human papillomavirus (hr-HPV) test results in an ethnically diverse screening population and to assess the agreement between cytology and hr-HPV testing to evaluate the feasibility of integrating the latter as a primary test in the national cervical cancer screening program. The cross-sectional pilot study included Roma women, other ethnic minorities, and women in rural remote areas. Samples were taken for liquid-based cytology and hr-HPV testing (Hybrid Capture 2 DNA test) by a ...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research

Is leisure time sitting associated with mortality rates among men diagnosed with localized prostate cancer?
Conclusions No significant association between leisure time sitting and mortality rates among men diagnosed with localized prostate cancer was seen. This study does not support an association between leisure time sitting per se; however, being physically active may have beneficial effects on survival among men diagnosed with localized prostate cancer. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Urological Cancer Source Type: research

Colorectal cancer risk factors in asymptomatic Chilean population: a survey of international collaboration between Japan and Chile
In Chile, the mortality from colorectal cancer has been on the rise. A national screening program based on a fecal immunochemical test was started in 2012 as an international collaboration with Japan. This case-control study was designed to identify the risk factors for colorectal cancer, with a goal of increasing the participation rate for colorectal cancer screening. In accordance with the Strengthening the Reporting of Observational Studies in Epidemiology guidelines, we conducted a case-control study from 2012 to 2017; 23 845 asymptomatic participants were enrolled in the study. Participants who were fecal immunochemic...
Source: European Journal of Cancer Prevention - February 4, 2020 Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research