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Regional variability of melanoma incidence and prevalence in Hungary. Epidemiological impact of ambient UV radiation and socioeconomic factors.
Background The incidence of cutaneous melanoma has risen faster than almost any other type of cancer in the last 50 years. Ultraviolet (UV) radiation and genetic susceptibility are the most important risk factors. Objective We aimed to determine the epidemiologic indicators of melanoma in Hungary, a country with an estimated population of 9.8 million and an area of 93 030 km2. Methods Anonymized patient records from the National Health Insurance Fund Management covering the entire population were used to determine the incidence and prevalence of melanoma in the counties of Hungary from 2013 to 2017. Altog...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Gynaecological cancer Source Type: research

Strategies for Lynch syndrome identification in selected and unselected gynecological cancers
In conclusion, gynecological cancers are heavily involved in LS and our study shows that MMR screening using immunohistochemical pattern and MSI analysis of endometrial and ovarian cancers as well as of rare entities such as non-HPV related endocervical cancers and synchronous endometrial and ovarian cancers are sentinels for LS. Tumor testing approach improves early identification of MMR defective gynecological cancers and this is an effective strategy to detect high-risk patients and to offer them and their relatives personalized cancer prevention. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Gynaecological cancer Source Type: research

TLR4 regulatory region variants reduce the susceptibility of small-cell lung cancer in Chinese population
This study aimed to investigate the impact of polymorphisms in the regulatory regions of TLRs on the susceptibility of SCLC. Methods The case–control study included 304 SCLC patients and 304 healthy controls. TLRs gene polymorphisms were genotyped by PCR-restrictive fragment length polymorphism analysis and TaqMan assay. Unconditional logistic regression was used to estimate odds ratio (OR) and its 95% confidence interval (95% CI). Results Our results showed that TLR4 rs1927914 GG genotype and TLR4 rs7869402 TT genotype reduced the risk of SCLC with OR (95% CI) of 0.54 (0.32–0.90) and 0.47 (0.28–0.80), ...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Breast cancer Source Type: research

Gene and prognostic value of N6-methyladenosine (m6A) modification regulatory factors in lung adenocarcinoma
Lung cancer is the leading cause of death worldwide, and its incidence continues to increase. The treatment of lung cancer is related to the subtypes and stages of cancer, but the therapeutic effect is still unsatisfactory. We found that 10 of the 13 genes were differentially expressed in lung cancer, YTHDF1, RBM15, HNRNPC, KIAA1429, METTL3 and YTHDF2 are high expression while METTL14, ZC3H13, FTO and WTAP are low expression. HNRNPC and METTL3 genes were associated with the risk and prognosis of LUAD and could regard as biomarkers for early diagnosis and treatment, which provides a theoretical basis for LUAD. (Source: Euro...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Women’s attitudes towards healthy life awareness and breast cancer screening during the coronavirus disease 2019 pandemic: a cross-sectional descriptive study
Background In the COVID-19 pandemic, fear of coronavirus infection has caused individuals to hesitate to access medical services and postpone their participation in diagnostic and screening programs. With this research, it was aimed to examine the relationship between women’s wellness awareness and attitudes towards breast cancer screening during the COVID-19 pandemic. Methods The descriptive cross-sectional type research was conducted between 30 January 2021 and 30 July 2021. The sample of the study consisted of 396 women between the ages of 40 and 69 who were in the breast cancer screening population under n...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research

Diabetes risk reduction diet and the risk of breast cancer
Conclusions Higher DRRD adherence may decrease the risk of breast cancer. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

Randomised clinical trial: comparison of efficacy and adverse effects of a standard triple clarithromycin-containing regimen with high-dose amoxicillin and bismuth therapy in Helicobacter pylori eradication
Background The clarithromycin-based triple therapy is the most prescribed Helicobacter pylori eradication regimen in Europe; it causes adverse effects in a significant proportion of subjects, leading to discontinuation. Alternative therapies are required because of increasing clarithromycin resistance or to decrease the adverse effects. Aims We compared the efficacy and spectrum of adverse effects of clarithromycin-based triple therapy with the high-dose amoxicillin/bismuth regimen. Methods A randomised clinical trial enrolled healthy individuals aged 40–64 years. H. pylori was assessed with a 13C-urea ...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

Risk of gastric cancer in chronic obstructive pulmonary disease
Objective Owing to the potential role of the gut-lung axis in carcinogenesis, we assessed the incidence of gastric cancer in patients with chronic obstructive pulmonary disease (COPD). Methods Using Quebec’s administrative databases, we assembled a cohort of 118 913 patients aged 40 years and older with COPD from 1995 to 2015. We calculated age-standardized incidence rate ratio (IRR) and 95% confidence interval (CI) for gastric cancer, comparing patients with COPD to the Quebec general population. We evaluated temporal changes in incidence by calculating annual percentage change (APC) and stratified the analys...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

New scoring systems for predicting advanced proximal neoplasia in asymptomatic adults with or without knowing distal colorectal findings: a prospective, cross-sectional study
Background Models estimating risk for advanced proximal colorectal neoplasia (APN) may be used to select colorectal cancer (CRC) screening test, either prior to knowing distal colorectal findings or afterward. Current models have only fair discrimination and nearly all require knowing distal findings. Objective Derive and test risk prediction models for APN with and without distal findings. Setting Selected endoscopy centers within central Indiana, USA. Participants Average-risk persons undergoing first-time screening colonoscopy Interventions Demographics, personal and family medical histor...
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Epidemiology Source Type: research

PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer
Conclusion Our study suggests that the minor allele G of PARP1 rs1136410 (A/G) is a predisposing factor for gallbladder carcinogenesis and is significantly associated with early onset of the disease. Interestingly, the minor allele G is significantly more frequent in the patients with jaundice, lymph node metastasis and gallbladder wall thickness. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 16, 2022 Category: Cancer & Oncology Tags: Epidemiology Source Type: research

Comment to: Inequalities in adherence to cervical cancer screening in Portugal
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 13, 2022 Category: Cancer & Oncology Tags: Letters Source Type: research

Why RNA viruses evolve more quickly than DNA viruses? A concern for cancer patients during the current pandemic
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 13, 2022 Category: Cancer & Oncology Tags: Letters Source Type: research

Thyroid cancer incidence and trends by demographic and tumor characteristics in Oran, Algeria: 1993–2013, a population-based analysis
We examined thyroid cancer incidence and trends by demographic and tumor characteristics based on 1443 patients with thyroid cancer diagnosed between 1993 and 2013 in Oran district, in Northwest Algeria. Methods All thyroid cancer cases were abstracted from medical records and pathology reports and classified according to the International Classification for Diseases in Oncology, third edition. Age-specific, age-standardized incidence rates per 100 000 person-years, and annual percent changes (APC) in the incidence were calculated. Results Age-standardized incidence was 11.7 per 100 000 for women and 2.0 ...
Source: European Journal of Cancer Prevention - April 13, 2022 Category: Cancer & Oncology Tags: Head & Neck cancer Source Type: research

Risk factors for cardiovascular mortality and melanoma-specific mortality among patients with melanoma: a SEER based study
Conclusions In patients with melanoma, the risk of cardiovascular death is higher in older patients, men, Blacks, separated, widowed and patients with nodular or lentigo maligna melanoma. The risk is lower in married, patients with superficial spreading or acral lentiginous melanoma, and patients who had chemotherapy, radiotherapy or surgery. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - April 13, 2022 Category: Cancer & Oncology Tags: Skin cancer Source Type: research

Risk factors of cervical cancer among ethnic minorities in Yunnan Province, China: a case–control study
Background Cervical cancer is a common malignant tumor of the female reproductive system in the world, which is a serious threat to women’s life and health. According to the latest report, the incidence of cervical cancer is 11.42 per 100 000, and the mortality rate is 3.77 per 100 000 in Yunnan Province, which is still higher than the national average. Although there have been some relevant studies on the risk factors of cervical cancer in recent years, research on ethnic minorities is lacking in Yunnan Province. Objective To analyze and explore the related risk factors of cervical cancer in women of ethn...
Source: European Journal of Cancer Prevention - April 13, 2022 Category: Cancer & Oncology Tags: Gynaecological cancer Source Type: research