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Evolving perspectives on stool testing for colorectal cancer: a qualitative systematic review
Conclusion This systematic review focuses on addressing and understanding the perception of FIT from first-hand accounts. Since its inception, FIT screening has increased colorectal cancer screening uptake due to its increased reliability and the simplicity of the test. However, there is a need to increase the uptake of FIT kits through increasing accessibility of the screening process and considering the holistic patient experience. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4)
Background The association among gallbladder disease, cholecystectomy, and pancreatic cancer is unclear. Moreover, time interval between gallbladder disease or cholecystectomy and pancreatic cancer diagnosis is not considered in most previous studies. Aim To quantify the association among gallbladder disease, cholecystectomy, and pancreatic cancer, considering time since first diagnosis of gallbladder disease or cholecystectomy. Methods We used data from nine case-control studies within the Pancreatic Cancer Case-Control Consortium, including 5760 cases of adenocarcinoma of the exocrine pancreas and 8437 controls. ...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

How do international gastric cancer prevention guidelines influence clinical practice globally?
Clinical guidelines recommend particular approaches, including ‘screen-and-treat’ strategy for Helicobacter pylori, to prevent gastric cancer. However, little of this is implemented in clinical practice. The aim of the study was to identify barriers to implementation of international guidelines. A web-based questionnaire distributed globally to specialists in the field. Altogether 886 responses from 75 countries were received. Of the responders, 570 (64%) were men of mean age 47 years. There were 606 gastroenterologists and 65 epidemiologists among the responders. Altogether, 79.8% of the responders disagreed that the ...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Years of life lost due to malignant neoplasms of the digestive system in Poland during 10 years of socioeconomic transformation
The aim of the study was to analyse years of life lost due to selected malignant neoplasms of the digestive system (colorectum, stomach, and pancreas) in Poland, a post-communist country in Central Europe, according to socioeconomic variables: sex, age, level of education, marital status, working status, and place of residence. The study included a dataset comprising death certificates of Polish citizens from 2002 (N = 359 486) and 2011 (N = 375 501). The data on deaths caused by malignant neoplasms of the digestive system, that is, coded as C15-C26 according to International Statistical Classification of Diseases and ...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Tea drinking and the risk of esophageal cancer: focus on tea type and drinking temperature
This study is to determine the association between tea drinking and esophageal squamous cell carcinoma focusing on drinking temperature and tea types. A population-based case-control study was conducted in a high esophageal squamous cell carcinoma risk area in China. A total of 942 incident esophageal squamous cell carcinoma cases with historical confirmation and 942 age- and sex- individually matched community controls were recruited from the study area. Trained interviewers using a structured questionnaire collected detailed information on tea drinking, diet, smoking and alcohol drinking habits. Habitual tea drinking tem...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Gastrointestinal cancer Source Type: research

Progress in cancer mortality, incidence, and survival: a global overview
Cancer mortality has declined over the last three decades in most high-income countries reflecting improvements in cancer prevention, diagnosis, and management. However, there are persisting and substantial differences in mortality, incidence, and survival worldwide. In order to provide an up-to-date overview of trends in mortality, incidence, and survival, we retrieved data from high-quality, population-based cancer registries for all cancers and 10 selected cancer sites in six high-income countries and the European Union. We computed age-standardized (world standard population) mortality and incidence rates, and applied ...
Source: European Journal of Cancer Prevention - August 3, 2020 Category: Cancer & Oncology Tags: Research Articles: Headline Source Type: research

Why is COVID-19 virus so deadly for cancer patients?
No abstract available (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Transcriptomic analysis reveals that heat shock protein 90α is a potential diagnostic and prognostic biomarker for cancer
In conclusion, we demonstrated that high HSP90AA1 expression was ubiquitous in cancer and that HSP90AA1 was a potential diagnostic and prognostic biomarker for hepatocellular carcinoma. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Early detection Source Type: research

The reduction of CA 125 serum levels in BRCA 1/2 mutation carriers after risk-reducing salpingo-oophorectomy is only partially associated with surgery: a prospective cohort, other biomarker controlled, study
Objectives A significant reduction in CA 125 postoperative serum levels was observed after risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers. In contrast to previous studies, where control groups were absent, we conducted a prospective study including also a screening only group (RSSO refusal) and a group having previously undergone RRSO. Methods Consecutive BRCA1 and BRCA2 mutation carriers, not hysterectomised,>35 years old and with completed childbearing, were recruited. Some women had previously undergone RRSO (previous RRSO group). The others, who had either chosen RRSO (actual RRSO group) or s...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

HPV vaccine acceptance and hesitancy – lessons learned during 8 years of regional HPV prophylaxis program in Wroclaw, Poland
In 2019, the WHO has announced that it will intensify efforts to eliminate cervical cancer worldwide by increasing coverage of the HPV (Human Papillomavirus) vaccine. Finding reasons for low HPV vaccine coverage and looking for solutions to address the problem should be the priorities for public health. The municipality of Wroclaw (Poland) attempted to meet the challenge earlier by introducing a Prophylaxis Program against HPV in 2010. The core of the program are educational meetings at schools and free vaccinations offered at GP offices. After five successful years (vaccination coverage>80% fully vaccinated), vaccination ...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

Factors associated with cervical intraepithelial neoplasia (CIN2/CIN3), early stage and advanced stage of cervical cancer diagnosis in the Brazilian Amazonian region
To understand the impact of demographic, behavioral and contextual factors on cervical cancer, we examined the profile of women classified according to cervical cancer staging [precursor lesions cervical intraephitelial neoplasia (CIN2/CIN3), early- and advanced-stage cancer]. Patients were identified in the main oncological reference hospital in Pará State, Brazil, from 2013 through 2015. Adjusted prevalence ratios and their respective 95% confidence intervals were estimated using Poisson regression with robust variance. The study included 172 cases of CIN2/CIN3 lesions, 158 of early stage and 552 of advanced stage of ce...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Gynecological cancer Source Type: research

Drug consumption and melanocytic nevi: correlation between oral contraceptives or hormone replacement therapy and a high melanocytic nevi count
The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk. Aims of the study were to evaluate a possible association between the above-mentioned drugs and features such as number and atypia of melanocytic nevi in long-term users. We retrospectively looked at pharmacological, clinical and dermoscopic records of 1321 patients that attended our unit for routine mole check between January 2013 and January 2018. Patients were divided into two groups...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Skin cancer Source Type: research

Association of rs8444 polymorphism in the LASS2 3′-UTR and bladder cancer risk in Chinese population
The aim of the present study was to explore the correlations between single nucleotide polymorphisms in LASS2 gene 3′-untranslated regions and bladder cancer risk in Chinese population. We first performed PCR and sequence for LASS2-3′-UTR in 105 bladder cancer patients and 100 control subjects. Next, multivariate logistic regression analysis was used to determine the relationship between single nucleotide polymorphisms frequency and susceptibility of bladder cancer, and clinical features in 105 cases. In addition, survival curves and Cox Regression analysis were used to investigate the effect of single nucleotide polym...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Urological cancer Source Type: research

Recent developments and advances in secondary prevention of lung cancer
Lung cancer prevention may include primary prevention strategies, such as corrections of working conditions and life style – primarily smoking cessation – as well as secondary prevention strategies, aiming at early detection that allows better survival rates and limited resections. This review summarizes recent developments and advances in secondary prevention, focusing on recent technological tools for an effective early diagnosis. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Lung cancer Source Type: research

The diagnostic efficiency of seven autoantibodies in lung cancer
This study aimed to evaluate the diagnostic efficacy of seven autoantibodies in all lung cancer, lung adenocarcinoma, lung squamous cell carcinoma and early-stage lung cancer patients. ELISA testing of a seven autoantibody panel was performed on 386 lung cancer patients and 238 normal controls. The sensitivity and specificity of each autoantibody were analyzed using the receiver operating characteristic curve analysis. The diagnostic efficacy of a combination of these seven autoantibodies was evaluated by binary logistic regression. The results indicated that six of the seven autoantibodies (p53, SOX2, GAGE7, GBU4-5, MAGEA...
Source: European Journal of Cancer Prevention - June 19, 2020 Category: Cancer & Oncology Tags: Research paper: Lung cancer Source Type: research