Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C
Regulatory elements such as promoters, enhancers, and insulators interact each other to mediate molecular processes. To capture chromatin interactions of regulatory elements, 3C-derived methods such as Hi-C an... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 21, 2022 Category: Genetics & Stem Cells Authors: Beoung Hun Lee, Zexun Wu and Suhn K. Rhie Tags: Research Source Type: research
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system
Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in targe... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 16, 2022 Category: Genetics & Stem Cells Authors: Takuro Horii, Sumiyo Morita, Mika Kimura and Izuho Hatada Tags: Methodology Source Type: research
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical region of human chromosome 21 (HSA21). Major studies were conducted in recent years to ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 3, 2022 Category: Genetics & Stem Cells Authors: Sean J. Farley, Alla Grishok and Ella Zeldich Tags: Review Source Type: research
Manipulating chromatin architecture in C. elegans
Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Unders... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 29, 2022 Category: Genetics & Stem Cells Authors: John L. Carter, Colton E. Kempton, Emily D. S. Hales and Steven M. Johnson Tags: Research Source Type: research
Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 24, 2022 Category: Genetics & Stem Cells Authors: Ana Cuadrado, Daniel Gim énez-Llorente, Magali De Koninck, Miguel Ruiz-Torres, Aleksandar Kojic, Miriam Rodríguez-Corsino and Ana Losada Tags: Research Source Type: research
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model
Three-dimensional (3D) cell culture has emerged as an alternative approach to 2D flat culture to model more accurately the phenotype of solid tissue in laboratories. Culturing cells in 3D more precisely recapi... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 21, 2022 Category: Genetics & Stem Cells Authors: Stephanie Stransky, Ronald Cutler, Jennifer Aguilan, Edward Nieves and Simone Sidoli Tags: Research Source Type: research
De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 21, 2022 Category: Genetics & Stem Cells Authors: David A. Vinson, Kimberly E. Stephens, Robert N. O ’Meally, Shri Bhat, Blair C. R. Dancy, Robert N. Cole, Srinivasan Yegnasubramanian and Sean D. Taverna Tags: Research Source Type: research
A standardized nomenclature for mammalian histone genes
Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resul... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 1, 2022 Category: Genetics & Stem Cells Authors: Ruth L. Seal, Paul Denny, Elspeth A. Bruford, Anna K. Gribkova, David Landsman, William F. Marzluff, Monica McAndrews, Anna R. Panchenko, Alexey K. Shaytan and Paul B. Talbert Tags: Review Source Type: research
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and whether the effects are heritable. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 10, 2022 Category: Genetics & Stem Cells Authors: Rose Schrott, Jennifer L. Modliszewski, Andrew B. Hawkey, Carole Grenier, Zade Holloway, Janequia Evans, Erica Pippen, David L. Corcoran, Edward D. Levin and Susan K. Murphy Tags: Research Source Type: research
Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals
The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 27, 2022 Category: Genetics & Stem Cells Authors: Teruhito Ishihara, Oliver W. Griffith, Shunsuke Suzuki and Marilyn B. Renfree Tags: Research Source Type: research
An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae
Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can provide phenotypic plasticity in reaction to environmental cues. While prior studies s... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 20, 2022 Category: Genetics & Stem Cells Authors: Rachel M. Reardon, Amanda K. Walsh, Clairine I. Larsen, LauraAnn H. Schmidberger, Lillian A. Morrow, Adriane E. Thompson, Isabel M. Wellik and Jeffrey S. Thompson Tags: Research Source Type: research
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene expression. The core cohesin trimer interacts with various HEAT repeat accessory subun... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 19, 2022 Category: Genetics & Stem Cells Authors: Nicole L. Arruda, Audra F. Bryan and Jill M. Dowen Tags: Research Source Type: research
Multi-omics analyses of MEN1 missense mutations identify disruption of menin –MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other typ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 9, 2022 Category: Genetics & Stem Cells Authors: Koen M. A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin and H. T. Marc Timmers Tags: Research Source Type: research
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite the... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 2, 2022 Category: Genetics & Stem Cells Authors: Basilia Acurzio, Francesco Cecere, Carlo Giaccari, Ankit Verma, Rosita Russo, Mariangela Valletta, Bruno Hay Mele, Claudia Angelini, Angela Chambery and Andrea Riccio Tags: Research Source Type: research
Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts
Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 2, 2022 Category: Genetics & Stem Cells Authors: John F. Dou, Lauren Y. M. Middleton, Yihui Zhu, Kelly S. Benke, Jason I. Feinberg, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, Janine M. LaSalle, Daniele Fallin, Rebecca J. Schmidt and Kelly M. Bakulski Tags: Research Source Type: research
