Etiology of super-enhancer reprogramming and activation in cancer
Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer landscape. These aberrant super... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 6, 2023 Category: Genetics & Stem Cells Authors: Royce W. Zhou and Ramon E. Parsons Tags: Review Source Type: research
Alterations in the hepatocyte epigenetic landscape in steatosis
Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 6, 2023 Category: Genetics & Stem Cells Authors: Ranjan Kumar Maji, Beate Czepukojc, Michael Scherer, Sascha Tierling, Cristina Cadenas, Kathrin Gianmoena, Nina Gasparoni, Karl Nordstr öm, Gilles Gasparoni, Stephan Laggai, Xinyi Yang, Anupam Sinha, Peter Ebert, Maren Falk-Paulsen, Sarah Kinkley, Jessic Tags: Research Source Type: research
The role of Dmnt1 during spermatogenesis of the insect Oncopeltus fasciatus
The function of DNA methyltransferase genes of insects is a puzzle, because an association between gene expression and methylation is not universal for insects. If the genes normally involved in cytosine methy... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 1, 2023 Category: Genetics & Stem Cells Authors: Christopher B. Cunningham, Emily A. Shelby, Elizabeth C. McKinney, Robert J. Schmitz, Allen J. Moore and Patricia J. Moore Tags: Research Source Type: research
Live-cell imaging of chromatin contacts opens a new window into chromatin dynamics
Our understanding of the organization of the chromatin fiber within the cell nucleus has made great progress in the last few years. High-resolution techniques based on next-generation sequencing as well as opt... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 23, 2023 Category: Genetics & Stem Cells Authors: Jente van Staalduinen, Thomas van Staveren, Frank Grosveld and Kerstin S. Wendt Tags: Review Source Type: research
Assignment of the somatic A/B compartments to chromatin domains in giant transcriptionally active lampbrush chromosomes
The three-dimensional configuration of the eukaryotic genome is an emerging area of research. Chromosome conformation capture outlined genome segregation into large scale A and B compartments corresponding mai... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 15, 2023 Category: Genetics & Stem Cells Authors: Alla Krasikova, Tatiana Kulikova, Juan Sebastian Rodriguez Ramos and Antonina Maslova Tags: Research Source Type: research
Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites
Gene expression in malaria parasites is subject to various layers of regulation, including histone post-translational modifications (PTMs). Gene regulatory mechanisms have been extensively studied during the m... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 15, 2023 Category: Genetics & Stem Cells Authors: Ashley B. Reers, Rodriel Bautista, James McLellan, Beatriz Morales, Rolando Garza, Sebastiaan Bol, Kirsten K. Hanson and Evelien M. Bunnik Tags: Research Source Type: research
PARP-dependent and NAT10-independent acetylation of N4-cytidine in RNA appears in UV-damaged chromatin
RNA modifications have been known for many years, but their function has not been fully elucidated yet. For instance, the regulatory role of acetylation on N4-cytidine (ac4C) in RNA can be explored not only in... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 15, 2023 Category: Genetics & Stem Cells Authors: Alena Svobodov á Kovaříková, Lenka Stixová, Aleš Kovařík and Eva Bártová Tags: Research Source Type: research
Var ∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data
High-throughput sequencing (HTS) offers unprecedented opportunities for the discovery of causative gene variants in multiple human disorders including cancers, and has revolutionized clinical diagnostics. Howe... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 14, 2023 Category: Genetics & Stem Cells Authors: Mohammad Salma, Elina Alaterre, J érôme Moreaux and Eric Soler Tags: Methodology Source Type: research
Correction: Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi ‑C, Micro‑C, and promoter capture Micro‑C
(Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 7, 2023 Category: Genetics & Stem Cells Authors: Beoung Hun Lee, Zexun Wu and Suhn K. Rhie Tags: Correction Source Type: research
CpG DNA methylation changes during epididymal sperm maturation in bulls
During epididymal transit spermatozoa acquire specific morphological features which enhance their ability to swim in a progressive manner and interact with the oocytes. At the same time, sperm cells undergo sp... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 30, 2023 Category: Genetics & Stem Cells Authors: Emanuele Capra, F. Turri, B. Lazzari, S. Biffani, A. Lange Consiglio, P. Ajmone Marsan, A. Stella and F. Pizzi Tags: Research Source Type: research
Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin
Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of three-dimensional (3D) chromatin... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 30, 2023 Category: Genetics & Stem Cells Authors: Igor S. Tolokh, Nicholas Allen Kinney, Igor V. Sharakhov and Alexey V. Onufriev Tags: Research Source Type: research
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations
Patients with balanced X-autosome translocations and premature ovarian insufficiency (POI) constitute an interesting paradigm to study the effect of chromosome repositioning. Their breakpoints are clustered wi... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 19, 2023 Category: Genetics & Stem Cells Authors: Adriana Di-Battista, Bianca Pereira Favilla, Mal ú Zamariolli, Natália Nunes, Alexandre Defelicibus, Lucia Armelin-Correa, Israel Tojal da Silva, Alexandre Reymond, Mariana Moyses-Oliveira and Maria Isabel Melaragno Tags: Research Source Type: research
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in differe... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 13, 2023 Category: Genetics & Stem Cells Authors: Eva Monte-Serrano, Patricia Morej ón-García, Ignacio Campillo-Marcos, Aurora Campos-Díaz, Elena Navarro-Carrasco and Pedro A. Lazo Tags: Research Source Type: research
Loss of CpG island immunity to DNA methylation induced by mutation
The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715 –731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 11, 2023 Category: Genetics & Stem Cells Authors: Bernhard Horsthemke and Adrian Bird Tags: Comment Source Type: research
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes
Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome. Altho... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 10, 2023 Category: Genetics & Stem Cells Authors: Benjamin H. Weekley and Judd C. Rice Tags: Research Source Type: research
