Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
Histone modifications are one of the many key mechanisms that regulate gene expression. Ash1 is a histone H3K36 methyltransferase and is involved in gene activation. Ash1 forms a large complex with Mrg15 and C... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 29, 2023 Category: Genetics & Stem Cells Authors: Eojin Yoon and Ji-Joon Song Tags: Research Source Type: research
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas
IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant h... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 28, 2023 Category: Genetics & Stem Cells Authors: Xinyu Wang, Lijun Dai, Yang Liu, Chenghao Li, Dandan Fan, Yue Zhou, Pengcheng Li, Qingran Kong and Jianzhong Su Tags: Research Source Type: research
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies
Single-cell technologies to analyze transcription and chromatin structure have been widely used in many research areas to reveal the functions and molecular properties of cells at single-cell resolution. Sampl... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 28, 2023 Category: Genetics & Stem Cells Authors: Betelehem Solomon Bera, Taylor V. Thompson, Eric Sosa, Hiroko Nomaru, David Reynolds, Robert A. Dubin, Shahina B. Maqbool, Deyou Zheng, Bernice E. Morrow, John M. Greally and Masako Suzuki Tags: Methodology Source Type: research
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart
Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberran... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 27, 2023 Category: Genetics & Stem Cells Authors: Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal and Sandhya L. Sitasawad Tags: Research Source Type: research
Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
Epigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are largely unknown. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 19, 2023 Category: Genetics & Stem Cells Authors: Jiamin Jin, Peipei Ren, Xiang Li, Yinyi Zhang, Weijie Yang, Yerong Ma, Mengru Lai, Chao Yu, Songying Zhang and Yin-Li Zhang Tags: Research Source Type: research
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of h... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 7, 2023 Category: Genetics & Stem Cells Authors: Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert and Jeffrey Fillingham Tags: Research Source Type: research
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including tumorigenesis. However, the function and expression of PCGF6 i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 9, 2023 Category: Genetics & Stem Cells Authors: Meng Zhu, Ruo-Nan Zhang, Hong Zhang, Chang-bao Qu, Xiao-chong Zhang, Li-Xin Ren, Zhan Yang and Jun-Fei Gu Tags: Research Source Type: research
Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
KDM5 family proteins are multi-domain regulators of transcription that when dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate transcription through their histone demethy... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 18, 2023 Category: Genetics & Stem Cells Authors: Matanel Yheskel, Simone Sidoli and Julie Secombe Tags: Research Source Type: research
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
Allele-specific methylation of the imprinting control region (ICR) is the molecular basis for the genomic imprinting phenomenon that is unique to placental mammals. We previously showed that the ICR at the mouse (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 17, 2023 Category: Genetics & Stem Cells Authors: Hitomi Matsuzaki, Shokichi Sugihara and Keiji Tanimoto Tags: Research Source Type: research
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In eukaryotes, three SMC complexes (cohesin, condensin and SMC5/6) play key roles i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 16, 2023 Category: Genetics & Stem Cells Authors: L. Mahrik, B. Stefanovie, A. Maresova, J. Princova, P. Kolesar, E. Lelkes, C. Faux, D. Helmlinger, M. Prevorovsky and J. J. Palecek Tags: Research Source Type: research
The impact of spatial correlation on methylation entropy with application to mouse brain methylome
With the advance of bisulfite sequencing technologies, massive amount of methylation data have been generated, which provide unprecedented opportunities to study the epigenetic mechanism and its relationship t... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 4, 2023 Category: Genetics & Stem Cells Authors: Xiaowei Wu and Joung Min Choi Tags: Methodology Source Type: research
Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
Cellular differentiation is marked by temporally and spatially coordinated gene expression regulated at multiple levels. DNA methylation represents a universal mechanism to control chromatin organization and i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 25, 2023 Category: Genetics & Stem Cells Authors: William Chang, Yilin Zhao, Danielle Ray êe, Qing Xie, Masako Suzuki, Deyou Zheng and Ales Cvekl Tags: Research Source Type: research
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization
Preconception exposure to phthalates such as the anti-androgenic dibutyl-phthalate (DBP) impacts both male and female reproduction, yet how this occurs largely remains unknown. Previously we defined a series o... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 24, 2023 Category: Genetics & Stem Cells Authors: G. M. Swanson, F. L. Nassan, J. B. Ford, R. Hauser, J. R. Pilsner and S. A. Krawetz Tags: Research Source Type: research
ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken
Sex determination and differentiation are complex and delicate processes. In female chickens, the process of sex differentiation is sensitive and prone to be affected by the administration of aromatase inhibit... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 9, 2023 Category: Genetics & Stem Cells Authors: Xiuan Zhang, Jianbo Li, Xiqiong Wang, Yuchen Jie, Congjiao Sun, Jiangxia Zheng, Junying Li, Ning Yang and Sirui Chen Tags: Research Source Type: research
Who ’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data
Many human disease phenotypes manifest differently by sex, making the development of methods for incorporating X and Y-chromosome data into analyses vital. Unfortunately, X and Y chromosome data are frequently... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 7, 2023 Category: Genetics & Stem Cells Authors: Amy M. Inkster, Martin T. Wong, Allison M. Matthews, Carolyn J. Brown and Wendy P. Robinson Tags: Methodology Source Type: research
