A comprehensive overview of bull sperm-borne small non-coding RNAs and their diversity across breeds
Mature sperm carry thousands of RNAs, including mRNAs, lncRNAs, tRNAs, rRNAs and sncRNAs, though their functional significance is still a matter of debate. Growing evidence suggests that sperm RNAs, especially... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 30, 2020 Category: Genetics & Stem Cells Authors: Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Jean-Philippe Perrier, S ébastien Fritz, Chrystelle Le Danvic, Mekki Boussaha, Hélène Kiefer, Hélène Jammes and Laurent Schibler Tags: Research Source Type: research
The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation
SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression, establishmen... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2020 Category: Genetics & Stem Cells Authors: Jacquelyn A. Myers, Tyler Couch, Zachary Murphy, Jeffrey Malik, Michael Getman and Laurie A. Steiner Tags: Research Source Type: research
The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure
Allele-specific DNA methylation (ASM) describes genomic loci that maintain CpG methylation at only one inherited allele rather than having coordinated methylation across both alleles. The most prominent of the... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2020 Category: Genetics & Stem Cells Authors: Dana M. Freeman, Dan Lou, Yanqiang Li, Suzanne N. Martos and Zhibin Wang Tags: Research Source Type: research
DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices
MeCP2 and MBD2 are members of a family of proteins that possess a domain that selectively binds 5-methylcytosine in a CpG context. Members of the family interact with other proteins to modulate DNA packing. St... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2020 Category: Genetics & Stem Cells Authors: Ming Liu, Saeid Movahed, Saroj Dangi, Hai Pan, Parminder Kaur, Stephanie M. Bilinovich, Edgar M. Faison, Gage O. Leighton, Hong Wang, David C. Williams Jr. and Robert Riehn Tags: Research Source Type: research
Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin conformation via aryl hydrocarbon receptor
Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic profile of the Nanog gene, but whether chromatin organizati... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 14, 2020 Category: Genetics & Stem Cells Authors: Francisco J. Gonz ález-Rico, Cristina Vicente-García, Almudena Fernández, Diego Muñoz-Santos, Lluís Montoliu, Antonio Morales-Hernández, Jaime M. Merino, Angel-Carlos Román and Pedro M. Fernández-Salguero Tags: Research Source Type: research
Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation
Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies have also implicated BET proteins as regulators of ce... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 10, 2020 Category: Genetics & Stem Cells Authors: Archit Trivedi, Aanchal Mehrotra, Caitlin E. Baum, Brandon Lewis, Tupa Basuroy, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Vijayasaradhi Setaluri and Ivana L. de la Serna Tags: Research Source Type: research
In vivo visualization of the i-motif DNA secondary structure in the Bombyx mori testis
A large number of in vitro experiments have confirmed that DNA molecules can form i-motif advanced structure when multiple cytosines exist in the sequence. However, whether these structures are present in vivo... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 5, 2020 Category: Genetics & Stem Cells Authors: Wenhuan Tang, Kangkang Niu, Guoxing Yu, Ying Jin, Xian Zhang, Yuling Peng, Shuna Chen, Huimin Deng, Sheng Li, Jian Wang, Qisheng Song and Qili Feng Tags: Research Source Type: research
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice
Maternal smoking of traditional or electronic cigarettes during pregnancy, which constitutes developmental nicotine exposure (DNE), heightens the risk of neurodevelopmental disorders including ADHD, autism, an... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 5, 2020 Category: Genetics & Stem Cells Authors: Jordan M. Buck, Heidi C. O ’Neill and Jerry A. Stitzel Tags: Research Source Type: research
Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes
H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50 –60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mou... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 4, 2020 Category: Genetics & Stem Cells Authors: Iyer Aditya Mahadevan, Sanjeev Kumar and Manchanahalli R. Satyanarayana Rao Tags: Research Source Type: research
Identification of DNA N6-methyladenine sites by integration of sequence features
An increasing number of nucleic acid modifications have been profiled with the development of sequencing technologies. DNA N6-methyladenine (6mA), which is a prevalent epigenetic modification, plays important rol... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 24, 2020 Category: Genetics & Stem Cells Authors: Hao-Tian Wang, Fu-Hui Xiao, Gong-Hua Li and Qing-Peng Kong Tags: Methodology Source Type: research
JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability
Maintaining a proper supply of soluble histones throughout the cell cycle is important to ensure chromatin and genome stability. Following their synthesis, histones undergo a series of maturation steps to prep... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 18, 2020 Category: Genetics & Stem Cells Authors: Francisco Saavedra, Zachary A. Gurard-Levin, Camila Rojas-Villalobos, Isabelle Vassias, Raquel Quatrini, Genevi ève Almouzni and Alejandra Loyola Tags: Research Source Type: research
Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish
Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases. This susceptibility may in part be caused by changes to the epigenetic landscape w... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 12, 2020 Category: Genetics & Stem Cells Authors: Marjo J. den Broeder, Jarle Ballangby, Leonie M. Kamminga, Peter Alestr öm, Juliette Legler, Leif C. Lindeman and Jorke H. Kamstra Tags: Research Source Type: research
Integrative prediction of gene expression with chromatin accessibility and conformation data
Enhancers play a fundamental role in orchestrating cell state and development. Although several methods have been developed to identify enhancers, linking them to their target genes is still an open problem. S... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 6, 2020 Category: Genetics & Stem Cells Authors: Florian Schmidt, Fabian Kern and Marcel H. Schulz Tags: Research Source Type: research
Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
Plant homeodomain (PHD) fingers are central “readers” of histone post-translational modifications (PTMs) with> 100 PHD finger-containing proteins encoded by the human genome. Many of the PHDs studied to date ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 24, 2020 Category: Genetics & Stem Cells Authors: Kanishk Jain, Caroline S. Fraser, Matthew R. Marunde, Madison M. Parker, Cari Sagum, Jonathan M. Burg, Nathan Hall, Irina K. Popova, Keli L. Rodriguez, Anup Vaidya, Krzysztof Krajewski, Michael-Christopher Keogh, Mark T. Bedford and Brian D. Strahl Tags: Research Source Type: research
Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 14, 2020 Category: Genetics & Stem Cells Authors: Hitomi Matsuzaki, Daichi Kuramochi, Eiichi Okamura, Katsuhiko Hirakawa, Aki Ushiki and Keiji Tanimoto Tags: Research Source Type: research
