Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans
Chromatin organization is central to precise control of gene expression. In various eukaryotic species, domains of pervasive cis-chromatin interactions demarcate functional domains of the genomes. In nematode Cae... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 9, 2020 Category: Genetics & Stem Cells Authors: Alexis V. Stutzman, April S. Liang, Vera Beilinson and Kohta Ikegami Tags: Research Source Type: research
MethylToSNP: identifying SNPs in Illumina DNA methylation array data
Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA. In the absence ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 20, 2019 Category: Genetics & Stem Cells Authors: Brenna A. LaBarre, Alexander Goncearenco, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Vanessa M. Hayes and Laura Elnitski Tags: Methodology Source Type: research
Age-associated sperm DNA methylation patterns do not directly persist trans-generationally
The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly unders... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Timothy G. Jenkins, Emma R. James, Kenneth I. Aston, Albert Salas-Huetos, Alexander W. Pastuszak, Ken R. Smith, Heidi A. Hanson, James M. Hotaling and Douglas T. Carrell Tags: Research Source Type: research
Nickel-induced transcriptional changes persist post exposure through epigenetic reprogramming
Nickel is an occupational and environmental toxicant associated with a number of diseases in humans including pulmonary fibrosis, bronchitis and lung and nasal cancers. Our earlier studies showed that the nick... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Cynthia C. Jose, Zhenjia Wang, Vinay Singh Tanwar, Xiaoru Zhang, Chongzhi Zang and Suresh Cuddapah Tags: Research Source Type: research
Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects
Neural tube defects (NTDs) are severe, common birth defects that result from failure of normal neural tube closure during early embryogenesis. Accumulating strong evidence indicates that genetic factors contri... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Juan Yu, Lei Wang, Pei Pei, Xue Li, Jianxin Wu, Zhiyong Qiu, Juan Zhang, Ruifang Ao, Shan Wang, Ting Zhang and Jun Xie Tags: Research Source Type: research
Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells
Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. T... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno & hel Tags: Research Source Type: research
Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1 α/β-mediated adaptive stress response pathway in skeletal muscle cells
While the role of Polycomb group protein-mediated “cell memory” is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells. Emergin... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba Nadeef and Valerio Orlando Tags: Research Source Type: research
Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model
Members of the HMGN protein family modulate chromatin structure and influence epigenetic modifications. HMGN1 and HMGN2 are highly expressed during early development and in the neural stem/progenitor cells of ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 12, 2019 Category: Genetics & Stem Cells Authors: Sylvia Garza-Manero, Abdulmajeed Abdulghani A. Sindi, Gokula Mohan, Ohoud Rehbini, Valentine H. M. Jeantet, Mariarca Bailo, Faeezah Abdul Latif, Maureen P. West, Ross Gurden, Lauren Finlayson, Silvija Svambaryte, Adam G. West and Katherine L. West Tags: Research Source Type: research
The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization
Data mining of The Cancer Genome Atlas (TCGA) data has significantly facilitated cancer genome research and provided unprecedented opportunities for cancer researchers. However, existing web applications for D... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 5, 2019 Category: Genetics & Stem Cells Authors: Yin Li, Di Ge and Chunlai Lu Tags: Methodology Source Type: research
The distributions of protein coding genes within chromatin domains in relation to human disease
Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented re... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 5, 2019 Category: Genetics & Stem Cells Authors: Enrique M. Muro, Jonas Ibn-Salem and Miguel A. Andrade-Navarro Tags: Research Source Type: research
Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington ’s Disease Monkey pluripotent stem cells
Huntington ’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and signific... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Alexandra V. Goodnight, Isaac Kremsky, Sujittra Khampang, Yoon Hee Jung, James M. Billingsley, Steven E. Bosinger, Victor G. Corces and Anthony W. S. Chan Tags: Research Source Type: research
BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex —a tumour suppressor or tumour-promoting factor?
BRM (BRAHMA) is a core, SWI2/SNF2-type ATPase subunit of SWI/SNF chromatin-remodelling complex (CRC) involved in various important regulatory processes including development. Mutations in SMARCA2, a BRM-encoding ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Iga Jancewicz, Janusz A. Siedlecki, Tomasz J. Sarnowski and Elzbieta Sarnowska Tags: Review Source Type: research
Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects
Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang and Ting Zhang Tags: Research Source Type: research
The impact of genetic background and cell lineage on the level and pattern of gene expression in position effect variegation
Chromatin-based transcriptional silencing is often described as a stochastic process, largely because of the mosaic expression observed in position effect variegation (PEV), where a euchromatic reporter gene i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Sidney H. Wang and Sarah C. R. Elgin Tags: Research Source Type: research
The role of cigarette smoke-induced epigenetic alterations in inflammation
Exposure to cigarette smoke (CS) is a major threat to human health worldwide. It is well established that smoking increases the risk of respiratory diseases, cardiovascular diseases and different forms of canc... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 11, 2019 Category: Genetics & Stem Cells Authors: Dandan Zong, Xiangming Liu, Jinhua Li, Ruoyun Ouyang and Ping Chen Tags: Review Source Type: research
