Virtual methylome dissection facilitated by single-cell analyses
Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It remains a ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 11, 2019 Category: Genetics & Stem Cells Authors: Liduo Yin, Yanting Luo, Xiguang Xu, Shiyu Wen, Xiaowei Wu, Xuemei Lu and Hehuang Xie Tags: Methodology Source Type: research
Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences
In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retai... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 17, 2019 Category: Genetics & Stem Cells Authors: Julianna Nechin, Emma Tunstall, Naideline Raymond, Nicole Hamagami, Chris Pathmanabhan, Samantha Forestier and Tamara L. Davis Tags: Research Source Type: research
DNA methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development
DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation remains poorly unde... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 10, 2019 Category: Genetics & Stem Cells Authors: Keith D. Harris, James P. B. Lloyd, Katherine Domb, Daniel Zilberman and Assaf Zemach Tags: Research Source Type: research
MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2
MeCP2 —a chromatin-binding protein associated with Rett syndrome—has two main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specifi... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 10, 2019 Category: Genetics & Stem Cells Authors: Alexia Mart ínez de Paz, Leila Khajavi, Hélène Martin, Rafael Claveria-Gimeno, Susanne Tom Dieck, Manjinder S. Cheema, Jose V. Sanchez-Mut, Malgorzata M. Moksa, Annaick Carles, Nick I. Brodie, Taimoor I. Sheikh, Melissa E. Freeman, Evgeniy V. Petrotche Tags: Research Source Type: research
Early-life DNA methylation profiles are indicative of age-related transcriptome changes
Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification r... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Niran Hadad, Dustin R. Masser, Laura Blanco-Berdugo, David R. Stanford and Willard M. Freeman Tags: Research Source Type: research
DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA me... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Ling Chen, Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai, Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu, Zanxian Xia and Yongguang Tao Tags: Research Source Type: research
Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate
Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Heidi G. Sutherland, Nicole White, Daniel Kennedy, Kerry Mengersen, Larisa M. Haupt and Lyn R. Griffiths Tags: Research Source Type: research
Joint inference and alignment of genome structures enables characterization of compartment-independent reorganization across cell types
Comparisons of Hi –C data sets between cell types and conditions have revealed differences in topologically associated domains (TADs) and A/B compartmentalization, which are correlated with differences in gene ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Lila Rieber and Shaun Mahony Tags: Methodology Source Type: research
Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator
Polycomb group (PcG) and trithorax group (trxG) proteins contribute to the specialization of cell types by maintaining differential gene expression patterns. Initially discovered as positive regulators of HOX ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2019 Category: Genetics & Stem Cells Authors: Zain Umer, Jawad Akhtar, Muhammad Haider Farooq Khan, Najma Shaheen, Muhammad Abdul Haseeb, Khalida Mazhar, Aziz Mithani, Saima Anwar and Muhammad Tariq Tags: Research Source Type: research
Histone chaperones and the Rrm3p helicase regulate flocculation in S. cerevisiae
Biofilm formation or flocculation is a major phenotype in wild type budding yeasts but rarely seen in laboratory yeast strains. Here, we analysed flocculation phenotypes and the expression of FLO genes in laborat... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2019 Category: Genetics & Stem Cells Authors: Hollie Rowlands, Kholoud Shaban, Barret Foster, Yannic Proteau and Krassimir Yankulov Tags: Research Source Type: research
CGGBP1 regulates CTCF occupancy at repeats
CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2019 Category: Genetics & Stem Cells Authors: Divyesh Patel, Manthan Patel, Subhamoy Datta and Umashankar Singh Tags: Research Source Type: research
Detailed insight into the dynamics of the initial phases of de novo RNA-directed DNA methylation in plant cells
Methylation of cytosines is an evolutionarily conserved epigenetic mark that is essential for the control of chromatin activity in many taxa. It acts mainly repressively, causing transcriptional gene silencing... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 11, 2019 Category: Genetics & Stem Cells Authors: Ad éla Přibylová, Vojtěch Čermák, Dimitrij Tyč and Lukáš Fischer Tags: Research Source Type: research
TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes
TH2B is a major histone variant that replaces about 80 –85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermato... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 7, 2019 Category: Genetics & Stem Cells Authors: Iyer Aditya Mahadevan, Satyakrishna Pentakota, Raktim Roy, Utsa Bhaduri and Manchanahalli R. Satyanarayana Rao Tags: Research Source Type: research
The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase
Maintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents prolonged stalling of the ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 21, 2019 Category: Genetics & Stem Cells Authors: Joanna Br ühl, Jonathan Trautwein, Agnes Schäfer, Uwe Linne and Karim Bouazoune Tags: Research Source Type: research
ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains
KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous retr... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 9, 2019 Category: Genetics & Stem Cells Authors: Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger and Anne C. Ferguson-Smith Tags: Research Source Type: research
