Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma
Laryngeal squamous cell carcinoma (LSCC) is among the most common malignant tumors with poor prognosis. Accumulating evidences have identified the important roles of long noncoding RNAs (lncRNAs) in the initia... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 13, 2019 Category: Genetics & Stem Cells Authors: Baoshan Wang, Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui and Wenxia Meng Tags: Research Source Type: research
Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites
Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epig... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 6, 2019 Category: Genetics & Stem Cells Authors: Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans and Menno P. J. de Winther Tags: Research Source Type: research
XL-DNase-seq: improved footprinting of dynamic transcription factors
As the cost of high-throughput sequencing technologies decreases, genome-wide chromatin accessibility profiling methods such as the assay of transposase-accessible chromatin using sequencing (ATAC-seq) are emp... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 4, 2019 Category: Genetics & Stem Cells Authors: Kyu-Seon Oh, Jisu Ha, Songjoon Baek and Myong-Hee Sung Tags: Methodology Source Type: research
p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes
The transcription factor p63 regulates epidermal genes and the enhancer landscape in skin keratinocytes. Its molecular function in controlling the chromatin structure is, however, not yet completely understood... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 4, 2019 Category: Genetics & Stem Cells Authors: Jieqiong Qu, Guoqiang Yi and Huiqing Zhou Tags: Research Source Type: research
Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation
TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phospho... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 4, 2019 Category: Genetics & Stem Cells Authors: Ting Zhang, Xiaowen Guan, Un Lam Choi, Qiang Dong, Melody M. T. Lam, Jianming Zeng, Jun Xiong, Xianju Wang, Terence C. W. Poon, Hongjie Zhang, Xuanjun Zhang, Hailin Wang, Ruiyu Xie, Bing Zhu and Gang Li Tags: Research Source Type: research
Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors
Both tissue-specific and ubiquitously expressed transcription factors, such as Sp-family members, are required for correct development. However, the molecular details of how ubiquitous factors are involved in ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 4, 2019 Category: Genetics & Stem Cells Authors: Jane Gilmour, Leigh O ’Connor, Christopher P. Middleton, Peter Keane, Nynke Gillemans, Jean-Baptiste Cazier, Sjaak Philipsen and Constanze Bonifer Tags: Research Source Type: research
Polymer coil –globule phase transition is a universal folding principle of Drosophila epigenetic domains
Localized functional domains within chromosomes, known as topologically associating domains (TADs), have been recently highlighted. In Drosophila, TADs are biochemically defined by epigenetic marks, this suggesti... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 13, 2019 Category: Genetics & Stem Cells Authors: Antony Lesage, Vincent Dahirel, Jean-Marc Victor and Maria Barbi Tags: Research Source Type: research
Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features
Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 13, 2019 Category: Genetics & Stem Cells Authors: Louis Legoff, Ouzna Dali, Shereen Cynthia D ’Cruz, Antonio Suglia, Aurore Gely-Pernot, Chloé Hémery, Pierre-Yves Kernanec, Abbassia Demmouche, Christine Kervarrec, Sergei Tevosian, Luc Multigner and Fatima Smagulova Tags: Research Source Type: research
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multipl... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 3, 2019 Category: Genetics & Stem Cells Authors: Henriette O ’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham and David J. Segal Tags: Research Source Type: research
Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways
Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding tran... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 3, 2019 Category: Genetics & Stem Cells Authors: Yilin Zhao, Deyou Zheng and Ales Cvekl Tags: Research Source Type: research
Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression
Neural tube defects (NTDs) are common birth defects involving the central nervous system. Recent studies on the etiology of human NTDs have raised the possibility that epigenetic regulation could be involved i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 16, 2019 Category: Genetics & Stem Cells Authors: Ye Lin, Juan Yu, Jianxin Wu, Shan Wang and Ting Zhang Tags: Research Source Type: research
Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat
Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 16, 2019 Category: Genetics & Stem Cells Authors: Chuan Li, Guillaume Mousseau and Susana T. Valente Tags: Research Source Type: research
The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning
Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive. In this ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 16, 2019 Category: Genetics & Stem Cells Authors: Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura and Eishi Noguchi Tags: Research Source Type: research
DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis
MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates wit... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 16, 2019 Category: Genetics & Stem Cells Authors: Yonghwan Shin, Nikhil B. Ghate, Byoungsan Moon, Kyungpyo Park, Wange Lu and Woojin An Tags: Research Source Type: research
Contribution of H3K4 demethylase KDM5B to nucleosome organization in embryonic stem cells revealed by micrococcal nuclease sequencing
Positioning of nucleosomes along DNA is an integral regulator of chromatin accessibility and gene expression in diverse cell types. However, the precise nature of how histone demethylases including the histone... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 2, 2019 Category: Genetics & Stem Cells Authors: Jiji T. Kurup, Ion J. Campeanu and Benjamin L. Kidder Tags: Research Source Type: research
