Epigenetic regulation of retinal development
In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determinat... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 9, 2021 Category: Genetics & Stem Cells Authors: Reza Raeisossadati, Merari F. R. Ferrari, Alexandre Hiroaki Kihara, Issam AlDiri and Jeffrey M. Gross Tags: Review Source Type: research
Histone crotonylation-centric gene regulation
Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histo... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 6, 2021 Category: Genetics & Stem Cells Authors: Kun Li and Ziqiang Wang Tags: Review Source Type: research
Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
We examined the effect of vita... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 4, 2021 Category: Genetics & Stem Cells Authors: Lawrence T. C. Ong, Stephen D. Schibeci, Nicole L. Fewings, David R. Booth and Grant P. Parnell Tags: Research Source Type: research
Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
In this study, we identifi... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 19, 2021 Category: Genetics & Stem Cells Authors: Martina Weigt, Qingsong Gao, Hyoju Ban, Haijin He, Guido Mastrobuoni, Stefan Kempa, Wei Chen and Fei Li Tags: Research Source Type: research
Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling
Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 13, 2021 Category: Genetics & Stem Cells Authors: Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche Jr., Carrie R. Graveel and Matthew R. Steensma Tags: Research Source Type: research
Integration of sperm ncRNA-directed DNA methylation and DNA methylation-directed histone retention in epigenetic transgenerational inheritance
Environmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheri... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 12, 2021 Category: Genetics & Stem Cells Authors: Daniel Beck, Millissia Ben Maamar and Michael K. Skinner Tags: Research Source Type: research
Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes
The vast majority of methods available to characterize genome-wide chromatin structure exploit differences in DNA accessibility to nucleases or chemical crosslinking. We developed a novel method to gauge genom... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 11, 2021 Category: Genetics & Stem Cells Authors: Luke T. Marr, Josefina Ocampo, David J. Clark and Jeffrey J. Hayes Tags: Research Source Type: research
DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna
Patterns of methylation influence lifespan, but methylation and lifespan may also depend on diet, or differ between genotypes. Prior to this study, interactions between diet and genotype have not been explored... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 6, 2021 Category: Genetics & Stem Cells Authors: Jack Hearn, Fiona Plenderleith and Tom J. Little Tags: Research Source Type: research
Cell –cell coupling and DNA methylation abnormal phenotypes in the after-hours mice
DNA methylation has emerged as an important epigenetic regulator of brain processes, including circadian rhythms. However, how DNA methylation intervenes between environmental signals, such as light entrainmen... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 6, 2021 Category: Genetics & Stem Cells Authors: Federico Tinarelli, Elena Ivanova, Ilaria Colombi, Erica Barini, Edoardo Balzani, Celina Garcia Garcia, Laura Gasparini, Michela Chiappalone, Gavin Kelsey and Valter Tucci Tags: Research Source Type: research
Chromatin accessibility maps provide evidence of multilineage gene priming in hematopoietic stem cells
Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 6, 2021 Category: Genetics & Stem Cells Authors: Eric W. Martin, Jana Krietsch, Roman E. Reggiardo, Rebekah Sousae, Daniel H. Kim and E. Camilla Forsberg Tags: Research Source Type: research
Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids
H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the e... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 6, 2021 Category: Genetics & Stem Cells Authors: Vasantha Shalini, Utsa Bhaduri, Anjhana C. Ravikkumar, Anusha Rengarajan and Rao M. R. Satyanarayana Tags: Research Source Type: research
Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice
Environmental impacts on a fetus can disrupt germ cell development leading to epimutations in mature germ cells. Paternal inheritance of adverse health effects through sperm epigenomes, including DNA methylome... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 2, 2020 Category: Genetics & Stem Cells Authors: Keiko Nohara, Kazuhiko Nakabayashi, Kazuyuki Okamura, Takehiro Suzuki, Shigekatsu Suzuki and Kenichiro Hata Tags: Research Source Type: research
The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex
The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a dep... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 30, 2020 Category: Genetics & Stem Cells Authors: Takeshi Tsusaka, Kei Fukuda, Chikako Shimura, Masaki Kato and Yoichi Shinkai Tags: Research Source Type: research
Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences
The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nucleosomes in intergenic sequences and poorly understood mechanisms of gene regulation. Variant... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 23, 2020 Category: Genetics & Stem Cells Authors: Jingyi Tang, Scott A. Chisholm, Lee M. Yeoh, Paul R. Gilson, Anthony T. Papenfuss, Karen P. Day, Michaela Petter and Michael F. Duffy Tags: Research Source Type: research
Comparison of methylation capture sequencing and Infinium MethylationEPIC array in peripheral blood mononuclear cells
Epigenome-wide association studies (EWAS) have been widely applied to identify methylation CpG sites associated with human disease. To date, the Infinium MethylationEPIC array (EPIC) is commonly used for high-... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 23, 2020 Category: Genetics & Stem Cells Authors: Chang Shu, Xinyu Zhang, Bradley E. Aouizerat and Ke Xu Tags: Research Source Type: research
