Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers
Nuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “closed” chromatin compartments, topologically associated domains (TADs) and chromatin loops. The DNA- and ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 20, 2024 Category: Genetics & Stem Cells Authors: Michael Camerino, William Chang and Ales Cvekl Tags: Research Source Type: research
The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
CTCF is highly likely to be the ancestor of proteins that contain large clusters of C2H2 zinc finger domains, and its conservation is observed across most bilaterian organisms. In mammals, CTCF is the primary ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 1, 2024 Category: Genetics & Stem Cells Authors: Sofia Kamalyan, Olga Kyrchanova, Natalia Klimenko, Valentin Babosha, Yulia Vasileva, Elena Belova, Dariya Fursenko, Oksana Maksimenko and Pavel Georgiev Tags: Research Source Type: research
Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through histone modifications and chromatin organisation, but exactly how these factors relate t... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 25, 2024 Category: Genetics & Stem Cells Authors: Stefan A. Koestler, Madeleine L. Ball, Leila Muresan, Vineet Dinakaran and Robert White Tags: Research Source Type: research
Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
Fusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘bakanae’ or stunting, most likely due to the production of various natural products (NPs) during infection. Fusaria have the gene... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 20, 2024 Category: Genetics & Stem Cells Authors: Anna K. Atanasoff-Kardjalieff, Harald Berger, Katharina Steinert, Slavica Janevska, Nadia Ponts, Hans-Ulrich Humpf, Svetlana Kalinina and Lena Studt-Reinhold Tags: Research Source Type: research
TP63 –TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high rate of large genomic rearrangements are often observed in PRAD. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 14, 2024 Category: Genetics & Stem Cells Authors: R. Sultanov, A. Mulyukina, O. Zubkova, A. Fedoseeva, A. Bogomazova, K. Klimina, A. Larin, T. Zatsepin, T. Prikazchikova, M. Lukina, M. Bogomiakova, E. Sharova, E. Generozov, M. Lagarkova and G. Arapidi Tags: Research Source Type: research
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Des... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 1, 2024 Category: Genetics & Stem Cells Authors: Haley V. Hobble and Christine E. Schaner Tooley Tags: Review Source Type: research
Research progress of SWI/SNF complex in breast cancer
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeling complex whose mutations are associat... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 17, 2024 Category: Genetics & Stem Cells Authors: Kexuan Li, Baocai Wang and Haolin Hu Tags: Review Source Type: research
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-associated H3K27me3 histone modifications on opposite tails of the same nucleosome occur... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 10, 2024 Category: Genetics & Stem Cells Authors: Janith A. Seneviratne, William W. H. Ho, Eleanor Glancy and Melanie A. Eckersley-Maslin Tags: Methodology Source Type: research
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal an... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 23, 2024 Category: Genetics & Stem Cells Authors: Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles and Gregory David Tags: Research Source Type: research
Role of sex in immune response and epigenetic mechanisms
The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inacti... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 22, 2024 Category: Genetics & Stem Cells Authors: Sombodhi Bhattacharya, Debasmita Sadhukhan and Radha Saraswathy Tags: Review Source Type: research
O-GlcNAcylation: the sweet side of epigenetics
Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function witho... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 14, 2023 Category: Genetics & Stem Cells Authors: Thomas Dupas, Benjamin Lauzier and Serge McGraw Tags: Review Source Type: research
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tube to close during early embryogenesis. Maternal folate deficiency could impact the occu... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 14, 2023 Category: Genetics & Stem Cells Authors: Xue Li, Pei Pei, Jinying Shen, Juan Yu, Fang Wang, Lei Wang, Changyun Liu and Shan Wang Tags: Research Source Type: research
Expanding the list of sequence-agnostic enzymes for chromatin conformation capture assays with S1 nuclease
This study presents a novel approach for mapping global chromatin interactions using S1 nuclease, a sequence-agnostic enzyme. We develop and outline a protocol that leverages S1 nuclease's ability to effective... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 11, 2023 Category: Genetics & Stem Cells Authors: Gridina Maria, Popov Andrey, Shadskiy Artem, Torgunakov Nikita, Kechin Andrey, Khrapov Evgeny, Ryzhkova Oxana, Filipenko Maxim and Fishman Veniamin Tags: Research Source Type: research
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) is known to be involved in the deposition of the di- and tri-methyl marks on H3K9 (H3K9m... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 7, 2023 Category: Genetics & Stem Cells Authors: Hanshen Luo, Xingliang Wu, Xue-Hai Zhu, Xin Yi, Dunfeng Du and Ding-Sheng Jiang Tags: Review Source Type: research
Chromatin balances cell redox and energy homeostasis
Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chroma... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 28, 2023 Category: Genetics & Stem Cells Authors: Tamaki Suganuma and Jerry L. Workman Tags: Review Source Type: research
