In vivo chromatin organization on native yeast telomeric regions is independent of a cis-telomere loopback conformation
DNA packaging into chromatin regulates all DNA-related processes and at chromosomal ends could affect both essential functions of telomeres: protection against DNA damage response and telomere replication. Des... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - May 22, 2020 Category: Genetics & Stem Cells Authors: Emeline Pasquier and Raymund J. Wellinger Tags: Research Source Type: research

BAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks
Next-generation sequencing allows genome-wide analysis of changes in chromatin states and gene expression. Data analysis of these increasingly used methods either requires multiple analysis steps, or extensive... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 22, 2020 Category: Genetics & Stem Cells Authors: Lorinc S. Pongor, Jacob M. Gross, Roberto Vera Alvarez, Junko Murai, Sang-Min Jang, Hongliang Zhang, Christophe Redon, Haiqing Fu, Shar-Yin Huang, Bhushan Thakur, Adrian Baris, Leonardo Marino-Ramirez, David Landsman, Mirit I. Aladjem and Yves Pommier Tags: Methodology Source Type: research

ATAC-seq normalization method can significantly affect differential accessibility analysis and interpretation
Chromatin dysregulation is associated with developmental disorders and cancer. Numerous methods for measuring genome-wide chromatin accessibility have been developed in the genomic era to interrogate the funct... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 22, 2020 Category: Genetics & Stem Cells Authors: Jake J. Reske, Mike R. Wilson and Ronald L. Chandler Tags: Methodology Source Type: research

EPIGENE: genome-wide transcription unit annotation using a multivariate probabilistic model of histone modifications
Understanding the transcriptome is critical for explaining the functional as well as regulatory roles of genomic regions. Current methods for the identification of transcription units (TUs) use RNA-seq that, h... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 7, 2020 Category: Genetics & Stem Cells Authors: Anshupa Sahu, Na Li, Ilona Dunkel and Ho-Ryun Chung Tags: Methodology Source Type: research

A comprehensive overview of bull sperm-borne small non-coding RNAs and their diversity across breeds
Mature sperm carry thousands of RNAs, including mRNAs, lncRNAs, tRNAs, rRNAs and sncRNAs, though their functional significance is still a matter of debate. Growing evidence suggests that sperm RNAs, especially... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 30, 2020 Category: Genetics & Stem Cells Authors: Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Jean-Philippe Perrier, S ébastien Fritz, Chrystelle Le Danvic, Mekki Boussaha, Hélène Kiefer, Hélène Jammes and Laurent Schibler Tags: Research Source Type: research

The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation
SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20. SETD8 and H4K20me1 play a role in a number of essential biologic processes, including cell cycle progression, establishmen... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2020 Category: Genetics & Stem Cells Authors: Jacquelyn A. Myers, Tyler Couch, Zachary Murphy, Jeffrey Malik, Michael Getman and Laurie A. Steiner Tags: Research Source Type: research

The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure
Allele-specific DNA methylation (ASM) describes genomic loci that maintain CpG methylation at only one inherited allele rather than having coordinated methylation across both alleles. The most prominent of the... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2020 Category: Genetics & Stem Cells Authors: Dana M. Freeman, Dan Lou, Yanqiang Li, Suzanne N. Martos and Zhibin Wang Tags: Research Source Type: research

DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices
MeCP2 and MBD2 are members of a family of proteins that possess a domain that selectively binds 5-methylcytosine in a CpG context. Members of the family interact with other proteins to modulate DNA packing. St... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 16, 2020 Category: Genetics & Stem Cells Authors: Ming Liu, Saeid Movahed, Saroj Dangi, Hai Pan, Parminder Kaur, Stephanie M. Bilinovich, Edgar M. Faison, Gage O. Leighton, Hong Wang, David C. Williams Jr. and Robert Riehn Tags: Research Source Type: research

Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin conformation via aryl hydrocarbon receptor
Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic profile of the Nanog gene, but whether chromatin organizati... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 14, 2020 Category: Genetics & Stem Cells Authors: Francisco J. Gonz ález-Rico, Cristina Vicente-García, Almudena Fernández, Diego Muñoz-Santos, Lluís Montoliu, Antonio Morales-Hernández, Jaime M. Merino, Angel-Carlos Román and Pedro M. Fernández-Salguero Tags: Research Source Type: research

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation
Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies have also implicated BET proteins as regulators of ce... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 10, 2020 Category: Genetics & Stem Cells Authors: Archit Trivedi, Aanchal Mehrotra, Caitlin E. Baum, Brandon Lewis, Tupa Basuroy, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Vijayasaradhi Setaluri and Ivana L. de la Serna Tags: Research Source Type: research

In vivo visualization of the i-motif DNA secondary structure in the Bombyx mori testis
A large number of in vitro experiments have confirmed that DNA molecules can form i-motif advanced structure when multiple cytosines exist in the sequence. However, whether these structures are present in vivo... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 5, 2020 Category: Genetics & Stem Cells Authors: Wenhuan Tang, Kangkang Niu, Guoxing Yu, Ying Jin, Xian Zhang, Yuling Peng, Shuna Chen, Huimin Deng, Sheng Li, Jian Wang, Qisheng Song and Qili Feng Tags: Research Source Type: research

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice
Maternal smoking of traditional or electronic cigarettes during pregnancy, which constitutes developmental nicotine exposure (DNE), heightens the risk of neurodevelopmental disorders including ADHD, autism, an... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 5, 2020 Category: Genetics & Stem Cells Authors: Jordan M. Buck, Heidi C. O ’Neill and Jerry A. Stitzel Tags: Research Source Type: research

Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes
H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50 –60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mou... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 4, 2020 Category: Genetics & Stem Cells Authors: Iyer Aditya Mahadevan, Sanjeev Kumar and Manchanahalli R. Satyanarayana Rao Tags: Research Source Type: research

Identification of DNA N6-methyladenine sites by integration of sequence features
An increasing number of nucleic acid modifications have been profiled with the development of sequencing technologies. DNA N6-methyladenine (6mA), which is a prevalent epigenetic modification, plays important rol... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 24, 2020 Category: Genetics & Stem Cells Authors: Hao-Tian Wang, Fu-Hui Xiao, Gong-Hua Li and Qing-Peng Kong Tags: Methodology Source Type: research

JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability
Maintaining a proper supply of soluble histones throughout the cell cycle is important to ensure chromatin and genome stability. Following their synthesis, histones undergo a series of maturation steps to prep... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 18, 2020 Category: Genetics & Stem Cells Authors: Francisco Saavedra, Zachary A. Gurard-Levin, Camila Rojas-Villalobos, Isabelle Vassias, Raquel Quatrini, Genevi ève Almouzni and Alejandra Loyola Tags: Research Source Type: research

Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish
Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases. This susceptibility may in part be caused by changes to the epigenetic landscape w... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 12, 2020 Category: Genetics & Stem Cells Authors: Marjo J. den Broeder, Jarle Ballangby, Leonie M. Kamminga, Peter Alestr öm, Juliette Legler, Leif C. Lindeman and Jorke H. Kamstra Tags: Research Source Type: research

Integrative prediction of gene expression with chromatin accessibility and conformation data
Enhancers play a fundamental role in orchestrating cell state and development. Although several methods have been developed to identify enhancers, linking them to their target genes is still an open problem. S... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 6, 2020 Category: Genetics & Stem Cells Authors: Florian Schmidt, Fabian Kern and Marcel H. Schulz Tags: Research Source Type: research

Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
Plant homeodomain (PHD) fingers are central “readers” of histone post-translational modifications (PTMs) with> 100 PHD finger-containing proteins encoded by the human genome. Many of the PHDs studied to date ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 24, 2020 Category: Genetics & Stem Cells Authors: Kanishk Jain, Caroline S. Fraser, Matthew R. Marunde, Madison M. Parker, Cari Sagum, Jonathan M. Burg, Nathan Hall, Irina K. Popova, Keli L. Rodriguez, Anup Vaidya, Krzysztof Krajewski, Michael-Christopher Keogh, Mark T. Bedford and Brian D. Strahl Tags: Research Source Type: research

Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 14, 2020 Category: Genetics & Stem Cells Authors: Hitomi Matsuzaki, Daichi Kuramochi, Eiichi Okamura, Katsuhiko Hirakawa, Aki Ushiki and Keiji Tanimoto Tags: Research Source Type: research

Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans
Chromatin organization is central to precise control of gene expression. In various eukaryotic species, domains of pervasive cis-chromatin interactions demarcate functional domains of the genomes. In nematode Cae... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 9, 2020 Category: Genetics & Stem Cells Authors: Alexis V. Stutzman, April S. Liang, Vera Beilinson and Kohta Ikegami Tags: Research Source Type: research

MethylToSNP: identifying SNPs in Illumina DNA methylation array data
Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA. In the absence ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 20, 2019 Category: Genetics & Stem Cells Authors: Brenna A. LaBarre, Alexander Goncearenco, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Vanessa M. Hayes and Laura Elnitski Tags: Methodology Source Type: research

Age-associated sperm DNA methylation patterns do not directly persist trans-generationally
The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly unders... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Timothy G. Jenkins, Emma R. James, Kenneth I. Aston, Albert Salas-Huetos, Alexander W. Pastuszak, Ken R. Smith, Heidi A. Hanson, James M. Hotaling and Douglas T. Carrell Tags: Research Source Type: research

Nickel-induced transcriptional changes persist post exposure through epigenetic reprogramming
Nickel is an occupational and environmental toxicant associated with a number of diseases in humans including pulmonary fibrosis, bronchitis and lung and nasal cancers. Our earlier studies showed that the nick... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Cynthia C. Jose, Zhenjia Wang, Vinay Singh Tanwar, Xiaoru Zhang, Chongzhi Zang and Suresh Cuddapah Tags: Research Source Type: research

Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects
Neural tube defects (NTDs) are severe, common birth defects that result from failure of normal neural tube closure during early embryogenesis. Accumulating strong evidence indicates that genetic factors contri... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Juan Yu, Lei Wang, Pei Pei, Xue Li, Jianxin Wu, Zhiyong Qiu, Juan Zhang, Ruifang Ao, Shan Wang, Ting Zhang and Jun Xie Tags: Research Source Type: research

Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells
Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. T... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno & hel Tags: Research Source Type: research

Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1 α/β-mediated adaptive stress response pathway in skeletal muscle cells
While the role of Polycomb group protein-mediated “cell memory” is well established in developmental contexts, little is known about their role in adult tissues and in particular in post-mitotic cells. Emergin... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 19, 2019 Category: Genetics & Stem Cells Authors: Peng Liu, Muhammad Shuaib, Huoming Zhang, Seba Nadeef and Valerio Orlando Tags: Research Source Type: research

Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model
Members of the HMGN protein family modulate chromatin structure and influence epigenetic modifications. HMGN1 and HMGN2 are highly expressed during early development and in the neural stem/progenitor cells of ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 12, 2019 Category: Genetics & Stem Cells Authors: Sylvia Garza-Manero, Abdulmajeed Abdulghani A. Sindi, Gokula Mohan, Ohoud Rehbini, Valentine H. M. Jeantet, Mariarca Bailo, Faeezah Abdul Latif, Maureen P. West, Ross Gurden, Lauren Finlayson, Silvija Svambaryte, Adam G. West and Katherine L. West Tags: Research Source Type: research

The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization
Data mining of The Cancer Genome Atlas (TCGA) data has significantly facilitated cancer genome research and provided unprecedented opportunities for cancer researchers. However, existing web applications for D... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 5, 2019 Category: Genetics & Stem Cells Authors: Yin Li, Di Ge and Chunlai Lu Tags: Methodology Source Type: research

The distributions of protein coding genes within chromatin domains in relation to human disease
Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented re... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - December 5, 2019 Category: Genetics & Stem Cells Authors: Enrique M. Muro, Jonas Ibn-Salem and Miguel A. Andrade-Navarro Tags: Research Source Type: research

Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington ’s Disease Monkey pluripotent stem cells
Huntington ’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and signific... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Alexandra V. Goodnight, Isaac Kremsky, Sujittra Khampang, Yoon Hee Jung, James M. Billingsley, Steven E. Bosinger, Victor G. Corces and Anthony W. S. Chan Tags: Research Source Type: research

BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex —a tumour suppressor or tumour-promoting factor?
BRM (BRAHMA) is a core, SWI2/SNF2-type ATPase subunit of SWI/SNF chromatin-remodelling complex (CRC) involved in various important regulatory processes including development. Mutations in SMARCA2, a BRM-encoding ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Iga Jancewicz, Janusz A. Siedlecki, Tomasz J. Sarnowski and Elzbieta Sarnowska Tags: Review Source Type: research

Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects
Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang and Ting Zhang Tags: Research Source Type: research

The impact of genetic background and cell lineage on the level and pattern of gene expression in position effect variegation
Chromatin-based transcriptional silencing is often described as a stochastic process, largely because of the mosaic expression observed in position effect variegation (PEV), where a euchromatic reporter gene i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 13, 2019 Category: Genetics & Stem Cells Authors: Sidney H. Wang and Sarah C. R. Elgin Tags: Research Source Type: research

The role of cigarette smoke-induced epigenetic alterations in inflammation
Exposure to cigarette smoke (CS) is a major threat to human health worldwide. It is well established that smoking increases the risk of respiratory diseases, cardiovascular diseases and different forms of canc... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 11, 2019 Category: Genetics & Stem Cells Authors: Dandan Zong, Xiangming Liu, Jinhua Li, Ruoyun Ouyang and Ping Chen Tags: Review Source Type: research

Virtual methylome dissection facilitated by single-cell analyses
Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It remains a ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 11, 2019 Category: Genetics & Stem Cells Authors: Liduo Yin, Yanting Luo, Xiguang Xu, Shiyu Wen, Xiaowei Wu, Xuemei Lu and Hehuang Xie Tags: Methodology Source Type: research

Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences
In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retai... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 17, 2019 Category: Genetics & Stem Cells Authors: Julianna Nechin, Emma Tunstall, Naideline Raymond, Nicole Hamagami, Chris Pathmanabhan, Samantha Forestier and Tamara L. Davis Tags: Research Source Type: research

DNA methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development
DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation remains poorly unde... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 10, 2019 Category: Genetics & Stem Cells Authors: Keith D. Harris, James P. B. Lloyd, Katherine Domb, Daniel Zilberman and Assaf Zemach Tags: Research Source Type: research

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2
MeCP2 —a chromatin-binding protein associated with Rett syndrome—has two main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specifi... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 10, 2019 Category: Genetics & Stem Cells Authors: Alexia Mart ínez de Paz, Leila Khajavi, Hélène Martin, Rafael Claveria-Gimeno, Susanne Tom Dieck, Manjinder S. Cheema, Jose V. Sanchez-Mut, Malgorzata M. Moksa, Annaick Carles, Nick I. Brodie, Taimoor I. Sheikh, Melissa E. Freeman, Evgeniy V. Petrotche Tags: Research Source Type: research

Early-life DNA methylation profiles are indicative of age-related transcriptome changes
Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification r... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Niran Hadad, Dustin R. Masser, Laura Blanco-Berdugo, David R. Stanford and Willard M. Freeman Tags: Research Source Type: research

DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA me... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Ling Chen, Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai, Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu, Zanxian Xia and Yongguang Tao Tags: Research Source Type: research

Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate
Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider i... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Heidi G. Sutherland, Nicole White, Daniel Kennedy, Kerry Mengersen, Larisa M. Haupt and Lyn R. Griffiths Tags: Research Source Type: research

Joint inference and alignment of genome structures enables characterization of compartment-independent reorganization across cell types
Comparisons of Hi –C data sets between cell types and conditions have revealed differences in topologically associated domains (TADs) and A/B compartmentalization, which are correlated with differences in gene ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 8, 2019 Category: Genetics & Stem Cells Authors: Lila Rieber and Shaun Mahony Tags: Methodology Source Type: research

Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator
Polycomb group (PcG) and trithorax group (trxG) proteins contribute to the specialization of cell types by maintaining differential gene expression patterns. Initially discovered as positive regulators of HOX ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2019 Category: Genetics & Stem Cells Authors: Zain Umer, Jawad Akhtar, Muhammad Haider Farooq Khan, Najma Shaheen, Muhammad Abdul Haseeb, Khalida Mazhar, Aziz Mithani, Saima Anwar and Muhammad Tariq Tags: Research Source Type: research

Histone chaperones and the Rrm3p helicase regulate flocculation in S. cerevisiae
Biofilm formation or flocculation is a major phenotype in wild type budding yeasts but rarely seen in laboratory yeast strains. Here, we analysed flocculation phenotypes and the expression of FLO genes in laborat... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2019 Category: Genetics & Stem Cells Authors: Hollie Rowlands, Kholoud Shaban, Barret Foster, Yannic Proteau and Krassimir Yankulov Tags: Research Source Type: research

CGGBP1 regulates CTCF occupancy at repeats
CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2019 Category: Genetics & Stem Cells Authors: Divyesh Patel, Manthan Patel, Subhamoy Datta and Umashankar Singh Tags: Research Source Type: research

Detailed insight into the dynamics of the initial phases of de novo RNA-directed DNA methylation in plant cells
Methylation of cytosines is an evolutionarily conserved epigenetic mark that is essential for the control of chromatin activity in many taxa. It acts mainly repressively, causing transcriptional gene silencing... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 11, 2019 Category: Genetics & Stem Cells Authors: Ad éla Přibylová, Vojtěch Čermák, Dimitrij Tyč and Lukáš Fischer Tags: Research Source Type: research

TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes
TH2B is a major histone variant that replaces about 80 –85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermato... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 7, 2019 Category: Genetics & Stem Cells Authors: Iyer Aditya Mahadevan, Satyakrishna Pentakota, Raktim Roy, Utsa Bhaduri and Manchanahalli R. Satyanarayana Rao Tags: Research Source Type: research

The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase
Maintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents prolonged stalling of the ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 21, 2019 Category: Genetics & Stem Cells Authors: Joanna Br ühl, Jonathan Trautwein, Agnes Schäfer, Uwe Linne and Karim Bouazoune Tags: Research Source Type: research

ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains
KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous retr... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 9, 2019 Category: Genetics & Stem Cells Authors: Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger and Anne C. Ferguson-Smith Tags: Research Source Type: research

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells
The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyan... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 9, 2019 Category: Genetics & Stem Cells Authors: Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, Stacie K. Loftus and William J. Pavan Tags: Research Source Type: research