Chromosome structural variation in tumorigenesis: mechanisms of formation and carcinogenesis
With the rapid development of next-generation sequencing technology, chromosome structural variation has gradually gained increased clinical significance in tumorigenesis. However, the molecular mechanism(s) u... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 10, 2020 Category: Genetics & Stem Cells Authors: Wen-Jun Wang, Ling-Yu Li and Jiu-Wei Cui Tags: Review Source Type: research
GBAF, a small BAF sub-complex with big implications: a systematic review
ATP-dependent chromatin remodeling by histone-modifying enzymes and chromatin remodeling complexes is crucial for maintaining chromatin organization and facilitating gene transcription. In the SWI/SNF family o... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - November 3, 2020 Category: Genetics & Stem Cells Authors: Sarah M. Innis and Birgit Cabot Tags: Review Source Type: research
Post-translational modifications of PRC2: signals directing its activity
Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays a... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 31, 2020 Category: Genetics & Stem Cells Authors: Yiqi Yang and Gang Li Tags: Review Source Type: research
SAGA –CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity
Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 28, 2020 Category: Genetics & Stem Cells Authors: Carme Nu ño-Cabanes, Varinia García-Molinero, Manuel Martín-Expósito, María-Eugenia Gas, Paula Oliete-Calvo, Encar García-Oliver, María de la Iglesia-Vayá and Susana Rodríguez-Navarro Tags: Research Source Type: research
Chromatin accessibility dynamics of Chlamydia-infected epithelial cells
Chlamydia are Gram-negative, obligate intracellular bacterial pathogens responsible for a broad spectrum of human and animal diseases. In humans, Chlamydia trachomatis is the most prevalent bacterial sexually tra... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 27, 2020 Category: Genetics & Stem Cells Authors: Regan J. Hayward, James W. Marsh, Michael S. Humphrys, Wilhelmina M. Huston and Garry S. A. Myers Tags: Research Source Type: research
The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells
The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent his... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 23, 2020 Category: Genetics & Stem Cells Authors: Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M Tags: Research Source Type: research
Epigenomic landscape of enhancer elements during Hydra head organizer formation
Axis patterning during development is accompanied by large-scale gene expression changes. These are brought about by changes in the histone modifications leading to dynamic alterations in chromatin architectur... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 12, 2020 Category: Genetics & Stem Cells Authors: Puli Chandramouli Reddy, Akhila Gungi, Suyog Ubhe and Sanjeev Galande Tags: Research Source Type: research
Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes
Transcription of genes residing within constitutive heterochromatin is paradoxical to the tenets of epigenetic code. The regulatory mechanisms of Drosophila melanogaster heterochromatic gene transcription remain ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 7, 2020 Category: Genetics & Stem Cells Authors: Parna Saha, Divya Tej Sowpati, Mamilla Soujanya, Ishanee Srivastava and Rakesh Kumar Mishra Tags: Research Source Type: research
Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing
5 ′ methylation of cytosines in DNA molecules is an important epigenetic mark in eukaryotes. Bisulfite sequencing is the gold standard of DNA methylation detection, and whole-genome bisulfite sequencing (WGBS) ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 7, 2020 Category: Genetics & Stem Cells Authors: Suhua Feng, Zhenhui Zhong, Ming Wang and Steven E. Jacobsen Tags: Research Source Type: research
Regulation of SETD2 stability is important for the fidelity of H3K36me3 deposition
The histone H3K36me3 mark regulates transcription elongation, pre-mRNA splicing, DNA methylation, and DNA damage repair. However, knowledge of the regulation of the enzyme SETD2, which deposits this functional... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 6, 2020 Category: Genetics & Stem Cells Authors: Saikat Bhattacharya and Jerry L. Workman Tags: Research Source Type: research
Characterization of universal features of partially methylated domains across tissues and species
Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, and cultured cell lines. Existing methods for deciding w... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - October 2, 2020 Category: Genetics & Stem Cells Authors: Benjamin E. Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R. V. Knott, Gregory J. Hannon and Andrew D. Smith Tags: Research Source Type: research
UTX/KDM6A suppresses AP-1 and a gliogenesis program during neural differentiation of human pluripotent stem cells
UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate gene activation, but its molecular activities in developmental gene re... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 25, 2020 Category: Genetics & Stem Cells Authors: Beisi Xu, Brett Mulvey, Muneeb Salie, Xiaoyang Yang, Yurika Matsui, Anjana Nityanandam, Yiping Fan and Jamy C. Peng Tags: Research Source Type: research
The social construction of the social epigenome and the larger biological context
Epigenetics researchers in developmental, cell, and molecular biology greatly diverge in their understanding and definitions of epigenetics. In contrast, social epigeneticists, e.g., sociologists, scholars of ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 23, 2020 Category: Genetics & Stem Cells Authors: Ute Deichmann Tags: Research Source Type: research
Correction to: N6 ‑Adenosine methylation on mRNA is recognized by YTH2 domain protein of human malaria parasite Plasmodium falciparum
An amendment to this paper has been published and can be accessed via the original article. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 22, 2020 Category: Genetics & Stem Cells Authors: Gayathri Govindaraju, Rajashekar Varma Kadumuri, Devadathan Valiyamangalath Sethumadhavan, C. A. Jabeena, Sreenivas Chavali and Arumugam Rajavelu Tags: Correction Source Type: research
Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark
Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly co... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 15, 2020 Category: Genetics & Stem Cells Authors: Marion Crespo, Lacey J. Luense, Marie Arlotto, Jialei Hu, Jean Dorsey, Encar Garc ía-Oliver, Parisha P. Shah, Delphine Pflieger, Shelley L. Berger and Jérôme Govin Tags: Research Source Type: research
