Citrullination of HP1 γ chromodomain affects association with chromatin
Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1 γ). As the principa... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - April 2, 2019 Category: Genetics & Stem Cells Authors: Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue and Tony Kouzarides Tags: Research Source Type: research
The BAF complex in development and disease
The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation. In the course of evolution from yeast to mammals, the BAF... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 21, 2019 Category: Genetics & Stem Cells Authors: Amelie Alfert, Natalia Moreno and Kornelius Kerl Tags: Review Source Type: research
DNA replication dynamics of vole genome and its epigenetic regulation
The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of these heterochromatin blocks have been studied, but... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 14, 2019 Category: Genetics & Stem Cells Authors: Kathrin S. Heinz, Alexander Rapp, Corella S. Casas-Delucchi, Anne Lehmkuhl, Ismael Romero-Fern ández, Antonio Sánchez, Oliver H. Krämer, J. Alberto Marchal and M. Cristina Cardoso Tags: Research Source Type: research
Targeted in vivo epigenome editing of H3K27me3
Epigenetic modifications have a central role in transcriptional regulation. While several studies using next-generation sequencing have revealed genome-wide associations between epigenetic modifications and tr... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - March 13, 2019 Category: Genetics & Stem Cells Authors: Hiroto S. Fukushima, Hiroyuki Takeda and Ryohei Nakamura Tags: Research Source Type: research
Combined analysis of dissimilar promoter accessibility and gene expression profiles identifies tissue-specific genes and actively repressed networks
The assay for transposase-accessible chromatin (ATAC-seq) is a powerful method to examine chromatin accessibility. While many studies have reported a positive correlation between gene expression and promoter a... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 22, 2019 Category: Genetics & Stem Cells Authors: Rebekah R. Starks, Anilisa Biswas, Ashish Jain and Geetu Tuteja Tags: Research Source Type: research
Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing
Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors. It also can influence alternative splicing decisions through the... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 18, 2019 Category: Genetics & Stem Cells Authors: Elena A. Matveeva, Qamar M. H. Al-Tinawi, Eric C. Rouchka and Yvonne N. Fondufe-Mittendorf Tags: Research Source Type: research
Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states
Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted gen... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 15, 2019 Category: Genetics & Stem Cells Authors: Ren é A. M. Dirks, Guido van Mierlo, Hindrik H. D. Kerstens, Andreia S. Bernardo, Julianna Kobolák, István Bock, Julien Maruotti, Roger A. Pedersen, András Dinnyés, Martijn A. Huynen, Alice Jouneau and Hendrik Marks Tags: Research Source Type: research
Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus
DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding th... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 14, 2019 Category: Genetics & Stem Cells Authors: Jianlin He, Xiguang Xu, Aboozar Monavarfeshani, Sharmi Banerjee, Michael A. Fox and Hehuang Xie Tags: Research Source Type: research
Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups
ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-cod... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 12, 2019 Category: Genetics & Stem Cells Authors: Katherine A. Giles, Cathryn M. Gould, Qian Du, Ksenia Skvortsova, Jenny Z. Song, Madhavi P. Maddugoda, Joanna Achinger-Kawecka, Clare Stirzaker, Susan J. Clark and Phillippa C. Taberlay Tags: Research Source Type: research
Coordination between TGF- β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition
Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer propagation. It can be orchestrated by the activation of multiple signaling pathways, which have been found to be highly coordinated wi... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 8, 2019 Category: Genetics & Stem Cells Authors: Congcong Lu, Simone Sidoli, Katarzyna Kulej, Karen Ross, Cathy H. Wu and Benjamin A. Garcia Tags: Research Source Type: research
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
Wilson disease (WD) is an autosomal recessive disease caused by mutations in ATP7B encoding a copper transporter. Consequent copper accumulation results in a variable WD clinical phenotype involving hepatic, neur... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - February 1, 2019 Category: Genetics & Stem Cells Authors: Charles E. Mordaunt, Dorothy A. Kieffer, Noreene M. Shibata, Anna Cz łonkowska, Tomasz Litwin, Karl-Heinz Weiss, Yihui Zhu, Christopher L. Bowlus, Souvik Sarkar, Stewart Cooper, Yu-Jui Yvonne Wan, Mohamed R. Ali, Janine M. LaSalle and Valentina Medici Tags: Research Source Type: research
Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming
Although clinical data support an association between paternal alcohol use and deficits in child neurocognitive development, the relationship between paternal drinking and alcohol-induced growth phenotypes rem... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 22, 2019 Category: Genetics & Stem Cells Authors: Richard C. Chang, Haiqing Wang, Yudhishtar Bedi and Michael C. Golding Tags: Research Source Type: research
The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region
The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57kip2 expression is finely regulated by several epigene... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 16, 2019 Category: Genetics & Stem Cells Authors: Oriella Andresini, Marianna Nicoletta Rossi, Francesca Matteini, Stefano Petrai, Tiziana Santini and Rossella Maione Tags: Research Source Type: research
Histone H3 lysine K4 methylation and its role in learning and memory
Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying change in the underlying genomic sequence. A number of studies in animal models have shown that dy... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 7, 2019 Category: Genetics & Stem Cells Authors: Bridget E. Collins, Celeste B. Greer, Benjamin C. Coleman and J. David Sweatt Tags: Review Source Type: research
Global distribution of DNA hydroxymethylation and DNA methylation in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression. More recently, an oxidized form of 5-mC, 5-hydroxymethylcytos... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - January 7, 2019 Category: Genetics & Stem Cells Authors: Sara Wernig-Zorc, Mukesh Pratap Yadav, Pradeep Kumar Kopparapu, Mats Bemark, Hallgerdur Lind Kristjansdottir, Per-Ola Andersson, Chandrasekhar Kanduri and Meena Kanduri Tags: Research Source Type: research
