MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells
The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyan... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 9, 2019 Category: Genetics & Stem Cells Authors: Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, Stacie K. Loftus and William J. Pavan Tags: Research Source Type: research
Accurate ethnicity prediction from placental DNA methylation data
The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches t... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 9, 2019 Category: Genetics & Stem Cells Authors: Victor Yuan, E. Magda Price, Giulia Del Gobbo, Sara Mostafavi, Brian Cox, Alexandra M. Binder, Karin B. Michels, Carmen Marsit and Wendy P. Robinson Tags: Methodology Source Type: research
Identification of a pituitary ER α-activated enhancer triggering the expression of Nr5a1, the earliest gonadotrope lineage-specific transcription factor
Gonadotrope lineage differentiation is a stepwise process taking place during pituitary development. The early step of gonadotrope lineage specification is characterized by the expression of the Nr5a1 transcripti... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - August 7, 2019 Category: Genetics & Stem Cells Authors: Vincent Pacini, Florence Petit, Bruno Querat, Jean-No ël Laverriere, Joëlle Cohen-Tannoudji and David L’hôte Tags: Research Source Type: research
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macrophage distal regulatory elements
Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination and maintenance of cell identity. In macrophages, spec... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 22, 2019 Category: Genetics & Stem Cells Authors: Federica Ferri, Vanessa Petit, Vilma Barroca and Paul-Henri Romeo Tags: Research Source Type: research
Crosstalk between chromatin structure, cohesin activity and transcription
A complex interplay between chromatin and topological machineries is critical for genome architecture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its m... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 22, 2019 Category: Genetics & Stem Cells Authors: Douglas Maya-Miles, Elo ísa Andújar, Mónica Pérez-Alegre, Marina Murillo-Pineda, Marta Barrientos-Moreno, María J. Cabello-Lobato, Elena Gómez-Marín, Macarena Morillo-Huesca and Félix Prado Tags: Research Source Type: research
Disruption of nuclear speckles reduces chromatin interactions in active compartments
Nuclei of eukaryotes contain various higher-order chromatin architectures and nuclear bodies (NBs), which are critical for proper nuclear functions. Recent studies showed that active chromatin regions are asso... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 17, 2019 Category: Genetics & Stem Cells Authors: Shibin Hu, Pin Lv, Zixiang Yan and Bo Wen Tags: Research Source Type: research
Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer
Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream eff... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 17, 2019 Category: Genetics & Stem Cells Authors: Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann and Dustin E. Schones Tags: Research Source Type: research
Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence
Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes ... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 17, 2019 Category: Genetics & Stem Cells Authors: Eriko Oya, Micka ël Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli and Karl Ekwall Tags: Research Source Type: research
Peak calling by Sparse Enrichment Analysis for CUT & RUN chromatin profiling
CUT&RUN is an efficient epigenome profiling method that identifies sites of DNA binding protein enrichment genome-wide with high signal to noise and low sequencing requirements. Currently, the analysis of CUT&... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 12, 2019 Category: Genetics & Stem Cells Authors: Michael P. Meers, Dan Tenenbaum and Steven Henikoff Tags: Methodology Source Type: research
BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene tra... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 2, 2019 Category: Genetics & Stem Cells Authors: P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes and P. Grandi Tags: Research Source Type: research
H3K4me2 functions as a repressive epigenetic mark in plants
In animals, H3K4me2 and H3K4me3 are enriched at the transcription start site (TSS) and function as epigenetic marks that regulate gene transcription, but their functions in plants have not been fully character... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 2, 2019 Category: Genetics & Stem Cells Authors: Yuhao Liu, Kunpeng Liu, Liufan Yin, Yu Yu, Ji Qi, Wen-Hui Shen, Jun Zhu, Yijing Zhang and Aiwu Dong Tags: Research Source Type: research
MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL
While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. DNA methyltransferases and ten-eleven t... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - July 2, 2019 Category: Genetics & Stem Cells Authors: Candace J. Poole, Atul Lodh, Jeong-Hyeon Choi and Jan van Riggelen Tags: Research Source Type: research
PRDM14 controls X-chromosomal and global epigenetic reprogramming of H3K27me3 in migrating mouse primordial germ cells
In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a gen... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 20, 2019 Category: Genetics & Stem Cells Authors: Anna Mallol, Maria Guirola and Bernhard Payer Tags: Research Source Type: research
The histone variant H2A.Z in gene regulation
The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 14, 2019 Category: Genetics & Stem Cells Authors: Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenr öther, Sandra B. Hake and Tilman Borggrefe Tags: Review Source Type: research
Dam mutants provide improved sensitivity and spatial resolution for profiling transcription factor binding
DamID, in which a protein of interest is fused to Dam methylase, enables mapping of protein-DNA binding through readout of adenine methylation in genomic DNA. DamID offers a compelling alternative to chromati... (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - June 13, 2019 Category: Genetics & Stem Cells Authors: Tomasz Szczesnik, Joshua W. K. Ho and Richard Sherwood Tags: Methodology Source Type: research
