MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyan...

Source: Epigenetics and Chromatin - August 9, 2019 Category: Genetics & Stem Cells Authors: Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, Stacie K. Loftus and William J. Pavan Tags: Research Source Type: research